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Tungsten 2025年第1期 183-194页

作者： Xin-Ran sun Hao-Ming Yuan Guo-Da Zhang Chao Wang shu-juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

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Endoscopic nasal surgery for mucocele and pyogenic mucocele of turbinate: Three case reports

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World Journal of Clinical Cases 2022年第32期10卷 12007-12014页

作者： shu-juan sun Ai-Ping Chen Yu-Zhu Wan Hong-Zhi Ji Department of Otolaryngology-Head and Neck Surgery Shandong Provincial ENT HospitalShandong UniversityJinan 250022Shandong ProvinceChina

BACKGROUND Cases of turbinate mucocele or pyogenic mucocele are extremely *** nasal endoscopy,turbinate hypertrophy can be detected in patients with turbinate or pyogenic ***,in many instances,differentiating between turbinate hypertrophy and turbinate mucocele is *** examinations,such as computed tomography(CT)or magnetic resonance imaging(MRI),are essential for the accurate diagnosis of turbinate ***,we report three cases of mucocele or pyogenic mucocele of turbinate,including their clinical presentation,imaging findings,and treatments,to help rhinologists understand this condition *** SUMMARY Three cases of turbinate and pyogenic mucocele were encountered in our *** all patients,nasal obstruction and headache were the most common symptoms,and physical examination revealed hypertrophic *** CT scan,mucocele appeared as non-enhancing,homogeneous,hypodense,well-defined,rounded,and expansile ***,MRI clearly illustrated the cystic nature of the lesion on T2 *** patients with inferior turbinate mucocele underwent mucocele lining removal,while the patient with pyogenic mucocele underwent endoscopic middle turbinate *** patients were followed up on the first,third,sixth month,and 1 year after discharge,and no complaints of headache and nasal congestion were reported during this *** In conclusion,both CT and MRI are helpful in the diagnosis of turbinate or pyogenic ***,endoscopic nasal surgery is considered to be the most effective treatment method.

关键词： Mucocele Pyogenic mucocele Inferior turbinate Middle turbinate Concha bullosa Case report

Influences of Copper Speciation on Toxicity to Microorganisms in Soils

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Biomedical and Environmental Sciences 2006年第6期19卷 409-413页

作者： shu-juan sun JIAN XU, shu-GuI DAI XUE HAN College of Environmental Science and Engineering Nankai University Tianjin 300071 China

Objective To investigate the relationship between copper speciation and microbial features （microbial communities and copper tolerance level） in order to determine the adverse effect of different forms of Cu on microorganisms. Methods Tessier＇s sequential extraction procedure was used to qualify the different Cu forms （exchangeable, carbonate bound, Fe/Mn oxide bound, residue and organic matter bound）, and the copper tolerance level （expressed as IC50, influence concentration） was measured by the plate-count method. Results By simple correlation analysis, the ICs0 was positively correlated with the concentration of exchangeable Cu （R2=0.8204）, while weakly correlated with other forms of Cu. Conclusion The bacterial community tolerance increases in the copper-contaminated soil while sensitive bacteria decrease in the copper-contaminated soils. The exchangeable Cu exerts high toxicity to microbial communities.

关键词： Copper speciation Toxicity Microbial community

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白念珠菌生物膜的研究

生命的化学 2008年第5期28卷 658-661页

作者：史文娜孙淑娟山东大学药学院济南250012 山东省千佛山医院济南250014

细菌生物膜相关感染发病率不断上升,且治疗困难,已受到广泛的关注。对于真菌,生物膜以及生物膜在真菌感染与耐药性产生过程中的作用只是近年来才受到国内外学者与临床专家的关注,目前的研究多集中在念珠菌属。本文综述了白念珠菌生物膜... 详细信息

细菌生物膜相关感染发病率不断上升,且治疗困难,已受到广泛的关注。对于真菌,生物膜以及生物膜在真菌感染与耐药性产生过程中的作用只是近年来才受到国内外学者与临床专家的关注,目前的研究多集中在念珠菌属。本文综述了白念珠菌生物膜的形成与特征、影响因素、耐药性的分子机制等几方面内容。

关键词：白念珠菌生物膜耐药性耐药机制

Molecular mechansims of atrial electrical remodeling in rats with atrial fibrillation

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Molecular mechansims of atrial electrical remodeling in rats...

基于ArcGIS的突发性大气污染应急预警系统——以上海市宝山区大场镇为例

中国药理学会药学监护专业委员会第二届第二次国际学术研讨会

作者： Yi-Qun Tang shu-juan sun Yue-Miao Yin:Min-Hui Wang Lu Huang Jiao-Jiao Shan (Department of Clinical Pharmacy.China Pharmaceutical University, Nanjing 210009,Jiangsu.China)

AIM:To investigate atrial electrical remodeling induced by atrial fibrillation at molecular ***:Forty male SD rats were randomized into 2 equal groups. Rats of control group were administrated physiological saline(i.v.) for 7 *** others were injected ACh-CaC12(i.v.) to induce AF for 7 *** duration and ECG parameters were *** day 8,all rats were anesthetized and the atriums were

关键词： atrial fibrillation animal model electrical remodeling connexin 40

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江苏环境科技 2008年第4期21卷 57-59页

作者：陈见平束炯孙娟华东师范大学学地理信息科学教育部重点实验室上海200062

以上海宝山区大厂镇突发性污染泄漏预警系统这一基于高斯扩散的大气污染扩散空间信息系统为例,将点源大气扩散模式——高斯模式与ArcGIS的有机结合,初步探讨了突发性大气污染的预警研究。预警系统具有相当的灵活性,可以通过多种插值方... 详细信息

以上海宝山区大厂镇突发性污染泄漏预警系统这一基于高斯扩散的大气污染扩散空间信息系统为例,将点源大气扩散模式——高斯模式与ArcGIS的有机结合,初步探讨了突发性大气污染的预警研究。预警系统具有相当的灵活性,可以通过多种插值方法有效地模拟底图上任一点的突发性大气污染扩散状况。与此同时,扩散模式与GIS软件的有机结合,实现了系统的可视化,简化了模式输入,而且使得系统具有了空间分析功能,是一次不错的尝试。

关键词：大气污染突发性预警空间插值

Effects of Total Saponins from Dioscorea Nipponica Makino on Monosodium Urate-Induced M1-Polarized Macrophages through Arachidonic Acid Signaling Pathway:An in vitro Study

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Chinese Journal of Integrative Medicine 2023年第1期29卷 44-51页

作者： ZHOU qi sun Hui-juan LIU shu-min Research Institute of Chinese Medicine Heilongjiang University of Chinese MedicineHarbin150040China Graduate School Heilongjiang University of Chinese MedicineHarbin150040China Technological Innovation Team of Basic Theory Study Research of Institution of Higher Education in Heilongjiang Province Heilongjiang University of Chinese MedicineHarbin150040China

Objective To investigate and reveal the underlying mechanism of the effect of total saponins from Dioscoreae nipponica Makino(TSDN)on the arachidonic acid pathway in monosodium urate(MSU)crystal-induced M1-polarized *** M1 polarization of RAW264.7 cells were induced by 1µg/mL lipopolysaccharide(LPS).The methylthiazolyldiphenyl-tetrazolium bromide method was then used to screen the concentration of ***(500µg/mL)was used to induce the gouty arthritis ***,10µg/L TSDN and 8µmol/L celecoxib,which was used as a positive control,were added to the above LPS and MSU-induced cells for 24 *** mRNA and protein expressions of cyclooxygenase(COX)2,5-lipoxygenase(5-LOX),microsomal prostaglandin E synthase derived eicosanoids(mPGES)-1,leukotriene B(LTB)4,cytochrome P450(CYP)4A,and prostaglandin E_(2)(PGE_(2))were tested by real-time polymerase chain reaction and Western blotting,*** enzyme-linked immunosorbent assay was used to test the contents of M1 markers,including inducible nitric oxid synthase(NOS)2,CD80,and *** TSDN inhibited the proliferation of M1 macrophages and decreased both the mRNA and protein expressions of COX2,5-LOX,CYP4A,LTB4,and PGE_(2)(P<0.01)while increased the mRNA and protein expression of mPGES-1(P<0.05 or P<0.01).TSDN could also significantly decrease the contents of NOS2,CD80,and CD86(P<0.01).Conclusion TSDN has an anti-inflammation effect on gouty arthritis in an in vitro model by regulating arachidonic acid signaling pathway.

关键词： gouty arthritis Dioscorea nipponica Makino arachidonic acid signaling pathway M1/M2 polarization

橇装式液化天然气加气站泄放气体处理及其加热器计算

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石油化工设备 2017年第4期46卷 53-57页

作者：雒淑娟孙俊胜刘福录任永平张鹏门建斌张兵上海蓝滨石化设备有限责任公司上海201518 甘肃蓝科石化高新装备股份有限公司甘肃兰州730070

液化天然气在储存和运输过程中会产生一定量的泄放气体。对橇装式液化天然气加气站泄放气体的两种处理方法进行了简单介绍。通过比较后得知,泄放气体经过斯特林制冷机再液化后可实现二次利用,也能体现节能减排的要求,同时从不同工况下... 详细信息

液化天然气在储存和运输过程中会产生一定量的泄放气体。对橇装式液化天然气加气站泄放气体的两种处理方法进行了简单介绍。通过比较后得知,泄放气体经过斯特林制冷机再液化后可实现二次利用,也能体现节能减排的要求,同时从不同工况下最大安全泄放量,加热器换热面积和长度,星型翅片管排列方式等方面对泄放气体加热器的设计进行了介绍。

关键词：加热器液化天然气泄放气体安全泄放量

Meniscus-Assisted Solution Printing Enables Cocrystallization in Poly(3-alkylthiophene)-based Blends for Field-Effect Transistors

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Chinese Journal of Polymer Science 2023年第8期41卷 1269-1276,I0009页

作者： shu-Yin Zhu juan Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

The formation of cocrystallization in two various conjugated components may endow the newly formed conjugated cocrystals with multiple functionalities and improved charge transport ***,compared to conjugated small molecules,this strategy is rather limitedly realized in conjugated ***,a simple meniscus-assisted solution printing(MASP)strategy is utilized to achieve the cocrystallization in the blends of two conjugated polymers,i.e.,poly(3-hexylthiophene)(P3HT)and poly(3-octylthiophene)(P3OT),and the cocrystalline structures are correlated closely to their charge *** P3HT/P3OT blends phase separate and crystallize individually in their drop-cast thin *** subjecting the P3HT/P3OT blended solution to MASP,the confined solvent evaporation between two nearly parallel plates triggers them to cocrystallize progressively when accelerating the moving lower *** cocrystallization kinetics and the changes in P3HT/P3OT molecular structures are ***,these different crystalline structures of P3HT/P3OT blends are applied in organic fieldeffect transistors,imparting the cocrystallization-enhanced charge transport than respective P3HT and P3OT crystal *** MASP method can be extended to craft cocrystals of other conjugated polymer blends for their diverse optoelectronic applications.

关键词： Conjugated polymer blends Polythiophene Cocrystallization Charge mobility Meniscus-assisted solution printing

Analysis of chaos behaviors of a bistable piezoelectric cantilever power generation system by the second-order Melnikov function

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Acta Mechanica Sinica 2017年第1期33卷 200-207页

作者： shu sun shu-Qian Cao Department of Mechanics School of Mechanical Engineering Tianjin University Tianjin 300350 China College of Science North China University of Science and Technology Tangshan 063009 China Tianjin Key Laboratory of Nonlinear Dynamics and Chaos Control Tianjin 300350 China

By applying the second order Melnikov function, the chaos behaviors of a bistable piezoelectric cantilever power generation system are analyzed. Firstly, the conditions for emerging chaos of the system are derived by the second order Melnikov function. Secondly, the effects of each item in chaos threshold expression are analyzed. The excitation frequency and resistance values, which have the most influence on chaos threshold value, are found. The result from the second order Melnikov function is more accurate compared with that from the first order Melnikov function. Finally, the attraction basins of large amplitude motions under different exciting frequency, exciting amplitude, and resistance parameters are given.

关键词： Bistable piezoelectric cantilever beam Second order Melnikov function Homoclinic bifurcation Basin of attraction