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Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng ma Jin-Xin Fu feng Duan mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical School Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between march 2019 and April *** survival(OS)and progression-free survival(PFS)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

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Enhancing the Circularly Polarized Luminescence of Self-assembled Cyanostilbenes through Extended π-Conjugation

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Chinese Journal of Chemistry 2024年第2期42卷 135-141页

作者： Tongjin Lv Song Wu Yu Jin Jianfei ma Sixun Jiang Yuncong Xue feng Wang Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiAnhui 230026China Department of Thoracic Surgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Chiral supramolecular assembly of π-conjugated luminophores provides a promising avenue for enhancing circularly polarized *** this study,we shed light on the impact of π-conjugation length on circularly polarized luminescent performance of the resulting supramolecular assemblies,by designing a tetra-cyanostilbene monomeric compound alongside two dicyanostilbene control *** cyanostilbene-based compounds possess the ability to form chiral supramolecular polymers in toluene,driven by a synergistic combination of intermolecular hydrogen bonding and π-stacking *** extended π π-aromatic skeleton brings bathochromic-shifted fluorescence and enhanced intermolecular stacking capability for the tetra-cyanostilbene ***,chiral supramolecular assemblies formed by the tetra-cyanostilbene compound demonstrate a remarkable two-fold increase in g_(lum) values relative to the assemblies formed by the dicyanostilbene ***,this study provides valuable insights into the relationship between-conjugation length and the circularly polarized luminescent performance of π-conjugatedsupramolecularassemblies.

关键词： Self-assembly Supramolecular polymer Supramolecular chirality Circularly polarized luminescence Cyanostilbene πInteractions Aggregation Nanostructures

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Geochemical Anomalies Identified by Multifractal Modeling: Implications for Mineral Exploration in the Ziyoutun Cu-Au District, Jilin Province, China

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 1111-1124页

作者： ma Huchao WANG Da BAI feng LIU Meng GONG Anzhou HU Haiyan State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesBeijing 100083China School of Gemmology China University of GeosciencesBeijing 100083China Guizhou Nengda Electric Power Design Co. Ltd.Guiyang 550002China Chongqing Chuandongnan Survey&Design Institute Co. Ltd.Chongqing 400038China

The Ziyoutun Cu-Au district is located in the Jizhong–Yanbian Metallogenic Belt and possesses excellent prospects. However, the thick regolith and complex tectonic settings present challenges in terms of detecting and decomposition of weak geochemical anomalies. To address this challenge, we initially conducted a comprehensive analysis of 1:10,000-scale soil geochemical data. This analysis included multivariate statistical techniques, such as correlation analysis, R-mode cluster analysis, Q–Q plots and factor analysis. Subsequently, we decomposed the geochemical anomalies, identifying weak anomalies using spectrum-area modeling and local singularity analysis. The results indicate that the assemblage of Au-Cu-Bi-As-Sb represents the mineralization at Ziyoutun. In comparison to conventional methods, spectrumarea modeling and local singularity analysis outperform in terms of identification of anomalies. Ultimately, we considered four specific target areas(AP01, AP02, AP03 and AP04) for future exploration, based on geochemical anomalies and favorable geological factors. Within AP01 and AP02, the geochemical anomalies suggest potential mineralization at depth, whereas in AP03 and AP04 the surface anomalies require additional geological investigation. Consequently, we recommend conducting drilling, following more extensive surface fieldwork, at the first two targets and verifying surface anomalies in the last two targets. We anticipate these findings will significantly enhance future exploration in Ziyoutun.

关键词： geochemical anomalies multivariate statistical analysis spectrum-area model local singularity analysis mineral prospecting Jilin Province

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Simulation design of thin film lithium niobate electro-optic modulator with bimetallic layer electrodes

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Optoelectronics Letters 2024年第6期20卷 339-345页

作者： WU Qiulin feng Xinkai CHEN Jiaying ma Lei CHEN Huaixi LIANG Wanguo Fujian Institute of Research on the Structure of matter Chinese Academy of SciencesFuzhou 350108China University of Chinese Academy of Sciences Beijing 100059China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China1

Thin-film lithium niobate electro-optical modulator will become the key device in the future optical communication,which has the advantages of high modulation rate,low half-wave voltage,large bandwidth,and easy integration compared with conventional bulk lithium niobate ***,because the electrode gap of the lithium niobate film modulator is very narrow,when the microwave frequency gets higher,it leads to higher microwave loss,and the electro-optical performance of the modulator will be greatly ***,we propose a thin film lithium niobate electro-optic modulator with a bimetallic layer electrode structure to achieve microwave loss less than 8 dB/cm in the range of 200 GHz,exhibiting a voltage-length product of 1.1 V·cm and a 3 dB electro-optic bandwidth greater than 160 ***-speed data transmission test has been performed,showing good performance.

关键词： Simulation design of thin film lithium niobate electro-optic modulator with bimetallic layer electrodes

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Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes

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Nanotechnology and Precision Engineering 2024年第1期7卷 63-70页

作者： Jingtong Bin Kerui feng Shang ma Ke Liu Yong Cheng Jing Chen Qifa Liu College of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China

A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is *** performance of the cavity is simulated and studied *** theﬁnite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance *** modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding *** optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength *** can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole ***,the energy can be conﬁned within a small mode volume to achieve an ultra-high Q/Vm ratio.

关键词： Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation Quality factor Mode volume

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The Inheritance and Innovation of Translation Theory——The Perspective on Original Works

Journal of Social Science Development Research

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Journal of Social Science Development Research 2024年第3期2卷 72-81页

作者： shu ma Geely University of China ChengduSichuanChina

For more than a thousand years since the formation of translation as a discipline,many translation theories and different translation schools have *** exploration of translation theories has lasted for hundreds and thousands of *** translation school has proposed different translation *** the development of translation theory,discussions have always centered on the relationship between the source text and the target text,encompassing translation strategies such as foreignization and domestication,as well as methods like literal translation and free *** relationship has been the main thread running through the history of translation theory *** the 1970s,Reiss,a representative of the German functionalist school,put forward the text type *** linked the function of language with language type and text to study *** explored the different functions of various types of source texts from the perspective of text ***,in this paper,the functions and positions of the source text in translation are the central *** paper consists of two *** the first part,the history of Western translation development is divided into three periods:classical,modern,and *** uses time as a clue to analyze the changes in the position and function of the source text in *** the second part,it uses Reiss’s text type theory as a basis to analyze the extent to which the source text restricts the translator.

关键词： Translation theory Source text Target text Text type theory

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English Text Sentiment Analysis Based on Convolutional Neural Network and U-network

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第2期2卷 81-90页

作者： shu ma College of International Business Shenyang Normal UniversityNo.253 Huanghe North StreetShenyang 110034China

English text sentiment orientation analysis is a fundamental problem in the field of natural language *** traditional word segmentation method can produce ambiguity when dealing with English ***,this paper proposes a novel English text sentiment analysis based on convolutional neural network and *** proposed method uses a parallel convolution layer to learn the associations and combinations between word *** results are then input into the hierarchical attention network whose basic unit is U-network to determine the affective *** experimental results show that the accuracy of bias classification on the English review dataset reaches 93.45%.Compared with many existing sentiment analysis models,it has more accuracy.

关键词： English text sentiment Convolutional neural network U-network

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English-Chinese Neural machine Translation Based on Self-organizing mapping Neural Network and Deep Feature matching

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第3期2卷 1-8页

作者： shu ma College of International Business Shenyang Normal University No.253 Huanghe North StreetShenyang 110034China

The traditional Chinese-English translation model tends to translate some source words repeatedly,while mistakenly ignoring some ***,we propose a novel English-Chinese neural machine translation based on self-organizing mapping neural network and deep feature *** this model,word vector,two-way LSTM,2D neural network and other deep learning models are used to extract the semantic matching features of question-answer ***-organizing mapping(SOM)is used to classify and identify the sentence *** attention mechanism-based neural machine translation model is taken as the baseline *** experimental results show that this framework significantly improves the adequacy of English-Chinese machine translation and achieves better results than the traditional attention mechanism-based English-Chinese machine translation model.

关键词： Chinese-English translation model Self-organizing mapping neural network Deep feature matching Deep learning

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A Comparative Study on the Translation of Automotive marketing Texts Based on an Automotive English Corpus

Journal of Social Science Development Research

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Journal of Social Science Development Research 2024年第2期2卷 92-103页

作者： shu ma Geely University of China ChengduSichuanChina

This study aims to construct an automotive English corpus to comprehensively compare the differences between English automotive marketing texts and their Chinese *** objective is to reveal challenges and opportunities in cultural and contextual *** research holds significant importance for understanding the impact of cross-cultural communication in the automotive market and providing more effective translation strategies for multinational automotive *** corpus analysis,focusing on common marketing phrases and text features,employing both quantitative and qualitative analysis methods,and examining the accuracy,naturalness,and cultural adaptability of translated texts,we delve into the similarities and differences in conveying automotive information between the two *** study finds that expressive and emotional expressions commonly used in English automotive contexts may encounter challenges in Chinese translations due to language and cultural *** necessitates the adoption of more flexible translation ***,Chinese translations tend to emphasize the practicality and safety of products more than their English counterparts,placing a greater emphasis on technical and functional *** primary conclusion of this research is that the translation of automotive marketing texts requires heightened cross-cultural sensitivity and an understanding of the target *** translating automotive advertisements and promotions,translators should consider consumer expectations and cultural values in different contexts to ensure the effectiveness and adaptability of the ***,the formulation of more flexible translation strategies,integrating local culture and market demands,will contribute to enhancing the image and influence of automotive brands in the international *** this study,we provide deeper insights for automotive manufacturers,assisting them in lever

关键词： English corpus marketing texts translation of automotive advertisements

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Achieving strength-ductility synergy in novel paramagnetic Fe-based medium-entropy alloys through deep cryogenic deformation

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Rare Metals 2024年第9期43卷 4493-4507页

作者： Hu-Wen ma Yan-Chun Zhao Li feng Tian-Zeng Liu Zhi-Qi Yu Bo Jin Wang-Chun Duan Peter K.Liaw Dong ma State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of TechnologyWenzhou 325105China Iron and Steel Research Institute Jiuquan Iron and Steel CorporationJiayuguan 735100China Lanzhou Resources and Environment Voc-Tech University Lanzhou 730123China Department of materials Science and Engineering The University of TennesseeKnoxvilleTN 37996-2200USA Neutron Science Center Songshan Lake Materials LaboratoryDongguan 523808China

Cryogenic pre-deformation treatment has been widely used to effectively improve the comprehensive mechanical properties of steels and novel ***,the dislocation evolution and phase transformation induced by different degrees of deep cryogenic deformation are not yet fully *** this study,the effects of multiple cryogenic pre-treatments on the mechanical properties and deformation mechanisms of a paramagnetic Fe_(63.3)Mn_(14-)Si_(9.1)Cr_(9.8)C_(3.8)medium-entropy alloy(MEA)were investigated,leading to the discovery of a pretreated MEA that exhibits exceptional mechanical properties,including a fracture strength of 3.0 GPa,plastic strain of 26.1%and work-hardening index of *** addition,X-ray diffraction(XRD)and transmission electron microscopy(TEM)analyses revealed that multiple cryogenic pre-deformation treatments significantly increased the dislocation density of the MEA(from 9×10^(15)to 4×10^(16)m^(-2)after three pretreatments),along with a transition in the dislocation type from predominantly edge dislocations to mixed dislocations(including screw-and edge-type dislocations).Notably,this pretreated MEA retained its paramagnetic properties(μ_(r)mately four(i.e.,from 9.7 to2.6 m J·m^(-2)),thereby activating the synergistic effects of transformation-induced plasticity,twinning-induced plasticity and dislocation strengthening *** synergistic effects lead to simultaneous strength and ductility enhancement of the MEA.

关键词： Deep cryogenic transformation Iron-based medium-entropy alloys Dislocation evolution Phase transformation Stacking fault energy

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