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(NH4)3B11PO19F3: a deep-UV nonlinear optical crystal with unique [B5PO10F]∞ layers

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National Science Review 2022年第8期9卷 138-143页

作者： Bingliang Cheng Zijian Li Yu chu Abudukadi Tudi Miriding Mutailipu Fangfang Zhang Zhihua Yang Shilie Pan CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics and Chemistry of Chinese Academy of Sciences Xinjiang Key Laboratory of Electronic Information Materials and Devices Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Deep-ultraviolet（DUV） nonlinear optical（NLO） crystals that can extend the output range of coherent light below 200 nm are pivotal materials for solid-state lasers. To date, KBe2BO3F2（KBBF） is the only usable crystal that can generate DUV coherent light by direct second harmonic generation（SHG）, but the layered growth habit and toxic ingredients limit its application. Herein, we report a new fluoroborophosphate,（NH4）3B11PO19F3（ABPF）, containing four different functional units: [BO3],[BO4], [BO3F] and [PO4]. ABPF exhibits a KBBF-like structure while eliminating the limitations of KBBF crystal. The unique [B5PO10F]∞layers enhance ABPF's performance; for example, it has a large SHG response（1.2 × KDP） and a sufficient birefringence（0.088 at 1064 nm） that enables the shortest phase-matching wavelength to reach the DUV region. Meanwhile, the introduction of strong B-O-P covalent bonds decreases the layered growth habit. These findings will enrich the structural chemistry of fluoroborophosphate and contribute to the discovery of more excellent DUV NLO crystals.

关键词： deep-ultraviolet nonlinear optical materials KBBF-like structure fluoroborophosphate

Eight Zhes Decoction ameliorates the lipid dysfunction of nonalcoholic fatty liver disease using integrated lipidomics, network pharmacology and pharmacokinetics

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1058-1069页

作者： Yuping Zhou Ze Dai Kaili Deng Yubin Wang Jiamin Ying Donghui chu Jinyue Zhou chunlan Tang The First Affiliated Hospital of Ningbo University NingboZhejiang315020China School of Public Health Health Science CenterNingbo UniversityNingboZhejiang315211China Institute of Digestive Disease of Ningbo University NingboZhejiang315020China

Nonalcoholic fatty liver disease(NAFLD)has developed into the most common chronic liver disease and can lead to liver *** laboratory previously developed a novel prescription for NAFLD,“Eight Zhes Decoction”(EZD),which has shown good curative effects in clinical ***,the pharmacodynamic material basis and mechanism have not yet been revealed.A strategy integrating lipidomics,network pharmacology and pharmacokinetics was used to reveal the active components and mechanisms of EZD against *** histopathological results showed that EZD attenuated the degrees of collagen deposition and steatosis in the livers of nonalcoholic steatofibrosis model ***,glycerophospholipid metabolism,arachidonic acid metabolism,glycerolipid metabolism and linoleic acid metabolism with phospholipase A2 group IVA(PLA2G4A)and cytochrome P450 as the core targets and 12,13-cis-epoxyoctadecenoic acid,12(S)-hydroxyeicosatetraenoic acid,leukotriene B4,prostaglandin E2,phosphatidylcholines(PCs)and triacylglycerols(TGs)as the main lipids were found to be involved in the treatment of NAFLD by ***,naringenin,artemetin,canadine,and bicuculline were identified as the active ingredients of EZD against NAFLD;in particular,naringenin reduces PC consumption by inhibiting the expression of PLA2G4A and thus promotes sufficient synthesis of very-low-density lipoprotein to transport excess TGs in the *** research provides valuable data and theoretical support for the application of EZD against NAFLD.

关键词： Eight Zhes Decoction Nonalcoholic fatty liver disease Lipidomics Network pharmacology Pharmacokinetics

The role of exosomes in the pathogenesis of Alzheimer’disease

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Translational Neurodegeneration 2017年第1期6卷 14-19页

作者： Tingting Xiao Weiwei Zhang Bin Jiao chu-Zheng Pan Xixi Liu Lu Shen Department of Neurology Xiangya HospitalCentral South UniversityChangshaChina State Key Laboratory of Medical Genetics ChangshaChina Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangshaChina

Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on nerve development,activation and *** addition,exosomes have been observed to be involved in spreading pathological misfolded proteins,thereby leading to the onset and propagation of *** disease(AD)is the most common form of dementia and characterized by two types of lesions:amyloid plaques and neurofibrillary *** evidence has demonstrated that exosomes are associated with amyloid precursor(APP)and Tau proteins and play a controversial role in Alzheimer’s disease *** this review,we will discuss the role of exosomes in the metabolism and secretion of APP and Tau proteins and their subsequent impact on AD pathogenesis.

关键词： Alzheimer pathogenesis metabolism

Resistive-type sensors based on few-layer MXene and SnO_(2)hollow spheres heterojunctions:Facile synthesis,ethanol sensing performances

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中国化学快报:英文版 2023年第8期34卷 502-507页

作者： Lihua chu Hao Yan Wanfeng Xie Yuxin Shi Muhammad Hilal Changxu Sun Ze Li Meicheng Li School of New Energy North China Electric Power UniversityBeijing 102206China College of Electronics and Information University-Industry Joint Center for Ocean Observation and Broadband CommunicationQingdao UniversityQingdao 266071China Department of Physics Dongguk UniversitySeoul 04620Republic of Korea

High-performance and low-cost gas sensors are highly desirable and involved in industrial production and environmental *** combination of highly conductive MXene and metal oxide materials is a promising strategy to further improve the sensing *** this study,the hollow SnO_(2)nanospheres and few-layer MXene are assembled rationally via facile electrostatic synthesis processes,then the SnO_(2)/Ti_(3)C_(2)T_(x)nanocomposites were *** with that based on either pure SnO_(2)nanoparticles or hollow nanospheres of SnO_(2),the SnO_(2)/Ti_(3)C_(2)T_(x)composite-based sensor exhibits much better sensing performances such as higher response(36.979),faster response time(5 s),and much improved selectivity as well as stability(15 days)to 100ppm C2H5OH at low working temperature(200°C).The improved sensing performances are mainly attributed to the large specific surface area and significantly increased oxygen vacancy concentration,which provides a large number of active sites for gas adsorption and surface catalytic *** addition,the heterostructure interfaces between SnO_(2)hollow spheres and MXene layers are beneficial to gas sensing behaviors due to the synergistic effect.

关键词： Heterostructure Few-layer MXene SnO_(2)hollow spheres Ethanol sensor Synergistic effect SnO_(2)/Ti_(3)C_(2)T_(x)composites

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两种合成活性肽对肉鸡免疫功能的影响研究

中国畜牧杂志 2016年第11期52卷 55-59页

作者：刘斌单虎张传美初欢欢王述柏青岛农业大学动物科技学院山东青岛266109

本试验旨在研究两种合成活性肽对肉鸡免疫功能的影响。1440只1 d AA肉鸡随机分为8个处理,设置2个对照组(空白对照组及杆菌肽锌组),试验组饮水供给两种肽(均设置3个剂量:10、20、40μg/kg体重),每组设6个重复,试验期42 d。结果表明:40μg... 详细信息

本试验旨在研究两种合成活性肽对肉鸡免疫功能的影响。1440只1 d AA肉鸡随机分为8个处理,设置2个对照组(空白对照组及杆菌肽锌组),试验组饮水供给两种肽(均设置3个剂量:10、20、40μg/kg体重),每组设6个重复,试验期42 d。结果表明:40μg/kg体重肽I和肽Ⅱ可显著提高21 d肉鸡血清新城疫抗体效价(P<0.05),显著提高21、42 d鸡血清Ig G水平(P<0.05);3个剂量肽I可显著提高血清Ig M水平(P<0.05),40μg/kg体重肽Ⅱ对42 d鸡亦有此作用(P<0.05)。21 d时各试验组血清IL-2含量均显著高于两个对照组(P<0.05或P<0.01),42 d时40μg/kg体重肽I组和肽Ⅱ组血清IL-2及IFN-r含量显著提高(P<0.01或P<0.05)。40μg/kg体重肽I和肽Ⅱ可显著提高42 d鸡血清溶菌酶含量(P<0.05),40μg/kg体重肽I可显著21 d鸡血清补体C3含量(P<0.05)。20μg/kg体重肽Ⅱ和肽I分别显著提高了21 d鸡法氏囊指数和42 d鸡胸腺指数(P<0.05)。可见,2种合成活性肽均有提高肉鸡免疫功能活性,均以饮水供给40μg/kg体重效果最好。

关键词：活性肽肉鸡免疫功能

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基于卷积长短时网络的调制识别技术研究

电子信息对抗技术 2024年第4期39卷 56-63页

作者：曹九霄朱锐邬伶凤褚鹏赵康西京学院电子信息学院西安710123

随着深度学习的发展,更多的研究者将调制方式识别与深度学习网络结合,充分利用了神经网络无需先验信息的特点,促进了自动调制识别(Automatic Modulation Recognition, AMR)技术的发展。但是AMR技术存在低信噪比下泛化能力有限,分类精度... 详细信息

随着深度学习的发展,更多的研究者将调制方式识别与深度学习网络结合,充分利用了神经网络无需先验信息的特点,促进了自动调制识别(Automatic Modulation Recognition, AMR)技术的发展。但是AMR技术存在低信噪比下泛化能力有限,分类精度不高的问题,提出了一种由卷积神经网络(Convolutional Neural Network, CNN),长短时记忆(Long Short-Term Memory, LSTM)网络和深度神经网络组成的模型-卷积长短时深度神经网络(Convolutional Long Short-Term Deep Neural Networks, CLDNN)。将预处理的数据集通过CNN对信号进行空间特征提取,再通过LSTM模块对数据集进行时间特征提取,最后通过全连接层对数据集分类。实验结果表明,CLDNN模型相对于主流使用的残差网络(Residual Network, ResNet)模型、CNN模型等在性能上有显著的提高,在信噪比为30 dB时保持93.09%的高效识别,在信噪比为-10 dB时,实现54.32%的有效识别。

关键词：调制方式识别深度学习网络长短时记忆网络时间特征提取

Bi_(2)S_(3) Nanotubes:Facile Synthesis and Growth Mechanism

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Nano Research 2009年第2期2卷 130-134页

作者： Dingsheng Wang Chenhui Hao Wen Zheng Xiaoling Ma Deren chu Qing Peng Yadong Li Department of Chemistry Tsinghua UniversityBeijing 100084China

Synthesis of tubular nanomaterials has become a prolific area of investigation due to their wide range of applications.A facile solution-based method has been designed to fabricate uniform Bi_(2)S_(3)nanotubes with average size of 20 nm×160 nm using only bismuth nitrate(Bi(NO_(3))_(3)·5H_(2)O)and sulfur powder(S)as the reactants and octadecylamine(ODA)as the *** X-ray diffraction(XRD),transmission electron microscopy(TEM),high-resolution TEM(HRTEM),and energy dispersive spectroscopy(EDX)experiments were employed to characterize the resulting Bi_(2)S_(3)nanotubes and the classic rolling mechanism was applied to explain their formation process.

关键词： Bi_(2)S_(3) nanotubes solution-based synthesis rolling mechanism

天然矿物材料的多孔结构、结构组装和光催化性能

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地学前缘 2005年第1期12卷 188-195页

作者：传秀云卢先初龚平北京大学地球和空间科学学院北京100871

自然界存在丰富的多孔矿物资源,其孔隙结构使其具有良好的吸附性能,能够吸附聚集水体中的污染物(特别是有机污染物)。在分析天然多孔矿物的孔结构基础上,文中提出了结构组装的概念,即在多孔矿物中进行功能粒子组装,对多孔矿物进行表面... 详细信息

自然界存在丰富的多孔矿物资源,其孔隙结构使其具有良好的吸附性能,能够吸附聚集水体中的污染物(特别是有机污染物)。在分析天然多孔矿物的孔结构基础上,文中提出了结构组装的概念,即在多孔矿物中进行功能粒子组装,对多孔矿物进行表面修饰、微结构组装(如层状结构矿物的插层)。通过结构组装,在多孔矿物中引进功能粒子(如有光催化性能的TiO2 颗粒)。组装在天然矿物中的功能粒子能够降解聚集在其中的污染物,大幅度提高功能粒子的效果,提高光催化降解的功效,获得性能优异、成本低廉的天然矿物型有机污染物降解材料。此外,在同一矿物材料中复合小孔、中孔、大孔不同大小的孔结构,实现不同大小的孔径组装,也能够扩大光催化剂TiO2 的承载面积,提高吸附性能。经过结构组装的天然多孔矿物材料复合了吸附、光催化等性能,在环境治理特别是有机物污染降解方面有很好的应用价值。

关键词：多孔矿物 TiO2 锐钛矿光催化剂载体

hs-CRP、HOMA-IR、SHBG与多囊卵巢综合征合并不孕症病情和预后的相关性

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中国性科学 2024年第3期33卷 62-66页

作者：徐晖储成美王德琴徐晓英海安市人民医院妇科江苏海安226600 海安市人民医院内分泌科江苏海安226600

目的探讨超敏C-反应蛋白(hs-CRP)、稳态模型胰岛素抵抗指数(HOMA-IR)、性激素结合球蛋白(SHBG)与多囊卵巢综合征(PCOS)合并不孕症患者病情和预后的相关性。方法选取2020年1月至2022年2月海安市人民医院收治的158例PCOS患者作为研究对象... 详细信息

目的探讨超敏C-反应蛋白(hs-CRP)、稳态模型胰岛素抵抗指数(HOMA-IR)、性激素结合球蛋白(SHBG)与多囊卵巢综合征(PCOS)合并不孕症患者病情和预后的相关性。方法选取2020年1月至2022年2月海安市人民医院收治的158例PCOS患者作为研究对象。根据子宫内膜容受性(ERT)检测结果分为容受性良好组和容受性不良组,根据促排卵治疗1年后是否受孕分为预后良好组和预后不良组。分析影响PCOS合并不孕症的高危因素;比较不同ERT和预后的hs-CRP、HOMA-IR和SHBG水平;分析PCOS合并不孕症hs-CRP、HOMA-IR、SHBG与体重指数(BMI)、甘油三酯葡萄糖指数(TyG)和抗米勒管激素(AMH)的相关性,绘制受试者工作特征(ROC)曲线分析hs-CRP、HOMA-IR和SHBG的评估效能。结果容受性不良组的hs-CRP和HOMA-IR水平显著高于容受性良好组,SHBG水平显著低于容受性良好组(P<0.05);预后不良组的hs-CRP和HOMA-IR水平显著高于预后良好组,SHBG水平显著低于预后良好组(P<0.05)。Pearson分析显示,PCOS合并不孕症的hs-CRP、HOMA-IR与BMI、TyG呈正相关,与AMH呈负相关(P<0.05);SHBG与AMH呈正相关,与BMI、TyG呈负相关(P<0.05)。ROC曲线显示,hs-CRP、HOMA-IR和SHBG联合诊断PCOS合并不孕症的曲线下面积、灵敏度、特异度均高于任一单项效能(P<0.05)。结论hs-CRP、HOMA-IR和SHBG联合检测对PCOS合并不孕症的病情和预后的评估价值较高。

关键词：多囊卵巢综合征不孕症超敏C-反应蛋白稳态模型胰岛素抵抗指数性激素结合球蛋白评估价值