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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian zha.g Kejia zha. Wenjing Zhou Ran Kang Shiyou Wei Yueli shu Cheng Yu Yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu zha.Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EGFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EGFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EGFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EGFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

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考虑作业环节完整性的企业车站进路选择优化

铁道科学与工程学报 2024年第2期21卷 499-509页

作者：谢贤亮查伟雄舒伟成李剑严利鑫华东交通大学交通运输工程学院江西南昌330013

传统企业车站进路选择优化问题,即当多项作业出现在同一时空,以行车作业优先,调车作业在冲突节点前停车等待至行车作业驶离冲突节点再继续作业。现实生产过程中易造成调车作业长时间停滞等待,导致调车作业无法准时到达目标地点,破坏了... 详细信息

传统企业车站进路选择优化问题,即当多项作业出现在同一时空,以行车作业优先,调车作业在冲突节点前停车等待至行车作业驶离冲突节点再继续作业。现实生产过程中易造成调车作业长时间停滞等待,导致调车作业无法准时到达目标地点,破坏了调车作业环节的完整性,损害了企业车站的利益。基于企业车站行车作业与调车作业并存且调车作业数量要远大于行车作业的特点,同时考虑调车作业环节完整性,将调车作业设定一个能充分完成作业的时间标准值,并动态实时更新作业过程中节点占用时间,以判断进路冲突并进行疏解,建立以调车作业时间成本、行车作业时间成本最小的多目标进路选择优化模型。为加快遗传算法的搜索效率,结合K短路算法特点改进了遗传算法,并且以进路为基本单元针对性地设计了个体编码方案、交叉变异策略,求解该模型。最后,以具有代表性的某企业车站为例进行了验证。研究结果表明:考虑作业环节完整性的进路选择优化模型得到的进路选择方案能够有效地避免作业冲突,并且能够依据作业的优先级为车站作业选择合理的进路,快速有效地得出满意的作业方案,满足车站工作的需求。与传统进路选择方案相比,总的作业时间降低了23.26%。研究成果对该企业车站进路选择具有一定的参考价值。

关键词：企业车站作业环节进路优化软时间窗 K短路-遗传算法

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分级梯度蜂窝结构的面内压溃行为

塑性工程学报 2024年第8期31卷 240-253页

作者：查曙光王士龙裴文杰黄志来安徽工业大学建筑工程学院安徽马鞍山243002 安徽工业大学机械工程学院安徽马鞍山243002

通过逐层在六边形胞元中引入次级结构的方式构建了4种具有分级梯度特性的蜂窝结构,采用ABAQUS/Explicit有限元软件对4种分级梯度构型蜂窝结构的面内压溃性能进行了数值模拟。结果表明,分级梯度的引入能够有效控制蜂窝结构准静态加载下... 详细信息

通过逐层在六边形胞元中引入次级结构的方式构建了4种具有分级梯度特性的蜂窝结构,采用ABAQUS/Explicit有限元软件对4种分级梯度构型蜂窝结构的面内压溃性能进行了数值模拟。结果表明,分级梯度的引入能够有效控制蜂窝结构准静态加载下变形带的产生和发展,使得不同分级阶数胞元的压溃失效进程以不同的平台应力水平反映在分级梯度蜂窝结构的宏观力学响应中。结合细观变形机制,分析了冲击速度和胞壁厚度对分级梯度蜂窝结构压溃响应和能量吸收性能的影响规律。在低速冲击下,采用中间高阶两端低阶胞元布置的对称分级梯度蜂窝结构表现出优异的吸能性能,与传统蜂窝结构相比,比吸能提高了95.66%。在高速冲击下,不同分级胞元的梯度设计能够改善蜂窝结构在压溃过程中的吸能性能,使得吸能结构的压溃过程能够得到有效调控。

关键词：分级梯度蜂窝结构面内压溃变形模式能量吸收

深冷轧制变形对新型Ni-W-Co-Ta高密度合金显微组织与性能的影响

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1214-1225页

作者：舒康豪熊毅厉勇岳赟陈正阁查小琴韩顺王春旭河南科技大学材料科学与工程学院洛阳471023 有色金属新材料与先进加工技术省部共建协同创新中心洛阳471023 钢铁研究总院特殊钢研究所北京100081 西北核技术研究所激光与物质相互作用国家重点实验室西安710024 中国船舶重工集团第725研究所洛阳471000

采用熔炼-浇铸-锻造流程制备新型Ni-W-Co-Ta高强度合金,并对Ni-W-Co-Ta合金经深冷轧制变形后的显微组织及力学性能演变规律进行表征。结果表明:随着变形量的增加,新型Ni-W-Co-Ta高密度合金中等轴晶粒沿轧制方向不断被拉长,同时产生大量... 详细信息

采用熔炼-浇铸-锻造流程制备新型Ni-W-Co-Ta高强度合金,并对Ni-W-Co-Ta合金经深冷轧制变形后的显微组织及力学性能演变规律进行表征。结果表明:随着变形量的增加,新型Ni-W-Co-Ta高密度合金中等轴晶粒沿轧制方向不断被拉长,同时产生大量的滑移带以协调剧烈的塑性变形,并最终形成纤维组织。变形量的增大导致位错密度急剧增大,位错交互作用显著加强,进而使晶粒尺寸细化至纳米量级;合金强度、硬度随着变形量的增加而显著提高,伸长率则急剧下降。断口形貌则由韧性断裂(未变形)向准解理-韧性混合型断裂转变(90%变形量)。

关键词： Ni-W-Co-Ta高密度合金深冷轧制纤维组织力学性能准解理-韧性混合型断裂

2022年夏季汉江中下游水华生消驱动因子及其贡献率量化研究

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水生态学杂志 2024年第1期45卷 143-151页

作者：查悉妮辛小康付婷李建白凤朋林枭舒鹏长江水资源保护科学研究所湖北武汉430051 长江水利委员会湖库水源地面源污染生态调控重点实验室湖北武汉430051 武汉大学水资源工程与调度全国重点实验室湖北武汉430072

为探究2022年夏季长江流域“汛期反枯”极端水文条件下汉江中下游首次出现的蓝藻水华成因,选取叶绿素浓度为水华表征指标,考虑各环境因子间的多重共线性关系,采用偏最小二乘回归(PLSR)量化了不同环境因子对汉江中下游仙桃、宗关断面蓝... 详细信息

为探究2022年夏季长江流域“汛期反枯”极端水文条件下汉江中下游首次出现的蓝藻水华成因,选取叶绿素浓度为水华表征指标,考虑各环境因子间的多重共线性关系,采用偏最小二乘回归(PLSR)量化了不同环境因子对汉江中下游仙桃、宗关断面蓝藻水华生消的贡献率。结果表明:(1)仙桃断面叶绿素a浓度与水温、pH、溶解氧和总磷均呈显著正相关关系,与氮磷比呈显著负相关关系;宗关断面叶绿素a浓度与水温、pH、溶解氧均呈显著正相关关系,与日均水位、水位日变幅、流量、总磷和氨氮均呈显著负相关关系;(2)溶解氧、pH和水温对水华生消的贡献程度较高,对仙桃断面的贡献率分别为15.18%、13.68%和14.50%,对宗关断面的贡献率分别为18.06%、15.93%和15.65%;(3)基于偏最小二乘路径模型(PLS-PM)的环境因子解析显示,气象因子是2022年夏季汉江中下游蓝藻水华暴发的诱导因子,水华“萌发”时段可能与汉江中下游涝旱急转时段重叠。建议后续研究结合准确的中长期气象预报信息,在涝旱急转时段优化汉江中下游水华防控调度的下泄流量与下泄时机,提高水华防控效果。

关键词：蓝藻水华环境因子量化归因贡献率汉江中下游

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基于生物反应器的猪流行性腹泻病毒(ZJ/15株)悬浮培养工艺研究

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黑龙江畜牧兽医 2024年第7期 11-17页

作者：查银河王芳何玉龙李肖梁舒建洪杭州洪晟生物技术股份有限公司杭州310002 浙江大学杭州310058

为了优化生物反应器全悬浮培养技术制备猪流行性腹泻病毒(ZJ/15株)的工艺,试验首先通过摇瓶培养对病毒接种时的细胞密度、胰酶浓度、接毒剂量和收毒时间等培养条件进行优化;之后按照摇瓶培养确认的工艺进行生物反应器全悬浮培养工艺验证... 详细信息

为了优化生物反应器全悬浮培养技术制备猪流行性腹泻病毒(ZJ/15株)的工艺,试验首先通过摇瓶培养对病毒接种时的细胞密度、胰酶浓度、接毒剂量和收毒时间等培养条件进行优化;之后按照摇瓶培养确认的工艺进行生物反应器全悬浮培养工艺验证,同时对pH值、溶氧值(DO)、转速等培养参数进行优化,以病毒含量(TCID_(50))为指标,最终筛选出在15L生物反应器中培养猪流行性腹泻病毒(ZJ/15株)的最优条件,并进一步在50L生物反应器中进行工艺验证,将病毒液灭活后稀释至1×10^(7).0TCID_(50)/mL免疫怀孕75~90d的健康易感初怀母猪,在分娩当日,采集母猪和仔猪血清,并对分娩的3日龄仔猪攻毒进行免疫原性试验。结果表明:猪流行性腹泻病毒(ZJ/15株)在摇瓶上的最适培养条件为当细胞密度达到6×10^(6)个/mL以上时,用含胰酶(终浓度为20μg/mL)的无血清培养基将细胞密度稀释至2×10^(6)个/mL,按感染复数(MOI)=0.1接毒,130 r/min摇床振荡培养36h可收获病毒液,病毒含量可稳定达到1×10^(7.5)TCID_(50)/mL以上;猪流行性腹泻病毒(ZJ/15株)在15L生物反应器上的最适培养条件为pH值7.0~7.2、DO值50%、转速80~100 r/min,培养36h收获的病毒液含量可稳定在1×10^(7.5)TCID_(50)/mL以上;在50L生物反应器上放大培养收获的病毒液含量为1×10^(7).8TCID_(50)/mL。母猪和仔猪中和抗体效价均≥1∶32,免疫保护力为100%。说明本试验条件下成功建立并优化了生物反应器全悬浮培养制备猪流行性腹泻病毒(ZJ/15株)的工艺,生产的猪流行性腹泻病毒(ZJ/15株)的免疫原性较好。

关键词：猪流行性腹泻病毒悬浮细胞培养生物反应器工艺放大免疫原性

Assess Medical Screening and Isolation Measures Based on Numerical Method for COVID-19 Epidemic Model in Japan

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 841-854页

作者： Zhongxiang Chen Huijua. zha.Zhiquan shu Juyi Ye Jiaji Pan College of Engineering and Design Hunan Normal UniversityChangsha410081China School of Engineering and Technology University ofWashingtonTacoma98195USA Faculty of Science Massey UniversityPalmerston North4442New Zealand State Key Laboratory of Developmental Biology of Freshwater Fish Hunan Normal UniversityChangsha410081China

This study aims to improve control schemes for COVID-19 by a numerical model with estimation of *** established a multi-level and multi-objective nonlinear SEIDR model to simulate the virus *** early spread in Japan was adopted as a case *** first 96 days since the infection were divided into five stages with parameters ***,we analyzed the trend of the parameter value,age structure ratio,and the defined PCR test index(standardization of the scale of PCR tests).It was discovered that the self-healing rate and confirmed rate were linear with the age structure ratio and the PCR test index using the stepwise regression *** transmission rates were related to the age structure ratio,PCR test index,and isolation *** isolation measures and PCR test medical screening can effectively reduce the number of infected cases based on the simulation ***,the strategy of increasing PCR test medical screening would encountered a bottleneck effect on the virus control when the index reached *** effectiveness of the policy would decrease and the basic reproduction number reached the extreme value at *** study gave a feasible combination for isolation and PCR test by *** isolation intensity could be adjusted to compensate the insufficiency of PCR test to control the pandemic.

关键词： SEIDR epidemic model multi-level and multi-objective problem PCR test index age structure isolation measure

XGBoost-based model for predicting hydrogen content in electroslag remelting

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Journal of Iron and Steel Research(International) 2023年第5期30卷 887-896页

作者： Yu-xiao Liu Yan-wu Dong Zhou-hua Jiang Yu-shuo Li Wei zha.Yao-xin Du shu-yang Du School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Ecological Metallurgy of Multimetallic Mineral Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

An Xtreme Gradient Boosting(XGBoost)-based endpoint hydrogen content prediction model was proposed for the electroslag remelting process,the data collected in the field were pre-processed,and the characteristic variables of the physical parameters related to the variation of hydrogen content in the electroslag remelting process were selected by machine learning analysis and metallurgical *** kernel ridge regression model,ridge regression model,XGBoost model,support vector regression model and gradient boosting regression model were developed and validated using the electroslag remelting data collected from the steel mills,and the model structure and parameters were adjusted several *** prediction accuracy of hydrogen content was compared *** XGBoost model was validated for the test set with the following hit rates:70.59%,82.35% and 100% for the endpoint hits at the allowable hydrogen content error of ±0.05×10^(-6),±0.10×10^(-6) and ±0.50×10^(-6),respectively.

关键词： Electroslag remelting Hydrogen content Machine learning XGBoost Prediction model

Dietary rumen-protected L-arginine or N-carbamylglutamate enhances placental amino acid transport and suppresses angiogenesis and steroid anabolism in underfed pregnant ewes

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Animal Nutrition 2023年第4期15卷 149-158页

作者： Hao zha.g Xia zha.Bei zha.g Yi Zheng Xiaoyun Liu Mabrouk Elsabagh Yi Ma Hongrong Wang Guihua shu Mengzhi Wang Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China Department of Animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityNigde 51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelSheikhEgypt Department of Pediatrics Northern Jiangsu People's HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China

This study aimed to investigate the effects of dietary supplementation of underfed Hu ewes from d 35 to110 of gestation with either rumen-protected L-arginine(RP-Arg)or N-carbamylglutamate(NCG)on placental amino acid(AA)transport,angiogenic gene expression,and steroid *** d 35 of gestation,32 Hu ewes carrying twin fetuses were randomly divided into four treatment groups,each consisting of eight ewes,and were fed the following diets:A diet providing 100%of NRC’s nutrient requirements for pregnant ewes(CON);A diet providing 50%of NRC’s nutrient requirements for pregnant ewes(RES);RES diet plus 5 g/d NCG(RES+NCG);or RES diet plus 20 g/d RP-Arg(RES+ARG).On the d 110 of pregnancy,blood samples were taken from the mother,and samples were collected from type A cotyledons(COT;the fetal portions of the placenta).The levels of 17β-estradiol and progesterone in the maternal serum and both the capillary area density(CAD)and capillary surface density(CSD)in type A COT were decreased in response to Arg or NCG supplementation when compared to the RES *** concentrations of arginine,leucine,putrescine and spermidine in type A COT were higher(P<0.05)in the RES+ARG or RES+NCG group than in the RES *** mRNA expression levels of inducible nitric oxide synthase(iNOS)and solute carrier family 15,member 1(SLC15A1)were increased(P<0.05)while those of progesterone receptor(PGR)and fibroblast growth factor 2(FGF2)were decreased in type A COT by supplementation with either NCG or RP-Arg compared to the RES *** results suggest that providing underfed pregnant ewes from d 35 to 110 of gestation with a diet supplemented with NCG or RP-Arg improves placental AA transport,and reduces the expression of angiogenic growth factor genes and steroid anabolism,leading to better fetal development.

关键词： Angiogenesis factor L-arginine N-carbamylglutamate Placental amino acid transport Pregnant ewes Steroid anabolism

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全膝关节置换术多用途挡板设计与应用

中国矫形外科杂志 2024年第6期32卷 557-560页

作者：袁札根卿勇孙淑梅李治敏苏展影李泽晖陈瑞娟曹学伟广东省中医院广东广州510120

[目的]介绍全膝关节置换术(total knee arthroplasty,TKA)多用途挡板设计与应用技术和初步临床结果。[方法]本多用途挡板结构包括相互连接的挡板、手柄与负压吸气器。挡板上设有圆形通透窗口、圆形通透窗口通道、矩形通透窗口。矩形通... 详细信息

[目的]介绍全膝关节置换术(total knee arthroplasty,TKA)多用途挡板设计与应用技术和初步临床结果。[方法]本多用途挡板结构包括相互连接的挡板、手柄与负压吸气器。挡板上设有圆形通透窗口、圆形通透窗口通道、矩形通透窗口。矩形通透窗口设置在挡板顶边的中部,圆形通透窗口设置在挡板的几何中心位置的一侧。手柄与挡板的下部连接;负压吸气器与手柄连接在挡板的下部,其前端开口延伸到挡板的中部形成吸气口,其后端开口连接外部负压抽气管道,将靠近挡板或附着在挡板表面上的血液、碎屑吸出。[结果]86例TKA患者术中应用多用途挡板,高效遮挡了飞溅的血液和碎骨渣,大大降低手术感染率,有效保护医护人员从而预防血源性职业暴露。86例患者均顺利完成手术,术后手术切口愈合良好。膝关节功能恢复良好,随访过程中未出现感染等严重并发症。[结论]本多用途挡板遮挡并吸附TKA手术过程中飞溅的血液和碎骨渣等污染物,降低了感染率,减少对医务人员的污染和伤害。

关键词：多用途挡板全膝关节置换术感染率职业暴露