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In situ synthesis of porous Pt-Pd bimetallic structures for sweat glucose biosensing using dynamic hydrogen bubble template method

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Rare Metals 2024年第7期43卷 3408-3414页

作者： Yi-wen guo Qian-Hui Wei Fei Wei Hao Liu Hong-Bin Zhao Dong Wang Hai-Ling Tu State Key Laboratory of Advanced Materials for Smart Sensing China GRINM Group Co.Ltd.Beijing 100088China Department of Advanced Electronic Materials GRIMAT Engineering Institute Co.Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China GRINM(Guangdong)Institute for Advanced Materials and Technology Foshan 528000China School of Chemical Engineering Northeast Electric Power UniversityJilin 132012China

For the practical application of sweat glucose biosensors,it is crucial to develop a method for modifying the working electrode with noble metals that ensures strong *** this study,we synthesized porous Pt-Pd bimetall... 详细信息

关键词： method bubble porous

Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： Jinbo Hu wen Liu Yi Zou Chenyang Jiao Jiazhen Zhu Qiang Xu Jianjun Zou Yang Sun wenjie guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator

Modification of solid electrolyte interface layer between PVDF-based electrolyte and lithium anode

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Journal of Materiomics 2024年第4期10卷 880-888页

作者： Ying Liang Jie Zhang shundong Guan Kaihua wen Chuangjie guo Yu-Hsien Wu Haocheng Yuan Sijie Liu Ying Qi wenbin Mo Xue Zhang Ce-wen Nan State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Qingtao Institute of New Energy Materials Qingtao(Kunshan)Energy Development Co.LtdKunshanJiangsu215300China

Poly(vinylidene fluoride)(PVDF)-based polymer electrolytes(PEs)with good electrochemical performance and processability as well as low-cost advantage,have great potential applications in solid-state lithium(Li)metal batteries(SSLMBs).PVDF-based PEs are generally produced by employing a solution-casting approach with N,N-dimethylformamide(DMF)as the solvent,accompanied by the formation of[DMF-Li^(+)]complex,which facilitates the Li-ion ***,the residual DMF can react continuously with lithium(Li)metal,thereby deteriorating the interface layer in the middle of the PVDF-based PEs and Li ***,we introduce propylene carbonate(PC)into the PVDF-based PEs to regulate the solvation structure and stabilize the interface layer between the PEs and Li *** accelerates the dissociation of lithium oxalyldifluoroborate(LiODFB).Consequently,“lithium propylene dicarbonate(LPDC)‒B-O”oligomer forms as the interfacial layer with high tenacity,homogeneity,and densification,which improves the interfacial contact and suppresses the continuous reaction between the residual DMF and Li *** further demonstrate that the PVDF-based PE prepared with DMF-PC mix-solvents shows improved room-temperature ionic conductivity(1.18×10^(-3) S/cm),enhanced stability against electrodes,and superior cycling performance in LiCoO_(2)-based SSLMBs(maintaining 84% of the initial discharge capacity after 300 cycles).

关键词： Solid-state battery Lithium metal Poly(vinylidene fluoride)electrolyte Propylene carbonate SEI layer

The inhibitory effect of adenosine on tumor adaptive immunity and intervention strategies

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1951-1964页

作者： Longsheng Wang Jie Zhang wenxin Zhang Mingming Zheng Hongjie guo Xiaohui Pan wen Li Bo Yang Ling Ding Zhejiang Province Key Laboratory of Anti-Cancer Drug Research Institute of Pharmacology and ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China The Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 310018China Nanhu Brain-Computer Interface Institute Hangzhou 311100China

Adenosine(Ado)is significantly elevated in the tumor microenvironment(TME)compared to normal *** binds to adenosine receptors(AdoRs),suppressing tumor antigen presentation and immune cell activation,thereby inhibiting tumor adaptive *** downregulates major histocompatibility complex II(MHC II)and co-stimulatory factors on dendritic cells(DCs)and macrophages,inhibiting antigen *** suppresses anti-tumor cytokine secretion and T cell activation by disrupting T cell receptor(TCR)binding and signal *** also inhibits chemokine secretion and KCa3.1 channel activity,impeding effector T cell trafficking and infiltration into the tumor ***,Ado diminishes T cell cytotoxicity against tumor cells by promoting immune-suppressive cytokine secretion,upregulating immune checkpoint proteins,and enhancing immune-suppressive cell *** Ado production in the TME can significantly enhance anti-tumor immune responses and improve the efficacy of other *** and clinical development of inhibitors targeting Ado generation or AdoRs is ***,this article will summarize and analyze the inhibitory effects and molecular mechanisms of Ado on tumor adaptive immunity,as well as provide an overview of the latest advancements in targeting Ado pathways in anti-tumor immune responses.

关键词： Adenosine Adenosine receptors Adenosine-generating enzymes Tumor microenvironment Immune suppression Immune escape Clinical treatment Targeting drugs

Emerging memristors and applications in reservoir computing

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Frontiers of physics 2024年第1期19卷 219-239页

作者： Hao Chen Xin-Gui Tang Zhihao Shen wen-Tao guo Qi-Jun Sun Zhenhua Tang Yan-Ping Jiang School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China

Recently, with the emergence of ChatGPT, the field of artificial intelligence has garnered widespread attention from various sectors of society. Reservoir Computing (RC) is a neuromorphic computing algorithm used to analyze time-series data. Unlike traditional artificial neural networks that require the weight values of all nodes in the trained network, RC only needs to train the readout layer. This makes the training process faster and more efficient, and it has been used in various applications, including speech recognition, image classification, and control systems. Its flexibility and efficiency make it a popular choice for processing large amounts of complex data. A recent research trend is to develop physical RC, which utilizes the nonlinear dynamic and short-term memory properties of physical systems (photonic modules, spintronic devices, memristors, etc.) to construct a fixed random neural network structure for processing input data to reduce computing time and energy. In this paper, we introduced the recent development of memristors and demonstrated the remarkable data processing capability of RC systems based on memristors. Not only do they possess excellent data processing ability comparable to digital RC systems, but they also have lower energy consumption and greater robustness. Finally, we discussed the development prospects and challenges faced by memristors-based RC systems.

关键词： reservoir computing memristor resistive switching artificial synapse neuromorphic computing

Fluorogenic sensing of amorphous aggregates,amyloid fibers,and chaperone activity via a near-infrared aggregation-induced emission-active probe

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Aggregate

Aggregate 2024年第1期5卷 309-320页

作者： Wei He Yuanyuan Yang Yuhui Qian Zhuoyi Chen Yongxin Zheng wenping Zhao Chenxu Yan Zhiqian guo shu Quan State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for Biomanufacturing(SCICB)East China University of Science and TechnologyShanghaiChina Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials ChemistryFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism East China University of Science and TechnologyShanghaiChina

The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these *** the development of various biosensors and fluorescent probes that selectively target amyloid fibers or amorphous aggregates,there is still a lack of tools capable of simultaneously detecting both types of ***,we demonstrate the quantitative discernment of amorphous aggregates by QM-FN-SO3,an aggregationinduced emission(AIE)probe initially designed for detecting amyloid *** probe easily penetrates the membranes of the widely-used prokaryotic model organism Escherichia coli,enabling the visualization of both amorphous aggregates and amyloid fibers through near-infrared ***,the probe exhibits sensitivity in distinguishing the varying aggregation propensities of proteins,regardless of whether they form amorphous aggregates or amyloid fibers in *** properties contribute to the successful application of the QM-FN-SO3 probe in the subsequent investigation of the antiaggregation activities of two outer membrane protein(OMP)chaperones,both in vitro and in their physiological ***,our work introduces a near-infrared fluorescent chemical probe that can quantitatively detect amyloid fibers and amorphous aggregates with high sensitivity in vitro and in ***,it demonstrates the applicability of the probe in chaperone biology and its potential as a high-throughput screening tool for protein aggregation inhibitors and folding factors.

关键词： aggregation-induced emission fluorescence molecular chaperone protein aggregation

Inhibiting oxygen vacancies and twisting NbO_(6) octahedron in erbium modified KNN-based multifunctional ceramics

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Journal of Materiomics 2024年第1期10卷 179-189页

作者： Lulu Gao Zhiyong Liu Pengrong Ren Renhong Liang Ting Li Kun guo Bing Xie Jinshan Lu Pu Mao Jun Tian Longlong shu School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Materials Science and Engineering Xi'an University of TechnologyXi'an710048China School of Physics and Materials Science Nanchang UniversityNanchang330031China Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang330096China

It is a challenge to obtain highly tunable multifunctional performances in one ferroelectric system by a simple approach to meet the miniaturization,integration,and functionalization requirements of advanced electronic ***,rare earth erbium(Er)modulated 0.9K_(0.5)Na_(0.5)NbO_(3)-0.1Sr(1-x)Er_(x)Ti_((1-x/4))O_(3),(0.9KNN-0.1ST:xEr)transparent-photoluminescent-ferroelectric energy storage multifunctional ceramics are prepared to solve this *** effect of lattice distortion and oxygen vacancies by Er doping on the optical and electrical properties is systematically *** Er^(3+)ions can introduce a large distortion of the NbO_(6) octahedron by replacing the A-site in KNN-based *** to the higher c/a ratio and lower oxygen vacancy content are simultaneously obtained in 0.9KNN-0.1ST:0.1Er *** effective energy storage density(Wrec)of 0.86 J/cm^(3),excellent near-infrared transmittance of 51.7%(1100 nm)and strong green upconversion photoluminescence are achieved in this multifunctional *** study provides a solid basis for rare earth ions doped ferroelectric ceramics with tunable multifunctional properties and has significant potential for applications in optoelectronic devices.

关键词： KNN Upconversion photoluminescence Multifunctional ceramics Oxygen vacancy Octahedron

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1147-1164页

作者： Yan guo Pan Xiang Xiaojiao Sun Wei Liu Jiafeng Zhou Bin Yin Lin Hou Boqin Qiang Huiliang Li Pengcheng shu Xiaozhong Peng Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina State Key Laboratory of Common Mechanism Research for Major Diseases Beijing 100005China Wolfson Institute for Biomedical Research University College LondonGower StreetLondon WC1E 6BTUK Chinese Institute for Brain Research Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,and this process requires the proper recruitment of adaptor molecules to selectively activate downstream ***,we identified that DOK6,a member of the Dok(downstream of tyrosine kinases)family,is required for the maintenance of peripheral axons,and that loss of Dok6 can cause typical peripheral neuropathy symptoms in mice,manifested as impaired sensory,abnormal posture,paw deformities,blocked nerve conduction,and ***,Dok6 is highly expressed in peripheral neurons but not in Schwann cells,and genetic deletion of Dok6 in peripheral neurons led to typical peripheral myelin outfolding,axon destruction,and hindered retrograde axonal ***,DOK6 acts as an adaptor protein for selectivitymediated neurotrophic signal transduction and retrograde transport for TrkC and Ret but not for TrkA and ***6 interacts with certain proteins in the trafficking machinery and controls their phosphorylation,including MAP1B,Tau and Dynein for axonal transport,and specifically activates the downstream ERK1/2 kinase pathway to maintain axonal survival and *** finding provides new clues to potential insights into the pathogenesis and treatment of hereditary peripheral neuropathies and other degenerative diseases.

关键词： impaired restrain peripheral

Optimal and robust control of population transfer in asymmetric quantum-dot molecules

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Chinese Physics B 2024年第2期33卷 353-359页

作者：郭裕马松山束传存 Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering School of Physics and Electronic ScienceChangsha University of Science and TechnologyChangsha 410114China Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangsha 410083China

We present an optimal and robust quantum control method for efficient population transfer in asymmetric double quantum-dot *** derive a long-duration control scheme that allows for highly efficient population transfer by accurately controlling the amplitude of a narrow-bandwidth *** overcome fluctuations in control field parameters,we employ a frequency-domain quantum optimal control theory method to optimize the spectral phase of a single pulse with broad bandwidth while preserving the spectral *** is shown that this spectral-phase-only optimization approach can successfully identify robust and optimal control fields,leading to efficient population transfer to the target state while concurrently suppressing population transfer to undesired *** method demonstrates resilience to fluctuations in control field parameters,making it a promising approach for reliable and efficient population transfer in practical applications.

关键词： population transfer quantum optimal control theory quantum-dot molecules