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Optimal timing of staged percutaneous coronary intervention in ST-segment elevation myocardial infarction patients with multivessel disease

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Journal of Geriatric Cardiology 2018年第5期15卷 356-362页

作者： Xue-Dong ZHAO Guan-Qi ZHAO Xiao WANG shu-tian shi Wen ZHENG Rui-Feng GUO Shao-Ping NIE Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China

Background Studies have shown that staged percutaneous coronary intervention （PCI） for non-culprit lesions is beneficial for prog- nosis of ST-segment elevation myocardial infarction （STEMI） patients with multivessel disease. However, the optimal timing of staged re- vascularization is still controversial. This study aimed to find the optimal timing of staged revascularization. Methods A total of 428 STEMI patients with multivessel disease who underwent primary PCI and staged PCI were included. According to the time interval between primary and staged PCI, patients were divided into three groups （〈 1 week, 1- weeks, and 2-12 weeks after primary PCI）. The primary endpoint was major adverse cardiovascular events （MACE）, a composite of all-cause death, non-fatal re-infarction, repeat revascularization, and stroke. Cox regression model was used to assess the association between staged PCI timing and risk of MACE. Results During the follow-up, 119 participants had MACEs. There was statistical difference in MACE incidence among the three groups （〈 1 week： 23.0%; 1-2 weeks： 33.0%; 2-12 weeks： 40.0%; P = 0.001）. In the multivariable adjustment model, the timing interval of staged PCI ≤ 1 week and l-2 weeks were both significantly associated with a lower risk of MACE [hazard ratio （HR）： 0.40, 95% confidence intervals （CI）： 0.24-4）.65; HR： 0.54, 95% CI： 0.3 lq3.93, respectively], mainly attributed to a lower risk of repeat revascularization （HR： 0.41, 95% CI： 0.24-0.70; HR： 0.36, 95% CI： 0.18-0.7）, compared with a strategy of 2-12 weeks later of primary PCI. Conclusions The optimal timing of staged PCI for non-culprit vessels should be within two weeks after primary PCI for STEMI patients.

关键词： Myocardial infarction Multivessel disease Non-culprit lesion Percutaneous coronary intervention Timing

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu Quan shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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HRCT对周围型小肺癌的诊断价值

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医学影像学杂志 2008年第2期18卷 129-131页

作者：胡伟良陈永红田树时解放军第261医院放射科北京100094

目的：评价HRCT对周围型小肺癌的诊断价值。方法：回顾分析43例确诊为周围型小肺癌的胸部HRCT表现，观察病变的分布特点，影像特征及增强后的特征。结果：病灶呈“小结节堆积征”23例（53．4％），病灶呈分叶34例（79％）。边缘毛刺33例... 详细信息

目的：评价HRCT对周围型小肺癌的诊断价值。方法：回顾分析43例确诊为周围型小肺癌的胸部HRCT表现，观察病变的分布特点，影像特征及增强后的特征。结果：病灶呈“小结节堆积征”23例（53．4％），病灶呈分叶34例（79％）。边缘毛刺33例（76．7％），血管纠集6例（13．9％），“胸膜凹陷征”20例（56．5％）。病灶以双肺下野外周分布为主。HRCT病灶增强表现：腺癌24例，病灶强化程度为26～58HU，平均为（48±16．8）HU；细支气管肺泡癌9例，增强范围为17～54HU，平均为（41．6±19．1）HU；鳞癌10例，增强后CT值为31～35．9HU，平均为（35．6±13．5）HU。结论：周围型小肺癌的肺部病变HRCT平扫及增强表现的认识对早期发现，早期治疗，提高存活率有重要的意义。HRCT是评价周围型小肺癌的肺部病变的敏感方法，为临床提供了更可靠的诊断依据。

关键词：小肺癌体层摄影术,X线计算机

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Controlling Chaos and Bifurcation by a Delayed Nonlinear Feedback

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Chinese Physics Letters 1996年第5期13卷 333-336页

作者： YANG shi-ping tian Gang XU shu-shan Department of Physics Hebei Teachers'CollegeShijiazhuang 050091

A method for stabilizing unstable periodic orbits(UPO)embedded in a chaotic attractor is *** conditions for controlling chaof and bifurcation through feeding back a delayed discrete rariable are *** feedback procedure is applicable without knowing a priori the location and the periodicity of the *** method can be applied not only to the chaotic attractor but also to the situation of bifurcation.

关键词： attractor chaotic Bifurcation

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning shi Lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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A four-dimensional interaction-based appraisal approach towards the performance enhancement of a vehicular waste heat recovery system

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Science China(Technological Sciences) 2022年第12期65卷 2921-2941页

作者： LU BoWen shi LingFeng tian Hua WANG Xuan ZHANG MeiYan shu GeQun Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Engines Tianjin UniversityTianjin 300072China

The non-linear multifactorial impacts on fuel-saving potential constrain the practical performance of the vehicular waste heat recovery system(WHRS). This study proposed a four-dimensional interaction-based appraisal approach to interpreting these impacts for enhancing WHRS's in-vehicle performance. The interaction incorporates a heat exchanger, configuration, engine,and vehicle. The proposed approach comprises two successive steps, emphasizing evaluation under the rated(Step 1) and off-design(Step 2) heat source conditions. A case study of waste heat recovery from a passenger vehicle was conducted to evaluate the in-vehicle performance of a novel co-split system and two single-split ones(with/without a regenerator) through this approach. The novel system theoretically modifies vehicular performance but remains ambiguous concerning real-world behaviour, which is assessed and verified by the proposed approach. Two key factors determining vehicular performance were identified by Step 1, namely, net power output and engine backpressure. As the co-split system modified both factors, its fuel-saving potential could be increased by up to 20.3% compared with single-split systems. Also, the limiting factor for off-design performance was pinpointed by Step 2, namely, the mismatch between the heat source and working fluid, which led to the solution, i.e., the synergistic split regulation of the working fluid and heat source. An up to 8.8% improvement in net power output was achieved by the co-split system at off-design heat sources compared with fixed split ratios. Consequently, the approach enables holistic performance improvement of the vehicular WHRS under design/off-design heat source conditions.

关键词： waste heat recovery passenger vehicle in-vehicle scenario dual heat source operational flexibility

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On the Sublinear Convergence Rate of Multi-block ADMM

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Journal of the Operations Research Society of China 2015年第3期3卷 251-274页

作者： tian-Yi Lin shi-Qian Ma shu-Zhong Zhang Department of Systems Engineering and Engineering Management The Chinese University of Hong KongShatinNew TerritoriesHong KongChina Department of Industrial and Systems Engineering University of MinnesotaMinneapolisMN 55455USA

The alternating direction method of multipliers(ADMM)is widely used in solving structured convex optimization *** its success in practice,the convergence of the standard ADMM for minimizing the sum of N(N≥3)convex functions,whose variables are linked by linear constraints,has remained unclear for a very long ***,Chen et al.(Math Program,doi:10.1007/s10107-014-0826-5,2014)provided a counter-example showing that the ADMM for N≥3 may fail to converge without further *** the ADMM for N≥3 has been very successful when applied to many problems arising from real practice,it is worth further investigating under what kind of sufficient conditions it can be guaranteed to *** this paper,we present such sufficient conditions that can guarantee the sublinear convergence rate for the ADMM for N≥***,we show that if one of the functions is convex(not necessarily strongly convex)and the other N-1 functions are strongly convex,and the penalty parameter lies in a certain region,the ADMM converges with rate O(1/t)in a certain ergodic sense and o(1/t)in a certain non-ergodic sense,where t denotes the number of *** a by-product,we also provide a simple proof for the O(1/t)convergence rate of two-blockADMMin terms of both objective error and constraint violation,without assuming any condition on the penalty parameter and strong convexity on the functions.

关键词： Alternating direction method of multipliers Sublinear convergence rate Convex optimization

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The key residues of OsTFIIAγ5/Xa5 protein captured by the argininerich TFB domain of TALEs compromising rice susceptibility and bacterial pathogenicity

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Journal of Integrative Agriculture 2019年第6期18卷 1178-1188页

作者： tian Jing-jing HUI shu-gang shi Ya-rui YUAN Meng National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan)Huazhong Agricultural University

Xanthomonas bacteria secrete transcription activator-like effector(TALE)proteins into host cells to activate plant disease susceptibility genes to cause disease,and the process is dependent on interaction between bacteria TFB domain of TALEs and host plant basal transcription factor IIA gamma subunit(TFIIAγ).The key domain or residues of plant TFIIAγand core residues of bacteria TFB domain that are indispensable for TFIIAγ-TALEs interaction in the process of TALE-carrying Xanthomonas invasion plants are ***,we showed that the thirdα-helix domain of OsTFIIAγ5/Xa5,especially the 38th,39th,40th and 42th residues were key sites for capturing by TALEs of Xanthomonas oryzae ***(Xoo),the causal agent of rice bacterial blight *** latter segment of Xoo TFB domain harboring seventy-two amino acid residues was vital for TALE specific binding with host plant OsTFIIAγ5/*** of some residues in this core region of TFB domain completely compromised capacity of TALEs capturing rice OsTFIIAγ5/*** rich and conserved arginine residues in this core region of TFB domain were responsible for TALE-dependent plant susceptibility gene activation and virulence of *** results provide a potential strategy for improving resistance to TALE-carrying pathogens in plants by site-specific modification of key residues of host plant TFIIAγ.

关键词： Xanthomonas transcription activator-like effector PthXo1 TFB rice

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie shi Changle Hou Jingjing Dong Dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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