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Chemical Research in Chinese Universities 2011年第2期27卷 339-344页

作者： KE Bei-bei WAN ling-shu huang Xiao-jun XU Zhi-kang Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationDepartment of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P. R. China

Porphyrin-filled nanofibrous membranes were facilely prepared by electrospinning of the mixtures of poly（acrylonitrile-co-acrylic acid）（PANCAA） and porphyrins. 5,10,15,20-Tetraphenylporphyrin（TPP） and its metal-loderivatives（ZnTPP and CuTPP） were studied as filling mediators for the immobilization of redox enzyme. Results indicate that the introduction of TPP, ZnTPP and CuTPP improves the retention activity of the immobilized catalase. Among these three porphyrins, the ZnTPP-filled PANCAA nanofibrous membrane exhibits an activity retention of 93%, which is an exciting improvement. This improvement is attributed to both the strong catalase-porphyrin affinity and the possible facilitated electron transfer induced by the porphyrin as evidenced by quartz crystal microbalance （QCM） and fluorescence spectroscopy studies.

关键词： Enzyme immobilization Nanofibrous membrane Electrospinning Quartz crystal microbalance(QCM) Porphyrin

Endoscopic submucosal dissection vs endoscopic mucosal resection for superficial esophageal cancer

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World Journal of Gastroenterology 2014年第18期20卷 5540-5547页

作者： Hui-Min Guo Xiao-Qi Zhang Min Chen shu-ling huang Xiao-Ping Zou Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM: To investigate the effectiveness of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) in treating superficial esophageal cancer (SEC).

关键词： Superficial esophageal cancer Endoscopic mucosal resection Endoscopic submucosal dissection Meta-analysis

Novel hydroxymethylbilane synthase gene mutation identified and confirmed in a woman with acute intermittent porphyria:A case report

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World Journal of Clinical Cases 2022年第33期10卷 12319-12327页

作者： Yu-Qing Zhou Xiao-Qing Wang Jun Jiang shu-ling huang Zhuo-Jin Dai Qiao-Qiong Kong Department of Endocrinology Dongguan Hospital of Traditional Chinese MedicineDongguan 523003Guangdong ProvinceChina Department of Science and Technology ServicesChina Beijing Macro and Micro Test Biotech Co.Ltd Beijing 100318China The First Clinical Medical College Guangdong Medical UniversityZhanjiang 523003Guangdong ProvinceChina Department of Medicine Wanjiang People's Hospital of DongguanDongguan 523003Guangdong ProvinceChina

BACKGROUND Acute intermittent porphyria(AIP)is a rare autosomal dominant porphyrin metabolic disease caused by a mutation in the hydroxymethylbilane synthase(HMBS)*** study aimed to explore the clinical manifestations of a patient with AIP,to identify a novel HMBS gene mutation in the proband and some of her family members,and to confirm the pathogenicity of the *** SUMMARY A 22-year-old Chinese woman developed severe abdominal pain,lumbago,sinus tachycardia,epileptic seizure,hypertension,and weakness in lower limbs in March,*** examinations indicated hypohepatia and *** last menstrual period was 45 d prior to admission,and she was unaware of the pregnancy,which was confirmed by a pregnancy test after *** exposure of her urine sample for 1 h turned it from yellow to wine *** porphyrin test result was *** on these clinical manifestations,AIP was *** increasing her daily glucose intake(250–300 g/d),abdominal pain was partially *** days after hospitalization,spontaneous vaginal bleeding occurred,which was confirmed as spontaneous abortion;thereafter,her clinical symptoms completely *** testing revealed a novel heterozygous splicing variant of the HMBS gene in exon 10(c.648_651+1delCCAGG)in the proband and four other family *** pathogenicity of the variant was verified through bioinformatic methods and a minigene *** We identified a novel HMBS gene mutation in a Chinese patient with AIP and confirmed its pathogenicity.

关键词： Acute intermittent porphyria Hydroxymethylbilane synthase gene Novel mutation Minigene assay Bioinformatics analysis Case report

C634Y mutation in RET-induced multiple endocrine neoplasia type 2A:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2627-2635页

作者： Hui-Fen Zhang shu-ling huang Wen-Li Wang Yu-Qing Zhou Jun Jiang Zhuo-Jin Dai Department of Endocrinology Dongguan Hospital of Guangzhou University of Chinese MedicineDongguan 523003Guangdong ProvinceChina Department of Science and Technology Services Beijing Macro and Micro Test Co.Ltd.Beijing 100318China The First Clinical Medical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina

BACKGROUND Multiple endocrine neoplasia type 2(MEN2)is a rare,autosomal dominant endocrine ***,the RET proto-oncogene is the only gene implicated in MEN2A *** an RET carrier is detected,family members should be screened to enable early detection of medullary thyroid carcinoma,pheochromocytoma,and *** these,medullary thyroid carcinoma is the main factor responsible for patient ***,delineating strategies to inform clinical follow-up and treatment plans based on genes is paramount for clinical *** SUMMARY Herein,we present RET proto-oncogene mutations,clinical characteristics,and treatment strategies in a family with MEN2A.A family study was conducted on patients diagnosed with *** was extracted from the peripheral blood of family members,and first-generation exon sequencing of the RET protooncogene was *** C634Y mutation was identified in three family members spanning three *** patients were sequentially diagnosed with pheochromocytomas and bilateral medullary thyroid carcinomas.A 9-yearold child harboring the gene mutation was diagnosed with medullary thyroid *** resection of the tumors was *** family members were advised to undergo complete genetic testing related to the C634Y mutation,and the corresponding treatments administered based on test results and associated clinical *** Advancements in MEN2A research are important for familial management,assessment of medullary thyroid cancer invasive risk,and deciding surgical timing.

关键词： Multiple endocrine neoplasia type 2A Mutation RET proto-oncogene Medullary thyroid carcinoma Pheochromocytoma Case report

用四探针及阳极氧化方法测量硅中扩散层杂质分布

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物理学报 1964年第7期 643-653页

作者：林绪伦黄敞徐炳华北京大学物理系中国科学院

本文讨论了:(1)用阳极氧化法在硅片表面去层的技术;(2)用四探针测量扩散层面电导的方法;(3)用阳极氧化去层及四探针测量面电导方法求得扩散层精细杂质分布。文中着重讨论了实验技术中的实际问题,如如何在阳极氧化过程中取得精细而均匀... 详细信息

本文讨论了:(1)用阳极氧化法在硅片表面去层的技术;(2)用四探针测量扩散层面电导的方法;(3)用阳极氧化去层及四探针测量面电导方法求得扩散层精细杂质分布。文中着重讨论了实验技术中的实际问题,如如何在阳极氧化过程中取得精细而均匀的去层(300—1500);如何控制及测量去层厚度;测量面电导及杂质分布时的误差来源及减小误差的措施。以典型的磷在硅中扩散的杂质分布测量为例:扩散深度为4.9μm,测量间距为400—1600,面电导测量误差估计小于3％,杂质分布误差估计小于20％。简单地提出了一些测量中尚待进一步解决的问题。

关键词：四探针阳极氧化杂质分布扩散层表面层

NUMERICAL BOUNDARY CONDITIONS FOR THE FAST SWEEPING HIGH ORDER WENO METHODS FOR SOLVING THE EIKONAL EQUATION

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Journal of Computational Mathematics 2008年第3期26卷 336-346页

作者： ling huang Chi-Wang shu Mengping Zhang Department of Mathematics University of Science and Technology of China Hefei Anhui 230026 China Division of Applied Mathematics Brown University Providence RI 02912 USA Department of Mathematics University of Science and Technology of China Hefei 230026 China

High order fast sweeping methods have been developed recently in the literature to solve static Hamilton-Jacobi equations efficiently. Comparing with the first order fast sweeping methods, the high order fast sweeping methods are more accurate, but they often require additional numerical boundary treatment for several grid points near the boundary because of the wider numerical stencil. It is particularly important to treat the points near the inflow boundary accurately, as the information would flow into the computational domain and would affect global accuracy. In the literature, the numerical solution at these boundary points are either fixed with the exact solution, which is not always feasible, or computed with a first order discretization, which could reduce the global accuracy. In this paper, we discuss two strategies to handle the inflow boundary conditions. One is based on the numerical solutions of a first order fast sweeping method with several different mesh sizes near the boundary and a Richardson extrapolation, the other is based on a Lax-Wendroff type procedure to repeatedly utilizing the PDE to write the normal spatial derivatives to the inflow boundary in terms of the tangential derivatives, thereby obtaining high order solution values at the grid points near the inflow boundary. We explore these two approaches using the fast sweeping high order WENO scheme in [18] for solving the static Eikonal equation as a representative example. Numerical examples are given to demonstrate the performance of these two approaches.

关键词： Fast sweeping method WENO scheme Boundary condition

临床护理路径在35例急性心肌梗死患者中应用效果观察

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中国民族民间医药 2013年第15期22卷 60-61页

作者：黄淑玲张焕芳袁惠萍广州医学院第三附属医院广东广州510150

目的:探讨临床护理途径在急性心肌梗死患者的应用效果。方法:急性心肌梗死的患者70例为研究对象,随机分为对照组35例和观察组35例,对照组患者的护理采用传统的护理模式进行,观察组采用我科编制的急性心肌梗死患者临床护理途径(CNP)进行... 详细信息

目的:探讨临床护理途径在急性心肌梗死患者的应用效果。方法:急性心肌梗死的患者70例为研究对象,随机分为对照组35例和观察组35例,对照组患者的护理采用传统的护理模式进行,观察组采用我科编制的急性心肌梗死患者临床护理途径(CNP)进行。结果:观察组较对照组患者的住院时间短,患者的住院费用花费少,并发症发生率低。结论:对于急性心肌梗死的患者采用临床护理途径进行护理,能够规范护理流程,改善护理服务质量,在临床上值得推广。

关键词：急性心肌梗死临床护理途径护理质量

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

腹式呼吸对PICC置管患者并发症发生率及不良情感状况的影响

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临床护理杂志 2017年第3期16卷 17-19页

作者：张舒梅黄凌雁张伟青王名英黄喜华深圳市宝安区沙井人民医院深圳518103

目的探讨腹式呼吸对PICC置管患者并发症发生率及不良情感状况的影响。方法选择2014年3月~2015年1月我院接受PICC置管的肿瘤患者80例作为研究对象,按随机数字表法分为观察组和对照组,各40例。对照组采用常规置管法。观察组在常规置管的... 详细信息

目的探讨腹式呼吸对PICC置管患者并发症发生率及不良情感状况的影响。方法选择2014年3月~2015年1月我院接受PICC置管的肿瘤患者80例作为研究对象,按随机数字表法分为观察组和对照组,各40例。对照组采用常规置管法。观察组在常规置管的基础上增加腹式呼吸。比较两组一次置管成功率、导管异位率、置管后并发症发生率、置管时VAS疼痛评分及对置管的满意度。结果观察组疼痛评分、操作时间、满意度评分分别为(3.76±0.61)分、(1.6±0.3)min、(97.9±4.6)分,对照组为(5.52±1.32)分、(4.5±0.5)min、(86.3±5.7)分,两组比较差异有统计学意义(P<0.05)。观察组一次置管成功率为100%,显著高于对照组85%(P<0.05)。观察组导管异位、血肿、堵管、血栓、静脉炎、导管感染发生率分别为0、0、2.5%、0、0、2.5%,对照组为20.0%、10.0%、17.5%、12.5%、10.0%、17.5%,观察组各并发症发生率均低于对照组,但导管异位发生率差异有统计学意义(P<0.05)。结论腹式呼吸有利于提高PICC置管患者置管成功率、缩短置管时间、提高患者满意度,并减少并发症的发生。

关键词：腹式呼吸外周静脉置入中心静脉导管

Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen huang Stephen Temitayo Bello Department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator