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The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans

Neural Regeneration Research 2023年第6期18卷 1386-1392页

作者： Hui-Qiang Long Jin Gao shu-qing he Jian-Fang Han Yu Tu Na Chen Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhouJiangsu ProvinceChina Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions SuzhouJiangsu ProvinceChina

Ionizing radiation can cause changes in nervous system ***,the underlying mechanism remains *** this study,Coenorhabditis elegans(***)was irradiated with 75 Gy of ^(60)Co whole-body γ *** indicators(head thrashes,touch avoidance,and foraging),and the development of dopaminergic neurons related to behavioral function,were evaluated to assess the effects of ionizing radiation on nervous system function in *** behaviors were impaired after whole-body irradiation and degeneration of dopamine neurons was *** suggests that 75 Gy of γ radiation is sufficient to induce nervous system *** genes nhr-76 and crm-1,which are reported to be related to nervous system function in human and mouse,were screened by transcriptome sequencing and bioinformatics analysis after irradiation or sham *** expression levels of these two genes were increased after ***,RNAi technology was used to inhibit the expression of crm-1,a gene whose homologs are associated with motor neuron development in other *** of crm-1 expression effectively alleviated the deleterious effects of ionizing radiation on head thrashes and touch *** was also found that the expression level of crm-1 was regulated by the nuclear receptor gene *** results of this study suggest that knocking down the expression level of nhr-76 can reduce the expression level of crm-1,while down-regulating the expression level of crm-1 can alleviate behavioral disorders induced by ionizing ***,inhibition of crm-1 may be of interest as a potential therapeutic target for ionizing radiation-induced neurological dysfunction.

关键词： behavior Caenorhabditis elegans degeneration disorder dysfunction nerve injury nervous system neurodevelopment neuron radiation

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凹凸棒土预分离/富集与FAAS联用分析粮食中Zn(Ⅱ)的研究

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化学试剂 2007年第4期29卷 217-219页

作者：舒和庆李春香徐婉珍闫永胜江苏大学化学化工学院江苏镇江212013

以火焰原子吸收光谱法(FAAS)为检测手段,探讨了微米凹凸棒土对Zn(Ⅱ)的吸附行为及影响吸附和解脱的主要因素,考察了共存离子的影响及凹凸棒土对Zn(Ⅱ)的吸附容量。在优化的实验条件下,实测了粮食样品红豆和绿豆中锌的含量,结果令人满意... 详细信息

以火焰原子吸收光谱法(FAAS)为检测手段,探讨了微米凹凸棒土对Zn(Ⅱ)的吸附行为及影响吸附和解脱的主要因素,考察了共存离子的影响及凹凸棒土对Zn(Ⅱ)的吸附容量。在优化的实验条件下,实测了粮食样品红豆和绿豆中锌的含量,结果令人满意,加标回收率可达95%以上。本法的检出限为0.2 mg/L相对标准偏差RSD=2.4%(Zn(Ⅱ):0.20 mg/L,n=9)。

关键词：凹凸棒土 FAAS 吸附 Zn(Ⅱ)

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薄层树脂相三元缔合体系分光光度法测定痕量Fe(Ⅲ)的研究

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分析试验室 2005年第10期24卷 74-76页

作者：李松田舒和庆徐婉珍闫永胜江苏大学化学化工学院

在酸性介质中, Fe(Ⅲ)能与硫氰酸盐生成稳定的络离子[Fe(SCN)4]3-,该络阴离子能被碱性717型阴离子交换树脂定量交换,形成阴离子交换树脂(R+)-金属离子(M+)-硫氰酸盐(SCN-)三元配合物体系,该三元配合物体系最大吸收波长为490 nm.通过制... 详细信息

在酸性介质中, Fe(Ⅲ)能与硫氰酸盐生成稳定的络离子[Fe(SCN)4]3-,该络阴离子能被碱性717型阴离子交换树脂定量交换,形成阴离子交换树脂(R+)-金属离子(M+)-硫氰酸盐(SCN-)三元配合物体系,该三元配合物体系最大吸收波长为490 nm.通过制作薄层测定了水中Fe(Ⅲ)量.本法具有很高的灵敏度, ε490=2.4×105 L·mol-1·cm-1,线性范围0～0.40 μg/mL,检出限为0.12 μmol/L.所拟方法用于水中痕量Fe(Ⅲ)的测定,结果与AAS法相吻合.

关键词：三元缔合体系薄层树脂相分光光度法痕量Fe(Ⅲ)

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纳米活性白土用于废水中锰的分离和预富集及其火焰原子吸收光谱法测定

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理化检验（化学分册） 2007年第12期43卷 1056-1058,1061页

作者：舒和庆徐婉珍李春香闫永胜江苏大学化学化工学院镇江212013

基于纳米活性白土的大比表面积和吸附特性,有效地解决了废水中锰(Ⅱ)的分离和预富集,对纳米活性白土的吸附性能作了较全面的研究。结果表明:在最佳试验条件下,当活性白土的用量为0.020 g时,其静态饱和吸附容量为6.13 mg.g-1;当在pH 4的... 详细信息

基于纳米活性白土的大比表面积和吸附特性,有效地解决了废水中锰(Ⅱ)的分离和预富集,对纳米活性白土的吸附性能作了较全面的研究。结果表明:在最佳试验条件下,当活性白土的用量为0.020 g时,其静态饱和吸附容量为6.13 mg.g-1;当在pH 4的含锰(Ⅱ)溶液中用0.500 g活性白土与之振摇5 min,随后令其静置6 h,锰的回收率达92%以上。吸附在纳米活性白土上的锰(Ⅱ)可用0.5 mol.L-1盐酸溶液25 mL与之振摇3 min并静置3 h使其解吸,解吸的回收率达95%以上。解吸溶液中的锰(Ⅱ)用火焰原子吸收光谱法测定,所提出的方法已用于磷化工艺的废水样中锰的测定,所得方法的检出限(3σ)、相对标准偏差(n=11)及回收率的数据依次为0.002 3 mg.L-1,1.0%及92.5%~99.0%范围内。

关键词：吸附预富集纳米活性白土锰(Ⅱ) 解吸火焰原子吸收光谱法

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干细胞的趋电性迁移及机制

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中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

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Empirical Entropy for Right Censored Data

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 395-404页

作者： Guo-qing ZHAO Wei LIANG shu-yuan he School of Mathematical Sciences Peking University School of Mathematical Sciences Xiamen University School of Mathematical Sciences Capital Normal University

The maximum entropy method has been widely used in many fields, such as statistical mechanics,economics, etc. Its crucial idea is that when we make inference based on partial information, we must use the distribution with maximum entropy subject to whatever is known. In this paper, we investigate the empirical entropy method for right censored data and use simulation to compare the empirical entropy method with the empirical likelihood method. Simulations indicate that the empirical entropy method gives better coverage probability than that of the empirical likelihood method for contaminated and censored lifetime data.

关键词： right censored data empirical entropy

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Resurgence of pertussis:reasons and coping strategies

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World Journal of Pediatrics 2024年第7期20卷 639-642页

作者： Chun-Zhen Hua Han-qing he Qiang shu Department of Infectious Diseases National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou310052China Department of Immunization Program Zhejiang Provincial Center for Disease Control and PreventionHangzhou310051China National Clinical Research Center for Child health Children’s HospitalZhejiang University School of MedicineHangzhou310052China

Pertussis(whooping cough)is an acute and contagious respiratory disease caused by the pathogen Bordetella pertussis(***).*** can infect individuals of all *** with pertussis may experience severe and persistent coughing and paroxysms;for newborns and infants,pertussis may be *** development and widespread administration of the pertussis vaccine had once successfully brought pertussis under control,maintaining it at a low level for many ***,resurgence of pertussis has been reported in many countries even with high vaccination coverage *** resurgence of pertussis was first reported in the United States(USA)in 1993[1].During 2000–2016,the baseline incidence increased and the age distribution of pertussis changed in the USA[2].Other countries including Canada[3],Australia[4],European Union countries,and South Korea have also reported a rise in pertussis outbreaks[2,5].

关键词： pertussis Canada surge

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Parameter optimization model in electrical discharge machining process

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 104-108页

作者： qing GAO Qin-he ZHANG shu-peng SU Jian-hua ZHANG School of Mechanical Engineering Shandong University Jinan 250061 China

Electrical discharge machining (EDM) process, at present is still an experience process, wherein selected parameters are often far from the optimum, and at the same time selecting optimization parameters is costly and time consuming. In this paper, artificial neural network (ANN) and genetic algorithm (GA) are used together to establish the parameter optimization model. An ANN model which adapts Levenberg-Marquardt algorithm has been set up to represent the relationship between material removal rate (MRR) and input parameters, and GA is used to optimize parameters, so that optimization results are obtained. The model is shown to be effective, and MRR is improved using optimized machining parameters.

关键词： Electrical discharge machining (EDM) Genetic algorithm (GA) Artificial neural network (ANN) Levenberg- Marquardt algorithm

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Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAHⅡ/eNOS/NO pathway

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Chinese Journal of Natural Medicines 2022年第1期20卷 22-32页

作者： CheN shu-Ping HU Tian-Hong ZHOU qing CheN Tian-Peng YIN Dong he Huan HUANG qing he Ming Institute of Cardiovascular Diseases Jiangxi Academy of Clinical Medical Sciencesthe First Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Provincial Key Laboratory of Basic Pharmacology School of Pharmaceutical ScienceNanchang UniversityNanchang 330006China Jiangxi Provincial Key Laboratory of Molecular Medicine the Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Provincial Institute of Cardiovascular Diseases Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China

Iron overload injury is considered to be a part of blood stasis syndrome of arthralgia in traditional Chinese *** primary therapies include clearing heat and detoxification,activating blood circulation,and removing blood *** japonica flos(LJF)has long been known as an excellent antipyretic and ***(Lut)is one of the main components of LJF and exhibits antioxidant,anti-inflammatory,and cytoprotective ***,the protection of Lut against iron overload injury and its underlying mechanisms remain ***,HUVECs were exposed to 50μmol·L^(−1)iron dextran for 48 h to establish an iron overload damage model and the effects of Lut were *** results showed that 20μmol·L^(−1)Lut not only increased cell viability and weakened LDH activity,but also significantly up-regulated DDAHⅡexpression and activity,increased p-eNOS/eNOS ratio and NO content,and reduced ADMA content in HUVECs exposed to iron ***,Lut significantly attenuated intracellular/mitochondrial ROS generation,improved SOD,CAT,and GSH-Px activities,reduced MDA content,maintained MMP,inhibited mPTP opening,prevented cyt c from mitochondria released into cytoplasm,reduced cleaved-caspase3 expression,and ultimately decreased cell apoptosis induced by iron *** effects of Lut were similar to those of L-arginine(an ADMA competitive substrate),cyclosporin A(a mPTP blocker agent),and edaravone(a free radical scavenger)as positive ***,addition of pAD/DDAHⅡ-shRNA adenovirus reversed the above beneficial effects of *** conclusion,Lut can protect HUVECs against iron overload injury via the ROS/ADMA/DDAHⅡ/eNOS/NO *** mitochondria are the target organelles of Lut’s protective effects.

关键词： Luteoloside Iron overload Endothelium dysfunction Mitochondria ROS/ADMA/DDAHⅡ/eNOS/NO pathway

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ULF electromagnetic precursors before the 1999 Jiji, Taiwan, earthquake and the comparison with results of simulating experiments

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Acta Seismologica Sinica(English Edition) 2001年第3期14卷 342-348页

作者： QIAN shu-qing 1. Laboratory of Tectonophysics & Institute of Geophysics China Seismological Bureau 100081 Beijing China 2. Seismological Bureau of Fujian Province 350003 Fuzhou China

There are many reports about the abnormal electromagnetic signals observed before great earthquakes. In particular, the signals of electromagnetic anomalies before the Hyogo-Ken Nanbu, Japan, MS=7.2 earthquake on January 17, 1995 (Hayakawa, et al, 1996) and those before the Loma Prieta, USA, MS=7.1 earthquake on October 19, 1989 (Fraser-Smith, et al, 1990) are especially remarkable. However, what the above authors reported are only the phenomena of one or two observatories. In order to confirm this phenomenon, the authors studied the results obtained by nine observatories in the southeast coastal areas of Chinese mainland within a range of 256~858 km to the epicenter of the 1999 Jiji, Taiwan, earthquake using instruments of the same type (the ULF/VLF electromag-netic wave observation system). By summarizing the data for the three months up to the time of earthquake occur-rence, the authors obtained the regional distribution of the signals of electromagnetic anomalies before the earth-quake and their features in the time domain and frequency domain.

关键词： Jiji earthquake experiment of rock fracture under compression ULF electromagnetic precursors mechanism of production and propagation P319

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