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Cold tolerance and cold hardening strategy of the Japanese pine sawyer Monochamus alternatus （Coleoptera： Cerambycidae）

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Insect Science 2008年第4期15卷 307-316页

作者： Jing Tian shu-guang Hao Wei-Na Kong Rui-yan Ma Le Kang Department of Entomology Shanxi Agncultural University Taigu Shanxi Province State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China

The Japanese pine sawyer, Monochamus alternatus, is an important pine forest pest and vector transmitting the pine wilt nematode that causes pine wilt disease. Low temperatures in autumn, winter and spring often differentially affect mortality of M. alternatus larvae. In this paper, we mainly compared the differences of mortality and cold hardening of larvae from different seasons, based on supercooling point （SCP） and cumulative probability of individuals freezing （CPIF）. The cold hardening of the larvae from autumn, winter and spring seasons were largely different. Correlations between mortality and CPIF of autumn and spring larvae were highest on day 1/4, and gradually decreased with prolonged exposure duration. This beetle＇s death mainly resulted from freezing in short exposure duration. However, the correlation between mortality and CPIF of winter larvae increased gradually with the prolonged exposure duration. Death did not mainly result from freezing in long exposure duration. Autumn larvae are more susceptible and adaptable than winter and spring larvae. Winter larvae have a slight freeze-tolerance trend. Our research showed that M. alternatus came into complex cold-hardening strategies under natural selection. Freeze avoidance is the primary strategy; with prolonged exposure duration to above SCP or 〈 0℃, chill tolerance is more important; this is followed by freeze tolerance during harsh winters.

关键词： cold acclimatization cold adaptation cold hardiness cold hardening strategy,Monochamus alternatus mortality supercooling point

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Joint offloading strategy based on quantum particle swarm optimization for MEC-enabled vehicular networks

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Digital Communications and Networks 2023年第1期9卷 56-66页

作者： Wanneng shu yan Li College of Computer Science South-Central University for NationalitiesWuhan430074China College of Science Huazhong Agricultural UniversityWuhan430070China

With the development of the mobile communication technology,a wide variety of envisioned intelligent transportation systems have emerged and put forward more stringent requirements for vehicular *** of computation-intensive and power-hungry applications result in a large amount of energy consumption and computation costs,which bring great challenges to the on-board *** is necessary to exploit traffic offloading and scheduling in vehicular networks to ensure the Quality of Experience(QoE).In this paper,a joint offloading strategy based on quantum particle swarm optimization for the Mobile Edge Computing(MEC)enabled vehicular networks is *** minimize the delay cost and energy consumption,a task execution optimization model is formulated to assign the task to the available service nodes,which includes the service vehicles and the nearby Road Side Units(RSUs).For the task offloading process via Vehicle to Vehicle(V2V)communication,a vehicle selection algorithm is introduced to obtain an optimal offloading decision ***,an improved quantum particle swarm optimization algorithm for joint offloading is proposed to optimize the task delay and energy *** maintain the diversity of the population,the crossover operator is introduced to exchange information among ***,the crossover probability is defined to improve the search ability and convergence speed of the ***,an adaptive shrinkage expansion factor is designed to improve the local search accuracy in the later *** results show that the proposed joint offloading strategy can effectively reduce the system overhead and the task completion delay under different system parameters.

关键词： Computation offloading MEC-enabled vehicular networks Mobile edge computing Task scheduling

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sDR5-Fc inhibits macrophage M1 polarization by blocking the glycolysis

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Journal of Geriatric Cardiology 2021年第4期18卷 271-280页

作者： guang-Yao ZHAI shu-yan QIE Qian-Yun GUO Yue QI Yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Department of Rehabilitation Beijing Rehabilitation Hospital of Capital Medical UniversityBeijingChina Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijingChina

BACKGROUND M1 polarization of macrophages is an important pathological process in myocardial ischemia reperfusion injury, which is the major obstacle for the treatment of acute myocardial infarction. Currently, the strategies and mechanisms of inhibiting M1 polarization are poorly explored. This study aims to investigate the role of soluble death receptor 5-Fc(s DR5-Fc) in regulating M1 polarization of macrophages under extreme conditions and explore the mechanisms from the aspect of *** Extreme conditions were induced in RAW264.7 cells. Real-time quantitative polymerase chain reaction and western blot were used to detect the expression of m RNA and proteins, respectively. Cell counting kit-8 was used to investigate the proliferation activity of cells. Expression levels of inflammatory cytokines were determined by enzyme-linked immunosorbent *** We found that s DR5-Fc rescues the proliferation of macrophages under extreme conditions, including nutrition deficiency, excessive peroxide, and ultraviolet irradiation. In addition, administration of s DR5-Fc inhibits the M1 polarization of macrophages induced by lipopolysaccharide(LPS) and interferon-gamma(IFN-γ), as the expression of M1 polarization markers CD86, CXC motif chemokine ligand 10, matrix metalloproteinase 9, and tumor necrosis factor-α, as well as the secretion of inflammatory factors interleukin(IL)-1β and IL-6, were significantly decreased. By further investigation of the mechanisms, the results showed that s DR5-Fc can recover the LPS and IFN-γ induced p H reduction, lactic acid elevation, and increased expression of hexokinase 2 and glucose transporter 1, which were markers of glycolysis in *** s DR5-Fc inhibits the M1 polarization of macrophages by blocking the glycolysis, which provides a new direction for the development of strategies in the treatment of myocardial ischemia reperfusion injury.

关键词： RNA IFN sDR5-Fc inhibits macrophage M1 polarization by blocking the glycolysis

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Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept

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Research 2022年第4期2022卷 609-620页

作者： Ming-shu Wang Yi Gong Lin-Sheng Zhuo Xing-Xing Shi yan-guang Tian Chang-Kang Huang Wei Huang guang-Fu yang Key Laboratory of Pesticide e Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Nanjing shuohui Pharmatechnology Co. Ltd.Nanjing 210046China

Conventional methods of drug design require compromise in the form of side effects to achieve sufficient efficacy because targeting drugs to specific organs remains ***,new strategies to design organ-specific drugs that induce little toxicity are *** on characteristic tissue niche-mediated drug distribution(TNMDD)and patterns of drug metabolism into specific intermediates,we propose a strategy of distribution-and metabolism-based drug design(DMBDD);through a physicochemical property-driven distribution optimization cooperated with a well-designed metabolism pathway,SH-337,a candidate potassium-competitive acid blocker(P-CAB),was ***-337 showed specific distribution in the stomach in the long term and was rapidly cleared from the systemic ***,SH-337 exerted a comparable pharmacological effect but a 3.3-fold higher no observed adverse effect level(NOAEL)compared with FDA-approved *** study contributes a proof-of-concept demonstration of DMBDD and provides a new perspective for the development of highly efficient,organ-specific drugs with low toxicity.

关键词： drugs organs Potassium

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Liobagrus chengduensis,a new species of torrent catfish(Teleostei:Siluriformes:Amblycipitidae)from the upper Changjiang River basin in southwest China

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Zoological Research 2022年第4期43卷 679-682页

作者： Zhong-guang Chen yan-shu Guo Jia-Yun Wu An-Xiang Wen College of Life Sciences Sichuan Agricultural UniversityYa’anSichuan 625014China Ecological Restoration and Conservation on Forest and Wetland Key Laboratory of Sichuan Province Sichuan Academy of Forestry SciencesChengduSichuan 610081China

DEAR EDITOR,A new torrent catfish species,Liobagrus chengduensis ***.,is described from the Xihe River,a tributary of the Minjiang River,Qionglai City,Chengdu City,Sichuan Province,*** can be distinguished from all other congeneric species by a unique combination of the following characters:3-4 serrations on posterior edge of pectoral-fin spine;anal fin with 15-16 rays;upper jaw obviously shorter than lower jaw;caudal fin rounded,with 42-44 rays;vertebral column with 36-37 post-Weberian elements;anus close to pelvic-fin insertion;adipose fin posteriorly continuous with caudal fin,with marked incision at confluence;body generally brownish yellow;all fins lacking well-defined light-colored margins,with color fading towards edge.

关键词： southwest colored insertion

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Dual-steering mode based on direct yaw moment control for multi-wheel hub motor driven vehicles:Theoretical design and experimental assessment

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Defence Technology（防务技术） 2022年第1期18卷 49-61页

作者： Zheng Zhang Xiao-jun Ma Chun-guang Liu shu-guang Wei Department of Weapons and Control Engineering Army Academy of Armored ForcesBeijing100072China

One of the main challenges for multi-wheel hub motor driven vehicles is the coordination of individual drivetrains to improve mobility and stability in the steering *** paper proposes a dual-steering mode based on direct yaw moment control for enhancing vehicle steering ability in complex environ *** control system is designed as a hierarchical structure,with a yaw moment decision layer and a driving force distribution *** the higher-level layer,the objective optimization function is con-structed to obtain the slip steering ratio,which represents the degree of vehicle slip steering in the dual-steering *** moment controller using active disturbance rejection control theory is designed for continuous yaw rate *** the actual yaw rate of the vehicle deviates from the reference yaw rate obtained by the vehicle reference model and the slip steering ratio,the yaw moment controller isactuated to determine the yaw moment demand for vehicle *** the lower-level layer,there is a torque distribution controller based on distribution rules,which meets the requirement of yaw moment demand without affecting the total longitudinal driving force of the *** verifying the validity and feasibility of the dual-steering mode,simulations were conducted on the hardware-in-loop real-time simulation ***,corresponding real vehicle tests were carried out on an eight-wheel prototype *** results were generally consistent with the simulation results,thereby demon-strating that the proposed dual-steering mode reduces steering radius and enhances the steering per-formance of the vehicle.

关键词： Multi-wheel hub motor driven vehide Dual-steering mode Direct ya w moment control Real-time simulation

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Influence of process parameters on interracial tensile strength of crosswedge rolling of 42CrMo/Q235 laminated shafts

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Journal of Iron and Steel Research International 2018年第10期25卷 1003-1009页

作者： Wen-fei Peng Chao yan Xiao Zhang Xue-dao shu guang-xing Huang Dong-ming Xu Zhejiang Provincial Key Lab of Part Rolling Technology Ningbo University Ningbo 315211 Zhejiang China Faculty of Mechanical Engineering and Mechanics NingboUniversity Ningbo 315211 Zhejiang China

Through rolling experiments and interfacial tensile strength tests of cross-wedge rolled laminated shafts of 42CrMo/Q235 composites, the influence of process parameters, including forming angle, spreading angle, area reduction, rolling temperature and core material diameter on the interfacial shear strength was analyzed. The results show that the sequence of process parameters in order of greatest influence on interfacial tensile strength was rolling temperature, area reduction, core material diameter, forming angle and spreading angle. At the interface of the combined materials, tensile strength decreased as forming angle and spreading angle increased, whereas the tensile strength first increased and then decreased as area reduction, rolling temperature and core material diameter increased.

关键词： Laminated shaft Process parameter Interfacial tensile strength Cross-wedge rolling

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What causes the absence of pulsations in Central Compact Objects in supernova remnants?

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Research in Astronomy and Astrophysics 2021年第11期21卷 243-254页

作者： Qi Wu Adriana MPires Axel Schwope guang-Cheng Xiao shu-Ping yan Li Ji Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210033China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Leibniz-Institut fur Astrophysik Potsdam(AIP) An der Sternwarte 1614482 PotsdamGermany

Most young neutron stars belonging to the class of Central Compact Objects(CCOs)in supernova remnants do not have known *** investigated seven such CCOs to understand the common reasons for the absence of detected *** use of XMM-Newton,Chandra,and NICER observations,we perform a systematic timing and spectral analysis to derive updated sensitivity limits for both periodic signals and multi-temperature spectral components that could be associated with radiation from hotspots on the neutron star *** on these limits,we then investigated for each target the allowed viewing geometry that could explain the lack of *** find that it is unlikely(<10-6)to attribute that we do not see pulsations to an unfavorable viewing geometry for five considered ***,the carbon atmosphere model,which assumes homogeneous temperature distribution on the surface,describes the spectra equally well and provides a reasonable interpretation for the absence of detected periodicities within current *** unusual properties of CCOs with respect to other young neutron stars could suggest a different evolutionary path,as that proposed for sources experiencing episodes of significant fallback accretion after the supernova event.

关键词： methods:data analysis stars:neutron X-rays:stars

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咯血的造影表现及栓塞治疗

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实用放射学杂志 2003年第7期19卷 635-637页

作者：王家平袁曙光闫东罗罡李迎春普成荣韩正林昆明医学院第二附属医院放射科DSA室昆明医学院第二附属医院放射科DSA室云南昆明650101

目的　探讨肺部疾病所致大咯血的DSA表现 ,观察栓塞治疗的疗效。方法　采用Seldinger技术行股动脉穿刺插管 ,将导管插入动脉 ,注入Omnipaque 6～ 9ml,1～ 2ml/s ,分析 84例病人出血动脉的表现。确诊后用对比剂稀释的明胶海绵颗粒 (4 0... 详细信息

目的　探讨肺部疾病所致大咯血的DSA表现 ,观察栓塞治疗的疗效。方法　采用Seldinger技术行股动脉穿刺插管 ,将导管插入动脉 ,注入Omnipaque 6～ 9ml,1～ 2ml/s ,分析 84例病人出血动脉的表现。确诊后用对比剂稀释的明胶海绵颗粒 (4 0例 )或永久栓塞 (4 4例 )进行栓塞治疗 ,62例随访 6～ 2 3 .5月。结果　 40例患者单纯用明胶海绵复发率 48% ,用永久栓塞治疗 ,复发 1例 ,复发率为 1.2 % ,栓塞材料永久栓塞剂优于单纯用明胶海绵。结论　超选择性支气管动脉栓塞是急性大咯血的有价值的治疗方法 ,尤其是当患者缺乏手术指征而药物不能有效控制大咯血时 ,并发症少

关键词：支气管动脉栓塞治疗咯血

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Real-time Quantitative RT-PCR for CT9 Level in Human Cancer

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Chemical Research in Chinese Universities 2006年第2期22卷 185-188页

作者： JIN Xiang-qun ZHANG Jing-min XU Hui ZHOU yan WANG guang-shu ZHAO yan-qiu ZHANG Han-qi College of Chemistry Jilin University Changchun 130012 P. R. China College of Phamercy Jilin University Changchun 130021 P. R. China College of Nurse Jilin University Changchun 130021 P. R. China No. 2 Affiliated Hospital Jilin University Changchun 130021 P. R. China

CT9 is a recently cloned cancer-testis antigen, which is a member of the bromodomain and extraterminal family. Each member of this protein family contains two N-terminal bromodomain motifs. We investigated the distribution of CT9 in different tissues and the possibility for it to be used as a potential therapeutic target in cancer treament. By using the real-time RT-PCR method and 18SrRNA as an internal standard, we analyzed the CT9 expression in several normal human tissues and in the tissues of patients suffering from cancer. The result of this study shows that the highest level of mRNA is only present in testis tissue because the CT9 expression has not been detected in other normal tissues. In 6 of 10 cases of gastric adenocarcinoma, in 3 of 10 cases of esophageal squamous cell carcinoma, in 2 of 9 cases of endometrial carcinoma and only in 1 of 12 cases of brain cancer, the low level expression of CT9 was detected. In none of the 12 cases of cervical squamous cell carcinoma, the expression of CT9 was detected. Since the high level expression of CT9 is only found in the normal testis tissue, but the low expression in cancer tissues, for example tissues of cervical squamous cell carcinoma, brain cancer, endometfial adenocarcinoma, esophageal squamous cell carcinoma, we conclude that CT9 cannot be used as a cancer therapeutic target molecule for cervical squamous cell carcinoma, brain cancer, endometrial adenocarcinoma, esophageal squamous cell carcinoma.

关键词： CT9 Cancer-testis antigen Real-time RT-PCR

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