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Association of higher resistin levels with inflammatory activation and endothelial dysfunction in patients with essential hypertension

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Chinese Medical Journal 2013年第4期126卷 646-649页

作者： FANG Chang LEI Juan ZHOU shu-xian zhang Yu-ling YUAN Gui-yi WANG Jing-feng Division of Cardiology Department of Internal Medicine and Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China

Background Some studies have shown that serum resistin levels increase in hypertensive patients. Whether the increase of resistin is related to inflammatory or vascular endothelial function is still unknown. We investigated the relationship of increased resistin levels to inflammatory factors and circulating biomarkers of vascular endothelial function in hypertensive patients. Methods One hundred and forty-four nondiabetic patients with new onset, hypertension were recruited. Blood pressure, blood glucose, insulin, resistin, tumour necrosis factor-a （TNF-a）, interleukin-6 （IL-6）, von Willebrand factor （vWF）, endothelin-1 （ET-1） and nitric oxide （NO） were measured. The homeostasis model assessment, insulin resistance index （HOMA-IR） was calculated. Patients were divided into two groups according to the median level of resistin. Cytokine levels and indicators of vascular endothelial function were compared. Multiple linear regression was used to determine factors influencing resistin. Results Serum resistin ranged from 2.57 ng/ml to 20.18 ng/ml in hypertensive patients. High resistin group （〉8.36 ng/ml） had higher levels of TNF-a, IL-6, vWF and ET-1 but lower level of NO compared with low resistin group （P 〈0.01）. Resistin was positively correlated with body mass index, systolic blood pressure, HOMA-IR, low-density lipoprotein cholesterol, TNF-a and ET-1 but negatively correlated with NO （all P 〈0.05）. Multiple linear regression analysis revealed that HOMA-IR, TNF-a, NO and ET-1 are independent predictors of resistin with standardized regression coefficients of 0.625, 0.368, -0.260 and 0.222, respectively （all P 〈0.01）. Conclusions We conclude that higher resistin levels are associated with inflammatory activation and endothelial dysfunction, because patients with essential hypertension have increased TNF-a, IL-6, vWF and ET-1 and decreased NO. Moreover, the statistical association of resistin with TNF-a, NO and ET-1 suggests involvement of resistin in the progression

关键词： hypertension resistin inflammatory factor endothelial function

Advanced sodium-ion capacitor based on antimony-carbon composite anode

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Rare Metals 2022年第10期41卷 3360-3369页

作者： Wei-Qing Yu Chun-Yan Zhu Ru-Tao Wang Jian-Chao Chen Qing-Yuan Liu shu-xian zhang Zhi-Jie Gao Cheng-xiang Wang Zhi-Wei zhang Long-Wei Yin Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationSchool of Materials Science and EngineeringShandong UniversityJinan250061China Suzhou Institute of Shandong University Suzhou215123China College of Chemical Engineering and Safety Binzhou UniversityBinzhou256603China

Alloy-type materials with the characteristics of high theoretical capacity,low sodiation/desodiation potential,and good conductivity are considered as one of the most promising anodes for sodium-ion batteries or ***,the large volume change during the sodiation leads to poor cyclability and slow kinetics,thus presenting the main issue impeding the practical ***,we propose a facile wet chemistry and pyrolysis method to synthesize Sb-carbon composite that Sb nanoparticles or single atoms are confined and/or dispersed in the wrinkled carbon framework with high nitrogen *** unique architecture of Sb-carbon composite increases atomic interface contact/interaction with Na~+,facilitating ion diffusion and alleviating the volume change of Sb during the charge/discharge ***-cell test shows that Sb-carbon composite exhibits a high-rate capability and stable cycling ***,sodium-ion capacitors fabricated by employing Sb-carbon composite as anode and home-made active carbon as cathode,deliver both high-energy density of 157 Wh·kg^(-1)and high-power density of 25 kW·kg^(-1)as well as excellent cycling performance exceeding 4000 cycles.

关键词： Antimony Nitrogen doping carbon Alloy-type anode Sodium-ion capacitor

Treatment of allergic airway inflammation and hyperrespon-siveness by imiquimod modulating transcription factors T-bet and GATA-3

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Chinese Medical Journal 2006年第8期119卷 640-648页

作者： BIAN Tao YIN Kai-sheng JIN shu-xian zhang Xi-long ZHOU Jin-yong MA Xiu-qin HU Jing-jing DE Wei Department of Respiratory Medicine First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Background Imiquimod is an imidazoquinoline, which class of compounds are known to have antiviral and antitumoural properties. In recent studies, it was shown that imiquimod modulates the T helper cell type Th1/Th2 response by inducing the production of Thl cytokines like IFN-γ, and by inhibiting the Th2 cytokines like interleukin （IL）-4. Several investigators have shown that T-bet and GATA-3 are master Thl and Th2 regulatory transcription factors. This study investigated whether irniquimod treatment inhibited airway inflammation by modulating transcription factors T-bet and GATA-3. Methods Thirty-six male SD rats were randomly divided into a control group, an asthmatic group, and an imiquimod group, which was exposed to an aerosol of 0.15% imiquimod. Twenty-four hours after the last ovalbumin （OVA） challenge, airway responsiveness was measured and changes in airway histology were observed. The concentrations of IL-4, IL-5 and IFN-γ in bronchoalveolar lavage fluid （BALF） and serum were measured by enzyme linked immunosorbent assay （ELISA）. The rnRNA expressions of IL-4, IL-5, IFN-γ, T-bet and GATA-3 in lung and in CD4^＋ T cells were determined by reverse transcription polymerase chain reaction （RT-PCR）. The protein expressions ofT-bet and GATA-3 were measured by Western blot. Results It was demonstrated that imiquimod 1） attenuated OVA induced airway inflammation; 2） diminished the degree of airway hyperresponsiveness （AHR）; 3） decreased the Th2 type cytokines and increased Thl type cytokines mRNA and protein levels; 4） modulated the Th1/Th2 reaction by inhibiting GATA-3 production and increasing T-bet production. Conclusion Imiquimod treatment inhibits OVA induced airway inflammation by modulating key master switches GATA-3 and T-bet that result in committing T helper cells to a Thl phenotype.

关键词： asthma T-bet GATA-3 imiquimod

Vanadium(V) Complexes Containing Unsymmetrical N-Heterocyclic Carbene Ligands: Highly Efficient Synthesis and Catalytic Behavior towards Ethylene/Propylene Copolymerization

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Chinese Journal of Polymer Science 2024年第1期42卷 32-41,I0006页

作者： Yi-Cong Wang Hui Zhat Pei-Yi Cheng shu zhang xiang-Wei Liu Yi-xian Wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBejing 100029China

The highly efficient method has been developed for the synthesis of NHC·VOCl_(3) containing symmetrical or unsymmetrical Nheterocyclic carbene(NHC) ligands by the transmetallation reaction of NHC·AgCl with VOCl_(3).The total isolated yield of VOCl_(3)[1,3-(2,4,6-Me_(3)C_(6)H_(2))_(2)(NCH=)_(2)C:](V4') reached 86% by transmetallation reaction,which is much higher than that(48%) by direct coordination *** methodology has also been used to synthesize the novel vanadium complexes containing unsymmetrical NHC ligands of VOCl_(3)[PhCH_(2)NCH=CHNR)C:](V5',R=2,4,6-Me_(3)C_(6)H_(2);V6',R=2,4-Me_(2)-6-Ph-C_(6)H_(2);V7',R=2,6-^(i)Pr_(2)-C_(6)H_(3)) with high yield,which could not be obtained by direct coordination *** catalytic activity and copolymerization ability would be improved by introducing unsymmetrical NHC ligands due to their less steric bulky *** vanadium complex V5' containing unsymmetrical NHC ligand exhibits higher catalytic activity(3.7×10^(5)g_(copolymer)·mol^(-1) of V·h^(-1)) than that of V4' containing symmetrical NHC ***,the higher propylene incorporation ratio(45.6 mol%) in the copolymers of ethylene with propylene could be obtained by using V5' than that(39.9%) by using V4'.The results would provide a highly efficient strategy for the synthesis of early transition metal complexes containing versitile NHC ligands,affording the catalyst with both high catalytic activity and copolymerization ability for the synthesis of high performance polyolefin elastomers.

关键词： Vanadium complex N-heterocyclic carbene ligand Transmetallation reaction Copolymerization of ethylene with propylene

Stabilization/solidification mechanisms of tin tailings and fuming slag-based geopolymers for different heavy metals

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 43-55页

作者： xian Zhou Zhengfu zhang Hui Yang School of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Kunming Metallurgical Research Institute Co. Ltd.Kunming650031China

Tin mine tailings(TMT)and fuming slag(FS)contain many heavy metals(As,Cr,Cu,Zn and Mn)that cause severe pollution to the ***,geopolymers were prepared using TMT,FS and flue gas desulfurization gypsum(FGDG)to immobilize heavy metals,and their compressive strength and heavy metal leaching toxicity were *** was first determined that T4F5(TMT:FS=4:5)sample exhibited the highest compressive strength(7.83 MPa).T4F5 achieved 95%immobilization efficiency for As and Cr,and nearly 100%for Cu,Zn and Mn,showing good immobilization performance.A series of characterization analyses showed that heavy metal cations can balance the charge in the geopolymer and replace Al in the geopolymer structure to form covalent *** addition,about 2%–20%of heavy metal Fe was immobilized in hydration products,heavy metal hydroxides and non-bridging Si–O and Al–O coordination with silica-aluminate ***_(3)^(3−) was oxidized into AsO_(4)^(3−),which may form Ca–As or Fe–As ***_(2)O_(7)^(2−)was converted to CrO_(4)^(2−)under alkaline environment and then combined with OH−to form Cr(OH)3 ***^(2+)may react directly with dissolved silicate to form Mn_(2)SiO_(4) and also form Mn(OH)_(2) *** unstable Mn(OH)_(2) can be further oxidized to MnO_(2).The heavy metal cations were immobilized in the silicoaluminate lattice,while the anions tended to form insoluble *** results may benefit the industry and government for better handling of TMT,FS and solid wastes containing the abovementioned five heavy metals.

关键词： Heavy metals Cementitious materials Tin tailings Stabilization/solidification Redox

Limit Theorems for Critical Galton-Watson Processes with Immigration Stopped at Zero

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Acta Mathematica Sinica,English Series 2024年第2期40卷 435-450页

作者： Dou Dou LI Mei zhang xian Yu zhang College of Statistics and Data Science Faculty of ScienceBeijing University of TechnologyBeijing 100124P.R.China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

In this paper,we consider a critical Galton-Watson branching process with immigration stopped at zero *** precise estimation on the probability generating function of the n-th population are obtained,and the tail prob... 详细信息

关键词： Branching immigration critical life period limit theorems

Three-dimensional porous bimetallic metal–organic framework/gelatin aerogels: A readily recyclable peroxymonosulfate activator for efficient and continuous organic dye removal

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Chinese Journal of Chemical Engineering 2024年第7期71卷 193-202页

作者： Wenlong xiang xian zhang Rou Xiao Yanhui zhang College of Chemistry Chemical Engineering and EnvironmentFujian Province Key Laboratory of Morden Analytical Science and Separation TechnologyMinnan Normal UniversityZhangzhou 363000China Fujian Provincial University Key Laboratory of Pollution Monitoring and Control Minnan Normal UniversityZhangzhou 363000China

As promising catalysts for the degradation of organic pollutants,metal–organic frameworks(MOFs)often face limitations due to the particle agglomeration and challenging recovery in liquid-catalysis application,stemming from their powdery *** macroscopic structures from pulverous MOF is thus of great importance for broadening their practical *** this study,three-dimensional porous MOF aerogel catalysts were successfully fabricated for degrading organic dyes by activating peroxymonosulfate(PMS).MOF/gelatin aerogel(MOF/GA)catalysts were prepared by directly integrating bimetallic FeCo-BDC with gelatin solutions,followed by freeze-drying and low-temperature *** FeCo-BDC-0.15/GA/PMS system exhibited remarkable performance in degrading various organic dyes,eliminating 99.2%of rhodamine B within a mere 5 *** to the GA/PMS system,there was over a 300-fold increase in the reaction rate ***,high removal efficiency was maintained across varying conditions,including different solution pH,co-existing inorganic anions,and natural water *** trapping experiments and electron paramagnetic resonance analysis revealed that the degradation involved radical(SO_(4)^(-)·)and non-radical routes(^(1)O_(2)),of which ^(1)O_(2) was ***,even after a continuous 400-min reaction in a fixed-bed reactor at a liquid hourly space velocity of 27 h^(-1),the FeCo-BDC/GA composite sustained a degradation efficiency exceeding 98.7%.This work presents highly active MOF-gelatin aerogels for dye degradation and expands the potential for their large-scale,continuous treatment application in organic dye wastewater management.

关键词： Catalyst Environment Wastewater Metal–organic framework Gelatin aerogel Peroxymonosulfate

Hybrid vibration isolation optimization of a flexible manipulator based on neural network agent model

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Chinese Journal of Aeronautics 2024年第5期37卷 482-505页

作者： Yongxin zhang Liang LI Dingguo zhang Wei-Hsin LIAO xian GUO School of Science Nanjing University of Science and TechnologyNanjing 210094China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

Segmented Active Constrained Layer Damping(SACLD)is an intelligent vibration-damping structure,which could be applied to the sectors of aviation,aerospace,and transportation engineering to reduce the vibration of flexible ***,machine learning technology is widely used in the engineering field because of its efficient multi-objective *** dynamic simulation of a rotational segmental flexible manipulator system is presented,in which enhanced active constrained layer damping is carried out,and the neural network model of Genetic Algorithm-Back Propagation(GA-BP)algorithm is *** suppression and structural optimization of the SACLD manipulator model are studied based on vibration mode and damping *** modal responses of the SACLD manipulator model at rest and rotation are *** addition,the four model indices are optimized using the GA-BP neural network:axial incision size,axial incision position,circumferential incision size,and circumferential incision ***,the best model for vibration suppression is obtained.

关键词： Machine learning Vibration suppression Flexible manipulator Segmented active constrained layer damping Structural optimization

Accumulated-state-error-based event-triggered sampling scheme and its application to H∞ control of sampled-data systems

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Science China(Information Sciences) 2024年第6期67卷 328-341页

作者： xian-Ming zhang Qing-Long HAN Bao-Lin zhang Xiaohua GE Dawei zhang School of Science Computingand Engineering TechnologiesSwinburne University of Technology College of Automation and Electronic Engineering Qingdao University of Science & Technology School of Mathematics Shandong University

This paper is concerned with event-triggered H∞control of sampled-data systems. Its novelties lie in three aspects:（i） A novel accumulated-state-error-based event-triggered scheme is introduced by comparing the integral of the state error from tk to t with the system state sampled at tk. This condition works well due to the fact that the so-called Zeno behaviour does not occur.（ii） A novel Lyapunov functional is constructed to establish a criterion to ensure some certain H∞performance of the closed-loop system. This Lyapunov functional is dependent on the integral of the state error involved in the event-triggered scheme.（iii） Under the event-triggered sampling scheme, suitable state-feedback controllers can be designed rather than be given a priori. Moreover, a self-triggered implementation of the proposed event-triggered sampling scheme is presented as well. Finally, a batch reactor model and an inverted pendulum system are given to demonstrate the effectiveness of the proposed method.

关键词： event-triggered sampling self-triggered implementation $H_\infty$ control looped-functional