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Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk:A meta-analysis

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World Journal of Gastroenterology 2010年第33期16卷 4210-4220页

作者： shu-juan yang Akira Yokoyama Tetsuji Yokoyama Yu-Chuan Huang Si-Ying Wu Ying Shao Jin Niu Jie Wang Yu Liu Xiao-Qiao Zhou Chun-Xia yang Departmentof Epidemiology West China School of Public HealthSichuan UniversityChengdu 610041Sichuan ProvinceChina Clinical Research Unit National HospitalOrganization Kurihama Alcoholism CenterYokosuka 239-0841Japan Department of Human Resources Development National Institute of Public HealthWako 351-0104Japan Technology Research and DevelopmentCenter China Tobacco Chuanyu IndustrialCorporationChengdu Department of Epidemiology and Health Statistics Fujian Medical Unive rsityFuzhou 350108Fujian ProvinceChina Department of Periodontology West China College of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Public Health Sichuan UniversityChengdu 610041Sichuan ProvinceChina 610066Sichuan ProvinceChina

AIM:To evaluate the contribution of alcohol dehydrogenase-1B(ADH1B)and aldehyde dehydrogenase-2 (ALDH2)polymorphisms to the risk of esophageal ***:Nineteen articles were included by searching MEDLINE,EMBASE and the Chinese Biomedical Database,13 on ADH1B and 18 on *** performed a meta-analysis of case-control studies including 13 studies on ADH1B(cases/controls:2390/7100)and 18 studies on ALDH2(2631/6030).RESULTS:The crude odds ratio[OR(95%confidence interval)]was 2.91(2.04-4.14)for ADH1B*1/*1(vs ADH1B*2/*2)and 1.32(1.17-1.49)for ADH1B*1/**** crude OR for ALDH2*1/*2(vs ALDH2*1/*1)was 2.52(1.76-3.61).ADH1B*1/*1 increased the risk of esophageal cancer among never/rare[1.56(0.93-2.61)],moderate[2.71(1.37-5.35)],and heavy drinkers[3.22 (2.27-4.57)].ADH1B*1/*2 was associated with a modest risk among moderate drinkers[1.43(1.09-1.87)].ALDH2*1/*2 increased the risk among never/rare[1.28 (0.91-1.80)],moderate[3.12(1.95-5.01)],and heavy [7.12(4.67-10.86)]drinkers,and among ex-drinkers [5.64(1.57-20.25)].ALDH2*2/*2 increased the risk among drinkers[4.42(1.72-11.36)].ADH1B*1/*1 plus ALDH2*1/*2 was associated with the highest risk for heavy drinkers[12.45(2.9-53.46)].The results of the meta-regression analysis showed that the effects of ADH1B*1/*1 and ALDH2*1/*2 increased with the level of alcohol ***2*1/*2 was associated with a high risk among Taiwan Chinese and Japanese drinkers,as opposed to a moderate risk among drinkers in high-incidence regions of China's ***1B*1/*1 in heavy drinkers and ALDH2*1/*2 in moderate-toheavy drinkers was associated with similarly high risk among both men and ***:ADH1B/ALDH2 genotypes affect the risk of esophageal cancer,and the risk is modified by alcohol consumption,ethnicity,and gender.

关键词： Alcohol dehydrogenase-1B Aldehyde dehy- drogenase-2 Esophageal cancer Meta-analysis

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming Yuan Guo-Da Zhang Chao Wang shu-juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

In vitro evaluation of the compatibility of a novel collagen-heparan sulfate biological scaffold with olfactory ensheathing cells

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Chinese Medical Journal 2010年第10期123卷 1299-1304页

作者： TANG Zhou-ping LIU Na LI Zai-wang XIE Xue-wei CHEN Yun SHI Yuan-hong ZENG Wen-gao WANG shu-xin CHEN juan yang Jie PAN Deng-ji Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background Stroke and traumatic injury to the nerve system may trigger axonal destruction and the formation of scar tissue, cystic cavitations and physical gaps. Olfactory ensheathing cells （OECs） can secrete neurotrophic factors to promote neurite growth and thus act as a prime candidate for autologous transplantation. Biological scaffolds can provide a robust delivery vehicle to injured nerve tissue for neural cell transplantation strategies, owing to the porous three-dimensional structures （3D）. So transplantation of the purposeful cells seeded scaffolds may be a promising method for nerve tissue repair. This study aimed to evaluate the compatibility of a novel collagen-heparan sulfate biological scaffold with olfactory ensheathing cells in vitro. Methods Collagen-heparan sulfate （CHS） biological scaffolds were made, and then the scaffolds and OECs were co-cultured in vitro. The viability of OECs was tested by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium （MTT） assay at days 1, 3, 5 and 7. Statistical analysis was evaluated by student＇s ttest. Significance was accepted at P 〈0.05. OECs were labeled with carboxyfluorescein diacetate succinimidyl ester （CFSE）, and the CFSE-labeled OECs were seeded into CHS scaffolds. The attachment and growth of OECs in CHS scaffolds were observed and traced directly by fluorescent microscopy and environmental scanning electron microscope （ESEM）. Results CHS biological scaffolds had steady porous 3D structures and no cytotoxicity to OECs （F=-0.14, P=-0.9330）. CHS biological scaffolds were good bridging materials for OECs attachment and proliferation, and they promoted the axonal growth. Conclusion The compatibility of CHS biological scaffolds with OECs is pretty good and CHS biological scaffold is a promising cell carrier for the implantation of OECs in nerve tissue bioengineering.

关键词： collagen-heparan sulfate biological scaffold olfactory ensheathing cells compatibility

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群体感应在动态代谢调控中的研究进展

中国生物工程杂志 2020年第6期40卷 74-83页

作者：薛艳婷吴胜波徐程杨袁博鑫杨书鹃刘家亨乔建军朱宏吉天津大学化工学院系统生物工程教育部重点实验室天津化学化工协同创新中心合成生物学平台天津300072

群体感应(quorum sensing,QS)是一种特殊的动态代谢调控机制,是细菌用于监控自身群体密度的环境信号感受系统。近年来,随着合成生物学的大力发展,基于稳定的菌群关系的人工合成菌群以及混菌共培养技术也取得了突破性的进展。群体感应系... 详细信息

群体感应(quorum sensing,QS)是一种特殊的动态代谢调控机制,是细菌用于监控自身群体密度的环境信号感受系统。近年来,随着合成生物学的大力发展,基于稳定的菌群关系的人工合成菌群以及混菌共培养技术也取得了突破性的进展。群体感应系统因为可以实现细菌自主控制菌群关系的目的,而在菌群关系构建以及代谢工程中的研究和应用受到越来越多的关注。在对群体感应系统进行概述的基础上,对单菌基于群体感应的动态代谢调控进行了总结;同时也对群体感应的动态调控在革兰氏阴性菌和革兰氏阳性菌之间以及混菌共培养过程中的研究进展进行综述,以期能对群体感应系统的其他应用提供一些建议和帮助。

关键词：代谢工程动态代谢调控群体感应菌群关系合成菌群

钢箱-混凝土组合截面梁的力学性能初步试验研究

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湘潭矿业学院学报 2002年第4期17卷 46-49页

作者：钟新谷郑玉国舒小娟阳国锋袁帅华邹中权湘潭工学院桥梁工程研究所湖南湘潭411201

在提出一种新组合截面即钢箱混凝土组合截面梁的基础上进行该类梁的P Δ曲线分析和试验.试验分析表明:该类梁具有良好的抵抗变形能力,钢箱对混凝土的套箍效应有作用,钢箱的顶底板的剪力滞后效应明显,钢箱混凝土组合截面梁在加载的过... 详细信息

在提出一种新组合截面即钢箱混凝土组合截面梁的基础上进行该类梁的P Δ曲线分析和试验.试验分析表明:该类梁具有良好的抵抗变形能力,钢箱对混凝土的套箍效应有作用,钢箱的顶底板的剪力滞后效应明显,钢箱混凝土组合截面梁在加载的过程中基本符合平截面假定、中性轴的移动规律.试验结果与理论分析基本一致.图7,参5.

关键词：力学性能钢筋-混凝土组合截面梁承载力套箍效应荷载-变形关系

高师数学教育专业开展数学科技活动的实践与思考

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新乡师范高等专科学校学报 2002年第4期16卷 74-75页

作者：郭淑娟杨瑞峰韩利亚新乡师范高等专科学校数学系，河南新乡453000

探讨了在高等师范院校数学教育专业开展数学科技活动，培养学生创新意识和实践能力的可行性，并在实践的基础上探讨了活动的具体形式、内容以及需要进一步解决的问题。

关键词：数学科技活动创新意识实践能力

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu Yun-Bo Ruan yang Zhang shu-juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

基于废旧锂电池的LED便携式亮度可控光源的设计

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湖北第二师范学院学报 2016年第8期33卷 40-44页

作者：吉紫娟舒晟杨李余展孙晓峰湖北第二师范学院物理与机电工程学院武汉430205

由于通信技术与设备更新换代速度的加快,产生大量闲置锂电池,若直接丢弃,将造成环境污染。废旧锂电池在对电压要求不太高的电器设备中仍可使用,且还能充电,性能优于普通干电池。本文从节能环保角度出发,设计了一种基于废旧电池的LED便... 详细信息

由于通信技术与设备更新换代速度的加快,产生大量闲置锂电池,若直接丢弃,将造成环境污染。废旧锂电池在对电压要求不太高的电器设备中仍可使用,且还能充电,性能优于普通干电池。本文从节能环保角度出发,设计了一种基于废旧电池的LED便携式亮度可控光源装置。该装置以废旧手机锂电池、节能LED灯珠及其驱动电路为基本模块;为实现亮度可调,辅以光敏电阻及STM32处理芯片。实验结果表明,所设计的便携式光源可在不同光照条件下自动实现亮度可调,且性能稳定,体积小成本低,具有较好的实用价值。

关键词：废旧锂电池 LED 便携光源亮度可控

Meniscus-Assisted Solution Printing Enables Cocrystallization in Poly(3-alkylthiophene)-based Blends for Field-Effect Transistors

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Chinese Journal of Polymer Science 2023年第8期41卷 1269-1276,I0009页

作者： shu-Yin Zhu juan Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

The formation of cocrystallization in two various conjugated components may endow the newly formed conjugated cocrystals with multiple functionalities and improved charge transport ***,compared to conjugated small molecules,this strategy is rather limitedly realized in conjugated ***,a simple meniscus-assisted solution printing(MASP)strategy is utilized to achieve the cocrystallization in the blends of two conjugated polymers,i.e.,poly(3-hexylthiophene)(P3HT)and poly(3-octylthiophene)(P3OT),and the cocrystalline structures are correlated closely to their charge *** P3HT/P3OT blends phase separate and crystallize individually in their drop-cast thin *** subjecting the P3HT/P3OT blended solution to MASP,the confined solvent evaporation between two nearly parallel plates triggers them to cocrystallize progressively when accelerating the moving lower *** cocrystallization kinetics and the changes in P3HT/P3OT molecular structures are ***,these different crystalline structures of P3HT/P3OT blends are applied in organic fieldeffect transistors,imparting the cocrystallization-enhanced charge transport than respective P3HT and P3OT crystal *** MASP method can be extended to craft cocrystals of other conjugated polymer blends for their diverse optoelectronic applications.

关键词： Conjugated polymer blends Polythiophene Cocrystallization Charge mobility Meniscus-assisted solution printing