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World Journal of Gastroenterology 2005年第38期11卷 5926-5930页

作者： Hong-Wei Shen shun-Liang Gao Yu-Lian Wu shu-you peng Department of Surgery 2^nd Affiliated Hospital of Medical CollegeZhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To characterize the expression and genomic amplification of decoy receptor 3 （DcR3） in hepatocellular carcinoma （HCC） and to evaluate the role of DcR3 in apoptosis.METHODS： We examined 48 cases of HCC for DcR3 expression by RT-PCR and DcR3 gene amplification by quantitative genomic PCR. DcR3 protein was detected by immunohistochemistry. Terminal deoxynucleotidyl transferase-mediated dUTP digoxigenin nick and labeling （TUNEL） was used to identify the apoptosis cells in tissues. Primary hepatoma cell culture and MTT test were used to evaluate the protection against FasL- and chemicalinduced apoptosis by DcR3 expression. RESULTS： DcR3 mRNA overexpression was detected in 60% HCC （29/48） patients. The occurrence of HCC was not associated with amplification of the gene. One sample base substitution was found in three sites as a sequence in Genbank. The expression of DcR3 in HCC was associated with the apoptotic index （0.067±0.04 vs 0.209±0.12, P〈0. 01）, size of mass, stage, and infiltration or metastasis （41.2% vs71.0%, 40% vs75%, 51.8% vs84.6%, P〈0. 05）. DcR3 expression could protect hepatoma cells against apoptosis induced by FasL, but not by chemicals. CONCLUSION： These data suggest that in addition to gene amplification there may be another mechanism underlying DcR3 overexpression. The effect of overexpression of DcR3 on the apoptosis of cancer cells may have direct therapeutic implications for the management of HCC.

关键词： DcR3 Hepatocellular carcinoma Apoptosis

Evolution of associating liver partition and portal vein ligation for staged hepatectomy: Simpler, safer and equally effective methods

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World Journal of Gastroenterology 2017年第23期23卷 4140-4145页

作者： shu-you peng Xu-An Wang Cong-Yun Huang you-Yong Zhang Jiang-Tao Li De-Fei Hong Xiu-Jun Cai Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Department of General Surgery Yuebei People’s Hospital Affiliated to Shantou University School of Medicine Department of Radiology Yuebei People’s Hospital Affiliated to Shantou University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial People's Hospital Department of Hepatobiliary and Pancreatic Surgery Sir Run Run Shaw HospitalZhejiang University

Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) has been recently demonstrated as a method to induce rapid and extensive hypertrophy within a short time and has been employed for a variety of primary and metastatic liver tumors. However, controversies remain due to its high morbidity and mortality. To enable safer surgery, liver surgeons have searched for better technical modifications, such as partial ALPPS, mini-ALPPS, minimally invasive ALPPS, and Terminal branches portal vein Embolization Liver Partition for Planned hepatectomy(TELPP). It seems that TELPP is very promising, because it has the main advantage of ALPPS-the rapid increase of future liver remnant volume, but the morbidity and mortality are much lower because only one surgical operation is required.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy Terminal branches portal vein embolization Terminal branches portal vein embolization liver partition for planned hepatectomy Transarterial chemoembolization

Experimental study on operative methods of pancreaticojejunostomy with reference to anastomotic patency and postoperative pancreatic exocrine function

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World Journal of Gastroenterology 2008年第3期14卷 441-447页

作者： Ming-Dong Bai Liang-Qun Rong Lian-Chen Wang Hai Xu Rui-Fang Fan Pei Wang Xiao-peng Chen Liu-Bin Shi shu-you peng Department of General Surgery The Second Affiliated HospitalXuzhou Medical College Xuzhou 221006 Jiangsu Province China Department of Hepatobiliary Surgery Lanzhou General Hospital Lanzhou Command PLA Lanzhou 730050Gansu Province China Second Department of Health Care Lanzhou General Hospital Lanzhou Command PLA Lanzhou 730050 GansuProvince China Department of General Surgery Affiliated Yijishan Hospital Wannan Medical College Wuhu 241001 AnhuiProvince China Department of General Surgery Affiliated Huashan Hospital College of Medicine Fudan University Shanghai 200433China Department of General Surgery Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou310016 Zhejiang Province China

AIM:To assess the patency of pancreaticoenterostomy and pancreatic exocrine function after three surgical methods. METHODS: A pig model of pancreatic ductal dilation was made by ligating the main pancreatic duct. After 4 wk ligation, a total of 36 piglets were divided randomly into four groups. The piglets in the control group underwent laparotomy only; the others were treated by three anastomoses: (1) end-to-end pancreaticojejunostomy invagination (EEPJ); (2) end-to-side duct-to- mucosa sutured anastomosis (ESPJ); or (3) binding pancreaticojejunostomy (BPJ). Anastomotic patency was assessed after 8 wk by body weight gain, intrapancreatic ductal pressure, pancreatic exocrine function secretin test, pancreatography, and macroscopic and histologic features of the anastomotic site. RESULTS: The EEPJ group had significantly slower weight gain than the ESPJ and BPJ groups on postoperative weeks 6 and 8 (P < 0.05). The animals in both the ESPJ and BPJ groups had a similar body weight *** ductal pressure was similar in ESPJ and BPJ. However, pressure in EEPJ was significantly higher than that in ESPJ and BPJ (P < 0.05). All three functional parameters, the secretory volume, the flow rate of pancreatic juice, and bicarbonate concentration, were significantly higher in ESPJ and BPJ as compared to EEPJ (P < 0.05). However, the three parameters were similar in ESPJ and BPJ. Pancreatography performed after EEPJ revealed dilation and meandering of the main pancreatic duct, and the anastomotic site exhibited a variable degree of occlusion, and even blockage. Pancreatography of ESPJ and BPJ, however, showed normal ductal patency. Histopathology showed that the intestinal mucosa had fused with that of the pancreatic duct, with a gradual and continuous change from one to the other. For EEPJ, the portion of the pancreatic stump protruding into the jejunal lumen was largely replaced by cicatricial fibrous tissue. CONCLUSION: A mucosa-to-mucosa pancreatico- jejunostomy

关键词： Pancreaticojejunostomy Animal model anastomotic patency Pancreatic exocrine function Histopathology Pancreatography

Better surgical treatment method for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2018年第40期24卷 4527-4535页

作者： shu-you peng Xu-An Wang Cong-Yun Huang Jiang-Tao Li De-Fei Hong Yi-Fang Wang Bin Xu Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Department of General Surgery Yuebei People's Hospital Affiliated to Shantou University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Sir Run Run Shaw Hospital Affiliated Hospital of Zhejiang University School of Medicine

Hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT) is a disease that is not uncommon, but the treatments vary drastically between Eastern and Western countries. In Europe and America, the first line of treatment is systemic therapy such as sorafenib and the surgical treatment is not a recommend option. While an increasing number of studies from China and Japan have suggested that surgical treatment results in better outcomes when compared to transcatheter arterial chemoembolization(TACE), sorafenib, or other nonsurgical treatments, and two classification systems, Japanese Vp classification and Chinese Cheng's classification, were very useful to guide the surgical treatment. We have also found that surgical treatment may be more effective, as we have performed surgical treatment for HCC-PVTT patients over a period of approximately 15 years and achieved good results with the longest surviving time being 13 years and onward. In this study, we review the efficacy and principles of current surgical treatments and introduce our new, more effective surgical technique named "thrombectomy first", which means the tumor thrombus in the main portal vein, the bifurcation or the contralateral portal vein should be removed prior to liver resection. Thus, compression and crushing of PVTT during the operation could be avoided and new intrahepatic metastases caused by tumor thrombus to the remnant liver minimized. The new technique is even beneficial to the prognosis of Cheng's classification Types Ⅲ and Ⅳ PVTT. The vital tips and tricks for the surgical approach are described.

关键词： Portal vein tumor thrombus Thrombectomy first Surgery Hepatocellular carcinoma

Pancreatogastrostomy vs pancreatojejunostomy after pancreaticoduodenectomy: An updated meta-analysis of RCTs and our experience

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World Journal of Gastrointestinal Surgery 2019年第7期11卷 322-332页

作者： Yun Jin Yang-Yang Feng Xiao-Gang Qi Geng Hao Yuan-Quan Yu Jiang-Tao Li shu-you peng Department of General Surgery the Second Affiliated Hospital College of Medicine Zhejiang University

BACKGROUND Pancreatoduodenectomy(PD)is one of the most important operations in hepatobiliary and pancreatic *** To evaluate the advantages and disadvantages of pancreaticojejunostomy(PJ)and pancreaticogastrostomy(PG).METHODS This meta-analysis was performed using Review Manager *** clinical randomized controlled trials,in which patients underwent PD with pancreaticodigestive tract reconstruction via PJ or PG,were *** The search of PubMed,Wanfang Data,EMBASE,and the Cochrane Library provided 125 *** further analysis,11 trials were included from nine *** all,909 patients underwent PG and 856 underwent ***-analysis showed that pancreatic fistula(PF)was a significantly lower morbidity in the PG group than in the PJ group(odds ratio[OR]=0.67,95%confidence interval[CI]:0.53-0.86,P=0.002);however,grades B and C PF was not significantly different between the two groups(OR=0.61,95%CI:0.34-1.09,P=0.09).Postoperative hemorrhage showed a significantly lower morbidity in the PJ group than in the PG group(OR=1.47,95%CI:1.05-2.06,P=0.03).Delayed gastric emptying was not significantly different between the two groups(OR=1.09,95%CI:0.83-1.41,P=0.54).CONCLUSION There is no difference in the incidence of grades B and C PF between the two ***,postoperative bleeding is significantly higher in PG than in *** PJ or binding PG is a safe and secure technique according to our decades of experience.

关键词： Pancreaticojejunostomy Pancreaticogastrostomy Systematic review Metaanalysis

Anatomic isolated caudate lobectomy: Is it possible to establish a standard surgical flow?

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World Journal of Gastroenterology 2017年第41期23卷 7433-7439页

作者： Yun Jin Liang Wang Yuan-Quan Yu Dong-Er Zhou Da-Ren Liu Jun-Jie Yang shu-you peng Jiang-Tao Li Department of General Surgery The Second Affiliated Hospital College of MedicineZhejiang University Department of General Surgery Xinchang People’s Hospital

AIM To establish the surgical flow for anatomic isolated caudate lobe resection. METHODS The study was approved by the ethics committee of the Second Affiliated Hospital Zhejiang University School of Medicine(SAHZU). From April 2004 to July 2014, 20 patients were enrolled who underwent anatomic isolated caudate lobectomy at SAHZU. Clinical and postoperative pathological data were analyzed. RESULTS Of the total 20 cases, 4 received isolated complete caudate lobectomy(20%) and 16 received isolated partial caudate lobectomy(80%). There were 4 caseswith the left approach(4/20, 20%), 6 cases with the right approach(6/20, 30%), 7 cases with the bilateral combined approach(7/20, 35%), 3 cases with the anterior approach(3/20, 15%), and the hanging maneuver was also combined in 2 cases. The median tumor size was 5.5 cm(2-12 cm). The median intraoperative blood loss was 600 m L(200-5700 m L). The median intra-operative blood transfusion volume was 250 m L(0-2400 m L). The median operation time was 255 min(110-510 min). The median post-operative hospital stay was 14 d(7-30 d). The 1-and 3-year survival rates for malignant tumor were 88.9% and 49.4%, respectively. CONCLUSION Caudate lobectomy was a challenging procedure. It was demonstrated that anatomic isolated caudate lobectomy can be done safely and effectively.

关键词： Caudate lobectomy Surgical flow Anatomic liver resection

Engineering classification recycling of spent lithium-ion batteries through pretreatment:a comprehensive review from laboratory to scale-up application

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Rare Metals 2024年第3期43卷 915-941页

作者： shu-Xuan Yan you-Zhou Jiang Xiang-Ping Chen Lu Yuan Ting-Ting Min Yu Cao Wan-Li peng Tao Zhou Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410083China School of Public Policy and Management Tsinghua UniversityBeijing 100084China China Nonferrous Metal Industry's Foreign Engineering and Construction Co. LtdBeijing 100029China

The lithium-ion batteries(LIBs)have been widely equipped in electric/hybrid electric vehicles(EVs/HEVs)and the portable electronics due to their excellent electrochemical ***,a large number of retired LIBs that consist of toxic substances(e.g.,heavy metals,electrolytes)and valuable metals(e.g.,Li,Co)will inevitably flow into the waste stream,and their incineration or landfill treatment will cause severe risks to ecosystem and human *** sustainable and efficient treatment or recycling of valuable resources from spent LIBs should be fully recognized for environmental and resource *** one of the most important processes for spent LIBs recycling,the pretreatment is an indispensable step,which is directly related to the subsequent metal extraction and separation *** considerable progresses have been made regarding the pretreatment technologies,there are few summarized reports concerning critical processes of spent LIBs recycling,especially combination of currently available recycling technologies with industrialized applications during ***,comprehensive review of the current prevailing pretreatment technologies in laboratory to existing scale-up applications is quite necessary to reveal cutting-edge development in the field of *** this review,the current pretreatment technologies are systematically categorized and introduced,along with critical *** review focused on the various options for pretreatment processes itself,instead of general spent LIBs recycling technologies without the focused topics that have been sophisticatedly reviewed by previous ***,the deactivation,discharge,dismantling,separation,liberation of active material and electrolyte treatment have been summarized with the in-depth discussion of the technology development and current status of each ***,current states of industrial development are also reviewed and discussed for the development of

关键词： Spent lithium-ion batteries(LIBs) Recycling Pretreatment Valuable metals Cutting-edge technologies Industrialized application

Highly anti-corrosive NiFe LDHs–NiFe alloy hybrid enables long-term stable alkaline seawater electrolysis

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Rare Metals 2024年第9期43卷 4321-4332页

作者： Jia-Hong Li Hao Chen Si-Hang you Gan-Xin Yang peng Liu Meng-Qi Gao shu-Guang Chen Fei-Fei Zhang School of Materials Science and Engineering Changsha University of Science and TechnologyHunan 410114China Department of Materials Science and Engineering Faculty of EngineeringNational University of SingaporeSingapore 117576Singapore School of Materials Science and Engineering Jilin UniversityJilin 130022China

Owing to the significant potential of alkalin seawater electrolysis for converting surplus power into eco friendly hydrogen fuel,we developed bifunctional elec trodes that integrate low-crystalline NiFe LDHs and amorphous NiFe alloy on a Ni foam(NF)substrate to enhance this *** by the battery-like charac teristics of NiFe LDHs,an anti-corrosive and active oute layer of NiFe^(vac)OOH continuously forms over time in th hybrid on the anode for the oxygen evolution reaction(OER),effectively mitigating powder shedding caused by corrosion induced by multiple anions in *** while,the strong bond between the hybrid and the NF substrate maintains intact hybrid coatings to ensure a rel atively high overall conductivity of the electrodes,signif icantly reducing the negative effects of structura degradation during the OER and hydrogen evolution reaction(HER),as well as the accumulation of contami nants on the electrode *** long-term tests,thes bifunctionalhybridelectrodesmaintained stable performance,even at a high current density o500 mA·cm^(-2).The cell voltage increased by only 88 m V over 1000 h to 1.970 V during saline electrolysis and by103 mV over 500 h to 2.062 V during seawater electroly ***,this study provides valuable insights into efficient and stable seawater electrolysis using NiFe LDHs–NiFe alloy hybrids.

关键词： NiFe LDHs Bifunctional Corrosion Stability Seawater electrolysis

Two-component dimers of ultracold atoms with center-of-mass-momentum dependent interactions

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Communications in Theoretical Physics 2024年第4期76卷 153-157页

作者： Yaru Liu shu Yang peng Zhang Department of Physics Renmin University of ChinaBeijing 100872China Graduate School of China Academy of Engineering Physics Beijing 100193China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China

In a previous paper[***.A95,060701(R)(2017)],we demonstrated that a new type of two-body interaction,which depends on the center of mass(CoM)momentum,can be realized for ultracold atoms via laser-modulated magnetic Feshbach resonance(MFR).Further studies(e.g.L He et al,***.120,045302(2018))show that various interesting phenomena,such as Fulde–Ferrell superfluids,can be induced by scattering between ultracold atoms with this *** this work we investigate the shallow bound states of two ultracold atoms with this type of *** show that when the magnetic field B is below the MFR point B0,two shallow bound states can appear in this ***,a'two-component dimer'or a dimer with pseudo-spin 1/2 can be formed by two ***,the dispersion curve of the dimer may have either single or double minimums in the CoM momentum *** latter case can be explained as a result from significant pseudo-spin-orbital coupling(SOC)*** results show that the ultracold gases with CoM momentum dependent interaction may be a candidate for quantum simulations with ultracold two-component molecules,especially the molecule gases with SOC.

关键词： center-of-mass-momentum dependent interaction Raman-laser modulated MFR two-component dimer

Pd-catalyzed intermolecular Si–O formation via Si–C activation

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Science China Chemistry 2024年第8期67卷 2661-2669页

作者： shuang Liu Yu-shu Chen Yichen Wu peng Wang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistryand Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China

The development of efficient Si–O bond formation reaction with 100% atom-economy, excellent functional group tolerance, and broad scope under mild conditions is highly desired due to the prevalence of silanol, silyl ether, and their derivatives in synthetic chemistry and materials science. Here, we have realized the Pd-catalyzed Si–O formation reaction via a Si–C activation approach with 100% atom-economy by employing silacyclobutanes(SCBs) and various hydroxy-containing substrates, including water,alcohols, phenols, and silanols. This protocol features a broad substrate scope, remarkable functional compatibility and mild conditions, providing a series of silanols, silyl ethers in high efficiency. Notably, this protocol could also be used for selective protection of hydroxy functionalities, and for the access of a class of novel polymers containing Si–O main chain. Preliminary mechanistic studies unveiled that this reaction underwent a Pd-catalyzed concerted ring-opening mechanism.

关键词： Si–O formation Si–C activation palladium silacyclobutane silanol silyl ether