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Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing Sun Dan-Dan Jiang shu-shu zuo Yan-Hui Wang Chun-Hua Zhang Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo TE Li-ger HUANG Xin zuo Xin HAN Xiao-ke WANG shu-song Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang(050024)China Xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying *** A reproductive damage model was established in rats by feeding of ***-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)*** in M,DS and LC groups received 40 mg/kg TGs *** from the 5th week,after administration of TGs for 4 h every day,rats in DS and LC groups were administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 *** in Group C continued to receive the control ***-eosin staining was used for histopathological analysis of rat testicular ***-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to determine the serum testosterone *** real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant *** Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(P<0.05).On the other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TG

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

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Effect of low-degree astigmatism on the objective visual quality

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1086-1093页

作者： Ling-Ying Ye shu-Feng Li Jing-Jing zuo Jin Li Hui-Xiang Ma National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal *** cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree *** was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality ***:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were *** increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),*** decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),*** the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were ***:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.

关键词： low-degree astigmatism objective visual quality Optical Quality Analysis System

Hydroxyapatite/palmitic acid superhydrophobic composite coating on AZ31 magnesium alloy with both corrosion resistance and bacterial inhibition

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Frontiers of Materials Science 2024年第1期18卷 71-83页

作者： Hang Zhang shu Cai Huanlin Zhang Lei Ling You zuo Hao Tian Tengfei Meng Guohua Xu Xiaogang Bao Mintao Xue Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Tianjin UniversityTianjin 300072China Department of Orthopedic Surgery Spine CenterChangzheng HospitalNaval Medical UniversityShanghai 200003China

The coating-modified magnesium(Mg)alloys exhibit controllable corrosion resistance,but the insufficient antibacterial performance limits their clinical applications as degradable *** coatings show excellent performance in terms of both corrosion resistance and inhibition of bacterial adhesion and *** this work,a hydroxyapatite(HA)/palmitic acid(PA)superhydrophobic composite coating was fabricated on the Mg alloy by the hydrothermal technique and immersion *** HA/PA composite coating showed superhydrophobicity with a contact angle of 153°and a sliding angle of 2°.The coated Mg alloy exhibited excellent corrosion resistance in the simulated body fluid,with high polarization resistance(77.10 kΩ·cm^(2))and low corrosion current density((0.491±0.015)μA·cm^(-2)).Meanwhile,the antibacterial efficiency of the composite coating was over 98% against *** and *** in different *** results indicate that the construction of such superhydrophobic composite coating(HA/PA)on the Mg alloy can greatly improve the corrosion resistance of Mg alloy implants within the human body and avoid bacterial infection during the initial stages of implantation.

关键词： superhydrophobic coating hydroxyapatite corrosion resistance antibacterial

Denitration of Nitroarenes Under Ambient Physiological Conditions Catalyzed by Graphdiyne-Supported Palladium

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CCS Chemistry 2024年第3期6卷 641-651页

作者： Endong Zhang Yanyan Chen Fengting Lv Zicheng zuo Feng He Yongjun Li Yiming Huang Yuliang Li shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 College of Chemistry University of Chinese Academy of SciencesBeijing 100049

The direct cleavage of C–NO_(2)bonds for reductive denitration of nitroarenes remains a challenging transformation in synthetic organic ***,we report a biocompatible palladium-deposited graphdiyne nanocatalyst(Pd@GDY/DSPE-PEG)that can catalyze reductive denitration of nitroarenes under ambient physiological *** studies support this transformation via the oxidative addition of nitroarenes with Pd(0)and subsequent ligand exchange to form arylpalladium *** one-step reductive denitration via Pd@GDY/DSPE-PEG successfully facilitates the repair of the nitrated proteins arising from endogenic ONOO−and restores their physiological function,including blocking the apoptosis pathway in living ***,Pd@GDY/DSPE-PEG was further successfully applied for catalytic denitration to reduce the level of 3-nitrotyrosine residues of proteins located in the mouse brain hippocampus in *** study provides an ideal strategy for designing highly active enzymatic mimicking synthetic catalysts for the regulation of the nitrated protein level and the detoxification of nitrative damage of living cells and tissues.

关键词： 3-nitrotyrosine artificial nanaocatalysts reductive denitration palladium-deposited graphdiyne repairing nitrated protein

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丁型病毒性肝炎治疗新药临床研发现状及考量

中国临床药理学杂志 2024年第3期40卷 464-471页

作者：左书凝赵建中国家药品监督管理局药品审评中心北京100163

相对于乙型病毒性肝炎病毒(HBV)单一感染,HBV/丁型病毒性肝炎病毒(HDV)重叠感染可能与更严重的肝病相关,导致肝硬化、肝细胞癌、肝功能失代偿和肝功能衰竭的发病率增加。慢性HDV感染具有治疗的必要性和急迫性。但目前全球范围内尚无确... 详细信息

相对于乙型病毒性肝炎病毒(HBV)单一感染,HBV/丁型病毒性肝炎病毒(HDV)重叠感染可能与更严重的肝病相关,导致肝硬化、肝细胞癌、肝功能失代偿和肝功能衰竭的发病率增加。慢性HDV感染具有治疗的必要性和急迫性。但目前全球范围内尚无确证安全有效且完全获批用于治疗慢性HDV感染的药物。目前境内外已有多个机制的新药在进行丁型病毒性肝炎临床研发,本文综述目前处于临床研发阶段新药的作用机制、研发进展、临床试验设计,以及目前监管机构、学术界对慢性HDV感染治疗新药临床试验设计的建议,并对确证性临床试验设计要点进行讨论。

关键词：丁型病毒性肝炎病毒慢性丁型病毒性肝炎新药研发临床试验设计

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The FRB-searching Pipeline of the Tianlai Cylinder Pathfinder Array

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Research in Astronomy and Astrophysics 2024年第08期24卷 115-134页

作者： Zijie Yu Furen Deng Shijie Sun Chenhui Niu Jixia Li Fengquan Wu Wei-Yang Wang Yougang Wang Shifan zuo Lin shu Jie Hao Xiaohui Liu Reza Ansari Ue-Li Pen Albert Stebbins Peter Timbie Xuelei Chen Department of Physics University of Wisconsin—Madison Fermi National Accelerator Laboratory Department of Physics College of SciencesNortheastern University Center of High Energy Physics Peking University National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Radio Astronomy and Technology Chinese Academy of Science Institute of Astrophysics Central China Normal University Institute of Automation Chinese Academy of Sciences Guangdong Institute of Artificial Intelligence and Advanced Computing UniversitéParis—Saclay CNRS/IN2P3IJCLab Institute of Astronomy and Astrophysics Academia Sinica Canadian Institute for Theoretical Astrophysics University of Toronto60 Saint George Street

This paper presents the design,calibration,and survey strategy of the Fast Radio Burst (FRB) digital backend and its real-time data processing pipeline employed in the Tianlai Cylinder Pathfinder *** array,consisting of three parallel cylindrical reflectors and equipped with 96 dual-polarization feeds,is a radio interferometer array designed for conducting drift scans of the northern celestial *** FRB digital backend enables the formation of 96 digital beams,effectively covering an area of approximately 40 square degrees with the 3 dB *** pipeline demonstrates the capability to conduct an automatic search of FRBs,detecting at quasi-realtime and classifying FRB candidates *** current FRB searching pipeline has an overall recall rate of88%.During the commissioning phase,we successfully detected signals emitted by four well-known pulsars:PSR B0329+54,B2021+51,B0823+26,and B2020+*** report the first discovery of an FRB by our array,designated as FRB *** also investigate the optimal arrangement for the digitally formed beams to achieve maximum detection rate by numerical simulation.

关键词： (stars:) pulsars: general instrumentation: interferometers methods: data analysis telescopes

The ALMaQUEST Survey XV: The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Niankun Yu Zheng Zheng Chao-Wei Tsai Pei zuo Sara L.Ellison David V.Stark Di Li Jingwen Wu Karen L.Masters Ting Xiao Yinghui Zheng Zongnan Li Kai Zhang Hongying Chen shu Liu Sihan Jiao Fanyi Meng School of Physics Zhejiang University National Astronomical Observatories Chinese Academy of Sciences Key Laboratory of Radio Astronomy and Technology Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Astronomy and Space Science University of Chinese Academy of Sciences Department of Physics & Astronomy University of Victoria Departments of Physics and Astronomy Haverford College Space Telescope Science Institute Zhejiang Laboratory New Cornerstone Science Laboratory

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public H i,CO,and optical IFU data from the Ma NGA survey together with new FAST H i *** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio Rmol=log MH2/MH1is correlated with the global stellar mass surface density μ*with a Kendall’sτcoefficient of 0.25and p<10-3,less tightly but still correlated with stellar mass and NUV-r color,and not related to the specific star formation rate （sSFR）.The cold gas distribution and kinematics inferred from the H i and CO global profile asymmetry and shape do not significantly rely on *** to the availability of kpc-scale observations of Ma NGA,we decompose galaxies into H ii,composite,and AGN-dominated regions by using the BPT *** increasing Rmol,the fraction of H ii regions within1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high Rmoltend to have high oxygen abundance,both at one effective radius with a Kendall’sτcoefficient of 0.37 (p<10-3) and their central *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global *** dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance（μ*） and Rmolindicates that the gas conversion is efficient in regions of high metallicity （density）.

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第四代住宅建筑设计理念及其实践探讨