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A reduced-order model for fast predicting ionized flows of hypersonic vehicles along flight trajectory

Chinese Journal of Aeronautics 2024年第1期37卷 89-105页

作者： Jingchao ZHANG Chunsheng NIE Jinsheng CAI shucheng pan School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle TechnologyBeijing 100076China Institute of Extreme Mechanics Northwestern Polytechnical UniversityXi’an 710072China

An improved Reduced-Order Model(ROM)is proposed based on a flow-solution preprocessing operation and a fast sampling strategy to efficiently and accurately predict ionized hypersonic *** ROM is generated in low-dimensional space by performing the Proper Orthogonal Decomposition(POD)on snapshots and is coupled with the Radial Basis Function(RBF)to achieve fast prediction ***,due to the disparate scales in the ionized flow field,the conventional ROM usually generates spurious negative ***,this issue is addressed by performing flow-solution preprocessing in logarithmic space to improve the conventional ***,extra orthogonal polynomials are introduced in the RBF interpolation to achieve additional improvement of the prediction *** addition,to construct high-efficiency snapshots,a trajectory-constrained adaptive sampling strategy based on convex hull optimization is *** evaluate the performance of the proposed fast prediction method,two hypersonic vehicles with classic configurations,i.e.a wave-rider and a reentry capsule,are used to validate the proposed *** two cases show that the proposed fast prediction method has high accuracy near the vehicle surface and the free-stream region where the flow field is *** with the conventional ROM prediction,the prediction results are significantly improved by the proposed method around the discontinuities,*** shock wave and the ionized *** a result,the proposed fast prediction method reduces the error of the conventional ROM by at least 45%,with a speedup of approximately 2.0×105compared to the Computational Fluid Dynamic(CFD)*** test cases demonstrate that the method developed here is efficient and accurate for predicting ionized hypersonic flows.

关键词： Reduced-order model Radial basis function Constrained sampling Transfer function Fast flow prediction Ionized hypersonic flows

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Microstructure and Mechanical Property of the Large Cross-Sectioned Mg-Gd-Y-Zn-Zr Alloy Produced by Small Extrusion Ratio

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 999-1006页

作者： Sen Wang Hucheng pan Caixia Jiang Zhihao Zeng Zhen pan Weineng Tang Chubin Yang Yuping Ren Gaowu Qin Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) College of Materials Science and EngineeringNortheastern UniversityShenyang110819China Mg and Mg Alloy Institute Technology CenterBaosteel Metal Co.LtdChina Baowu Steel GroupShanghai200940China Jiangxi Provincial Engineering Research Center for Magnesium Alloy Gannan Normal UniversityGanzhou341000China

In this work,the microstructure and mechanical properties of large cross-sectioned Mg-9Gd-3Y-1.2Zn-0.5Zr(VWZ931)samples produced by the small extrusion ratio has been *** as-extruded VWZ931 sample with diameter of~30 mm can exhibit the high yield strength(YS)of 339 MPa,ultimate tensile strength(UTS)of 387 MPa and elongation of 8.2%,*** peak-aged,the YS and UTS of the Mg samples were significantly increased to 435 MPa and 467 *** small extrusion ratio leads to the low fraction of dynamic recrystallized(DRX)grains in VWZ931 sample,and the texture hardening effect can be fully utilized to achieve high *** combined effect of precipitation strengthening due to the long-period stacking ordered phases and theβ′phase,grain boundary strengthening due to the fine DRX grains,heterogeneous deformation-induced strengthening caused by bimodal microstructure,can together contribute to the high strength of present Mg *** findings can shed light on designing other large-sized Mg wrought alloys with high mechanical performance.

关键词： Mg-RE alloy Mechanical property Bimodal grains Texture hardening

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Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

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Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： shu-Hao Zhang Yue-Bin Zhang Duo-Te Cai Tao pan Ken Chen Yi Jin Wen-Juan Luo Zong-Wei Huang Qing-Jiang Chen Zhi-Gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm toting the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

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Electric tuning of plasmonic resonances in ultrathin gold nanoribbon arrays

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Photonics Research 2024年第8期12卷 1750-1759页

作者： ZHENXIN WANG ALEXEY VKRASAVIN CHENXINYU pan JUNSHENG ZHENG ZHIYONG LI XIN GUO ANATOLY VZAYATS LIMIN TONG pan WANG State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Physics and London Centre for Nanotechnology King’s College LondonStrandLondon WC2R 2LSUK Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Intelligent Optics&Photonics Research CenterJiaxing Research Institute Zhejiang UniversityJiaxing 314000China

Ultrathin plasmonic nanostructures offer an unparalleled opportunity for the study of light–matter interactions at the nanoscale and realization of compact nanophotonic *** this study,we introduce an ultrathin gold nanoribbon array and demonstrate an electric approach to actively tuning its plasmonic resonance,which leveraging the extreme light confinement capability in the ultrathin plasmonic nanostructure and a robust nanoscale electro-optical effect in indium tin *** the design(to a total thickness as small as 12 nm for a 2-nmthick gold nanoribbon array),we numerically demonstrate a spectral shift in the plasmonic resonance up to 36 nm along with an approximately 16%change in the transmission at a gate voltage below 1.7 V at the wavelength of1.47μ*** work presents progress towards electric tuning of plasmonic resonances in ultrathin metallic nanostructures for various applications including surface-enhanced spectroscopy,spontaneous emission enhancement,and optical modulation.

关键词： plasmon tuning realization

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Mobile Crowdsourcing Task Allocation Based on Dynamic Self-Attention GANs

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Computers, Materials & Continua 2024年第4期79卷 607-622页

作者： Kai Wei Song Yu Qingxian pan School of Computer and Control Engineering Yantai UniversityYantai264005China School of Computer and Information Science Southwest UniversityChongqing400715China

Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource *** traditional methods for task allocation can help reduce costs and improve efficiency,they may encounter challenges when dealing with abnormal data flow nodes,leading to decreased allocation accuracy and *** address these issues,this study proposes a novel two-part invalid detection task allocation *** the first step,an anomaly detection model is developed using a dynamic self-attentive GAN to identify anomalous *** to the baseline method,the model achieves an approximately 4%increase in the F1 value on the public *** the second step of the framework,task allocation modeling is performed using a twopart graph matching *** phase introduces a P-queue KM algorithm that implements a more efficient optimization *** allocation efficiency is improved by approximately 23.83%compared to the baseline *** results confirm the effectiveness of the proposed framework in detecting abnormal data nodes,enhancing allocation precision,and achieving efficient allocation.

关键词： Mobile crowdsourcing task allocation anomaly detection GAN attention mechanisms

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Guest editorial:Special Issue on Artificial Intelligence and Emerging Computational Approaches for Tribology

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Friction 2024年第6期12卷 1057-1059页

作者： Zhinan ZHANG shuaihang pan Bart RAEYMAEKERS State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA Department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA

Tribo-behavior is a complex system-based time-dependent process,and it is difficult to accurately model a tribo-system and predict its ***,tribology research,in most cases,has relied on extensive *** by the artificial intelligence(AI)-for-science revolution,AI and other emerging computational approaches provide opportunities to explore the complex processes in tribo-systems and the physical mechanisms of tribo-behavior in an efficient way,significantly pushing the boundaries of tribology research.

关键词： behavior editorial artificial

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On Leray's problem in an infinitely long pipe with the Navier-slip boundary condition

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Science China Mathematics 2024年第4期67卷 819-854页

作者： Zijin Li Xinghong pan Jiaqi Yang School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China School of Mathematics and Key Laboratory of Ministry of Industry and Information Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Mathematics and Statistics Northwestern Polytechnical UniversityXi'an 710129China

The original Leray’s problem concerns the well-posedness of weak solutions to the steady incompressible Navier-Stokes equations in a distorted pipe,which approach the Poiseuille flow subject to the no-slip boundary condition at spatial *** this paper,the same problem with the Navier-slip boundary condition instead of the no-slip boundary condition,is *** to the complexity of the boundary condition,some new ideas,presented as follows,are introduced to handle the extra difficulties caused by boundary ***,the Poiseuille flow in the semi-infinite straight pipe with the Navier-slip boundary condition will be introduced,which will serve as the asymptotic profile of the solution to the generalized Leray’s problem at spatial ***,a solenoidal vector function defined in the whole pipe,satisfying the Navierslip boundary condition,having the designated flux and equalling the Poiseuille flow at a large distance,will be carefully *** plays an important role in reformulating our ***,the energy estimates depend on a combined L2-estimate of the gradient and the stress tensor of the velocity.

关键词： stationary Navier-Stokes system Navier-slip boundary condition Leray's problem

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Influence of temperature, stress, and grain size on behavior of nano-polycrystalline niobium

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Chinese Physics B 2024年第7期33卷 467-474页

作者：晏玉平张柳亭张丽攀芦刚涂志新 School of Acronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang 330063China

Atomic simulations are executed to investigate the creep responses of nano-polycrystalline(NC) niobium established by using the Voronoi algorithm. The effects of varying temperature, applied stress, and grain size(GS) on creep properties and mechanisms are investigated. Notably, the occurrence of tertiary creep is exclusively observed under conditions where the applied stress exceeds 4.5 GPa and the temperature is higher than 1100 K. This phenomenon can be attributed to the significant acceleration of grain boundary and lattice diffusion, driven by the elevated temperature and stress levels. It is found that the strain rate increases with both temperature and stress increasing. However, an interesting trend is observed in which the strain rate decreases as the grain size increases. The stress and temperature are crucial parameters governing the creep behavior. As these factors intensify, the creep mechanism undergoes a sequential transformation: initially from lattice diffusion under low stress and temperature conditions to a mixed mode combining grain boundaries(GBs) and lattice diffusion at moderate stress and mid temperature levels, and ultimately leading to the failure of power-law controlled creep behavior, inclusive of grain boundary recrystallization under high stress and temperature conditions. This comprehensive analysis provides in more detail an understanding of the intricate creep behavior of nano-polycrystalline niobium and its dependence on various physical parameters.

关键词： creep behavior molecular dynamics simulation activation energy stress exponent nano-polycrystalline niobium

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Noncanonical pyroptosis pathway: a promising target of traditional Chinese medicine in the treatment of sepsis-related injury

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Integrative Medicine Discovery 2024年第20期8卷 1-4页

作者： Yan-Yan Cen pan Wang ting Zhu Ya-Lan Xiong Xi-Chun pan Department of Pharmacology College of PharmacyArmy Medical UniversityChongqing 400038China.

Sepsis is a life-threatening disease of organ failure caused by dysregulated host responses to infection and other infectious ***-organ injury is the leading cause of high mortality and septic shock during *** studies suggest that noncanonical pyroptosis,characterized mainly by the direct activation of caspase-11-gasdermin D-mediated pyroptosis by cytoplastic lipopolysaccharide,is closely related to sepsis-related organ ***,this review summarizes recent advances in the regulatory mechanisms and targeted natural products from traditional Chinese medicine of the noncanonical pyroptosis pathway in sepsis-related injury.

关键词： sepsis-related injury noncanonical pyroptosis caspase-11 gasdermin D

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