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Construction of clinical research nurse training program based on position competence

World Journal of Clinical Cases 2023年第30期11卷 7363-7371页

作者： Jie Sun Wen-Chuan Shan Jun-Mei Liu Qin-Qin Zhang Yi Ye shu-ting huang Keng Zhong Department of Nursing The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Outpatient The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Cardiology Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Reproductive Center The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Cardiovascular Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND As one of the most important members in clinical trials,the number of clinical research nurses(CRN)can't keep up with the growth of experimental projects,so it is urgent to build clinical research training and strengthen the background knowledge of *** To construct CRN training program based on position competence,accelerate the construction of CRN talent pool,and provide scientific guidance significance for CRN *** Based on the position competence model,combined with literature research and qualitative interview results,the first draft was prepared of the CRN training *** rounds of correspondence with 16 experts were conducted using the Delphi method to determine the training *** The effective recovery rate of the expert correspondence questionnaire was 100%and the authority coefficients of the 2 rounds of experts were 0.826 and ***,4 first-level indicators and determine 15 s-level indicators of training *** training program included 4 first-level indicators,training requirements,content,methods,assessment and evaluation,15 s-level indicators,and 74 third-level *** The CRN training program based on position competence is scientific and extendable,providing a basis for participation in CRN training.

关键词： Research nurses Position competence Training program Delphi method

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Traditional Chinese medicine combined with low-dose glucocorticoid for treating nephrotic syndrome: A case report

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Drug Combination Therapy 2020年第1期2卷 34-44页

作者： shu-ting huang Si-Chao Ding Gan-Feng Xu Heilongjiang Academy of Traditional Chinese Medicine Harbin 150036China Heitongjiang Provincial Hospital of Traditional Chinese Medicine Harbin 150036China

Nephrotic syndrome(NS)is a common refractory clinical disease that can develop into end-stage renal disease(ESRD)if cannot be *** present,in Western medicine,glucocorticoid or immunosuppressant drugs with heavy dose and long course are used for the therapy of *** are still few reports on the combined treatment of traditional Chinese medicine and low-dose glucocorticoid for ***,we reported a case of a 48-year-old man diagnosed with NS,accompanied by severe pulmonary infection,abundant proteinuria,and pleural *** traditional Chinese and Western medicine was used as the therapeutic regimen of this *** Chinese medicine(TCM)mainly focused on invigorating spleen and kidney,promoting blood circulation,removing blood stasis and promoting diuresis,and Chinese patent medicines or TCM immunosuppressants were given to consolidate the *** Western medicine,small dose and short course glucocorticoids combined with symptomatic treatment were ***,proteinuria subsided after 5 months treatment with integrated TCM and Western medicine and all laboratory reports were negative after 10 months,which has been normal so far(July 2019).This case report indicates that the combination of TCM and low-dose glucocorticoid is effective in curing NS,with low recurrence rate and few side effects.

关键词： Nephrotic syndrome Traditional Chinese medicine Integrated Chinese and Western medicine Treatment based on syndrome differentiation Glucocorticoid

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei huang Jiayi Wen Xin Xiong ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Buried interface bridging for inverted cesium-formamidinium triiodide perovskite solar cells with long operational stability

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Science China Chemistry 2025年第01期 163-173页

作者： Chenhui Zhang Chunjun Liang Fulin Sun ting Zhu Xinghai huang Yuzhu Guo Xinyu Guo Kunyang Ge Dan Li Fangtian You Zhiqun He Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic TechnologyBeijing Jiaotong University Department of Physics School of Physical Science and Engineering Beijing Jiaotong University

In the field of perovskite solar cells(PSCs), the research on defects in the buried interface has been relatively limited due to its non-exposure; however, this interface significantly impacts the performance enhancement of inverted PSCs. This study employs phenylethylammonium chloride(PEACl) molecules as a buffer layer to modify the buried interface of p-i-n structured PSCs,aiming to enhance the uniformity of self-assembled monolayers(SAMs) and facilitate the uniform nucleation and growth of perovskite films on the substrate. Furthermore, the introduction of the PEACl buffer layer effectively passivates defects at the bottom of the perovskite layer and notably enhances the crystal quality of the perovskite film by mitigating residual stress,thereby reducing nonradiative recombination loss. Following these optimizations, the MA-free PSCs treated with PEACl achieve a power conversion efficiency(PCE) of 24.11%, with significant improvements in storage, thermal stability, and operational stability. Particularly noteworthy is the device's performance in an unencapsulated state, whereas after 1,500 hours of continuous light operation stability testing, it retains 97% of its original efficiency. This study not only enriches the systematic understanding of the characteristics of the buried interface in PSCs but also contributes significantly to advancing the commercial production of perovskite photovoltaic technology.

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A general stabilizing strategy based on vitamin C for n-type organic semiconductors

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Science China Materials 2025年第01期 303-304页

作者： Hui huang College of Materials Science and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Organic semiconductors (OSCs), as an emerging next-generation semiconductor material, hold promising prospects in fields such as flexible displays, electronic skins, smart healthcare,and the Internet of Things, due to their excellent flexibility,solution processability, and tunable band structures [1,2]. These molecules are often classified into n-type and p-type, depending on whether the prevalent charge carriers are electrons or holes[3].

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Efficient white-light-emitting lead-free halide double perovskites enabling full-spectrum pc-WLEDs

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Science China Materials 2025年第1期 305-306页

作者： Xiaoyong huang College of Physics and Optoelectronics Taiyuan University of Technology

With the rapid development of solid-state lighting, an important goal of phosphor-converted white light-emitting diodes (pc-WLEDs) is to provide a healthy and comfortable fullspectrum artificial light source with a co...

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Capture Performance of A Multi-Freedom Wave Energy Converter with Different Power Take-off Systems

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China Ocean Engineering 2019年第3期33卷 288-296页

作者： huang shu-ting SHI Hong-da DONG Xiao-chen College of Engineering Ocean University of China Qingdao 266100 China Shandong Provincial Key Laboratory of Ocean Engineering Qingdao 266100 China

Among the wave energy converters (WECs), oscillating buoy is a promising type for wave energy development in offshore area. Conventional single-freedom oscillating buoy WECs with linear power take-off (PTO) system are less efficient under off-resonance conditions and have a narrow power capture bandwidth. Thus, a multi-freedom WEC with a nonlinear PTO system is proposed. This study examines a multi-freedom WEC with 3 degrees of freedom: surge, heave and pitch. Three different PTO systems (velocity-square, snap through, and constant PTO systems) and a traditional linear PTO system are applied to the WEC. A time-domain model is established using linear potential theory and Cummins equation. The kinematic equation is numerically calculated with the fourth-order Runge–Kutta method. The optimal average output power of the PTO systems in all degrees of freedom are obtained and compared. Other parameters of snap through PTO are also discussed in detail. Results show that according to the power capture performance, the order of the PTO systems from the best to worst is snap through PTO, constant PTO, linear PTO and velocity-square PTO. The resonant frequency of the WEC can be adjusted to the incident wave frequency by choosing specific parameters of the snap through PTO. Adding more DOFs can make the WEC get a better power performance in more wave frequencies. Both the above two methods can raise the WEC’s power capture performance significantly.

关键词： oscillating buoy wave energy converter nonlinear power take-off multi-freedom power capture

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Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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Quasi-Optimized Overlapping Schwarz Waveform Relaxation Algorithm for PDEs with Time-Delay

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Communications in Computational Physics 2013年第8期14卷 780-800页

作者： shu-Lin Wu ting-Zhu huang School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengduSichuan 610054China School of Science Sichuan University of Science and EngineeringZigongSichuan 643000China

Schwarzwaveformrelaxation(SWR)algorithmhas been investigated deeply and widely for regular time dependent *** for time delay problems,complete analysis of the algorithm is *** this paper,by using the reaction diffusion equations with a constant discrete delay as the underlying model problem,we investigate the convergence behavior of the overlapping SWR algorithm with Robin transmission *** key point of using this transmission condition is to determine a free parameter as better as possible and it is shown that the best choice of the parameter is determined by the solution of a min-max problem,which is more complex than the one arising for regular problems without *** propose new notion to solve the min-max problem and obtain a quasi-optimized choice of the parameter,which is shown efficient to accelerate the convergence of the SWR *** results are provided to validate the theoretical conclusions.

关键词： Schwarz method waveform relaxation time delay min-max problem

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Hydrodynamic Response and Power Performance of A Heave and Pitch Buoy Wave Energy Converter Under Bimodal Ochi-Hubble Wave Spectrum

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China Ocean Engineering 2022年第1期36卷 28-37页

作者： huang shu-ting LIU Yan-jun XUE Gang XUE Yi-fan Institute of Marine Science and Technology Shandong UniversityQingdao 266237China School of Mechanical Engineering Shandong UniversityJinan 250061China

In coastal sea areas with the bimodal Ochi-Hubble wave spectrum, such as parts of the China Sea and Indian Ocean,wave energy is the superposition of wind wave and swell. Traditional heaving buoy wave energy converters developed with narrowband wave spectrums suffer from big energy loss in these areas, leading to lower power absorption efficiency and higher generating costs. In contrast, multi-freedom buoy has different resonant frequencies and maximal power capture wave frequencies in different degrees of freedom(DOFs). Therefore, this study proposed using two DOFs to capture the energy of wind wave and swell correspondingly. A heave and pitch buoy model was established by potential flow theory and validated by experimental data. Coupling effect on the motion and power absorption, power capture frequency distribution and power absorption with different linear power takeoff system damping coefficients were analyzed to reveal the hydrodynamic response and the power performance of the two DOFs. The results indicate that by using heave and pitch DOFs, the wave energy components of wind wave and swell were captured in a targeted manner. It demonstrates that the 2-DOF buoy is an effective tool to avoid the energy loss and realize the efficient power absorption in coastal sea areas with bimodal Ochi-Hubble waves.

关键词： wave energy power performance oscillating buoy multi degrees of freedom Ochi−Hubble spectrum

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