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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

自体角膜缘干细胞移植术治疗翼状胬肉43例临床观察

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咸宁学院学报（医学版） 2004年第2期18卷 120-121页

作者：舒强林汉云张劲黄石市第一人民医院眼科湖北黄石435000

目的评价自体角膜缘干细胞移植术治疗翼状胬肉的疗效。方法采用自体角膜缘干细胞移植术治疗5 4眼 (4 3例 )翼状胬肉 ,其中原发性翼状胬肉 38眼 ,复发性翼状胬肉 16眼。 16眼复发性胬肉均经过两次以上的单纯胬肉切除术或结膜下转移术。... 详细信息

目的评价自体角膜缘干细胞移植术治疗翼状胬肉的疗效。方法采用自体角膜缘干细胞移植术治疗5 4眼 (4 3例 )翼状胬肉 ,其中原发性翼状胬肉 38眼 ,复发性翼状胬肉 16眼。 16眼复发性胬肉均经过两次以上的单纯胬肉切除术或结膜下转移术。结果术后随访 6 - 18个月 ,无术后并发症发生。 4 9眼无胬肉组织再生 ,5眼在术后 8- 11个月复发 ,复发率为 9.3%。结论自体角膜缘干细胞移植术能为受损的角膜缘提供新的干细胞 ,是一种安全、有应用前景的治疗翼状胬肉的手术方式。

关键词：翼状胬肉角膜缘干细胞自体移植并发症手术方法

Comparative transcriptomics highlights convergent evolution of energy metabolic pathways in group-living spiders

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Zoological Research 2021年第2期42卷 195-206页

作者： han Yang Bin Lyu Hai-qiang Yin shu-qiang Li Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China College of Life Science Hunan Normal UniversityChangshaHunan 410081China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Although widely thought to be aggressive, solitary,and potentially cannibalistic, some spider species have evolved group-living behaviors. The distinct transition provides the framework to uncover groupliving evolution. Here, we conducted a comparative transcriptomic study and examined patterns of molecular evolution in two independently evolved group-living spiders and twelve solitary species. We report that positively selected genes among groupliving spider lineages are significantly enriched in nutrient metabolism and autophagy pathways. We also show that nutrient-related genes of group-living spiders convergently experience amino acid substitutions and accelerated relative evolutionary rates. These results indicate adaptive convergence of nutrient metabolism that may ensure energy supply in group-living spiders. The decelerated evolutionary rate of autophagy-related genes in group-living lineages is consistent with an increased constraint on energy homeostasis as would be required in a group-living environment. Together, the results show that energy metabolic pathways play an important role in the transition to group-living in spiders.

关键词： Autophagy Cannibalism Convergent Group-living Nutrient Spider

Science Letters:A robust polysilicon-assisted SCR in ESD protection application

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1879-1883页

作者： CUI qiang han Yan DONG shu-rong LIOU Juin-jie ESD Lab Institute of Microelectronics and Photoelectronics Zhejiang University Hangzhou 310027 China Research Center for Embedded System Zhejiang University Hangzhou 310027 China Department of Electrical and Computer Engineering University of Central Florida Orlando 32816 USA

A novel polysilicon-assisted silicon-controlled rectifier （SCR） is presented and analyzed in this paper, which is fabricated in HHNEC＇s 0.18μm EEPROM process. The polysilicon-assisted SCRs take advantage of polysilicon layer to help bypass electro-static discharge （E S D） current without occupying extra layout area. TLP current-voltage （I-V） measurement results show that given the same layout areas, robustness performance of polysilicon-assisted SCRs can be improved to 3 times of conventional MLSCR＇s. Moreover, one-finger such polysilicon-assisted SCRs, which occupy only 947 [3mz layout area, can undergo 7-kV HBM ESD stress. Results further demonstrate that the S-type I-V characteristics of polysilicon-assisted SCRs are adjustable to different operating conditions by changing the device dimensions. Compared with traditional SCRs, this new SCR can bypass more ESD currents and consumes smaller IC area.

关键词： Electro-static discharge (ESD) Silicon-controlled rectifier (SCR) Robustness performance Polysilicon-assisted Human body model (HBM)

Prediction of blast furnace gas generation based on data quality improvement strategy

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Journal of Iron and Steel Research International 2023年第5期30卷 864-874页

作者： shu-han Liu Wen-qiang Sun Wei-dong Li Bing-zhen Jin Department of Energy Engineering School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina State Environmental Protection Key Laboratory of Eco-Industry(Northeastern University) Ministry of Ecology and EnvironmentShenyang 110819LiaoningChina State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114009LiaoningChina Ansteel Iron and Steel Research Institute Ansteel Group Corporation LimitedAnshan 114009LiaoningChina General Heavy Section Mill Angang Steel Company LimitedAnshan 114021LiaoningChina

The real-time energy flow data obtained in industrial production processes are usually of low *** is difficult to accurately predict the short-term energy flow profile by using these field data,which diminishes the effect of industrial big data and artificial intelligence in industrial energy *** real-time data of blast furnace gas(BFG)generation collected in iron and steel sites are also of low *** order to tackle this problem,a three-stage data quality improvement strategy was proposed to predict the BFG *** the first stage,correlation principle was used to test the sample *** the second stage,the original sample set was rectified and *** the third stage,Kalman filter was employed to eliminate the noise of the updated sample *** method was verified by autoregressive integrated moving average model,back propagation neural network model and long short-term memory *** results show that the prediction model based on the proposed three-stage data quality improvement method performs *** short-term memory model has the best prediction performance,with a mean absolute error of 17.85 m3/min,a mean absolute percentage error of 0.21%,and an R squared of 95.17%.

关键词： Blast furnace gas Iron and steel industry Data quality improvement Artificial intelligence Gas generation prediction

Direct electrochemical N-doping to carbon paper in molten LiCl-KCl-Li3N

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International Journal of Minerals,Metallurgy and Materials 2020年第12期27卷 1687-1694页

作者： Dong-hua Tian Zhen-chao han Ming-yong Wang shu-qiang Jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Graphite materials are widely used as electrode materials for electrochemical energy storage.N-doping is an effective method for enhancing the electrochemical properties of graphite.A novel one-step N-doping method for complete and compact carbon paper was proposed for molten salt electrolysis in the Li Cl-KCl-Li3 N *** results show that the degree of graphitization of carbon paper can be improved by the electrolysis of molten salts,especially at 2.0 *** gas was produced at the anode and nitrogen atoms can substitute carbon atoms of carbon paper at different sites to create nitrogen doping during the electrolysis *** doping content of N in carbon paper is up to 13.0 wt%.There were three groups of nitrogen atoms,*** N(N-Q),pyrrolic N(N-5),and pyridinic N(N-6)in N-doping carbon paper.N-doping carbon paper as an Al-ion battery cathode shows strong charge-recharge properties.

关键词： N-doping carbon paper molten salt electrolysis electrochemical process

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干细胞的趋电性迁移及机制

中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

Resurgence of pertussis:reasons and coping strategies

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World Journal of Pediatrics 2024年第7期20卷 639-642页

作者： Chun-Zhen Hua han-Qing He qiang shu Department of Infectious Diseases National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou310052China Department of Immunization Program Zhejiang Provincial Center for Disease Control and PreventionHangzhou310051China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou310052China

Pertussis(whooping cough)is an acute and contagious respiratory disease caused by the pathogen Bordetella pertussis(***).*** can infect individuals of all *** with pertussis may experience severe and persistent coughing and paroxysms;for newborns and infants,pertussis may be *** development and widespread administration of the pertussis vaccine had once successfully brought pertussis under control,maintaining it at a low level for many ***,resurgence of pertussis has been reported in many countries even with high vaccination coverage *** resurgence of pertussis was first reported in the United States(USA)in 1993[1].During 2000–2016,the baseline incidence increased and the age distribution of pertussis changed in the USA[2].Other countries including Canada[3],Australia[4],European Union countries,and South Korea have also reported a rise in pertussis outbreaks[2,5].

关键词： pertussis Canada surge

Pseudo-Magnetotelluric 2D Inversion Technology of Magnetic-Source Transient Electromagnetics

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Applied Geophysics 2020年第5期17卷 784-795,903页

作者： han Zi-qiang Jiang shu-ping Fengbing School of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Gansu Transportation Planning Survey and Design Institute Co.Ltd. Lanzhou 730030China School of Geology Engineering and Geomatics Chang’an UniversityXi’an 710054China

Based on the fact that it is diffi cult to implement optimum inversion using 2D and 3D forward modeling with magnetic-source transient electromagnetics(TEM),this paper explores a novel approach to the implementation of 2D magnetic-source TEM *** particular,we converted magnetic-source TEM data into magnetotelluric(MT)data and then used a 2D MT inversion method to implement a 2D magnetic-source TEM inversion ***,we studied the similarity between magnetic-source TEM waves and MT waves and between magnetic-source TEM all-time apparent resistivity and MT Cagniard apparent ***,we selected an optimal time-frequency transformation coeffi cient to implement rapid time-frequency transformation of all-time TEM apparent resistivity to MT Cagniard apparent ***,we conducted 1D pseudo-MT inversions of magnetic-source 1D TEM theoretical *** 1D inversion results demonstrated that the diff erence between the inversion parameters and model parameters was small,while the MT 1D inversion method could be used to conduct magnetic 1D TEM inversion within a certain margin of *** further conducted 2D pseudo-MT inversions of 3D magnetic-source TEM theoretical models,and the 2D inversion results indicated that selecting a joint 2D pseudo-MT transverse-electric(TE)and transverse-magnetic(TM)inversion method based on measuring the line above a 3D anomalous body can help to accurately implement a 2D inversion interpretation of the 3D TEM response.

关键词： TEM MT All-time apparent resistivity Time–frequency transformation 2D pseudo-MT inversion