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Adiponectin gene polymorphisms and risk of gestational diabetes mellitus:A meta-analysis

World Journal of Clinical Cases 2019年第5期7卷 572-584页

作者： Lin-Ting Huang Shi-Lan Wu Xin Liao shu-juan ma Hong-Zhuan Tan Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University

BACKGROUND Adiponectin(ADIPOQ) is an important factor involved in the regulation of both carbohydrate and lipid metabolism. Polymorphisms in the ADIPOQ gene are known to influence an individual's predisposition to metabolic syndrome and type 2 diabetes. Moreover, women with gestational diabetes mellitus(GDM) are at an increased risk of developing type 2 diabetes. Several studies have been conducted previously to assess the association between ADIPOQ polymorphisms and GDM; however, the results of the association are *** To quantitatively evaluate the association between ADIPOQ +45 T/G, +276 G/T,and-11377 C/G polymorphisms and the risk of *** A systematic search of EMBASE, PubMed, CNKI, Web of Science, and WANFANG DATA was conducted up to October 20, 2018. We calculated merged odds ratios(ORs) with 95% confidence intervals(CIs) using a fixed-effects or random-effects model depending on the between-study heterogeneity to evaluate the association between AIDPOQ +45 T/G, +276 G/T, and-11377 C/G polymorphisms and the risk of GDM. Subgroup analysis was performed by ethnicity. Publication and sensitivity bias analyses were performed to test the robustness of the association. All statistical analyses were conducted using Stata *** Nine studies of +45 T/G included 1024 GDM cases and 1059 controls, five studies of +276 G/T included 590 GDM cases and 595 controls, and five studies of-11377 C/G included 722 GDM cases and 791 controls. Pooled ORs indicated that+45 T/G increased GDM risk in Asians(allelic model: OR = 1.47, 95%CI: 1.27-1.70,P = 0.000; dominant model: OR = 1.54, 95%CI: 1.27-1.85, P = 0.000; recessive model: OR=2.00, 95%CI: 1.43-2.85, P = 0.000), not in South Americans(allelic model: OR = 1.21, 95%CI: 0.68-2.41, P = 0.510; dominant model: OR = 1.13, 95%CI:,0.59-2.15, P = 0.710; recessive model: OR = 2.18, 95%CI: 0.43-11.07, P = 0.350).There were no significant associations between +276 G/T(allelic model: OR = 0.88,95%CI: 0.74-1.05, P = 0

关键词： Gestational diabetes mellitus Single nucleotide Polymorphism Adiponectin Gene Meta-analysis

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Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis

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World Journal of Clinical Cases 2020年第19期8卷 4320-4330页

作者： Mian Wang shu-juan ma Xin-Yin Wu Xian Zhang Julius Abesig Zheng-Hui Xiao Xin Huang Hai-Peng Yan Jing Wang Meng-Shi Chen Hong-Zhuan Tan Hunan Provincial Key Laboratory of Clinical Epidemiology Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Department of Occupational and Environmental Hygiene Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Hunan Provincial Key Laboratory of Pediatric Emergency Hunan Children's HospitalChangsha 410007Hunan ProvinceChina Department of Epidemiology and Health Statistics Hunan Normal UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway,and its dysregulation is associated with various *** studies have demonstrated that tea drinking is a protective factor against tuberculosis(TB).This study was designed to explore five single nucleotide polymorphisms(SNPs)of mTOR in the Han population of China to determine how their interactions with tea drinking affect susceptibility to *** To investigate if the polymorphisms of mTOR gene and the gene-tea interaction are associated with susceptibility to *** In this case-control study,503 patients with TB and 494 healthy controls were enrolled by a stratified sampling *** cases were newly registered TB patients from the county-level centers for disease control and prevention,and the healthy controls were permanent residents from Xin'ansi Community,Changsha *** data and environmental exposure information including tea drinking were obtained from the study *** genotyped five potentially functional SNP sites(rs2295080,rs2024627,rs1057079,rs12137958,and rs7525957)of mTOR gene and assessed their associations with the risk of TB using logistic regression analysis,and marginal structural linear odds models were used to estimate the gene-environment *** The frequencies of four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)were found to be associated with susceptibility to TB(P<0.05).Genotypes GT(OR 1.334),GG(OR 2.224),and GT+GG(OR 1.403)at rs2295080;genotypes CT(OR 1.562)and CT+TT(OR 1.578)at rs2024627,genotypes CT(OR 1.597),CC(OR 2.858),and CT+CC(OR 1.682)at rs1057079;and genotypes CT(OR 1.559)and CT+CC(OR 1.568)at rs7525957 of mTOR gene were significantly more prevalent in TB patients than in healthy *** relative excess risk of interaction between the four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)of mTOR genes and tea drinking were found to be-1.5187(95%CI:-1.9826,-1.0547,P<0.05),-1.8270(95%CI:-2.3587,-

关键词： Tuberculosis mTOR Tea drinking Gene-environment interaction The relative excess risk of interaction Single nucleotide polymorphism

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C反应蛋白/白蛋白比值对2型糖尿病合并急性心肌梗死患者远期不良心脑血管事件的预测价值研究

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中国全科医学 2025年第6期28卷 705-712页

作者：马娟马盛宗燕茹马学平贾绍斌宁夏医科大学总医院心血管内科宁夏回族自治区银川市750000 宁夏回族自治区人民医院妇产科宁夏回族自治区银川市750000

背景急性心肌梗死(AMI)是威胁全球公众健康的主要原因之一。虽然已有相应的再灌注治疗策略,但AMI相关的主要不良心脑血管事件(maCCEs)仍然是全世界人口死亡的原因之一。尤其合并糖尿病的AMI患者,因冠状动脉病变复杂,病变程度严重,尽早... 详细信息

背景急性心肌梗死(AMI)是威胁全球公众健康的主要原因之一。虽然已有相应的再灌注治疗策略,但AMI相关的主要不良心脑血管事件(maCCEs)仍然是全世界人口死亡的原因之一。尤其合并糖尿病的AMI患者,因冠状动脉病变复杂,病变程度严重,尽早发现和判断该部分患者远期预后相对困难,因此寻找相对简便、易获得的实验室指标,有利于为2型糖尿病(T2DM)合并AMI患者经皮冠状动脉介入(PCI)术后maCCEs的预测提供依据。目的探讨血清C反应蛋白(CRP)/白蛋白(Alb)比值(CAR)对T2DM合并AMI患者PCI术后远期maCCEs的预测价值。方法纳入2014—2019年就诊于宁夏医科大学总医院心血管内科1683例T2DM合并AMI患者为研究对象,收集患者的一般临床资料与检查结果。对所有患者进行电话或门诊随访,以全因死亡、非致死性心肌梗死、再发不稳定型心绞痛、非致死性脑卒中、新发心力衰竭或心力衰竭加重再入院、再次血运重建作为maCCEs。根据患者随访期间是否发生maCCEs分为maCCEs组(508例)和非maCCEs组(1175例)。采用单因素及多因素Logistic回归分析探讨T2DM合并AMI患者maCCEs事件的影响因素。采用Kaplan-Meier法绘制患者的生存曲线,生存曲线的比较采用Log-rank检验。采用受试者工作特征(ROC)曲线分析CAR对T2DM合并AMI患者远期发生maCCEs的预测效能,使用净重分类改善指标(NRI)和综合判别指数(IDI)评价CAR对T2DM合并AMI患者预后评估的改善效果。结果1683例患者中508例(30.18%)患者发生maCCEs。多因素Logistic回归分析显示高血压病[OR(95%CI)=1.994(1.142~3.483)]、冠状动脉植入支架长度[OR(95%CI)=1.031(1.002~1.062)]、CRP[OR(95%CI)=0.950(0.915~0.986)]、Alb[OR(95%CI)=0.933(0.880~0.989)]及CAR[OR(95%CI)=5.582(1.705~18.277)]是T2DM合并AMI患者PCI术后发生maCCEs的影响因素(PmaCCEs发生率高于CARmaCCEs的ROC曲线下面积为0.728(95%CI=0.702~0.754),最佳截断值为0.576,灵敏度为0.617,特异度为0.747。在基线模型基础上,与CRP、Alb相比,CAR能明显改善对患者发生maCCEs的预测效果(NRI=0.377,IDI=0.166,C指数=0.690;PmaCCEs发生风险的有效预测指标。

关键词：心肌梗死糖尿病,2型主要不良心脑血管事件 C反应蛋白白蛋白预测

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Kinetics Analysis on the Polycondensation Process of Poly(p-phenylene terephthalamide):Experimental Verification and Molecular Simulation

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Chinese Journal of Polymer Science 2018年第5期36卷 675-682页

作者： Jing Liu Hai-juan Kong Yu ma shu Zhu Mu-Huo Yu State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and Engineering Donghua University School of materials Engineering Shanghai University of Engineering Science Key Laboratory of Shanghai City for Lightweight Composites State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University

The conventional low-temperature method of solution polycondensation was developed to realize the reaction of p-phenylenediamin and terephthaloyl chloride for the preparation of poly（p-phenylene terephthalamide）（PPTA）. Some main factors influencing this process were investigated to determine the optimum condition for high molecular weight. Experiment showed significant slowing of the reaction and gradual deviation of second-order reaction kinetics due to diffusion control. These phenomena were studied theoretically via dynamic Monte Carlo simulation. A concise expression,n～c0^-0.88·t^0.37, was proposed to describe the diffusioncontrolled polycondensation process as a function of the monomer concentration and reaction time. The theoretical results provided a good description of diffusion-effected kinetics for the polycondensation process of PPTA, and demonstrated good agreement with the experimental data. Some differences of scaling relations between model and experiment results were also discussed.

关键词： Poly(p-phenylene terephthalamide) Molecular weight Reaction kinetics Molecular simulation

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Meniscus-Assisted Solution Printing Enables Cocrystallization in Poly(3-alkylthiophene)-based Blends for Field-Effect Transistors

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Chinese Journal of Polymer Science 2023年第8期41卷 1269-1276,I0009页

作者： shu-Yin Zhu juan Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

The formation of cocrystallization in two various conjugated components may endow the newly formed conjugated cocrystals with multiple functionalities and improved charge transport ***,compared to conjugated small molecules,this strategy is rather limitedly realized in conjugated ***,a simple meniscus-assisted solution printing(maSP)strategy is utilized to achieve the cocrystallization in the blends of two conjugated polymers,i.e.,poly(3-hexylthiophene)(P3HT)and poly(3-octylthiophene)(P3OT),and the cocrystalline structures are correlated closely to their charge *** P3HT/P3OT blends phase separate and crystallize individually in their drop-cast thin *** subjecting the P3HT/P3OT blended solution to maSP,the confined solvent evaporation between two nearly parallel plates triggers them to cocrystallize progressively when accelerating the moving lower *** cocrystallization kinetics and the changes in P3HT/P3OT molecular structures are ***,these different crystalline structures of P3HT/P3OT blends are applied in organic fieldeffect transistors,imparting the cocrystallization-enhanced charge transport than respective P3HT and P3OT crystal *** maSP method can be extended to craft cocrystals of other conjugated polymer blends for their diverse optoelectronic applications.

关键词： Conjugated polymer blends Polythiophene Cocrystallization Charge mobility Meniscus-assisted solution printing

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Characteristics of life-cycle carbon dioxide emissions of arterial highway maintenance and the influencing factors

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Advances in Climate Change Research 2024年第4期15卷 751-765页

作者： Yao WANG Yuan-Qing WANG shu-juan JI Si-Jia SUN shu-Hong ma Ya-Nan GAO Key Laboratory of Transport Industry of management Control and Cycle Repair Technology for Traffic Network Facilities in Ecological Security Barrier Area Chang'an UniversityXi'an 710064China Guangzhou Aids to Navigation Office Southem Navigation Service CenterMaritime Safety AdministrationGuangzhou 51000China

With the focus of highway development transitioning from construction to maintenance,a comprehensive understanding of the characteristics and influencing factors of carbon dioxide(CO_(2))emissions from highway maintenance activities is crucial for formulating effective strategies to promote the low-carbon development of road ***,the quantitative relationships between CO_(2) emissions from highway maintenance schemes and factors such as pavement deterioration,traffic volume,and road grade remain unclear owing to a lack of compre-hensive,multi-category,and real *** real maintenance data from 340 arterial highway segments in China,this study conducts the life cycle assessment(LCA)to estimate CO_(2) emissions from maintenance activities and examines the primary emission sources among various structural layers and ***,multiple linear regression(MLR)analysis is conducted to investigate the impact of traffic volume,road grade,and pavement deterioration on CO_(2) emissions from maintenance projects,and factors influencing the early-stage degradation of pavement *** results demonstrate that average CO_(2) emissions from heavy rehabilitation projects are 6.97 times higher than those from medium rehabilitation *** from heavy rehabilitation projects exhibit a significantly negative linear relationship with the riding quality index(RQI)before maintenance(pmaintenance(pmaintenance(pmaintenance(p<0.05).The early-stage d

关键词： Life cycle assessment(LCA) Arterial highway maintenance Emission factor Pavement performance Traffic volume

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Left-Right Non-Linear Dynamical Higgs

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Communications in Theoretical Physics 2016年第12期65卷 643-662页

作者： Jing shu juan Yepes State Key Laboratory of Theoretical Physics and Kavli Institute for Theoretical Physics China Institute of Theoretical Physics Chinese Academy of Sciences

All the possible CP-conserving non-linear operators up to the p^4-order in the Lagrangian expansion are analysed here for the left-right symmetric model in the non-linear electroweak chiral context coupled to a light dynamical Higgs. The low energy effects will be triggered by an emerging new physics field content in the nature, more specifically,from spin-1 resonances sourced by the straightforward extension of the SM local gauge symmetry to the larger local group SU(2)_L × SU(2)_R× U(1)_(B-L). Low energy phenomenology will be altered by integrating out the resonances from the physical spectrum, being manifested through induced corrections onto the left handed operators. Such modifications are weighted by powers of the scales ratio implied by the symmetries of the model and will determine the size of the effective operator basis to be used. The recently observed diboson excess around the invariant mass 1.8 TeV–2 TeV entails a scale suppression that suggests to encode the low energy effects via a much smaller set of effective operators.

关键词： left-right model nonlinear invariance CP symmetry SU(2)×SU(2)×U(1) effective Lagrangian Higgs couplings

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LONG-TIME BEHAVIOR OF FINITE DIFFERENCE SOLUTIONS OF A NONLINEAR SCHRODINGER EQUATION WITH WEAKLY DAMPED

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Journal of Computational mathematics 2001年第4期19卷 393-406页

作者： Fa-yong Zhang shu-juan Lu Department of mathematics Heilongjiang UniversityHarbin 150080China Department of mathematics Beijing University of Aeronautics&AstronauticsBeijing 100083China

A weakly demped Schrodinger equation possessing a global attractor are considered. The dynamical properties of a class of finite difference scheme axe analysed. The exsitence of global attractor is proved for the discrete system. The stability of the difference scheme and the error estimate of the difference solution are obtained in the autonomous system case. Finally, long-time stability and convergence of the class of finite difference scheme also are analysed in the nonautonomous system case.

关键词： global attractor nonlinear Schrodinger equation finite difference method stibility and convergence

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Effect of Nitric Oxide on the Interaction Between Mitochondrial malate Dehydrogenase and Citrate Synthase

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Journal of Integrative Agriculture 2014年第12期13卷 2616-2624页

作者： LIU Yu-chen WANG juan SU Pei-ying ma Chun-mei ZHU shu-hua College of Chemistry and material Science Shandong Agricultural University Department of Horticultural and Forest Engineer Heze University Tai’an Tumor Prevention and Treatment Hospital

Mitochondrial malate dehydrogenase （mMDH） and citrate synthase （CS） are sequential enzymes in Krebs cycle. mMDH, CS and the complex between mMDH and CS （mMDH＋CS） were treated with nitric oxide solution. The roles of notric oxide （NO） on the secondary structures and the interactions between mMDH and CS were studied using circular diehroism （CD） and Fourier transform surface plasmon resonance （FT-SPR）, respectivley. The effects of NO on the activities of mMDH, CS and mMDH＋CS were also studied. And the regulations by NO on mMDH and CS were simulated by PyMOL software. The results of SPR conifrmed that strong interaction between mMDH and CS existed and NO could signiifcantly regulate the interaction between the two enzymes. NO reduced the mass percents ofα-helix and increased that of random in mMDH, CS and mMDH＋CS. NO increased the activities of CS and mMDH＋CS, and inhibited the activity of mMDH. Graphic simulation indicated that covalent bond was formed between NO and Asn242 in active site of CS. However, there was no direct bond between NO and mMDH. The increase in activity of mMDH＋CS complex depended mostly on the interaction between NO and CS. All the results suggested that the regulations by NO on the activity and interaction between mMDH and CS were accord with the changes in mMDH, CS and mMDH＋CS caused by NO.

关键词： Krebs cycle nitric oxide surface plasmon resonance protein-protein interaction citrate synthase malate dehydrogenase

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Dynamic adsorption of Xe on a fixed-bed adsorber at 77 K

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Nuclear Science and Techniques 2017年第8期28卷 89-96页

作者： Bin Long Jun-Li Li Qun-shu Wang shu-juan Feng Guo-Qing Zhou Tian-Cheng Feng Yan-Jie Tian Huai-Cheng ma Key Laboratory of Particle and Radiation Imaging of Ministry of Education Department of Engineering PhysicsTsinghua University Beijing 100084 China Northwest Institute of Nuclear Technology Xi'an 710024China

In designing a fixed-bed adsorber, it is vital to understand dynamic adsorption properties of the unit. Temperature is an important effect on adsorbent performance, as the dynamic adsorption coefficients tend to increase with decreasing temperature. To minimize the volume of the fixed-bed adsorber, the dynamic adsorption characteristics of Xe were studied at 77 K by employing a variety of adsorbents under different operational conditions. The carbon molecular sieve performed better than that of activated carbon. Both operational conditions and the presence of gaseous impurities were found to affect the adsorption properties.

关键词：固定床吸附器动态吸附性能动态吸附特性操作条件吸附系数碳分子筛 TEM 吸附量

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