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硅基调制器的最新研究进展(特邀)

光学学报 2024年第15期44卷 273-294页

作者：韩昌灏王皓玉舒浩文秦军王兴军北京大学电子学院区域光纤通信网与新型光通信系统国家重点实验室北京100871 美国加利福尼亚大学圣芭芭拉分校电子与计算机工程系加利福尼亚圣芭芭拉931063 北京大学集成电路学院北京100871 北京大学长三角光电科学研究院江苏南通226010 北京大学纳光电子前沿科学中心北京100871 北京信息科技大学信息与通信系统实验室北京100101 鹏城实验室广东深圳518055

随着新一代信息技术的大规模应用,全球数据总量呈现指数式增长趋势,光通信凭借其大带宽、大容量、低损耗、低串扰等优势成为信息通信网络的重要组成部分。硅基光电子技术作为光电子集成技术的重要分支,是实现光通信小型化、多功能化的... 详细信息

随着新一代信息技术的大规模应用,全球数据总量呈现指数式增长趋势,光通信凭借其大带宽、大容量、低损耗、低串扰等优势成为信息通信网络的重要组成部分。硅基光电子技术作为光电子集成技术的重要分支,是实现光通信小型化、多功能化的重要方法。在硅基光电子系统中,硅基调制器是完成信息传输与处理的核心功能单元。本文从硅基调制器的理论基础出发,综述硅基调制器的最新研究进展,按照材料体系的不同,分别对纯硅调制器与硅基异质材料调制器进行系统介绍,最后对该领域的未来发展进行详细讨论。

关键词：集成光学硅基调制器光电子学光通信光互连

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-jun Lv Nian-Hua Tan Zhe Deng jun-Yi Chen Zi-shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： Xiao-Wei Tang Wen-Sen Ren shu Huang Kang Zou Huan Xu Xiao-Min Shi Wei Zhang Lei Shi Mu-han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways

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Food Science and Human Wellness 2024年

作者： Hong Duan Wei Wang shu Li han Li Ghulam Jilany Khan Fawang Liu Kefeng Zhai Lili Li Zhaojun Wei General Clinical Research Center， Anhui Wanbei Coal-Electricity Group General Hospital Department of Pharmacology and Therapeutics， Faculty of Pharmacy， University of Central Punjab College of Biological and Food Engineering， Anhui Polytechnic University School of Biological and Food Engineering， Engineering Research Center for Development and High Value Utilization of Genuine Medicinal Materials in North Anhui Province， Suzhou University School of Food and Biological Engineering， Hefei University of Technology

Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. Isodon suzhouensis has good anti-inflammatory and antioxidant stress effects， which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets， and Lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from suzhouensis and 1194 COVID-19 related targets were selected. Among these， 164 common targets were obtained from the intersection of suzhouensis and COVID-19. GO and KEGG enriched 582 function targets and 87 target proteins pathways， respectively. The results from molecular docking studies revealed that rutin， vitexin， isoquercitrin and quercetin had significant binding ability with SARS-CoV-23CLpro and ACE2. In vitro studies showed that Isodon suzhouensis extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of EGFR in RAW264.7 cells induced by LPS. In addition， ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall， the network pharmacology and in vitro studies conclude that active components from suzhouensis have strong therapeutic potential against COVID-19 through multi-target， multi-pathway dimensions and can be a promising candidate against COVID-19.

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基于DIC技术的钢筋混凝土梁剪切裂缝自动提取与量化方法

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工程力学 2024年第S1期41卷 187-196页

作者：杨子涵舒江鹏杨静滢李俊白勇浙江大学建筑工程学院浙江杭州310058

针对钢筋混凝土梁实验中剪切斜裂缝的自动化定位、全域范围内各方向宽度量化及扩展追踪问题,该文提出一种基于数字图像相关技术(DIC)的裂缝自动提取与宽度量化的计算方法。由DIC计算得出的水平、竖直、剪切应变场来计算试件表面的主拉... 详细信息

针对钢筋混凝土梁实验中剪切斜裂缝的自动化定位、全域范围内各方向宽度量化及扩展追踪问题,该文提出一种基于数字图像相关技术(DIC)的裂缝自动提取与宽度量化的计算方法。由DIC计算得出的水平、竖直、剪切应变场来计算试件表面的主拉伸应变场,并将试件表面主应变大于某一阈值的部分视为开裂。对开裂部分进行形态学操作,提取出裂缝骨架线。在骨架线两侧定义裂缝运动参考点,根据参考点的运动来计算裂缝的发展规律。该计算方法实现了混凝土梁加载过程中任意方向上裂缝自动化检测及高精度量化,并且能够处理试件局部旋转的问题,充分了利用DIC测量技术的潜力。通过实验室内四组钢筋混凝土梁剪切实验验证该方法的有效性与精度。结果表明:该方法能够在多加载阶段实时追踪全域范围内各方向的裂缝开展并量化。

关键词：钢筋混凝土梁剪切裂缝数字图像相关实时追踪量化主应变场

Layered oxide cathodes for sodium-ion batteries:microstructure design,local chemistry and structural unit

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Science China Chemistry 2024年第1期67卷 191-213页

作者： Ling-Yi Kong han-Xiao Liu Yan-Fang Zhu Jia-Yang Li Yu Su Hong-Wei Li Hai-Yan Hu Yi-Feng Liu Ming-Jing Yang Zhuang-Chun Jian Xin-Bei Jia shu-Lei Chou Yao Xiao Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Because of the low price and abundant reserves of sodium compared with lithium,the research of sodium-ion batteries(SIBs)in the field of large-scale energy storage has returned to the research *** oxides distinguish themselves from the mains cathode materials of SIBs owing to their advantages such as high specific capacity,simple synthesis route,and environmental ***,the commercial development of the layered oxides is limited by sluggish kinetics,complex phase transition and poor air *** on the research ideas from macro-to micro-scale,this review systematically summarizes the current optimization strategies of sodium-ion layered oxide cathodes(SLOC)from different dimensions:microstructure design,local chemistry regulation and structural unit *** the dimension of microstructure design,the various structures such as the microspheres,nanoplates,nanowires and exposed active facets are prepared to improve the slow kinetics and electrochemical ***,from the view of local chemistry regulation by chemical element substitution,the intrinsic electron/ion properties of SLOC have been enhanced to strengthen the structural ***,the optimization idea of endeavors to regulate the physical and chemical properties of cathode materials essentially is put forward from the dimension of structural unit *** opinions and strategies proposed in this review will provide some inspirations for the design of new SLOC in the future.

关键词： sodium-ion batteries layered oxide cathodes microstructure design local chemistry structural unit

Effect of Fe_(2)O_(3)on the Structure,Physical Properties and Crystallization of CaO-Al_(2)O_(3)-SiO_(2)Glass

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 954-961页

作者：张峰 XIONG Dehua 谢俊张继红 han Jianjun CHEN Dequan WEN Zhongquan FAN Zhenhua CHEN Lina SUN Tengfei State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Hepu Research Center for Silicate Materials Industry Technology Beihai 536100China Hainan Institute of Wuhan University of Technology Sanya 430079China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China Chongqing Polycomp Inter-national Corporation Chongqing 400400China

The calcium aluminosilicate-based glasses(CaO-Al_(2)O_(3)-SiO_(2),CAS)with different Fe_(2)O_(3)content(0.10wt%,0.50wt%,0.90wt%,and 1.30wt%)were prepared by traditional melt-quenching *** glass network structure,thermal and mechanical properties,and crystallization behavior changes were investigated by nuclear magnetic resonance spectrometer,Fourier-transform infrared spectro-photometer,X-ray diffractometer,differential scanning calorimetry and field emission scanning electron microscope *** change of Q^(n)in glass structures reveals the glass network connectivity decreases due to the increasing content of Fe_(2)O_(3)addition,resulting in the increasing of non-bridging number in glass *** glass densities slightly rise from 2.644 to 2.681 g/cm^(3),while Vickers’s hardness increases at first,from 6.469 to 6.901 GPa,then slightly drops to 6.745 GPa,with Fe_(2)O_(3)content *** is almost no thermal expansion coefficient change from different Fe_(2)O_(3)*** glass transmittance in visible range gradually decreases with higher Fe_(2)O_(3)content,resulting from the strong absorption of Fe^(2+)and Fe^(3+)*** calculated activation energy from thermal analysis results first decreases from 282.70 to 231.18 kJ/mol,and then increases to 244.02 kJ/mol,with the Fe_(2)O_(3)content increasing from 0.10wt%to 1.30wt%.Meanwhile,the maximum Avrami constant of 2.33 means the CAS glasses exhibit two-dimensional *** of the CAS glass-ceramics samples contain main crystal phase of anorthite,the microstructure appears lamellar and columnar crystals.

关键词： calcium aluminosilicate glass network structure physical properties crystallization

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“鸢飞鱼跃”:一个理学隐喻的生成

浙江大学学报（人文社会科学版） 2024年第2期54卷 152-160页

作者：韩书安浙江大学哲学学院浙江杭州310058

在重绘中国哲学之思想图景的当代进程中,开拓道学话语的研究空间是极为有益的探索。以“鸢飞鱼跃”为例,它本是《诗经》比兴修辞手法的运用,但经过子思“断章取义”的创造性解读后,逐步脱离诠释文本而进入使用文本。汉宋之间的经学家与... 详细信息

在重绘中国哲学之思想图景的当代进程中,开拓道学话语的研究空间是极为有益的探索。以“鸢飞鱼跃”为例,它本是《诗经》比兴修辞手法的运用,但经过子思“断章取义”的创造性解读后,逐步脱离诠释文本而进入使用文本。汉宋之间的经学家与理学家出于维系政教或发明心性的不同考虑,分别对“鸢飞鱼跃”作了方位隐喻和本体隐喻两种差异化的概念结构改造。相较而言,二程、朱熹等人以诗思合一、情理交融的方式,从本体、工夫、境界、价值等方面系统阐发“鸢飞鱼跃”的隐喻意涵,将之塑造成具有诗性审美气质的儒者生命存在之精神符号,在思想史上影响尤为深远。借鉴当代隐喻学的前沿理论,阐发经典文本中的诗性智慧,或许更能揭示出中国哲学寓道于器、即事言理的精神传统,亦有助于在返本开新、中西互鉴的基础上建设中华民族现代文明。

关键词：鸢飞鱼跃断章取义诗化隐喻道学话语

shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO Ying-jie CAO Ya-xuan LI Wei-xia WANG Xiao-yan SI Chun-ying XIA han ZHU Ming-jun TANG Jin-fa WANG He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of Ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and Gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRING database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of Genes and Genomes(KEGG) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway shuxuening Injection apoptosis Ginkgo biloba leaves