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Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome

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Traditional Medicine Research 2022年第3期7卷 44-54页

作者： Leanne Lee Leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng George Pak-Heng Leung Jin Yu Ren-Min Yao shu-jia sun Sydney Chi-Wai Tang Hai-Yong Chen jia Zhao Zhang-Jin Zhang Calvin Kai-Fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin Wei Meng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Workstation for Training and Research(Hong Kong Branch) Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative MedicineHong Kong 999077China Shanghai Taikuntang Chinese Medicine Hospital Shanghai 200023China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Virginia University of Integrative Medicine Virginia 22031USA Department of Ophthalmology Peking University Third HospitalBeijing 100191China Workstation of Zhu Nansun National Master of Chinese MedicineHong Kong Branch of Zhu’s School of Gynaecology of Chinese Medicine from ShanghaiHong Kong 999077China

Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing age.Moreover,PCOS patients have decreased pregnancy rates and clomiphene citrate resistance.The traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with PCOS.However,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been confirmed.Methods:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established disease.The serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was evaluated.Results:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with PCOS.The serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ovaries.Notably,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated groups.Network pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also closely involved.Conclusion:KT1A and KT1S treatmen

关键词： polycystic ovary syndrome traditional Chinese medicine ovulation Kun-Tai-1A seahorse endocrine disease

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Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence

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Biomedical and Environmental Sciences 2024年第2期37卷 146-156页

作者： LIAO Zhen Yu YANG shuo HU Song LIU jia MAO Yong Jun sun shu Qin Department of Geriatrics the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were collected.Fourteen SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic regression.The multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)modeling.Results Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 rs1053605.Carriers of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased risk.CCL2 rs4586 and MMP-2 rs14070 exhibited the most significant interactions.Conclusion CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

关键词： Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

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Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics

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Chinese Journal of Integrative Medicine 2024年第6期30卷 507-514页

作者： ZHAO Jing TIAN Xin-chen ZHANG jia-qi HUANG Chen sun Yan QIAO Sen jiaNG shu-long Clinical Medical Laboratory Center Jining First People’s HospitalJiningShandong Province272000China Cheeloo College of Medicine Shandong UniversityJinan250000China

Objective:To investigate the anti-liver cancer effects and aspartic acid(Asp)-related action mechanism of Euphorbia fischeriana Steud.(LD).Methods:The mice model of liver cancer was established by injection of H22 cells.After 5 days,mice were randomly divided into model group,sorafenib group(20 mg/kg),LD high-dose(LDH,1.36 g/kg) group,LD medium-dose(LDM,0.68 g/kg) group,and LD low-dose(LDL,0.34 g/kg)group,10 mice each group.Drugs were intragastrically administered to the mice once daily for 10 days,respectively.Body weight,tumor size and tumor weight were recorded.Hepatic index was calculated.Pathological changes of liver cancer tissues were evaluated by hematoxylin and eosin staining and TUNEL staining.Liquid chromatography-mass spectrometer was used to analyze different metabolites between the model and LDH groups.Results:After LD treatment,tumor weight,tumor size and hepatic index were reduced compared with the model group.Necrocytosis and karyorrhexis of tumor cells were found.Moreover,61 differential metabolites(18 up-regulated,43 down-regulated) were affirmed and 20 pathways of KEGG(P<0.05) were gotten.In addition,Bel-7402,HepG2 and H22 cell viabilities were significantly increased after adding Asp into the medium.And then,the cell proliferation effect induced by Asp was ameliorated by LD.Conclusion:The anti-liver cancer efficacy of LD extract was validated in H22 mice model,and inhibition of Asp level might be the underlying mechanism.

关键词： liver cancer Euphorbia fischeriana Steud. aspartic acid metabolomics

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Visual observation of photonic Floquet–Bloch oscillations

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Light(Science & Applications) 2024年第5期13卷 921-929页

作者： Zhen Zhang Yuan Li Xiankai sun Xuewen shu Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhanHubei 430074China Department of Electronic Engineering The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

Bloch oscillations(BOs),an important transport phenomenon,have been studied extensively in static systems but remain mysterious in Floquet systems.Here,by harnessing notions from photonic analogy,we propose a generalization of the existing BOs in photonic Floquet lattices,namely the“photonic Floquet–Bloch oscillations”,which refer to rescaled photonic Bloch oscillations with a period of extended least common multiple of the modulation period and the Bloch oscillation period.Next,we report the first visual observation of such photonic Floquet–Bloch oscillations(FBOs)by employing waveguide fluorescence microscopy.Most significantly,the FBOs surpass the existing BOs in Floquet systems and exhibit exotic properties on their own,including fractal spectrum and fractional Floquet tunneling.This new transport mechanism offers an intriguing method of wave manipulation that may contribute to rapidly developing fields in photonics,condensed matter physics,and quantum physics.

关键词： Bloch analogy generalization

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Progress in preparation of AlN-reinforced magnesium matrix composites:A review

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China Foundry 2024年第1期21卷 1-10页

作者： Lu Chen shu-lin Lü Di-jia Zhao Wei Guo jian-yu Li shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As a ceramic material,AlN has very good thermophysical and mechanical properties.In addition,AlN is an effective refining agent for Mg alloys because it has a lattice constant similar to that of Mg.Therefore,AlN is an ideal reinforcement for magnesium matrix composites(MMCs),and is attracting increasing attention.This review addresses the development of preparation technologies for AlN-reinforced Mg matrix composites.The mainstream preparation techniques include stir casting,melt infiltration,powder metallurgy,and in-situ methods.In addition,the advantages and disadvantages of these techniques are analyzed in depth,and it is pointed out that the next direction for the preparation of high-performance AlN-reinforced MMCs is less aluminization and multiple technologies integration.

关键词： AlN MMCs preparation thermophysical property mechanical property

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Origin and evolution of false brinelling and fretting corrosion under rolling conditions

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Friction 2024年第4期12卷 618-631页

作者： Xin jia Lu HUANG Miao sun Wenbin LI National Institute of Metrology Beijing 100029China Yantai Tiancheng Machinery Co. Ltd.Yantai 264006China

Rolling bearings working in oscillating applications often suffer from false brinelling and fretting corrosion that limit their service life.At present,the study of oscillation-induced failures is primarily dominated by a large number of sliding and bench tests.However,most of the previous work are not able to fully describe the two closely related but different failure mechanisms.In this study,the origin and evolution of the two failures are thoroughly investigated under strictly controlled oscillating rolling conditions.The results show that failure evolves from false brinelling to fretting corrosion under dry friction conditions regardless of the oscillation amplitude.This process is accompanied by a large area peeling and serious oxidation,and the oxygen content increases from 2.50 wt%to 21.22 wt%.Oxidation is a crucial factor in the evolution of false brinelling into fretting corrosion.However,the distribution of microwear and oxygen content depend on the oscillation amplitude.Under lubrication conditions,the friction coefficient(COF)is smaller in the initial stage and led to local slip or transient instability of rolling elements.Therefore,the size of the wear marks and COF increased and appeared to be larger than those under a dry friction condition.However,grease can separate the contact surfaces,only surface deformation owing to false brinelling and slight damage at the roughness level occurred.The evolution of false brinelling and fretting corrosion is also closely related to residual stress.False brinelling often occurrs with residual stress accomulation,meanwhile,the residual stress increases from 120 to 300 MPa.When peeling occurs,residual stress is released.The failure pattern transformed from false brinelling to fretting corrosion and is accompanied by oxidation.So far,none of investigation is able to show satisfactory evolution of oscillating-induced failures,this study may contribute to more scientific understanding of rolling bearings against long-run reciprocating oscillating wear.

关键词： oscillating false brinelling fretting corrosion wear residual stress

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Acupuncture for obesity and related diseases:Insight for regulating neural circuit

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Journal of Integrative Medicine 2024年第2期22卷 93-101页

作者： Lin-yan jiang Jun Tian Ya-nan Yang Shao-hui jia Qing shu Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071Hubei ProvinceChina School of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Department of Traditional Chinese Medicine China Resources&Wu Gang General HospitalWuhan 430080Hubei ProvinceChina

Obesity is defined as abnormal or excessive fat accumulation that may impair health.Obesity is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related diseases.These comorbidities comprise a significant public health threat.Existing anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and stroke.Acupuncture treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side effects.However,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural circuits.In this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was summarized.Based on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

关键词： Obesity Acupuncture Neural circuit Appetite Energy metabolism

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Universal dynamic scaling and Contact dynamics in quenched quantum gases

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Frontiers of physics 2024年第2期19卷 213-220页

作者： jia-Nan Cui Zhengqiang Zhou Mingyuan sun School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Lab of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

Recently universal dynamic scaling is observed in several systems,which exhibit a spatiotemporal self-similar scaling behavior,analogous to the spatial scaling near phase transition.The latter one arises from the emergent continuous scaling symmetry.Motivated by this,we investigate the possible relation between the scaling dynamics and the continuous scaling symmetry in this paper.We derive a theorem that the scaling invariance of the quenched Hamiltonian and the initial density matrix can lead to the universal dynamic scaling.It is further demonstrated both in a two-body system analytically and in a many-body system numerically.For the latter one,we calculate the dynamics of quantum gases quenched from the zero interaction to a finite interaction via the non-equilibrium high-temperature virial expansion.A dynamic scaling of the momentum distribution appears in certain momentum-time windows at unitarity as well as in the weak interacting limit.Remarkably,this universal scaling dynamics persists approximately with smaller scaling exponents even if the scaling symmetry is fairly broken.Our findings may offer a new perspective to interpret the related experiments.We also study the Contact dynamics in the BEC−BCS crossover.Surprisingly,the half-way time displays a maximum near unitarity while some damping oscillations occur on the BEC side due to the dimer state,which can be used to detect possible two-body bound states in experiments.

关键词： dynamic scaling Contact dynamics quantum gases cold atom quench dynamics virial expansion continuous scaling symmetry

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Novel heterozygous USH1C mutation impacts hair cell mechanotransduction and causes progressive hearing loss

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Science Bulletin 2024年第2期69卷 167-172页

作者： Yanyan jia Gaogan jia Luo Guo Nan Song Yu-Meng Wang Luoying jiang Yilai shu Yan Chen shujia Zhu Huawei Li Wenyan Li ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200031China The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200032China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular MedicineXinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China

Hearing loss is one of the most common sensory disorders worldwide,affecting approximately 466 million people,including 34 million children[1].Genetic mutations accounts for approximately 60%of inherited hearing loss cases[2,3].These genetic changes result in a wide variety of clinical manifestations,ranging from nonsyndromic hearing loss(NSHL)to over 400 syndromes involving hearing loss and from mild adult-onset hearing loss to profound congenital deafness,covering the entire spectrum of Mendelian inheritance.

关键词： mec hearing approximate

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Rapid chemical recycling of waste polyester plastics catalyzed by recyclable catalyst

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Green Chemical Engineering 2024年第2期5卷 257-265页

作者： Yu-Ji Luo jia-Yin sun Zhi Li School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Waste plastics are serious environmental threats due to their low degradability and low recycling rate.Rapid and efficient waste plastics recycling technologies are urgently demanded for a sustainable future.Herein,we report a rapid,closed-loop,and streamlined process to convert polyesters such as poly(ethylene terephthalate)(PET)back to its purified monomers.Using trifluoromethanesulfonic acid or metal triflates as the recyclable catalyst,polyesters such as PET can be completely depolymerized by simple carboxylic acids within 1 h.By coupling this acidolysis with a subsequent hydrogenolysis process,the consumed carboxylic acid was recovered and the closed-loop of PET depolymerization could be established.All catalysts and depolymerization agents are fully recycled while only PET and hydrogen are consumed.

关键词： Chemical recycling Waste polyester plastics Acidolysis Recyclable catalyst

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