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The thickness and volume of the choroid,outer retinal layers and retinal pigment epithelium layer changes in patients with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1957-1962页

作者： Xiang-Ning Wang shu-ting li Wei li Yan-Jun Hua Qiang Wu Department of Ophthalmology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Shanghai Key Laboratory of Diabetes Mellitus Shanghai 200233China

AIM: To evaluate the thickness and volume changes of the choroidal, outer retinal layers(ORL) and retinal pigment epithelium(RPE) in patients with diabetic retinopathy(DR) using optical coherence tomography(OCT) and correlate them with visual ***: We carried out a retrospective observational case series. Consecutive DR patients were recruited for color fundus photography and OCT assessment. The RPE, ORL and choroidal thickness were measured. The correlation with the best-corrected visual acuity(BCVA) was also ***: The study included 128 eyes, comprising 45 eyes of 25 diabetic macular edema(DME) patients, 34 eyes of 20 DR without DME(non-DME) patients, and 49 eyes of 25 age-matched normal individuals. The choroidal thickness in DR patients were decreased statistically significantly compared with the control group(P<0.05). The mean macular ORL thickness in DME(73.02±15.34 μm) and non-DME groups(76.35±7.32 μm) were decreased statistically significantly compared with the control group(80.20±5.85 μm; P=0.006, P=0.013, respectively). In both the non-DME and DME groups, the RPE thickness were decreased compared with the control group(P<0.05), except in the macular and central ring. The BCVA were significant interactions with the total inner retinal volume and macular RPE thickness in the DME group(r=0.115, P<0.001, r=-0.013, P=0.017, respectively).CONCLUSION: The choroid, ORL and RPE thickness are significantly decreased in DR patients compared with controls in different segments.

关键词： choroid diabetic macular edema outer retinal layers retinal pigment epithelium diabetic retinopathy

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Author Reply to the Editor

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1367-1368页

作者： Xiang-Ning Wang shu-ting li Qiang Wu Department of Ophthalmology Shanghai Jiao Tong UniversityAffiliated Sixth People’s HospitalShanghai200233China Shanghai Key Laboratory of Diabetes Mellitus Shanghai200233China

Dear Editor,We very much appreciate Professor Dan C?lug?ru and Mihai C?lug?ru’s comments on our study of the thickness and volume of the choroid, outer retinal layers and retinal pigment epithelium(RPE) layer changes... 详细信息

关键词： Author Editor DME

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Interaction between Colon Cancer Cells and Human liver Sinusoidal Endothelial Cells Promotes liver Metastasis of Tumor Cells

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Clinical oncology and cancer researeh 2011年第3期8卷 138-143页

作者： li-chao SUN shu-ting li Long YU li-xin SUN Lu-lu HAN Tong liU Zhi-hua YANG Yu-liang RAN State Key Laboratory of Molecular Oncology Cancer Institute （Hospital） Chinese Academy of Medical Sciences Peking Union Medical College Beijing People＇s Republic of China Internal Medicine Cancer Institute （Hospital） Chinese Academy of Medical Sciences Peking Union Medical College Beijing People＇s Republic of China.

OBJECTIVE To investigate the effect of co-culture between colon cancer cells （SW1116） and human liver sinusoidal endothelial cells （HLSECs） on cancer cell metastasis, and to provide a novel model for studying the mechanism of colon cancer liver metastasis. METHODS HLSECs and SW1116 were co-cultured for 21 rounds in vitro. Transwell migration, gelatin-zymography, CCK-8 proliferation and colony formation assays were used to examine the invasion, proliferation, and colony forming ability of cancer cells. Assays were carried out to examine tumor growth ability and liver metastasis. The associated molecular change was examined by western blotting. RESULTS After 21 selection rounds, colon cancer cells SWl 1161）21 displayed a clear boundary. Compared with the 5W1116 cells, SW1116P21 cells had a greater invasive ability, cell proliferation and colony formation in soft agar. A gelatin-zymography assay showed that the ability of SW1116P21 cells to secrete matrix metalloproteinase-2/9 was significantly greater than that of SWl116 cells. Additionally, the capacity for subcutaneous tumor formation of SW1116P21 was significantly increased. It was found that mice injected with SW1116P21 cells developed significantly more visually observable liver nodules than mice injected with SW1116 cells. Western blotting showed increased vimentin expression and decreased E-cadherin expression in the SW1116P21 cells, compared with the SWl 116 cells. CONCLUSION The interaction between SW1116 and HLSECs may promote tumor cell invasion, proliferation and colony formation in vitro, and tumor formation and liver metastasis in vivo. An epithelial-mesenchymal transition occurs in SWl 116P21 cells, which contributes to the change in the characteristics of tumor cells.

关键词： colon cancer human liver sinusoidal endothelial cells co-culture liver metastasis

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远程医疗在糖尿病视网膜病变筛查项目中应用的价值及前景

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国际眼科杂志 2021年第2期21卷 257-261页

作者：李淑婷吴强中国江苏省常州市第一人民医院眼科 213000 上海交通大学附属第六人民医院眼科中国上海市200233

糖尿病视网膜病变(DR)是工作年龄人群中可预防性失明的疾病最常见原因,全球糖尿病人数众多,医疗卫生资源不平衡,患者眼底检查依从性低,DR筛查任务艰巨。远程眼科可通过网络信息技术传输患者医学影像和相关信息至远端医生,增加了偏远地... 详细信息

糖尿病视网膜病变(DR)是工作年龄人群中可预防性失明的疾病最常见原因,全球糖尿病人数众多,医疗卫生资源不平衡,患者眼底检查依从性低,DR筛查任务艰巨。远程眼科可通过网络信息技术传输患者医学影像和相关信息至远端医生,增加了偏远地区的糖尿病患者接受及时DR评估的机会。本文应用Wilson和Jungner关于慢性疾病筛查的10个标准评估DR筛查的远程医疗项目,并按照美国远程医疗协会制定的《糖尿病视网膜病变远程医疗实践指南》中筛查项目的临床验证分类,对目前发表的DR远程筛查项目应用研究的概况进行综述分析。

关键词：糖尿病视网膜病变远程医疗远程眼科筛查

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基于4块排样方式的电机用圆形片下料算法

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微特电机 2017年第10期45卷 74-77页

作者：高淑婷李碧青河南农业职业学院郑州451450 贺州学院贺州542899

介绍一种基于4块排样方式的下料算法。构造4块排样方式的无约束生成算法和有约束生成算法;然后采用线性规划规划算法迭代调用无约束排样算法生成第一部分下料方案,采用顺序启发式算法顺序调用有约束排样算法生成第二部分下料方案;最后... 详细信息

介绍一种基于4块排样方式的下料算法。构造4块排样方式的无约束生成算法和有约束生成算法;然后采用线性规划规划算法迭代调用无约束排样算法生成第一部分下料方案,采用顺序启发式算法顺序调用有约束排样算法生成第二部分下料方案;最后组合两部分下料方案形成最终下料方案。以参考文献中具体的生产实例进行计算分析,结果表明该下料算法比一般的下料算法更能节省板材。

关键词：圆形片下料 4块排样方式下料算法电机铁心

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, Yu-Ze Wang, Yu-Chang liu, ting-ting Zhao, Quan-liang li, Chen-Sha Cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-li li Xiao-ting Sun li-ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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同轴波导虚阴极振荡器二极管参数优化的研究

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物理学报 2011年第10期60卷 465-471页

作者：刘静舒挺李志强国防科技大学光电科学与工程学院长沙410073

采用粒子模拟研究了同轴波导虚阴极振荡器二极管参数对微波效率和频率的影响,得到了由二极管参数改变引起的二极管阻抗变化及其对微波效率的影响规律.借鉴具有慢波结构的高功率微波器件中微波模式特性阻抗的计算方法,给出同轴波导虚阴... 详细信息

采用粒子模拟研究了同轴波导虚阴极振荡器二极管参数对微波效率和频率的影响,得到了由二极管参数改变引起的二极管阻抗变化及其对微波效率的影响规律.借鉴具有慢波结构的高功率微波器件中微波模式特性阻抗的计算方法,给出同轴波导虚阴极振荡器中微波主模式特性阻抗的理论计算公式.将理论计算结果与由粒子模拟对器件进行优化后得到的二极管阻抗进行比较,发现当反映电子束特性的二极管阻抗与微波主模式特性阻抗匹配时,虚阴极振荡器具有较高的束波功率转换效率.进一步用特性阻抗对其他几种典型结构的虚阴极振荡器进行分析,验证了该方法的合理性,为设计高效率虚阴极振荡器提供了理论指导.

关键词：虚阴极振荡器同轴波导二极管参数特性阻抗

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柔性制造仿真系统中机器三维可视化建模

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系统仿真学报 2002年第4期14卷 422-425页

作者：罗建利刘怀兰王书亭陈立平华中科技大学CAD中心武汉430074

采用面向对象的分析方法,针对制造系统虚拟仿真动态建模的实际需求,通过对三维可视化仿真建模技术的研究,提出了柔性制造系统中机器仿真建模的三个层次,即几何建模、运动建模和仿真建模,并重点描述了机器几何模型中节点的层次结构和运... 详细信息

采用面向对象的分析方法,针对制造系统虚拟仿真动态建模的实际需求,通过对三维可视化仿真建模技术的研究,提出了柔性制造系统中机器仿真建模的三个层次,即几何建模、运动建模和仿真建模,并重点描述了机器几何模型中节点的层次结构和运动模型的动画实现方法等关键技术,最后给出了机器仿真模型在离散事件仿真中的基本处理算法。

关键词：柔性制造系统仿真系统机器三维可视化建模几何建模运动建模

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