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Longitudinal associations of cardiovascular health and vascular events with incident dementia

Stroke & Vascular Neurology 2024年第4期9卷 418-428,I0066-I0130页

作者： Ya-Nan Ou Kevin Kuo Liu Yang Ya-Ru Zhang shu-yi huang Shi-Dong Chen Yue-Ting Deng Yu Guo Rui-Qi Zhang Bang-Sheng Wu Lan Tan Qiang Dong Jian-Feng Feng Wei Cheng Jin-Tai Yu Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandongPeople's Republic of China Department of Neurology and National Center for Neurological Disorders Huashan HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiPeople's Republic of China Institute of Science and Technology for Brain-inspired Intelligence Fudan UniversityShanghaiPeople's Republic of China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityMinistry of EducationShanghaiPeople's Republic of China

Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented.A comprehensive study to illuminate the distinctive associations across different dementia types is still *** study is sought to:(1)determine the clinical validity of Framingham General Cardiovascular Risk Score(FGCRS)for dementia assessment and(2)examine the associations between cardiovascular diseases and the risk of *** A total of 432079 dementia-free individuals at baseline from UK Biobank were *** Cox proportional hazard models were used to investigate the prospective associations for FGCRS and a series of cardiovascular diseases with all-cause dementia(ACD)and its major components,Alzheimer’s disease(AD)and vascular dementia(VaD).Results During a median follow-up of 110.1 months,4711 individuals were diagnosed with *** was associated with increased risks across the dementia *** stratification analysis,high-risk groups have demonstrated the greatest dementia burdens,particularly to *** 74 traits,9 adverse associations,such as chronic ischaemic heart disease(ACD:HR=1.354;AD:HR=1.269;VaD:HR=1.768),atrioventricular block(ACD:HR=1.562;AD:HR=1.556;VaD:HR=2.069),heart failure(ACD:HR=1.639;AD:HR=1.543;VaD:HR=2.141)and hypotension(ACD:HR=2.912;AD:HR=2.361;VaD:HR=3.315)were *** distinctions were also found,with atrial fibrillation,cerebral infarction,and haemorrhage only associated with greater risks of ACD and *** By identifying distinctive associations between cardiovascular diseases and dementia,this study has established a comprehensive‘mapping’that may untangle the long-standing *** has demonstrated its predictivity beyond cardiovascular diseases burdens,suggesting potential opportunities for implantation.

关键词： cardiovascular diseases supporting

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Risk Assessment of Deep-Water Horizontal X-Tree Installation

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China Ocean Engineering 2024年第2期38卷 210-220页

作者： MENG Wen-bo FU Guang-ming huang yi LIU shu-jie huang Liang GAOYong-hai CNOOC China Limited Zhanjiang BranchZhanjiang 524057China Key Laboratory of Unconventional Oil and Gas Development Ministry of Education(China University of Petroleum(East China))Qingdao 266580China

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault ***,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was ***,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top ***,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

关键词： subsea horizontal X-tree risk assessment fuzzy fault tree modular risk evaluation model

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Precipitation evolution and properties of Cu-15Ni-8Sn alloys via Al microalloying during ageing

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Rare Metals 2024年第10期43卷 5216-5228页

作者： Wei Luo Li-Jun Peng Xu-Jun Mi Hao-Feng Xie yi-Cheng Cao shu-Hui huang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd. GRIMAT Engineering Institute Co. Ltd. General Research Institute for Nonferrous Metals School of Materials Science and Engineering South China University of Technology

Studies have shown that microalloying Cu-Ni-Sn alloys using Al inhibits discontinuous precipitation reactions;however,the mechanism has not been investigated ***,this study explored the properties and precipitation evolution of Cu-15Ni-8Sn alloys without and with 1 wt%Al（Cu-15Ni-8Sn-1Al） during ageing at 500℃ through X-ray diffraction （XRD）,scanning electron microscopy and high-angle annular dark-field scanning transmission electron *** results revealed that in Cu-15Ni-8Sn alloy,DO22ordering first occurred after spinodal decomposition,subsequently transitioning to an L12ordering phase,during which the discontinuous precipitates gradually nucleated at the grain boundaries and formed *** alloy hardness increased sharply with ordering and then decreased rapidly after reaching its peak value,due to the dominance of the discontinuous precipitation ***,the DO22ordered phase did not appear during the ageing of Cu-15Ni-8Sn-1Al alloy,and a Ni3(Alx,Sn1-x) intermetallic compound with L12structure was formed,consuming Ni and Sn atoms,thereby significantly suppressing the discontinuous precipitation reaction and improving the stability during prolonged *** tensile strength （yield strength） of Cu-15Ni-8Sn and Cu-15Ni-8Sn-1Al alloys at peak hardness were 855 （755） and 936 MPa （892 MPa）,respectively,and their main strengthening mechanisms were solid solution strengthening and precipitation *** addition of 1 wt% Al effectively improved the precipitation strengthening effect of Cu-Ni-Sn alloys but severely decreased the ductility.

关键词： Al addition Cu-15Ni-8Sn Precipitation sequence Strengthening mechanism

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Modulating the electrode–electrolyte interface enables switchable selectivity in electrocatalytic furfural reduction

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Science China Chemistry 2024年第10期67卷 3193-3194页

作者： Jingfang Zhang yi huang Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education School of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan 430205China College of Chemistry Central China Normal UniversityWuhan 430079China

Furfural(FF),an important bio-based platform molecule,can be valorized to high-value-added chemicals(e.g.,furfuryl alcohol(FA)or 2-methylfuran(MF))through catalytic hydrogenation[1].The traditional thermocatalytic transformation of FF always requires high-temperature and highpressure conditions[2].Accordingly,electrocatalytic hydrogenation is emerging as a promising approach for the selective reduction of FF to FA or MF under environmentally friendly and benign conditions.

关键词： hydrogenation electrolyte selectivity

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A Semiparametric Additive-multiplicative Rates Model for the Weighted Composite Endpoint of Recurrent and Terminal Events

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Acta Mathematica Sinica,English Series 2024年第4期40卷 985-999页

作者： yi DENG Qiang XIONG shu Wei LI School of Economics and Statistics Guangzhou UniversityGuangzhou 510006P.R.China

Recurrent event data are commonly encountered in many scientific fields,including biomedical studies,clinical trials and epidemiological surveys,and many statistical methods have been proposed for their *** this paper,we consider to use a weighted composite endpoint of recurrent and terminal events,which is weighted by the severity of each event,to assess the overall effects of covariates on the two types of events.A flexible additive-multiplicative model incorporating both multiplicative and additive effects on the rate function is proposed to analyze such weighted composite event process,and more importantly,the dependence structure among the recurrent and terminal events is left *** the estimation,we construct the unbiased estimating equations by virtue of the inverse probability weighting technique,and the resulting estimators are shown to be consistent and asymptotically normal under some mild regularity *** evaluate the finite-sample performance of the proposed method via simulation studies and apply the proposed method to a set of real data arising from a bladder cancer study.

关键词： Additive-multiplicative rates model estimating equation recurrent events terminal event weighted composite endpoint

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Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 405-417页

作者： yi Yu Guo-Ping Liu yi huang Peng Shi IEEE Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and TechnologyShenzhen 518055China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China School of Electrical and Mechanical Engineering the University of AdelaideSA 5005Australia Research and Innovation Centre Obuda University1034 BudapestHungary

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.

关键词： DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control

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Vanadium(V) Complexes Containing Unsymmetrical N-Heterocyclic Carbene Ligands: Highly Efficient Synthesis and Catalytic Behavior towards Ethylene/Propylene Copolymerization

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Chinese Journal of Polymer Science 2024年第1期42卷 32-41,I0006页

作者： yi-Cong Wang Hui Zhat Pei-yi Cheng shu Zhang Xiang-Wei Liu yi-Xian Wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBejing 100029China

The highly efficient method has been developed for the synthesis of NHC·VOCl_(3) containing symmetrical or unsymmetrical Nheterocyclic carbene(NHC) ligands by the transmetallation reaction of NHC·AgCl with VOCl_(3).The total isolated yield of VOCl_(3)[1,3-(2,4,6-Me_(3)C_(6)H_(2))_(2)(NCH=)_(2)C:](V4') reached 86% by transmetallation reaction,which is much higher than that(48%) by direct coordination *** methodology has also been used to synthesize the novel vanadium complexes containing unsymmetrical NHC ligands of VOCl_(3)[PhCH_(2)NCH=CHNR)C:](V5',R=2,4,6-Me_(3)C_(6)H_(2);V6',R=2,4-Me_(2)-6-Ph-C_(6)H_(2);V7',R=2,6-^(i)Pr_(2)-C_(6)H_(3)) with high yield,which could not be obtained by direct coordination *** catalytic activity and copolymerization ability would be improved by introducing unsymmetrical NHC ligands due to their less steric bulky *** vanadium complex V5' containing unsymmetrical NHC ligand exhibits higher catalytic activity(3.7×10^(5)g_(copolymer)·mol^(-1) of V·h^(-1)) than that of V4' containing symmetrical NHC ***,the higher propylene incorporation ratio(45.6 mol%) in the copolymers of ethylene with propylene could be obtained by using V5' than that(39.9%) by using V4'.The results would provide a highly efficient strategy for the synthesis of early transition metal complexes containing versitile NHC ligands,affording the catalyst with both high catalytic activity and copolymerization ability for the synthesis of high performance polyolefin elastomers.

关键词： Vanadium complex N-heterocyclic carbene ligand Transmetallation reaction Copolymerization of ethylene with propylene

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Ultra-compact lithium niobate microcavity electro-optic modulator beyond 110 GHz

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Chip 2022年第4期1卷 29-36页

作者： Bing-Cheng Pan Hong-Xuan Liu Hao-Chen Xu yi-shu huang Huan Li Ze-Jie Yu Liu Liu Yao-Cheng Shi Dao-Xin Dai State Key Laboratory for Modern Optical Instrumentation Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInterna-tional Research Center for Advanced PhotonicsZhejiang UniversityZijingang CampusHangzhou 310058China Ningbo Research Institute Zhejiang Uni-versityNingbo 315100China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Jiaxing 314000China Intelligent Optics&Photonics Re-search Center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China

A lithium-niobate-on-insulator(LNOI)electro-optic(EO)modulator based on a 2×2 FP-cavity was designed and realized with an ultra-compact footprint and an ultra-high bandwidth.A comprehensive analysis on the present LNOI FP-cavity modulator was conducted to reveal the dependence of modulation bandwidth and modulation effi-ciency on the cavity Q-factor and the operation wavelength detuning to the *** particular,the 2×2 FP cavity was designed to achieve an optimal Q factor by reducing the reflectivity of reflectors and the cavity length,thus reducing the photon lifetime in the *** ultra-short effective cavity length of only∼50μm was achieved for the designed LNOI FP-cavity modulator,with itsfootprint being as compact as∼4×500μm *** was demonstrated theoretically that the modulation bandwidth could be improved significantly to be over 200 GHz by utilizing the peaking enhancement *** fabricated device exhibited an excess loss of∼1 dB and an extinction ratio of∼20 dB in experiments,while the measured 3-dB bandwidth was higher than 110 GHz(beyond the maximal range of the facilities in experiments).Up till now,to our best knowledge,this has been the first LNOI microcavity modulator with a bandwidth higher than 110 ***,high-quality eye-diagrams of 100 Gbps on-off keying(OOK)and 140 Gbps 4-pulse amplitude modulation(PAM4)signals were demonstrated experimentally,and the energy consumption for the OOK signals was as low as 4.5 fJ/bit.

关键词： Lithium niobate Microcavity Electro-optic Modulator

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T2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 819-832页

作者： Hui-Da Zheng Qiao-yi huang Qi-Ming huang Xiao-Ting Ke Kai Ye shu Lin Jian-Hua Xu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Computed Tomography/Magnetic Resonance Imaging The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Group of Neuroendocrinology Garvan Institute of Medical ResearchSydneyNSW 2010Australia

BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported *** a non-invasive model to predict the differentiation grade of CRC is of great *** To develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on T2-weighted images(T2WI).METHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July *** were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 *** were delineated layer by layer on high-resolution *** absolute shrinkage and selection operator regression was applied to screen for radiomic *** and clinical models were constructed using the multilayer perceptron(MLP)*** radiomic features and clinically relevant variables(selected based on a significance level of P<0.05 in the training set)were used to construct radiomics-clinical *** performance of the three models(clinical,radiomic,and radiomic-clinical model)were evaluated using the area under the curve(AUC),calibration curve and decision curve analysis(DCA).RESULTS After feature selection,eight radiomic features were retained from the initial 1781 features to construct the radiomic *** different classifiers,including logistic regression,support vector machine,k-nearest neighbours,random forest,extreme trees,extreme gradient boosting,light gradient boosting machine,and MLP,were used to construct the model,with MLP demonstrating the best diagnostic *** AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation *** AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation *** clinical model achieved an AUC of 0.7

关键词： Radiomics Colorectal cancer Differentiation grade Machine learning T2-weighted imaging

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Effect of the yaw angle on turbulent flow structures around the submarine model

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Journal of Hydrodynamics 2024年第3期36卷 421-434页

作者： yi-jing Hu yi Qu Qin Wu Biao huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China Beijing Institute of Electronic System Engineering Beijing100854China

The objective of this paper is to investigate the turbulent flow structures around the submarine model and evaluate the effect of the yaw angle on the turbulent flow *** large eddy simulation based on the boundary data immersion method is used to *** computational domain consists of 1.2×10^(8)uniformly distributed Cartesian orthogonal grid nodes to capture the basic flow characteristics around the *** pressure coefficient,friction coefficient and wake velocity distribution are in good agreement with the experimental *** different types of vortex structures were mainly captured around the model,including horseshoe vortex,sail tip vortex and crossflow separation *** the increase of the yaw angle,the asymmetry of the horseshoe vortex and the tip vortex gradually increases,and the vortex strength of the vortex leg on the windward of the horseshoe vortex and the vortex strength of the tip vortex also increase *** the crossflow separation vortex,the flow separation zone gradually expands and migrates downstream with the increase of the yaw angle.

关键词： Vortex structure submarine model boundary data immersion method yaw angle

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