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World Journal of Stem Cells 2023年第10期15卷 960-978页

作者： Wen-Bo Xing shu-ting wu Xin-Xin Wang Fen-Yao Li Ruo-Xuan Wang Ji-Hui He Jiao Fu Yan He Institute of Regenerative and Translational Medicine Tianyou HospitalWuhan University of Science and TechnologyWuhan 430000Hubei ProvinceChina First Clinical College Wuhan University of Science and TechnologyWuhan 430000Hubei ProvinceChina Department of Stomatology Tianyou HospitalWuhan University of Science and TechnologyWuhan 430000Hubei ProvinceChina Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022Hubei ProvinceChina

Peripheral nerve injury(PNI)seriously affects people’s quality of *** cell therapy is considered a promising new option for the clinical treatment of *** stem cells,particularly dental pulp stem cells(DPSCs),are adult pluripotent stem cells derived from the *** have significant potential in the field of neural tissue engineering due to their numerous advantages,such as easy isolation,multidifferentiation potential,low immunogenicity,and low transplant rejection *** are extensively used in tissue engineering and regenerative medicine,including for the treatment of sciatic nerve injury,facial nerve injury,spinal cord injury,and other neurodegenerative *** article reviews research related to DPSCs and their advantages in treating PNI,aiming to summarize the therapeutic potential of DPSCs for PNI and the underlying mechanisms and providing valuable guidance and a foundation for future research.

关键词： Dental pulp stem cells Peripheral nerve injury Regenerative medicine Neural regeneration Schwann cells Stem cells engineering

Role of gut microbiota in identification of novel TCM-derived active metabolites

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Protein & Cell 2021年第5期12卷 394-410页

作者： Tzu-Lung Lin Chia-Chen Lu Wei-Fan Lai ting-shu wu Jang-Jih Lu Young-Mao Chen Chi-Meng Tzeng Hong-Tao Liu Hong Wei Hsin-Chih Lai Department of Medical Biotechnology and Laboratory Science College of MedicineChang Gung UniversityGueishanTaoyuan 33302TaiwanChina Department of Respiratory Therapy Fu Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Chest Medicine Internal MedicineFu Jen Catholic University HospitalFu Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Medicine Chang Gung UniversityTaoyuan 33302TaiwanChina Department of Laboratory Medicine and Internal Medicine Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Central Research Laboratory Xiamen Chang Gung HospitalXiamen 361026China Bachelor Degree Program in Marine Biotechnology College of Life SciencesNational Taiwan Ocean UniversityKeelung 20224TaiwanChina School of Pharmaceutical Sciences Xiamen UniversityXiamen 361005China College of Basic Medicine Hubei University of Chinese MedicineWuhan 430065China Central Laboratory Clinical Medicine Scientific and Technical Innovation ParkShanghai Tenth People's HospitalTongji UniversityShanghai 200435China Microbiota Research Center and Emerging Viral Infections Research Center Chang Gung UniversityTaoyuan 33302TaiwanChina Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety College of Human EcologyChang Gung University of Science and TechnologyGueishanTaoyuan 33303TaiwanChina

Traditional Chinese Medicine(TCM)has been extensively used to ameliorate diseases in Asia for over thousands of ***,owing to a lack of formal scientific validation,the absence of information regarding the mechanisms underlying TCMs restricts their *** oral administration,TCM herbal ingredients frequently are not directly absorbed by the host,but rather enter the intestine to be transformed by gut *** gut microbiota is a microbial community living in animal intestines,and functions to maintain host homeostasis and *** evidences indicate that TCM herbs closely affect gut microbiota composition,which is associated with the conversion of herbal components into active *** may significantly affect the therapeutic activity of *** analyses,in conjunction with modern multiomics platforms,can together identify novel functional metabolites and form the basis of future TCM research.

关键词： Traditional Chinese Medicine herbs microbiota transformation multiomics

Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

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Zoological Research 2024年第2期45卷 355-366页

作者： Jing-Yi Jia Guang-Hui Chen ting-ting shu Qi-Yong Lou Xia Jin Jiang-Yan He wu-Han Xiao Gang Zhai Zhan Yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ARE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

Design and Implementation of Nonlinear Precoding for MIMO-SDMA Toward 6G Wireless

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China Communications 2024年第1期21卷 69-87页

作者： Chaowu wu Yue Xiao shu Fang Gang wu National Key Laboratory of Wireless Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In this paper,we present a novel and robust nonlinear precoding(NLP)design and detection structure specifically tailored for multiple-input multipleoutput space division multiple access(MIMO-SDMA)systems toward 6G *** approach aims to effectively mitigate the impact of imperfect channel estimation by leveraging the channel fluctuation mean square error(MSE)for reconstructing a highly accurate precoding matrix at the ***,we introduce a simplified receiver structure that eliminates the need for equalization,resulting in reduced interference and notable enhancements in overall system *** conduct both computer simulations and experimental tests to validate the efficacy of our proposed *** results reveals that the proposed NLP scheme offers significant performance improvements,making it particularly well-suited for the forthcoming 6G wireless.

关键词： MIMO-SDMA nonlinear precoding Tomlinson-Harashima precoding(THP) vector perturbation(VP)

Mechanism Design for Ancillary Service Market Considering Social Welfare and Fairness

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1000-1010页

作者： Zhi wu Yuanxi wu Wei Gu Zheng Xu shu Zheng Jingtao Zhao School of Electrical Engineering Southeast UniversityNanjing 210096China NARI Technology Co. Ltd.Nanjing 211106China IEEE CSEE

Increasing penetration of distributed energy resources in the distribution network(DN)is threatening safe operation of the DN,which necessitates setup of the ancillary service market in the *** the ancillary service market,distribution system operator(DSO)is responsible for safety of the DN by procuring available capacities of *** existing studies,this paper proposes a novel market mechanism composed of two parts:choice rule and payment *** proposed choice rule simultaneously considers social welfare and fairness,encouraging risk-averse aggregators to participate in the ancillary service *** is then formulated as a linear programming problem,and a distributed solution using the multi-cut Benders decomposition is ***,successful implementation of the choice rule depends on each aggregator’s truthful adoption of private ***,a payment rule is also designed,which is proved to possess two properties:incentive compatibility and individual *** results demonstrate effectiveness of the proposed choice rule on improving fairness and verify properties of the payment rule.

关键词： Aggregator ancillary service market distributed mechanism fairness mechanism design

Structure attack on full-round DBST

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Frontiers of Computer Science 2024年第4期18卷 223-225页

作者： Chenhao JIA Qing LING ting wu tingting CUI School of Cyberspace Hangzhou Dianzi UniversityHangzhou 310018China Hangzhou Innovation Institute Beihang UniversityHangzhou 310052China Key Laboratory of Cryptologic Technology and Information Security(Ministry of Education) Shandong UniversityQingdao 266237China

1 Introduction Block cipher is one of the most important part of symmetric cipher,which has been widely used in the field of computer communication and information system *** order to meet the increasing demand for ensuring secure data transmission in Internet of Things(IoT)environment,lightweight block ciphers have become more and more important due to their easy software implementation,low resource consumption,ease of standardization and high ***,in order to satisfy the constraints of resource-limited devices,lightweight block ciphers strive to achieve a balance between the cost of software and hardware implementation,efficiency,and ***,sometimes the security of lightweight block ciphers might be challenged due to the simplified ***,it is meaningful to study the type of simplified lightweight block ciphers.

关键词： hardware computer simplified

Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

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Current Medical Science 2024年第3期44卷 611-622页

作者： Ying CHEN Bi-xia LI ting-ting NIU shu-jun YANG Li-chao wu Le-huai SHI Duo-bing ZOU Ning-ning wu Li-xia SHENG Xiao YAN Gui-fang OUYANG Qi-tian MU Laboratory of Stem Cell Transplantation The First Affiliated Hospital of Ningbo UniversityNingbo315300China Ningbo Clinical Research Center For Hematologic Malignancies Ningbo315300China Department of Hematology The First Affiliated Hospital of Ningbo UniversityNingbo315300China School of Medicine Hangzhou City UniversityZhejiang UniversityHangzhou310000China Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo315300China

Objective Acute myeloid leukemia(AML)is an aggressive hematological malignancy characterized by abnormal myeloid blast *** studies have demonstrated that circular RNAs play a role in AML *** this study,we aimed to investigate the clinical significance of circ_0012152 in AML and elucidate its underlying molecular mechanism in the pathogenesis of this *** Circ_0012152 expression was detected by quantitative real-time polymerase chain reaction in samples obtained from 247 patients with AML and 40 healthy controls.A systematic analysis of clinical characteristics and prognostic factors was also *** growth was assessed using the Cell Counting Kit-8(CCK-8)assay,and apoptosis and cell cycle progression were evaluated by flow ***,RNA pull-down was performed to identify target microRNAs,and transcriptome RNA sequencing and bioinformatics analyses were utilized to identify downstream mRNA *** Circ_0012152 was significantly upregulated in samples from patients with AML and served as an independent adverse prognostic factor for overall survival(OS)(hazard ratio:2.357;95%confidence interval 1.258–4.415).The circ_0012152 knockdown reduced cell growth,increased apoptosis,and inhibited cell cycle progression in AML cell *** pull-down and sequencing identified miR-652-3p as a target microRNA of circ_*** growth inhibition by circ_0012152 knockdown was significantly relieved by miR-652-3p *** suggested that miR-652-3p targeted SOX4,as the decrease in SOX4 expression resulting from circ_0012152 knockdown was upregulated by miR-652-3p inhibitors in AML *** Circ_0012152 is an independent poor prognostic factor for OS in AML,and it promotes AML cell growth by upregulating SOX4 through miR-652-3p.

关键词： acute myeloid leukemia circ_0012152 miR-652-3p SOX4 cell growth

Arbuscular mycorrhizal fungi and endophytic fungi differentially modulate polyamines or proline of peach in response to soil flooding

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Pedosphere 2024年第2期34卷 460-472页

作者： Shengmin LIANG Yingning ZOU Bo shu Qiangsheng wu Ministry of Education Engineering Research Center of Ecology and Agricultural Use of WetlandHubei Key Laboratory of Waterlogging Disaster and Agricultural Use of WetlandCollege of Horticulture and GardeningYangtze UniversityJingzhou 434025China

Symbiotic fungi are involved in plant flooding tolerance,while the underlying mechanism is not yet *** polyamines(PAs)and proline are also associated with stress tolerance,it is hypothesized that the enhancement of stress resistance by symbiotic fungi is associated with changes in PAs and/or *** aim of this study was to analyze the effect of inoculation with Funneliformis mosseae and Serendipita indica on plant growth,PAs,and proline and the metabolisms in peach(Prunus persica)under ***-week flooding did not affect root colonization frequence of ***,while it promoted root colonization frequence of *** flooding,plants inoculated with *** and *** maintained relatively higher growth rates than uninoculated *** mosseae promoted root ornithine(Orn)contentration and arginine(Arg)and Orn decarboxylase activities under flooding,which promoted putrescine(Put),cadaverine(Cad),and spermidine(Spd)***,*** decreased contentrations of Arg,Orn,and agmatine and Arg decarboxylase activities,thus decreasing PA contentrations under *** were negatively correlated with the expression of PA uptake transporter genes,PpPUT1 and PpPUT2,in *** transporter genes of ***(FmTPO)and ***(SiTPO)were regulated by flooding,of which FmTPO1 was positively correlated with Put,Cad,and Spd,along with positive correlations of Spd with SiTPO1,SiTPO2,and *** flooding,*** decreased proline concentration,while *** increased proline concentration and correlated with expression of a△^(1)-pyrroline-5-carboxylate synthetase gene,*** was thus concluded that *** modulated polyamine accumulation,while *** induced proline accumulation to tolerate flooding.

关键词： △^(1)-pyrroline-5-carboxylate synthetase flooding tolerance Funneliformis mosseae ornithine aminotransferase root colonization Serendipita indica spermidine transporter

Pd-catalyzed intermolecular Si–O formation via Si–C activation

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Science China Chemistry 2024年第8期67卷 2661-2669页

作者： shuang Liu Yu-shu Chen Yichen wu Peng Wang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistryand Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China

The development of efficient Si–O bond formation reaction with 100% atom-economy, excellent functional group tolerance, and broad scope under mild conditions is highly desired due to the prevalence of silanol, silyl ether, and their derivatives in synthetic chemistry and materials science. Here, we have realized the Pd-catalyzed Si–O formation reaction via a Si–C activation approach with 100% atom-economy by employing silacyclobutanes(SCBs) and various hydroxy-containing substrates, including water,alcohols, phenols, and silanols. This protocol features a broad substrate scope, remarkable functional compatibility and mild conditions, providing a series of silanols, silyl ethers in high efficiency. Notably, this protocol could also be used for selective protection of hydroxy functionalities, and for the access of a class of novel polymers containing Si–O main chain. Preliminary mechanistic studies unveiled that this reaction underwent a Pd-catalyzed concerted ring-opening mechanism.

关键词： Si–O formation Si–C activation palladium silacyclobutane silanol silyl ether

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A survey of energy-efficient strategies for federated learning in mobile edge computing

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 645-663页

作者： Kang YAN Nina shu Tao wu Chunsheng LIU Panlong YANG School of Electronic Engineering National University of Defense TechnologyHefei 230009China Department of Computing Hong Kong Polytechnic UniversityHong Kong 999077China School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026China

With the booming development of fifth-generation network technology and Internet of Things,the number of end-user devices(EDs)and diverse applications is surging,resulting in massive data generated at the edge of *** process these data eficiently,the innovative mobile edge computing(MEC)framework has emerged to guarantee low latency and enable eficient computing close to the user ***,federated learning(FL)has demonstrated its empirical success in edge computing due to its privacy-preserving ***,it becomes a promising solution for analyzing and processing distributed data on EDs in various machine learning tasks,which are the major workloads in ***,EDs are typically powered by batteries with limited capacity,which brings challenges when performing energy-intensive FL *** address these challenges,many strategies have been proposed to save energy in *** the absence of a survey that thoroughly summarizes and classifies these strategies,in this paper,we provide a comprehensive survey of recent advances in energy-efficient strategies for FL in ***,we first introduce the system model and energy consumption models in FL,in terms of computation and *** we analyze the challenges regarding improving energy efficiency and summarize the energy-efficient strategies from three perspectives:learning-based,resource allocation,and client *** conduct a detailed analysis of these strategies,comparing their advantages and ***,we visually illustrate the impact of these strategies on the performance of FL by showcasing experimental ***,several potential future research directions for energy-efficient FL are discussed.

关键词： Mobile edge computing Federated learning Energy-efficient