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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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基于混合PSO算法的语义Web服务发现

计算机工程 2011年第3期37卷 195-197页

作者：侯丽娟李蜀瑜陕西师范大学计算机科学学院西安710062

基于服务质量的语义Web服务发现方法存在未成熟收敛以及Pareto集分布不均等问题。为此,在引入基于阈值的粒子比较准则、拥挤距离函数和合力变异算子的基础上,给出一种基于混合粒子群优化算法的语义Web服务发现方法。实验结果表明,该方... 详细信息

基于服务质量的语义Web服务发现方法存在未成熟收敛以及Pareto集分布不均等问题。为此,在引入基于阈值的粒子比较准则、拥挤距离函数和合力变异算子的基础上,给出一种基于混合粒子群优化算法的语义Web服务发现方法。实验结果表明,该方法具有较高的匹配度和查准率。

关键词： Web服务服务质量粒子群优化算法拥挤距离变异算子

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神经网络在光纤故障预警系统中的应用仿真

计算机仿真 2012年第12期29卷 255-258页

作者：楼树美李淑玉南京理工大学计算机学院江苏南京210094 信阳职业技术学院数学与计算机科学学院河南信阳464000 武汉理工大学计算机学院湖北武汉430000

研究光纤故障预警系统的预警及时性问题。由于光纤承载业务量的不断增加,光纤线路产生大量的光功率告警信息,给预警系统带来巨大数据负担而影响预警及时性,传统的数据库方法对每一个光功率告警信息逐一进行预警分析,无法快速获取预警因... 详细信息

研究光纤故障预警系统的预警及时性问题。由于光纤承载业务量的不断增加,光纤线路产生大量的光功率告警信息,给预警系统带来巨大数据负担而影响预警及时性,传统的数据库方法对每一个光功率告警信息逐一进行预警分析,无法快速获取预警因子,而造成预警及时性不高。为解决上述问题,提出神经网络技术应用在光纤故障预警系统中。通过神经网络技术构建数据挖掘模型,将大量光功率告警信息输入到模型中进行数据分析,从中挖掘出具有最大决策价值的数据并快速提取其预警因子,避免逐一分析造成的预警因子提取效率不高的问题,利用预警因子快速完成预警。仿真结果表明,改进方法能够从大量光功率信息中快速获取预警因子,及时完成光纤故障的预警。

关键词：神经网络光纤故障预警因子

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期68卷 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang li Wei Chen yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

关键词： reduced graphene oxide polyoxometalates membranes gradient separation nanoparticles

COMPrompter: reconceptualized segment anything model with multiprompt network for camouflaged object detection

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Science China(Information Sciences) 2025年第1期68卷 189-203页

作者： Xiaoqin ZHANG Zhenni yu li ZHAO Deng-Ping FAN Guobao XIAO Zhejiang Province Key Laboratory of Intelligent Informatics for Safety and Emergency Wenzhou University Nankai International Advanced Research Institute (SHENZHEN FUTIAN) College of Computer Science Nankai University School of Computer Science and Technology Tongji University

We rethink the segment anything model(SAM) and propose a novel multiprompt network called COMPrompter for camouflaged object detection(COD). SAM has zero-shot generalization ability beyond other models and can provide an ideal framework for COD. Our network aims to enhance the single prompt strategy in SAM to a multiprompt strategy. To achieve this, we propose an edge gradient extraction module, which generates a mask containing gradient information regarding the boundaries of camouflaged objects. This gradient mask is then used as a novel boundary prompt, enhancing the segmentation process. Thereafter, we design a box-boundary mutual guidance module, which fosters more precise and comprehensive feature extraction via mutual guidance between a boundary prompt and a box prompt. This collaboration enhances the model's ability to accurately detect camouflaged objects. Moreover, we employ the discrete wavelet transform to extract high-frequency features from image embeddings. The high-frequency features serve as a supplementary component to the multiprompt ***, our COMPrompter guides the network to achieve enhanced segmentation results, thereby advancing the development of SAM in terms of COD. Experimental results across COD benchmarks demonstrate that COMPrompter achieves a cutting-edge performance, surpassing the current leading model by an average positive metric of 2.2% in COD10K. In the specific application of COD, the experimental results in polyp segmentation show that our model is superior to top-tier methods as well. The code will be made available at https://***/guobaoxiao/COMPrompter.

关键词： segment anything model camouflaged object detection boundary prompt

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： li shuiping CHENG Jian WEI Chao yuAN Bin yu Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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青藏高原东北部上地壳剪切波分裂特征

地震地质 2024年第4期46卷 916-933页

作者：李抒予高原金红林刘同振中国地震局地震预测研究所地震预测重点实验室北京100036

由羌塘、巴颜喀拉、柴达木和祁连等几个二级块体组成的青藏高原东北部与华南块体及华北块体接触,产生强烈的构造变形。文中利用青藏高原东北部2010年1月—2021年9月的小地震波形事件,使用剪切波分裂分析方法计算得到快波偏振方向与慢波... 详细信息

由羌塘、巴颜喀拉、柴达木和祁连等几个二级块体组成的青藏高原东北部与华南块体及华北块体接触,产生强烈的构造变形。文中利用青藏高原东北部2010年1月—2021年9月的小地震波形事件,使用剪切波分裂分析方法计算得到快波偏振方向与慢波时间延迟2个各向异性参数,并对参数的空间分布进行分析。快波偏振方向以NEE为主导,与区域主压应力方向大致平行,祁连块体北部和东南部、羌塘块体北部存在NNW、NWW或近EW等多个相对较弱的第2快波偏振方向,与区域内广泛分布的NW走向断裂近平行。柴达木块体东北缘的快波偏振方向较离散,受到应力、断裂、岩石性质等因素的共同作用。祁连块体北部逆冲断裂系东部的时间延迟大于西部,体现了两者应力环境的差异。祁连块体东南部及柴达木块体东北缘大致相当的时间延迟分布可能与其具有类似的岩石类别物性及构造环境相关。柴达木盆地北缘存在NWW向快波优势偏振方向和相对一致的时间延迟,可能是断裂在深部高压变质作用的响应。羌塘块体北部的时间延迟小于拉脊山断裂周缘(祁连块体东南部与柴达木块体东北缘),可能与岩石类别物性与构造环境的差异有关。

关键词：青藏高原东北部剪切波分裂各向异性上地壳快波偏振慢波时间延迟变形

颞叶癫癎大鼠模型内嗅皮质和齿状回内Sema3A及其受体Np1的表达变化

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中华神经科杂志 2007年第3期40卷 169-172页

作者：袁学谦肖波唐铁钰李玲李蜀渝李国良中南大学湘雅医院神经内科

目的探讨颞叶癫癎大鼠脑内 Sema3A 及其受体 Np1的表达变化在癫癎发病中的作用。方法 SD 大鼠制成颞叶癫癎模型,Neo-Timm 染色证实苔藓纤维出芽,免疫组化和原位杂交技术对致癎后不同时间点内嗅皮质和齿状回的 Sema3A mRNA、Np1 mRNA 和... 详细信息

目的探讨颞叶癫癎大鼠脑内 Sema3A 及其受体 Np1的表达变化在癫癎发病中的作用。方法 SD 大鼠制成颞叶癫癎模型,Neo-Timm 染色证实苔藓纤维出芽,免疫组化和原位杂交技术对致癎后不同时间点内嗅皮质和齿状回的 Sema3A mRNA、Np1 mRNA 和蛋白表达进行分析。结果与对照组比较,颞叶癫癎大鼠海马齿状回内分子层存在苔藓纤维出芽(7 d:0.70±0.42,15 d:1.50±0.52,30 d:2.20±0.41,60 d:2.50±0.51,P<0.05);在匹罗卡品致癎后7 d,实验组内嗅皮质区Sema3A mRNA 的表达(0.3006±0.0675)明显低于对照组(0.4562±0.0457,P<0.01);齿状回内 Np1mRNA(0.2337±0.0358)及蛋白(0.2706±0.0389)的表达亦明显低于对照组(P<0.01)。结论内嗅皮质区 Sema3A mRNA、齿状回内 Np1 mRNA 和蛋白的表达下调,可能参与了苔藓纤维的出芽机制。

关键词：癫痫颞叶嗅通路齿状回苔藓纤维海马信号素3A