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Impact of Antiretroviral Therapy on the Spread of Human Immunodeficiency Virus in Chaoyang District, Beijing, China： Using the Asian Epidemic Model

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Chinese Medical Journal 2017年第1期130卷 32-38页

作者： li-li Tao Min liu shu-ming li Jue liu shu-lin Jiang li-Juan Wang Feng-Ji Luo Ning Wang Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of STD and AIDS Prevention and Control Beijing Chaoyang District Centre for Disease Control and Prevention Beijing 100021 China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Background： Successful antiretroviral therapy （ART） has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus （HIV）. We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model （AEM）. Methods： The AEM baseline workbook was used to determine the current infection status and to project the future spread of HIV under current conditions. We changed the input on the ART coverage from 2014 to 2025 and also modified the treatment eligibility in the AEM intervention workbook, in order to allow for analysis of the projected downstream impact of ART. Results： By gradually increasing the ART coverage rate from 29.7% （rate of 2013） to 40.0%, 50.0%, 60.0%, 70.0%, 80.0%, and 90.0% （at CD4＋ ≤350 cells/μl）, and by changing the dates of coverage from 2014 to 2020, the number of new infections showed a cumulative decline of 0.60%, 1.59%, 2.94%, 5.33%, 9.32%, and 14.98%, respectively. After 2020, the projected rates of infection rebounded slightly, so with the exception of the years with very high coverage （90.0%）, new infections continued to decrease. When we changed the initial threshold of therapy to CD4＋ cell counts ≤500 cells/μl, new infections decreased 6.00%, 11.64%, 15.92%, 21.11%, 26.92%, 33.05%, and 38.75%, respectively, under varying ART coverages. Conclusion： Our study demonstrates that the early initiation of ART for people living with HIV/acquired immune deficiency syndrome （AIDS） has a positive effect in slowing the spread of HIV.

关键词： Antiretroviral Therapy Asian Epidemic Model Human Immunodeficiency Virus Impact Transmission

Identification of metabolites of Radix Paeoniae Alba extract in rat bile, plasma and urine by ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry

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Journal of Pharmaceutical Analysis 2014年第1期4卷 14-25页

作者： Zheng-Wei Chen ling Tong shu-ming li Dong-Xiang li Ying Zhang shui-Ping Zhou Yong-Hong Zhu He Sun Department of Pharmaceutical Analysis China Pharmaceutical University Tasly R&D Institute Tianjin Tasly Group Co. Ltd. Center of Drug Metabolism and Pharmacokinetics China Pharmaceutical University

Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry （UPLC-Q-TOF/MS） was developed to identify the absorbed parent components and metabolites in rat bile, plasma and urine after oral administration of Radix Paeoniae Alba extract （RPAE）. A total of 65 compounds were detected in rat bile, plasma and urine samples, including 11 parent compounds and 54 metabolites. The results indicated that glucuronidation, hydroxylation and methylation were the major metabolic pathways of the components of RPAE. Furthermore, the results of this work demonstrated that UPLC-Q-TOF/MS combined with MetaboLynx？ software and mass defect filtering （MDF） could provide unique high throughput capabilities for drug metabolism study, with excellent MS mass accuracy and enhanced MSE data acquisition. With the MSE technique, both precursor and fragment mass spectra can be simultaneously acquired by alternating between high and low collision energy during a single chromatographic run.

关键词： Radix Paeoniae Alba Metabolite profiling UPLC-Q-TOF/MS Monoterpene glycosides

Semi-solid Processing of Steel-Al-7 Graphite Binding Plate

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Journal of Wuhan University of Technology(Materials Science) 2002年第3期17卷 46-49页

作者：张鹏 NorthrnJiaotongUniversity

The bonding of steel plate to Al 7graphite slurry was studied for the first time. The relationship model about preheat temperature of steel plate,solid fraction of Al 7graphite slurry, rolling speed and interfacial shear strength of bonding plate could be established by artificial neural networks *** model could be optimized with a genetic *** optimum bonding parameters are:516℃ for preheat temperature of steel plate,32.5% for solid fraction of Al 7graphite slurry and 12mm/s for rolling speed,and the largest interfacial shear strength of bonding plate is 70.6MPa.

关键词： bonding of steel plate to Al 7graphite slurry artificial neural networks genetic algorithm

Measurement of the Mass Excess of ^(158)Sm

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Chinese journal of nuclear physics 1995年第3期17卷 234-238页

作者： Zhao Kui Guo Ji-yu Lu Xiu-qin Cheng Ye-hao Huang Xiao-lin Ma Yong li shu-yuan Ruan ming li Zhi-chang Jiang Cheng-lie China Institute of Atomic Energy,P.O.Box 275(10),Beijing 102413 中国原子能科学院北京

A Q-value of —4.076±0.151 MeV has been determined for the two-proton transfer reaction160Gd(18O,20Ne)158Sm,which yields a first experimental measured value of —65.764±0.151 MeV forthe mass excess of 158Sm,the nucl... 详细信息

关键词： Heavy ion reaction Q-value Mass excess

Temperature and drain bias dependence of single event transient in 25-nm FinFET technology

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Chinese Physics B 2012年第8期21卷 590-594页

作者：秦军瑞陈书明李达维梁斌刘必慰 College of Computer National University of Defense Technology

In this paper, we investigate the temperature and drain bias dependency of single event transient （SET） in 25-nm fin field-effect-transistor （FinFET） technology in a temperature range of 0-135 ℃ and supply voltage range of 0.4 V- 1.6 V. Technology computer-aided design （TCAD） three-dimensional simulation results show that the drain current pulse duration increases from 0.6 ns to 3.4 ns when the temperature increases from 0 to 135 ℃. The charge collected increases from 45.5 ℃ to 436.9 fC and the voltage pulse width decreases from 0.54 ns to 0.18 ns when supply voltage increases from 0.4 V to 1.6 V. Furthermore, simulation results and the mechanism of temperature and bias dependency are discussed.

关键词： fin field-effect transistor single event transient temperature dependence drain bias dependence

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南沙群岛珊瑚礁海域黑边鳍真鲨的年龄与生长

台湾海峡 2006年第2期25卷 267-272页

作者：舒黎明李永振中国水产科学研究院南海水产研究所广东广州510300

利用脊椎骨鉴定 2004年5～7月于南沙群岛珊瑚礁海域捕获的黑边鳍真鲨的年龄,进一步推算其Von Bertalanffy生长方程.结果表明：南沙群岛珊瑚礁海域黑边鳍真鲨优势年龄组为雌性5～7a,雄性4～7a;v-b生长方程相关参数为：K=0.127,L∞=188cm... 详细信息

利用脊椎骨鉴定 2004年5～7月于南沙群岛珊瑚礁海域捕获的黑边鳍真鲨的年龄,进一步推算其Von Bertalanffy生长方程.结果表明：南沙群岛珊瑚礁海域黑边鳍真鲨优势年龄组为雌性5～7a,雄性4～7a;v-b生长方程相关参数为：K=0.127,L∞=188cm,t0＝-1.442a;其重量生长的拐点年龄为8.22a.

关键词：黑边鳍真鲨年龄生长拐点年龄脊椎骨珊瑚礁南沙群岛海域

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang li Shen Du ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

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Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun Wang mingjie Wang Zijie li Ken Chen Jiatian Mei shu Zhang Key Laboratory of Education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan Key Laboratory of Smart Education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach