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Obesity, metabolic abnormalities, and mortality in older men

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Journal of Geriatric Cardiology 2018年第6期15卷 422-427页

作者： Rong zhang Sheng-Yong DONG Wei-Min WANG shu-Yang fei Hang XIANG Qiang ZENG Health Management Institute Chinese PLA General Hospital Beijing China Department of Cardiology Chinese Navy General Hospital Beijing China Healtheare Department Agency for Offices Administration of PLA Beijing China Department of Clinical Medicine School of Preclinical Medicine Capital University of Medical Sciences Beijing China

Background Older adults are prone to obesity and metabolic abnormalities and recommended to pursue a normal weight especially when obesity and metabolic abnormalities are co-existed. However, few studies have reported the possible differences in the effect of obesity on outcomes between older adults with metabolic abnormalities and those without metabolic abnormalities. Methods A total of 3485 older men were included from 2000 to 2014. All-cause mortality and cardiovascular mortality were obtained during a mean follow-up of five years Metabolic abnormalities were defined as having established hypertension, diabetes, or dyslipidemia and taking the disease-related medications. All participants were stratified by the presence or absence of metabolic abnormalities. Results In the non-metabolic abnormalities group, all-cause and cardiovascular deaths were lowest in overweight participants and highest in obese participants. In the metabolic abnormalities group, mortality was also lowest in overweight participants but highest in participants with normal weight. After adjustment for covariates, hazard ratios （95% CI） for all-cause death and cardiovascular death were 0.68 （0.51, 0.92） and 0.59 （0.37, 0.93）, respectively, in overweight participants with metabolic abnormalities. Furthermore, obesity was not associated with mortality risk in both groups. These findings were unchanged in stratified analyses. Conclusions Overweight was negatively associated with mortality risk in older men with metabolic abnormalities but not in those without metabolic abnormalities. Obesity did not increase death risk regardless of metabolic abnormalities. These findings suggest that the recommendation of pursuing a normal weight may be wrong in overweight/obese older men, especially for those with metabolic abnormalities.

关键词： Obesity Older men Metabolic abnormality Mortality

Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

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Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-fei Sun Xu zhang shu-Ping Song Ya-Qun Yao Yan zhang Cheng-Liang Wang Jing-Jiang Sun Qing-Fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

Agent's Optimal Compensation Under Inflation Risk by Using Dynamic Contract Model

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Journal of Systems Science & Complexity 2021年第6期34卷 2291-2309页

作者： fei Chen fei Weiyin zhang Fanhong YANG Xiaoguang School of Business University of Shanghai for Science and TechnologyShanghai 200093China School of Mathematics-Physics and Finance Anhui Polytechnic UniversityWuhu 241000China School of Mathematics Shanghai University of Finance and EconomicsShanghai 200433China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

This paper studies the problem of principal-agent with moral hazard in continuous *** firm’s cash flow is described by geometric Brownian motion(hereafter GBM).The agent affects the drift of the firm’s cash flow by her hidden ***,the firm rewards the agent with corresponding compensation and equity which depend on the *** model extends dynamic optimal contract theory to an inflation ***,the authors obtain the dynamic equation of the firm’s real cash flow under inflation by using the It?***,the authors use the martingale representation theorem to obtain agent’s continuation value ***,the authors derive the Hamilton-Jacobi-Bellman(HJB)equation of investor’s value process,from which the authors derive the investors’scaled value function by solving the second-order ordinary differential *** with He;,the authors find that inflation risk affects the agent’s optimal compensation depending on the firm’s position in the market.

关键词： Equity incentive inflation risk It?formula principal-agent problem the martingale representation theorem

Bimetallic water oxidation: One-site catalysis with two-sites oxidation

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Journal of Energy Chemistry 2021年第12期30卷 1-7,I0001页

作者： fei Xie Ming-Tian zhang Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084China

Water oxidation is the key half reaction to achieve full splitting of water to hydrogen and ***,a binuclear complex,[(L^(4-))Co_(2)~Ⅲ(OH)]ClO_(4),was reported as a stable and efficient homogenous catalyst for electrocatalytic water oxidation in 0.1 M phosphate buffer(pH 7.0).Cyclic voltammetry experiments indicated that the catalytic process proceed via "one-site catalysis with two-sites oxidation" mechanism in which both two metal sites store the required oxidation equivalents for water oxidation and O-O bond formation occurs by single-site water nucleophilic attack(WNA).

关键词： Water oxidation Bimetallic catalysis O-O bond formation Cobalt catalyst Oxygen evolution

Analyses of mechanically-assembled 3D spiral mesostructures with applications as tunable inductors

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Science China(Technological Sciences) 2019年第2期62卷 243-251页

作者： zhang Fan LIU fei zhang YiHui Key Laboratory of Applied Mechanics of Ministry of Education Department of Engineering Mechanics Tsinghua University Center for Flexible Electronics Technology and Center for Mechanics and Materials Tsinghua University

Mechanically-guided assembly allows the formation of 3D spiral-shaped inductors through controlled buckling, which could provide an increased quality(Q) factor and broadened working angle in near field communication, as compared to the planar design. An understanding of the microstructure-property relationship is essential in the design optimization of the assembly process. This work presents a theoretical model to analyze the deformations during the assembly of the 3D spiral-shaped mesostructure from a bilayer precursor that consists of a supporting ribbon and a 2D coil on its top. As validated by both the experiments and finite element analyses(FEA), this mechanics model allows accurate predictions of the assembled 3D configurations. In combination of electromagnetic simulations, we investigated the effects of various key design parameters on the final 3D configuration and the Q factor when operated as an inductor. The results suggest a significant role of the gravity effect on the assembled spiral configuration, especially for flexible coil designs with relative small cross-sectional areas or long *** study can serve as a reference for the design of spiral-shaped 3D inductors in different device applications.

关键词： 3D assembly modeling buckling multilayer tunable inductor

Forecast for weighing neutrinos in cosmology with SKA

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Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 53-60页

作者： Jing-fei zhang Bo Wang Xin zhang Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Ministry of Education’s Key Laboratory of Data Analytics and Optimization for Smart Industry Northeastern UniversityShenyang 110819China Center for High Energy Physics Peking UniversityBeijing 100080China

We investigate what role the SKA neutral hydrogen(HI)intensity mapping(IM)and galaxy sky surveys will play in weighing neutrinos in *** use the simulated data of the baryon acoustic oscillation(BAO)measurements from the HI surveys based on SKA1(IM)and SKA2(galaxy)to do the *** the current observations,we use the Planck 2015 cosmic microwave background(CMB)anisotropies observation,the optical BAO measurements,the type Ia supernovae(SN)observation(Pantheon compilation),and the latest H0 *** consider three mass ordering cases for massive neutrinos,i.e.,the normal hierarchy(NH),inverted hierarchy(IH),and degenerate hierarchy(DH)*** is found that the SKA observation can significantly improve the constraints on?m and *** to the current observation,the SKA1 data can improve the constraints on?m by about 33%,and on H0 by about 36%;the SKA2 data can improve the constraints on?m by about 58%,and on H0 by about 66%.It is also found that the SKA observation can only slightly improve the constraints on∑mν.Compared to the current observation,the SKA1 data can improve the constraints on∑mνby about 4%,3%,and 10%,for the NH,IH,and DH cases,respectively;the SKA2 data can improve the constraints on∑mνby about 7%,7%,and 16%,for the NH,IH,and DH cases,respectively.

关键词： 21 cm observation intensity mapping survey Square Kilometre Array baryon acoustic oscillations neutrino mass

Global Well-posedness for gKdV-3 in Sobolev Spaces of Negative Index

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Acta Mathematica Sinica,English Series 2008年第5期24卷 857-866页

作者： Zhi fei zhang School of Mathematical Science Peking University Beijing 100871 P. R. China

The initial value problem for the generalized Korteweg-deVries equation of order three on the line is shown to be globally well posed for rough data. Our proof is based on the multilinear estimate and the I-method int... 详细信息

关键词： KdV equation Global well posedness I-method Multilinear estimate

EBSD parameter assessment and constitutive models of crept HR3C austenitic steel

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Journal of Iron and Steel Research International 2023年第4期30卷 772-781页

作者： Jie zhang Zheng-fei Hu Zhen zhang Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167JiangsuChina

Creep damage and evolution of HR3C steel at 650℃ were investigated using electron backscatter diffraction(EBSD),and EBSD-based parameter assessments were *** analyses show that the grain size is almost unchanged and no obvious texture formed after creep at different creep *** lowest proportion of low Σ coincidence site lattice grain boundaries under 150 MPa implies that the primary twin structures are preserved under the low stress level,while some twin structures evolved into general grain boundaries at the high creep *** main damage features of microcracks and cavities can be seen along the grain boundaries:the former emerged at higher stress levels,while the latter appeared at the lower stress level,and both were shown under medium *** contrast shows that the most severe creep damage is present at 170 *** implies that the creep mechanism differs distinctly under different stress levels,and the transition point is around 170 *** average misorientation is better to describe the local plastic deformation related to the strain distribution while grain reference orientation deviation describes the inhomogeneous strain *** lifetime prediction models including the isothermal method,Larson-Miller parameter method and Monkman–Grant relation were evaluated by the experimental data and literature data,and they are valid for predicting creep behavior.

关键词： Austenitic heat-resistant steel Creep damage Electron backscatter diffraction Creep constitutive model Creep lifetime prediction

Solution of Semi-Boundless Mixed Problem for Time-fractional Telegraph Equation

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Acta Mathematicae Applicatae Sinica 2007年第4期23卷 611-618页

作者： shu-qin zhang Department of Mathematics China University of Mining and Technology Beijing 100083 China

In this paper, we study the semi-boundless mixed problem for time-fractional telegraph equation. We are able to use the integral transform method （the Fourier sin and cos transforms） to obtain the solution.

关键词： Time-fractional telegraph equation the Fourier sin and cos transforms mittag-leffier function,H-function