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Expression of the Grifola frondosa Trehalose Synthase Gene and Improvement of Drought-Tolerance in Sugarcane （Saccharum officinarum L.）

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Journal of Integrative Plant Biology 2006年第4期48卷 453-459页

作者： shu-zhen zhang Ben-Peng Yang Cui-Lian Feng Ru-Kai Chen Jing-Ping Luo Wen-Wei cai Fei-Hu Liu State Key Laboratory of Tropical Crop Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China Institute of Tropical Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China Key Laboratory of Ecophysiology and Genetic Improvement for Sugarcane Ministry of Agriculture Fuzhou 350002 China College of Life Sciences Yunnan University Kunming 650091 China

Trehalose Is a nonreduclng dlsaccharlde of glucose that functions as a protectant In the stabilization of blologlcal structures and enhances stress tolerance to abiotic stresses in organisms. We report here the expression of a Grlfola frondosa trehalose synthase （TSase） gene for Improving drought tolerance In sugarcane （Saccharum offlclnarum L.）. The expression of the transgene was under the control of two tandem copies of the CaMV35S promoter and transferred Into sugarcane by Agrobacterium tumefaciens EHA105. The transgenlc plants accumulated high levels of trehalose, up to 8.805-12.863 mg/g fresh weight, whereas It was present at undetectable level in nontransgenlc plants. It has been reported that transgenlc plants transformed with Escherlchla coil TPS （trehalose-6-phosphatesynthase） and/or TPP （trehalose-6-phosphate phosphatase） are severely stunted and have root morphologlc alterations. Interestingly, our transgenlc sugarcane plants had no obvious morphological changes and no growth Inhibition in the field. Trehalose accumulation in 35S-35S：TSase plants resulted In In- creased drought tolerance, as shown by the drought and the drought physiological Indexes, such as the rate of bound water/free water, plasma membrane permeability, malondlaldehyde content, chlorophyll a and b contents, and activity of SOD and POD of the excised leaves. These results suggest that transgenlc plants transformed with the TSase gene can accumulate high levels of trehalose and have enhanced tolerance to drought.

关键词： drought tolerance Grifola frondosa Saccharum officinarum trehalose synthase gene.

Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation

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Translational Neurodegeneration 2019年第1期8卷 24-37页

作者： Shen-zhao Lu Yong-shun Guo Pei-zhou Liang shu-zhen zhang shu Yin Yan-qing Yin Xiao-min Wang Fei Ding Xiao-song Gu Jia-wei Zhou Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Future Techology University of Chinese Academy of SciencesBeijing 100049China Center for Brain Disorders Research Capital Medical University and Center of Parkinson’s DiseaseBeijing Institute for Brain DisordersBeijing 100053China Co-innovation Center of Neuroregeneration School of MedicineNantong UniversityNantong 226001JiangsuChina

Background:Parkinson’s disease(PD)is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions(Lewy bodies)within some remaining neurons in the substantia ***,astroglial inclusion body has also been found in some neurodegenerative diseases including ***,the underlying molecular mechanisms of how astroglial protein aggregation forms remain largely ***,we investigated the contribution ofαB-crystallin(CRYAB),a small heat shock protein,inα-synuclein inclusion formation in ***:Small interfering RNA(siRNA)-mediated CRYAB(siCRYAB)knockdown or CRYAB overexpression was performed to investigate the impact of CRYAB on the autophagy in human glioblastoma cell line U251 ***(co-IP)and immunoblotting were used to dissect the interaction among multiple *** clearance ofα-synuclein in vitro was evaluated by *** transgenic mice and transgenic mice overexpressing A30P mutant form of humanα-synuclein were used to examine the influence of CRYAB toα-synuclein accumulation in ***:We found that knockdown of CRYAB in U251 cells or primary cultured astrocytes resulted in a marked augmentation of autophagy *** contrast,exogenous CRYAB disrupted the assembly of the BAG3-HSPB8-HSC70 complex via binding with BAG3,thereby suppressing the autophagy ***,CRYAB-regulated autophagy has relevance to PD *** of CRYAB remarkably promoted cytoplasmic clearance ofα-synuclein preformed fibrils(PFFs).Conversely,selective overexpression of CRYAB in astrocytes markedly suppressed autophagy leading to the accumulation of α-synuclein aggregates in the brain of transgenic mice expressing humanα-synuclein A30P ***:This study reveals a novel function for CRYAB as a natural inhibitor of astrocytic autophagy and shows that knockdown of CYRAB may provide a therapeutic target against proteinopathies such as synuclein

关键词： αB-crystallin Astrocytes Parkinson’s disease Autophagy

Synthesis and Characterization of Sulfonated Polyphosphazene-graft-Polystyrene Copolymers for Proton Exchange Membranes

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Chinese Journal of Polymer Science 2014年第2期32卷 151-162页

作者： Min-lan He Hu-lin Xu Yan Dong Jia-hong Xiao Peng Liu Feng-yan Fu Saghir Hussain shu-zhen zhang Chao-jun Jing Qun Yu 朱长进 Department of Applied Chemistry Beijing Institute of Technology Beijing Qintian Science & Technology Development Co. Ltd Beijing Institute of Transfusion Medicine

A novel series of polyphosphazene-grafl-polystyrene （PP-g-PS） copolymers were successfully prepared by atom transfer radical polymerization （ATRP） of styrene monomers and brominated poly（bis（4-methylphenoxy）phosphazene） macroinitiator. The graft density and the graft length could be regulated by changing the bromination degree of the macroinitiator and the ATRP reaction time, respectively. The PP-g-PS copolymers readily underwent a regioselective sulfonation reaction, which occurred preferentially at the polystyrene sites, producing the sulfonated PP-g-PS copolymers with a range of ion exchange capacities. The resulting sulfonated PP-g-PS membranes prepared by solution casting showed high water uptake, low water swelling and considerable proton conductivity. They also exhibited good oxidative stability and high resistance to methanol crossover. Morphological studies of the membranes by transmission electron microscopy showed clear nanophase-separated structures resulted from hydrophobic polyphosphazene backbone and hydrophilic polystyrene sulfonic acid segments, indicating the formation of proton transferring tunnels. Therefore, these sulfonated copolymers may be candidate materials for proton exchange membranes in direct methanol fuel cell （DMFC） applications.

关键词： Atom transfer radical polymerization Direct methanol fuel cell Graft copolymers Proton exchange membrane Polyphosphazenes.

Nickel extraction from nickel laterites: Processes, resources, environment and cost

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China Geology 2025年第1期8卷 187-213页

作者： zhen-fang zhang Wei-bo zhang zhen-guo zhang Xiu-fa Chen Development Research Center of China Geological Survey Ministry of Natural ResourcesBeijing 100037China Inner Mongolia University of Technology Hohhot 010062China

With the development of the new energy industry and the depletion of nickel sulfide ore resources,laterite nickel ore has become the main source of primary nickel,and nickel for power batteries has become a new growth point in *** paper systematically summarizes the processes,parameters,products,recovery rates,environmental indicators,costs,advantages,disadvantages and the latest research progress of mainstream nickel extraction processes from laterite nickel *** also provides a comparative analysis of the environmental impact and economic efficiency of different nickel extraction *** is found that the current nickel extraction processes from laterite nickel ore globally for commercial production mainly include the RKEF process for producing ferronickel and the HPAL process for producing intermediate *** former accounts for about 80%of laterite nickel ore *** to each other,the investment cost per ton of nickel metal production capacity for the RKEF is about 43000$,with an operational cost of about 16000$per ton of nickel metal and a total nickel recovery rate of 77%–90%.Its products are mainly used in stainless *** the HPAL process,the investment cost per ton of nickel metal production capacity is about 56000$,with an operational cost of about 15000$per ton of nickel metal and a total nickel recovery rate of 83%–90%.Its products are mainly used in power *** significant differences between the two lies in energy consumption and carbon emissions,with the RKEF being 2.18 and 2.37 times that of the HPAL,*** the use of clean energy can greatly reduce the operational cost and environmental impact of RKEF,if RKEF is converted to producing high Ni matte,its economic and environmental performance still cannot match that of the HPAL and oxygen-enriched side-blown ***,it can be inferred that with the increasing demand for nickel in power batteries,HPAL and oxygen-enriched side

关键词： Laterite nickel ore Limonite Saprolite Nickel extraction Pyrometallurgy Power batteries Hydrometallurgy Cost Environmental impact Life cycle assessment Comprehensive utilization Mineral exploration engineering

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu Quan Shi zhen zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Gender specific association of neonatal characteristics and cardiovascular risk factors on carotid intima-media thickness in a Chinese cohort

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Chinese Medical Journal 2010年第17期123卷 2310-2314页

作者： LIN Xue ZHU Wen-ling TAN Li XU Tao XU Rui-yi FANG Quan zhang shu-yang zhang zhen-xin Chinese Academy of Medical Sciences & Peking Union Medical College Peking Union Medical College Hospital Beijing 100730 China

Background Multiple neonatal characteristics and adult cardiovascular risk factors are associated with the development of atherosclerosis, however little conclusive evidence exists characterizing the relative strength of these factors. In a large retrospective study, we investigated the association between both objective neonatal measurements and comprehensive adult cardiovascular risk factors with the development of atherosclerosis, quantified by carotid intima-media thickness （CIMT）. Further, we assessed the impact of gender on the relative impact of these risk *** CIMT, a measure of atherosclerosis, was determined by carotid ultrasound on 1568 participants （age 50-85）whose birth records were obtained from Peking Union Medical College Hospital. In addition, each participant was given a physical examination, and completed a medical questionnaire to identify a panel of cardiovascular risk factors. Multiple regression analysis was performed on the population and on the male and female cohorts individually, to identify the relative contribution of these risk factors to increased *** For the total population the Framingham score, renal function, adult abdominal circumference and mother＇s gestational age were associated with CIMT, accounting for 14.7%, 1.4%, 0.9%, and 0.2% of total variance, *** the male population the Framingham score, renal function, abdominal circumference and hemoglobin were the most significant risk factors for CIMT. Risk in the female population was associated with Framingham score, renal function,insulin resistance and gestational age. No relationship between birth weight or head circumference and CIMT were *** Adult cardiovascular risk factors were the most significantly associated with the development of atherosclerosis; however mother＇s age at birth was associated with CIMT, particularly in the female cohort. The relative contribution of the risk factors analyzed varied between the male and fem

关键词： atherosclerosis risk factors gestational age gender

An improved method to evaluate trap depth from thermoluminescence

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Journal of Rare Earths 2025年第2期43卷 262-269页

作者： Shiyou zhang Fangyi Zhao Shengqiang Liu zhen Song Quanlin Liu The Beijing Municipal Key Laboratory of New Energy Materials and Technologies School of Materials Science and EngineeringUniversity of Science and Technology Beijing

Rare earth-doped inorganic compounds contribute mostly to the family of persistent luminescent materials due to the versatile energy levels of rare earth *** of the key research aims is to match the trap level stemming from the doped rare earth ion or intrinsic defects to the electronic structure of the host,and therefore thermoluminescence measurement becomes a radical technology in studying trap depth,which is one of the significant parameters that determine the properties of persistent luminescence and photostimulated ***,the results of trap depth obtained by different thermoluminescence methods are quite different so that they are not ***,we analyzed different thermoluminescence methods,selected and improved the traditional peak position method of Tm/500 to be E=（-0.94Inβ+30.09）*** the experimental heating rate（β） is needed additionally,but the accuracy is improved greatly in most *** convenient and accurate method will accelerate the discovery of novel rare earth-doped materials.

关键词： Persistent luminescence Photostimulated luminescence Rare earths Thermoluminescence Trap depth

Wafer‑Scale Ag_(2)S‑Based Memristive Crossbar Arrays with Ultra‑Low Switching‑Energies Reaching Biological Synapses

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Nano-Micro Letters 2025年第3期17卷 328-339页

作者： Yuan Zhu Tomas Nyberg Leif Nyholm Daniel Primetzhofer Xun Shi zhen zhang Division of Solid‑State Electronics Department of Electrical EngineeringUppsala University75121 UppsalaSweden Department of Chemistry Uppsala UniversityUppsalaSweden Department of Physics and Astronomy Uppsala UniversityUppsalaSweden State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China

Memristive crossbar arrays(MCAs)offer parallel data storage and processing for energy-efficient neuromorphic ***,most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor(CMOS)technology still suffer from substantially larger energy consumption than biological synapses,due to the slow kinetics of forming conductive paths inside the memristive *** we report wafer-scale Ag_(2)S-based MCAs realized using CMOS-compatible processes at temperatures below 160℃.Ag_(2)S electrolytes supply highly mobile Ag+ions,and provide the Ag/Ag_(2)S interface with low silver nucleation barrier to form silver filaments at low energy *** further enhancing Ag+migration in Ag_(2)S electrolytes via microstructure modulation,the integrated memristors exhibit a record low threshold of approximately−0.1 V,and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological *** low-temperature process also enables MCA integration on polyimide substrates for applications in flexible ***,the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training *** impressive accuracy of 92.6%in image recognition simulations is demonstrated with the MCAs after the *** demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag_(2)S films Reactive sputter Silver nucleation Ag^(+)migration Energy-efficient neuromorphic computing

Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

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Science China Chemistry 2025年第2期68卷 492-498页

作者： Hailong Xiong Chunyu Qi Lantian Xue Ling zhang Hanyu Liu zhen-An Qiao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Mesoporous metals with large surface area,high pore volume,and uniform pore structure hold excellent advantages for various ***,the state-of-the-art synthesis methods are still limited to wet chemistry,which requires excessive solvents and a time-consuming drying ***,we report a facile and general mechanochemical coordination self-assembly strategy to prepare mesoporous metals(e.g.,Rh,Ru,Ir,Pt,Pd,Ag,Co,and Ni)with remarkable porous properties by using metal chlorides and cationic polymer *** with the wet chemistry process,this method proceeds without solvents and does not need complicated experimental conditions and long synthetic periods,which not only greatly reduces the consumption of cost and energy and environmental pollution,but also improves the synthesis efficiency and yield of target *** believe the developed approach will provide a general pathway for the scalable preparation of advanced porous materials.

关键词： mechanochemistry self-assembly mesoporous materials mesoporous metals electrocatalysis