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Hysteroscopic Appearence of Midsecretory Endometrium in Relation to Pinopodes Expression and the Reproductive Outcome in Infertile Women

中华医学会第十次全国妇产科学术会议妇科内镜会场（妇科内镜学组）

作者： Huan xiao Zhang shu qin Chen Hong ye Jiang shu zhong yao The first affiliated hospital of Sun Yat-sen university

Purpose Primary amenorrhea caused by separation of the cervix from uterine body resulting from closed pelvic fracture is exceptionally *** purpose of this case report is to describe the diagnosis and successful laparoscopic approximation of traumatic separation of the cervix from the uterine corpus. Methods A 16-years girl with primary amenorrhea and cyclic abdominal pain was referred to our hospital. She had a car accident at the age of 2 years which resulted in closed pelvic fracture.A conservative

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Journal of Reproduction and Contraception 2010年第1期21卷 17-26页

作者： Su-chun LI Ping PAN shu-zhong yao Miao FENG Jie-hua WU Yun SU Biao-ying LIU Department of Gynecology Family Planning Research Institute of Guangdong Province Guangzhou 510600 China First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China

Objective To investigate the relation between hysteroscopic finding and pinopodes expression, meanwhile to explore whether hysteroscopic finding was a predictor of reproductive outcome for infertile women. Methods A total of 79 infertile patients underwent hysteroscopic assessement of the midsecretory endometrium and hormonal measurement 7 9 d after a spontaneous ovulation assessed with transvaginal ultrasound. Pinopodes expression by scanning electron microscope was examined simultaneously in randomly selected 32 patients. All patients were followed up to determine their reproductive outcomes. Results Twenty-six （32.9%） patients were diagnosed as having ＇good＇ midsecretory endometrium and 53 （67.1%） as ＇poor＇ midsecretory endometrium by hysteroscopy. There were no significant differences of endometrial thickness and pattern in the ＇good＇ group compared with the ＇poor＇ group. Serum progesterone level in the ＂good＇ group was apparently higher than that in the ＇poor＇ group （P=0.025）, but no correlation was observed between serum oestradiol level and hysteroscopic finding. Significant differences of the development stage and number of pinopodes were observed between the two groups （P〈O.05）. The pregnancy rate was significantly higher in the ＇good＇ group （53.9%） than in the ＇poor＇ group （26.4%）（P=O.O17）. Conclusion The hysteroscopic appearance of the midsecretory endometrium is associated with serum progesterone level and pinopodes expression, which provides prognostic information with regard to the reproductive outcome of infertile women.

关键词： infertility hysteroscopy midsecretory endometrium pinopodes

脂肪酸分子印迹对sol-gel固定化脂肪酶酯化活性和胶体结构的影响

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分子催化 2010年第1期24卷 77-81页

作者：杨江科曹雄文舒钟瑶分子生物物理教育部重点实验室、华中科技大学生命科学与技术学院武汉430074

基于sol-gel工艺的生物印迹对提高脂肪酶在非水相体系中的活性,扩大其应用范围具有重要作用.本研究以乙烯基三甲氧基硅烷(VTMOS)和四甲氧基硅烷(TMOS)为前趋体,系统考察了脂肪酸印迹分子对sol-gel脂肪酶固定化率和活性的影响,获得了最... 详细信息

基于sol-gel工艺的生物印迹对提高脂肪酶在非水相体系中的活性,扩大其应用范围具有重要作用.本研究以乙烯基三甲氧基硅烷(VTMOS)和四甲氧基硅烷(TMOS)为前趋体,系统考察了脂肪酸印迹分子对sol-gel脂肪酶固定化率和活性的影响,获得了最优的工艺条件.当VTMOS/TMOS为7∶1时,印迹后脂肪酶的比酶活和总酶活分别达到3311.0μmol/h/mg和2506.9μmol/h/gGel,比未印迹同摩尔比的固定化脂肪酶分别提高了2.06和1.79倍.系统考察了脂肪酸生物印迹效应和胶体结构对固定化酶表观活性的影响.氮气吸附—解吸附分析和扫描电镜观察表明,随着脂肪酸分子的参入,固定化脂肪酶颗粒平均孔径增大,对底物的传质阻力逐渐降低,但比表面积和孔体积的变化并不显著;印迹酶平均颗粒直径明显减小,各有机硅烷单体之间的成键能力减弱.表明脂肪酶活性的增加主要来源于疏水性脂肪酸侧链引起的脂肪酶的界面激活效应(生物印迹效应),同时固定化颗粒孔径的改变增加了底物和酶分子的结合,提高了固定化酶的表观活性.

关键词：脂肪酶脂肪酸分子印迹界面激活孔径

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通海海菜花的核型研究

陕西师范大学学报（自然科学版） 2001年第S1期29卷 84-87页

作者：翟书华姚忠庆邹晓菊昆明高等师范专科学校生物系云南昆明650031

首次报道产于我国云南省的通海海菜花 (*** .Li)的体细胞染色体数目和核型 ( 2n =2x =2 2 =1 8m + 2sm + 2st) .属“2B”型 ,与海菜花属 (Ottelia)的核型非常相近。

关键词：通海海菜花海菜花染色体核型

Posttraumatic stress symptoms among Chinese university students during the COVID-19 pandemic:Prevalence,correlates,and mental health help-seeking

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World Journal of Psychiatry 2025年第1期15卷 145-152页

作者： Rui-yao Wu Lin-Feng Ge Bao-Liang zhong Department of Psychiatry The Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430012Hubei ProvinceChina Department of Psychiatry Wuhan Mental Health CenterWuhan 430012Hubei ProvinceChina

BACKGROUND Revisiting the epidemiology of posttraumatic stress symptoms(PTSSs)among university students during the coronavirus disease 2019(COVID-19)pandemic as well as understanding the mental health help-seeking behavior of individuals with PTSSs has critical implications for public mental health strategies in future medical *** To investigate the prevalence and correlates of PTSSs among university students during the first wave of the COVID-19 pandemic in China and to examine mental health help-seeking behaviors among these *** A total of 2507 Chinese university students were recruited via snowball *** students completed the Seven-item Screening Scale for Post-traumatic Stress Disorder during the first wave of the COVID-19 pandemic in ***-graphic characteristics,pandemic-related characteristics,and mental health help-seeking behaviors of students with PTSSs were also *** The prevalence of PTSSs among the participants was 28.0%.Seven significant correlates of PTSSs were identified(odds ratio=1.23-3.65,P≤0.024):Female sex,being 19 years old or older,living with others or alone,a low level of family economic status,fair or poor interpersonal relationships,severe or very severe local pandemic,and having family members diagnosed with ***,only 3.28%of the students with PTSSs reported seeking help from mental health *** the 23 students who sought help from mental health specialists,13 opted for online or telephone-based psychological *** Our data suggest that there was a high risk of PTSSs among university students and a high level of unmet mental health needs during the COVID-19 *** delivery of mental health services online or via telephone is a promising approach to address these unmet needs.

关键词： Posttraumatic stress symptoms University students COVID-19 Mental health help-seeking China

Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

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Nano Research 2025年第1期18卷 628-641页

作者： Min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi yao He Yiling zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

综放工作面停采回撤封闭期间防灭火技术应用研究

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山东煤炭科技 2016年第12期34卷 89-90,93页

作者：张宁刘淑金仲耀龙岩学院福建龙岩364012 兖州煤业股份有限公司鲍店煤矿山东邹城273500

本文结合某矿综放工作面的工程地质条件,对工作面停采撤面期间防灭火工作进行了系统研究,得出停采撤面期间防灭火工作根据时间点的不同可分为停采前、停采期间和封闭后,并根据不同阶段特征制定了相应的防灭火措施,对类似条件矿井工作面... 详细信息

本文结合某矿综放工作面的工程地质条件,对工作面停采撤面期间防灭火工作进行了系统研究,得出停采撤面期间防灭火工作根据时间点的不同可分为停采前、停采期间和封闭后,并根据不同阶段特征制定了相应的防灭火措施,对类似条件矿井工作面防灭火具有一定的指导意义。

关键词：综放工作面防灭火停采前停采撤面期间封闭后

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第1期 157-162页

作者： Rong-De He Yun-Lei Luo Qiu-Quan Pan Qi-Wei yao Xing-zhong shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

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Preparation and Photocatalytic Activity of Ce, H3PW12O40 co-doped TiO2 Hollow Fibers

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Chinese Journal of Chemical Physics 2014年第3期27卷 343-349页

作者： shu-hua yao shuang Chen zhong-liang Shi School of Applied Chemistry Shenyang University of Chemical Technology Shenyang 110142 China

A series of Ce, H3PW12O40 co-doped TiO2 hollow fibers photocatalysts have been prepared by sol-gel method using ammonium ceric nitrate, H3PW12O40 and tetrabutyltitanate as precursors and cotton fibers as template, followed by calcination at 500 ℃ in N2 atmosphere for 2 h. Scanning electron microscopy, X-ray diffraction, nitrogen adsorption-desorption mea- surements, and UV-Vis spectroscopy are employed to characterize the morphology, crystal structure, surface structure, and optical absorption properties of the samples. The photo- catalytic performance of the samples has been studied by photodegradation phenol in water under UV and visible light irradiation. The results show that the TiO2 fiber materials have hollow structures, and the co-doped TiO2 hollow fibers exhibit higher photocatalytic activities for the degradation of phenol than un-doped, single-doped TiO2 hollow fibers under UV and visible light. In addition, the recyclability of co-doped TiO2 fibers is also confirmed that the TiO2 fiber retains ca. 90% of its activity after being used four times. It is shown that the co-doped TiO2 fibers can be activated by visible light and may be potentially applied to the treatment of water contaminated by organic pollutants. The synergistic effect of Ce and H3PW12O40 co-doping plays an important role in improving the photocatalytic activity.

关键词： TiO2 hollow fibers Ce and H3PW12O40 co-doping Photocatalytic activity Template method Phenol

Mechanochemical Coupling of Kinesin Studied with a Neck-Linker Swing Model

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Communications in Theoretical Physics 2009年第6期51卷 1143-1148页

作者： LI Ming shu yao-Gen OU-YANG zhong-Can College of Physical Science Graduate University of Chinese Academy of Sciences Beijing 100190 China Key Laboratory of Frontiers in Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China

A neck-linker swing model has been proposed in this work to investigate the mechanochemical coupling of kinesin. The difference between force-velocity curves given by force clamp and fixed trap respectively has been satisfactorily interpreted by this model. The study implies that ADP releasing and ATP hydrolysis are much less forcedependent in force clamp experiments than that in fixed trap experiments in the regime of moderate loading force, which might be a consequence of the delayed response of servo system in force clamp experiments.

关键词： kinesin neck-linker swing force clamp fixed trap