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Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome:a meta-analysis

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Journal of Integrative Medicine 2017年第2期15卷 95-101页

作者： qian-wen Ma Yong Tan The First Clinical Medical College Nanjing University of Chinese Medicine Department of Gynecology Zhenjiang Hospital of Traditional Chinese Medicine

BACKGROUND： Polycystic ovary syndrome （PCOS） is an endocrine disease that affects gynecologica health. Treatment of PCOS remains a big challenge for clinicians. OBJECTIVE： This meta-analysis was developed to compare the efficacy of co-treatment with traditiona Chinese medicine （TCM） and letrozole against letrozole monotherapy in the treatment of PCOS. SEARCH STRATEGY： Randomized controlled trials （RCTs） were electronically retrieved from PubMed, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data; related papers that were not available electronically were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions and the valid data were analyzed using Revman software （The Cochrane Collaboration, Copenhagen, Denmark） INCLUSION CRITERIA： We included RCTs that compared co-treatment with TCM and letrozole against letrozole monotherapy in women with PCOS, which was defined by anovulation, biochemical or clinical hyperandrogenemia and polycystic ovaries. We included trials from all sources. DATA EXTRACTION AND ANALYSIS： Two independent reviewers extracted data, and evaluated study quality according to the Cochrane Handbook for Systematic Reviews of Interventions criteria for RCT, including issues of patient randomization, blinding and bias. RESULTS： Eight RCTs, involving a total of 537 patients, were included in the present study. The meta-analysis showed that the cycle ovulation rate, the pregnancy rate and the total effective rate of symptom treatment were higher in treatments combining TCM with letrozole, compared with letrozole monotherapy. Although the rate of luteinizing hormone （LH）/follicle-stimulating hormone （FSH） and the body mass index of the group receiving combined therapy were lower than in letrozole monotherapy, no statistical difference was found in the LH and FSH level between the two groups. CONCLUSION： Available evidence showed that c

关键词： medicine, Chinese traditional letrozole polycystic ovary syndrome meta-analysis

Biomass derived Fe-N/C catalyst for efficiently catalyzing oxygen reduction reaction in both alkaline and neutral pH conditions

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Chinese Chemical Letters 2023年第1期34卷 465-468页

作者： Lin-qian Yu Hao Wang shu-La Chen Te-Er wen Bao-Cheng Huang Ren-Cun Jin Laboratory of Water Pollution Remediation School of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China

Fe-N/C is a promising oxygen reduction reaction(ORR)catalyst to substitute the current widely used precious metal ***-effectively fabricating the Fe-N/C material with high catalytic activity and getting in-depth insight into the responsible catalytic site are of great *** this work,we proposed to use biomass,tea leaves waste,as the precursor to prepare ORR *** adding 5%FeCl3(wt%)into tea precursor,the pyrolysis product(i.e.,5%Fe-N/C)exhibited an excellent four-electron ORR activity,whose onset potential was only 10 m V lower than that of commercial Pt/*** limiting current density of 5%Fe-N/C(5.75 m A/cm^(2))was even higher than Pt/C(5.44 m A/cm^(2)).Compared with other biomass or metal organic frameworks derived catalysts,5%Fe-N/C showed similar ORR ***,both the methanol tolerance and material stability performances of as-prepared 5%Fe-N/C catalyst were superior to that of Pt/C.X-ray adsorption fine structure characterization revealed that the FeN4O2might be the possible catalytic *** appropriate amount of iron chloride addition not only facilitated catalytic site formation,but also enhanced material conductivity and reaction *** results of this work may be useful for the Fe based transition metal ORR catalyst design and application.

关键词： Fe-N/C Oxygen reduction reaction Biomass Fe coordination Polyphenol

Giant magneto impedance effect of Co-rich amorphous fibers under magnetic interaction

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1415-1420页

作者： shu-ling Zhang Wei-ye Chen Ning Cui qian-qian Wu You-liang Su School of Mechanical&Automotive Engineering Qingdao University of TechnologyQingdao 266520China School of Material of Science and Engineering North Minzu UniversityYinchuan 750021China School of Mechanical Engineering Ningxia UniversityYinchuan 750021China

The quasi-metallic fibers were selected from 1 to 40 pieces and connected in parallel in this *** giant magneto impedance(GMI)effect of Co-based melt extract fibers in the bundle mode was investigated,and the distribution of the surface circumferential magnetic field on the fibers was also *** distribution was induced by the driving current,which gave rise to the circular magnetization process and the GMI *** improved GMI effect with much higher field sensitivity was observed in these fiber *** show that the field sensitivities of the four-fiber and six-fiber bundles reach 19.5 V·m·kA−1(at 1 MHz)and 30.8 V·m·kA−1(at 5 MHz).The circumferential magnetic field distributed throughout the fiber’s circumferential surface is rearranged and becomes uneven due to the magnetic interaction among *** are both strengthened and weakened magnetic field parts around these fibers’*** strengthened magnetic field improves the circumferential domain magnetization of the surface,resulting in larger GMI ***,the weakened parts inhibit the circumferential magnetization process and,therefore,the GMI *** also induces greater magnetization damp because of the increased domain interactions under the strong skin *** co-effect between the magnetic domains and the circumferential magnetization induces the optimization of the GMI effect in the four-fiber *** observed GMI effect proves that fibers in bundle form can modify the sensitivity of the GMI ***,different fiber bundles could be tuned according to the working conditions in order to manipulate the GMI response.

关键词： giant magneto impedance metallic fibers magnetization sensitivity

Recent advances of long noncoding RNAs involved in the development of multiple sclerosis

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Chinese Journal of Natural Medicines 2020年第1期18卷 36-46页

作者： LI qian-wen LEI wen CHEN Cong GUO Wei School of Life Science and Technology China Pharmaceutical UniversityJiangsu Key Laboratory of Druggability of BiopharmaceuticalsNanjing 210009China Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China

Given the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies,the discovery of novel and effective therapeutic targets have been in an urgent *** studies have revealed that long noncoding RNAs(lncRNAs)play crucial roles in the development of multiple sclerosis(MS),which provides a new opportunity of uncovering novel mechanism associated with the progression of *** review highlights the dysregulation of lncRNAs in the development of MS in patients and animal ***,the potential clinical relevance of lncRNAs severed as therapeutic targets and diagnostic markers are discussed.

关键词： Multiple sclerosis Long noncoding RNA Experimental autoimmune encephalomyelitis Clinical relevance Dysregulation

Weakly Approximate Diagonalization of Homomorphisms into Finite von Neumann Algebras

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2187-2194页

作者： wen Hua qian Jun Hao SHEN wen Ming WU School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331P.R.China Department of Mathematics and Statistics University of New HampshireDurhamNH 03824USA

Let A be a unital C^(∗)-algebra and B a unital C^(∗)-algebra with a faithful traceτ.Let n be a positive *** give the definition of weakly approximate diagonalization(with respect toτ)of a unital homomorphismφ:A→Mn(B).We give an equivalent characterization of McDuff Ⅱ_(1) *** show that,if A is a unital nuclear C^(∗)-algebra and B is a type Ⅱ_(1) factor with faithful traceτ,then every unital^(∗)-homomorphism φ:A→M_(n)(B)is weakly approximately *** B is a unital simple infinite dimensional separable nuclear C^(∗)-algebra,then any finitely many elements in Mn(B)can be simultaneously weakly approximately diagonalized while the elements in the diagonals can be required to be the same.

关键词： Weakly approximately diagonalizable McDuff factors nuclear hyperfinite

Stereoselective construction of azepine-containing bridged scaffolds via organocata-lytic bicyclization of yne-allenone esters with nitrones

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Chinese Chemical Letters 2023年第4期34卷 309-312页

作者： Meng-Fan Li Shao-Qing Shi Ting Xu qian Zhang wen-Juan Hao shu-Liang Wang Jianyi Wang shu-Jiang Tu Bo Jiang School of Chemistry and Materials Science and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal UniversityXuzhou 221116China Medical College Guangxi UniversityNanning530004China

A new organocatalytic double annulation cascade involving scission/recombination of N-O bonds of nitrones is reported for the first time, and used to produce a range of hitherto unprecedented tricyclic bridged-fused benzo[d]azepines bearing three stereogenic centers with moderate to good yields and complete diastereoselectivity. A quinine-catalyzed reaction of yne–allenone esters with nitrones worked well and provided a convergent and regioselective pathway to access these three-dimensional scaffolds from the planar conjugated system. Density functional theory(DFT) calculations have been applied to understand the key process for forming diradical intermediates.

关键词： Bicyclization Diastereoselectivity Organocatalysis Bridged heterocycles YNE-allenone esters Nitrones

Influence of reaction piles on test pile response in a static load test

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 198-205页

作者： qian-qing ZHANG shu-cai LI Zhong-miao ZHANG Geotechnical and Structural Engineering Research Center Shandong University MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University

This work presents a new analytical method to analyze the influence of reaction piles on the test pile response in a static load *** our method,the interactive effect between soil and pile is simulated using independent springs and the shear displacement method is adopted to analyze the influence of reaction piles on test pile ***,the influence of the sheltering effect between reaction piles and test pile on the test pile response is taken into *** cases are analyzed to verify the rationality and efficiency of the present *** method can be easily extended to a nonlinear response of an influenced test pile embedded in a multilayered soil,and the validity is also demonstrated using centrifuge model tests and a computer program presented in the *** present analyses indicate that the proposed method will lead to an underestimation of the test pile settlement in a static load test if the influence of the presence of reaction piles on the test pile response is neglected.

关键词： Test pile Reaction pile Shear displacement method Sheltering effect Multilayered soil

Wear Resistance, Cytotoxicity and Antibacterial Properties of Polyetheretherketone Composite Modified by Carbon Fiber and Black Phosphorus

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Journal of Bionic Engineering 2022年第1期19卷 155-166页

作者： Jingdan Li qian Liang wen Qin Jing Ma School of Material Science and Engineering Taiyuan University of TechnologyTaiyuan030024China

High wear resistance,low cytotoxicity and excellent antibacterial properties are the basis for osseointegration of implant ***(PEEK)has been considered as a potential implant material due to its excellent biocompatibility,natural radiolucency and mechanical *** this work,to improve the wear resistance,cytotoxicity and antibacterial properties of PEEK,carbon fiber(CFR)and Black Phosphorus(BP)were used to synergistically modify PEEK by two methods,deposition of BP coating on CFR-PEEK and BP/CFR-PEEK coating on Ti6Al4V(TC4)through electrostatic *** CFR and BP synergistically modified PEEK,the friction coefficient of BP coating on CFR-PEEK and BP/CFR-PEEK coating were 0.14±0.01 and 0.09±0.02,*** wear volume of BP coating on CFR-PEEK(30.54±1.32)was higher than that of BP/CFR-PEEK coating(9.46±1.32),which indicated that BP/CFR-PEEK coating showed high wear *** difference in wear resistance may be caused by the fact that BP was not easily oxidized in BP/CFR-PEEK *** addition,BP coating on CFR-PEEK and BP/CFR-PEEK coating showed no obvious cytotoxicity to L929 cell and presented excellent antibacterial efficiency(up to 94.5%±2.8%and 96.0%±3.8%,respectively)against Staphylococcus aureus(***).It was concluded that BP/CFR-PEEK coating exhibited high wear resistance,low cytotoxicity and excellent antibacterial properties against ***,which might provide a foundation for osseointegration of implants.

关键词： Surface deposition Electrostatic spraying Wear resistance Cytotoxicity Antibacterial properties

Enhanced sulfidization of azurite surfaces by ammonium phosphate and its effect on flotation

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1150-1160页

作者： qian Zhang shuming wen Qicheng Feng Han Wang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China

Although azurite is one of the most important copper oxide minerals,the recovery of this mineral via sulfidization-xanthate flotation is typically *** present work demonstrated the enhanced sulfidization of azurite surfaces using ammonia phosphate((NH_(4))_(3)PO_(4)) together with Na_(2)S,based on micro-flotation experiments,time-of-flight secondary ion mass spectrometry(ToF-SIMS),X-ray photoelectron spectroscopy(XPS),zeta-potential measurements,contact angle measurements,Fourier-transform infrared(FT-IR)spectroscopy,and ultraviolet-visible(UV-Vis)***-flotation experiments showed that the floatability of azurite was increased following the simultaneous addition of(NH_(4))_(3)PO_(4)and Na_(2)***-SIMS and XPS analyses demonstrated the formation of a high content of S species on the azurite surface and an increase in the number of Cu(I)species after exposure to(NH_(4))_(3)PO_(4)and Na_(2)S,compared with the azurite-Na_(2)S *** zeta potential of azurite particles was negatively shifted and the contact angle on the azurite surface was increased with the addition of(NH_(4))_(3)PO_(4)prior to Na_(2)*** results indicate that treatment with(NH_(4))_(3)PO_(4) enhances the sulfidization of azurite surfaces,which in turn promotes xanthate ***-IR and UV-Vis analyses confirmed that the addition of(NH_(4))_(3)PO_(4) increased the adsorption of xanthate with reducing the consumption of xanthate during the azurite flotation ***,(NH_(4))_(3)PO_(4) has a beneficial effect on the sulfidization flotation of azurite.

关键词： azurite ammonium phosphate enhanced sulfidization reagent adsorption flotation enhancement