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Development of the high-strength ductile ferritic alloys via regulating the intragranular and grain boundary precipitation of G-phase

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Journal of Materials Science & Technology 2023年第5期136卷 180-199页

作者： Mujin Yang Chao huang Jiajia Han Haichen Wu Yilu Zhao Tao Yang Shenbao Jin Chenglei Wang Zhou Li Ruiying shu Cuiping Wang huanming Lu Gang Sha Xingjun liu School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China Test Center Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Materials Science and Engineering City University of Hong KongHong KongChina Department of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyShenzhen 150001China Institute of Materials Genome and Big Data Harbin Institute of TechnologyShenzhen 518055China

A typical G-phase strengthened ferritic model alloy(1Ti:Fe-20Cr-3Ni-1Ti-3Si,wt.%)has been carefully studied using both advanced experimental(EBSD,TEM and APT)and theoretical(DFT)techniques.During the classic“solid solution and aging”process,the superfine(Fe,Ni)_(2)TiSi-L2_(1)particles densely precipitate within the ferritic grain and subsequently transform into the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase.In the meanwhile,the elemental segregation at grain boundaries and the resulting precipitation of a large amount of the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase are also observed.These nanoscale microstructural evolutions result in a remarkable increase in hardness(100-300 HV)and severe embrittlement.When the“cold rolling and aging”process is used,the brittle fracture is effectively suppressed without loss of nano-precipitation strengthening ef-fect.Superhigh yield strength of 1700 MPa with 4%elongation at break is achieved.This key improvement in mechanical properties is mainly attributed to the pre-cold rolling process which effectively avoids the dense precipitation of the G-phase at the grain boundary.These findings could shed light on the further exploration of the precipitation site via optimal processing strategies.

关键词： G-phase Precipitation strengthening Grain boundary segregation Nano-precipitates

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基于热泵技术的余热回收供热系统

节能 2024年第5期43卷 67-70页

作者：杨晓玮慕佳琪李孜绪刘媛媛徐胜利刘晓华大连理工大学辽宁大连116024 中国航空发动机集团有限公司北京100089

传统热电厂的循环冷却水中含有大量的低品位余热,利用热泵技术对其进行回收,能够显著提升供热系统的能源利用效率,有利于实现节能减排和“碳中和”目标。设计基于单、双吸收式热泵机组的余热回收供热系统,旨在有效利用循环冷却水中的余... 详细信息

传统热电厂的循环冷却水中含有大量的低品位余热,利用热泵技术对其进行回收,能够显著提升供热系统的能源利用效率,有利于实现节能减排和“碳中和”目标。设计基于单、双吸收式热泵机组的余热回收供热系统,旨在有效利用循环冷却水中的余热,增加供热能力并分析系统性能。结果表明,与传统供热系统相比,两种余热回收供热系统均可显著回收循环冷却水的热量,提高系统供热量并大幅减少能源消耗,带来可观的经济收益;双吸收式热泵机组系统展现出更优异的热力性能,具备显著的节能减排优势。分析循环冷却水入口温度和一次网回水温度对双吸收式热泵机组性能的影响,发现循环冷却水温度对系统性能影响较大,随着循环冷却水温度的升高,系统的供热量增加比例、节约标煤量和新增供热面积均增加,而一次网回水温度对系统性能的影响较小,随一次网回水温度的升高,系统的供热量增加比例、节约标准煤量和新增供热面积几乎不变。

关键词：吸收式热泵循环冷却水余热回收供热系统热电厂

Upregulation of β-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain

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Bone Research 2023年第2期11卷 316-327页

作者： Ke Lu Qingyun Wang hua Jiang Jun Li Zhou Yao Yongcan huang Jianquan Chen Yejia Zhang Guozhi Xiao Xueyu Hu Zhuojing Luo liu Yang Liping Tong Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Division of Spine Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxiChina Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Institute of Orthopedics Xijing Hospitalthe Fourth Military Medical UniversityXi’anChina Department of Spine Surgery Peking University Shenzhen HospitalShenzhenChina Department of Clinical Medicine School of MedicineZhejiang University City CollegeHangzhouZhejiangChina Departments of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPAUSA School of Medicine Southern University of Science and TechnologyShenzhenChina

Spine degeneration is an aging-related disease,but its molecular mechanisms remain unknown,although elevatedβ-catenin signaling has been reported to be involved in intervertebral disc degeneration.Here,we determined the role ofβ-catenin signaling in spinal degeneration and in the homeostasis of the functional spinal unit(FSU),which includes the intervertebral disc,vertebra and facet joint and is the smallest physiological motion unit of the spine.We showed that pain sensitivity in patients with spinal degeneration is highly correlated withβ-catenin protein levels.We then generated a mouse model of spinal degeneration by transgenic expression of constitutively activeβ-catenin in Col2^(+) cells.We found thatβ-catenin-TCF7 activated the transcription of CCL2,a known critical factor in osteoarthritic pain.Using a lumbar spine instability model,we showed that aβ-catenin inhibitor relieved low back pain.Our study indicates thatβ-catenin plays a critical role in maintaining spine tissue homeostasis,its abnormal upregulation leads to severe spinal degeneration,and its targeting could be an avenue to treat this condition.

关键词： degeneration smallest homeostasis

Animal experimental studies using small intestine endoscope

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World Journal of Gastroenterology 2017年第20期23卷 3684-3689页

作者： Jin-hua liu Dan-Yang liu Li Wang Li-Ping Han Zhe-Yu Qi Hai-Jun Ren Yan Feng Feng-Ming Luan Liang-Tian Mi shu-Mei Shan Department of General Surgery Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University Department of Endocrinology Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University Department of Anesthesiology Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University Dalian Ming Sheng Technology Development Co. Ltd.

AIM To assess the feasibility and safety of a novel enteroscope,negative-pressure suction endoscope in examining the small intestine of a porcine model.METHODS In vitro experiments in small intestinal loops from 20pigs and in vivo experiments in 20 living pigs were conducted.RESULTS In in vitro experiments,a negative pressure of>0.06MPa was necessary for optimal visualization of the intestine,and this pressure did not cause gross or histological damage to the mucosa.For satisfactory examination of the small intestine in vivo,higher negative pressure(>1.00 MPa)was required.Despite this higher pressure,the small intestine did not show any gross or microscopic damage in the suctioned areas.The average time of examination in the living animals was 60±7.67 min.The animals did not experience any apparent ill effects from the procedure.CONCLUSION Small intestine endoscope was safely performed within a reasonable time period and enabled complete visualization of the intestine in most cases.

关键词：小肠内诊镜内诊镜动物实验内视镜的检查否定压力的吸

Heat shock protein 70 protects PC12 cells against ischemia-hypoxia/reoxygenation by maintaining intracellular Ca^(2+) homeostasis

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Neural Regeneration Research 2016年第7期11卷 1134-1140页

作者： Yuan liu Xue-chun Wang Dan Hu shu-ran huang Qing-shu Li Zhi Li Yan Qu Department of Intensive Care Unit Affiliated Qingdao Municipal Hospital of Qingdao University Department of Intensive Care Unit Affiliated Hospital of Jining Medical University

Heat shock protein 70（HSP70） maintains Ca^2＋ homeostasis in PC12 cells,which may protect against apoptosis;however,the mechanisms of neuroprotection are unclear.Therefore,in this study,we examined Ca^2＋ levels in PC12 cells transfected with an exogenous lentiviral HSP70 gene expression construct,and we subsequently subjected the cells to ischemia-hypoxia/reoxygenation injury.HSP70 overexpression increased neuronal viability and ATPase activity,and it decreased cellular reactive oxygen species levels and intracellular Ca^2＋ concentration after hypoxia/reoxygenation.HSP70 overexpression enhanced the protein and m RNA expression levels of sarcoplasmic/endoplasmic reticulum Ca^2＋-ATPase（SERCA）,but it decreased the protein and m RNA levels of inositol 1,4,5-trisphosphate receptor（IP3R）,thereby leading to decreased intracellular Ca^2＋concentration after ischemia-hypoxia/reoxygenation.These results suggest that exogenous HSP70 protects against ischemia-hypoxia/reoxygenation injury,at least in part,by maintaining cellular Ca^2＋ homeostasis,by upregulating SERCA expression and by downregulating IP_3 R expression.

关键词： homeostasis intracellular reticulum neuronal endoplasmic maintaining ATPase unclear minutes exogenous

Effects of moxibustion and acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) on chronic atrophic gastritis in rats

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Journal of Traditional Chinese Medicine 2020年第5期40卷 827-835页

作者： liu Mi Shen Jiacheng liu Caichun Zhong huan Yang Qing shu Wenna Ma Mingzhu Dong Jiyang Yang Zongbao Chang Xiaorong She Chang Yu shu College of Acupuncture&Moxibustion and Tui-na Hunan University of Chinese MedicineChangsha 410208China liuyang Hospital of Chinese Medicine Liuyang 410300China Department of Traditional Chinese Medicine Department of Electronic ScienceXiamen UniversityXiamen 361005China Department of Electronic Science Fujian Provincial Key Laboratory for Plasma and Magnetic ResonanceXiamen UniversityXiamen 361005China City University of Hong Kong Hong Kong 999077China Changsha Hospital of Traditional Chinese Medicine(Changsha Eighth Hospital) Changsha 410002China Tat Chee Avenue KowloonHong Kong 999077China

OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their actions.METHODS:Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40%ethanol combined with free drinking of N-methyl-N′-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks,followed by daily treatment with moxibustion or acupuncture for 2 weeks.Histopathologic examination,Western blotting of cytokines[epidermal growth factor(EGF),EGF receptor(EGFR),extracellular signal-regulated kinase(ERK),phosphorylated ERK(p-ERK)],and1 H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and treatment.RESULTS:Moxibustion and acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and p-ERK.Only moxibustion treatment regulated the expression of EGF and EGFR.Metabolites that were increased in gastric tissue by CAG induction(alanine,nicotinamide adenine dinucleotide phosphate,uracil DNA glycosylase,lactate,glycerol and adenosine)were restored to normal levels after moxibustion treatment;acupuncture treatment only normalized the levels of adenosine monophosphate and glycerol.CONCLUSION:Our findings suggest that moxibustion or acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)can significantly improve the condition of CAG in rats.These treatments exert their effects on CAG through different mechanisms.

关键词： Gastritis,atrophic Moxibustion Acupuncture Metabolomics Proton magnetic resonance spectroscopy

Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors

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Journal of Pharmaceutical Analysis 2023年第4期13卷 367-375页

作者： Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang hua Zhu Guizhou University Medicine College Guiyang550025China The Ministry of Education Key Laboratory of Carcinogenesis and Translational Research NMPA Key Laboratory for Research and Evaluation of RadiopharmaceuticalsDepartment of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing100142China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan646000China Suzhou Transcenta Therapeutics Co. LtdSuzhouJiangsu215127China Institute of Biomedical Engineering Peking University Shenzhen Graduate SchoolShenzhenGuangdong518055China

Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.***.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors.

关键词： Claudin18.2 Gastrointestinal cancers Zirconium-89 Positron emission tomography Good Manufacturing Practices

Evaluation of heavy roller compaction on a large-thickness layer of subgrade with full-scale field experiments

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第11期23卷 933-944页

作者： shu-jian WANG Hong-guang JIANG Zong-bao WANG Yu-jie WANG Yi-xin LI Xue-yu GENG Xin-yu WANG Kai WANG Yi-yi liu Yan-kun GONG School of Qilu Transportation Shandong UniversityJinan 250002China Shandong Hi-Speed Engineering Test Co. Ltd.Jinan 250002China Shandong High-Speed Jiqing Middle Line Highway Co. Ltd.Weifang 261599China School of Engineering University of WarwickCoventry CV48UWUK Shandong Hi-Speed Group Co. Ltd.Jinan 250002China

Subgrade construction is frequently interrupted due to precipitation,soil shortage,and environmental protection.Therefore,increasing the thickness layer is required to reduce construction costs and to allow highways to be placed into service earlier.This paper presents a series of full-scale field experiments evaluating the compaction quality of gravel subgrade with large-thickness layers of 65 cm and 80 cm using heavy vibratory rollers.An improved sand cone method was first proposed and calibrated to investigate the distribution of soil compaction degree across the full subgrade depth.Results showed that dynamic soil stresses caused by the heavy vibratory rollers were 2.4–5.9 times larger than those of traditional rollers,especially at deeper depths,which were large enough to densify the soils to the full depth.A unified empirical formula was proposed to determine the vertical distribution of dynamic soil stresses caused by roller excitation.It was demonstrated that soils were effectively compacted in a uniform fashion with respect to the full depth to 96.0%–97.2%and 94.1%–95.4%for the large-thickness layers of 65 cm and 80 cm within 6 or 7 passes,respectively.Empirically,linear formulae were finally established between soil compaction degree and the subgrade reaction modulus,dynamic modulus of deformation,dynamic deflection,and relative difference of settlement to conveniently evaluate the compaction qualities.It is demonstrated that increasing the thickness layer by means of heavy rollers can significantly reduce the cost and time burdens involved in construction while ensuring overall subgrade quality.

关键词： Highway subgrade Heavy vibratory roller Thickness layer Dynamic soil stress Compaction degree Compaction quality control

Effect of Chromium on Microstructure and Mechanical Properties of Cold Rolled Hot-dip Galvanizing DP450 Steel

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Journal of Iron and Steel Research(International) 2015年第11期22卷 1055-1061页

作者： Yun HAN shuang KUANG hua-sai liu Ying-hua JIANG Guang-hui liu Shougang Research Institute of Technology

Two cold rolled hot-dip galvanizing dual phase（DP） 450 steels with different amounts of chromium were designed and the effects of the chromium concentration and galvanizing processes on the microstructure and mechanical properties were also investigated. The results show that the experimental steels exhibit typical dual phase microstructure character. However, the ferrite phase of steel with higher chromium is more regular and its boundaries are clearer. Meanwhile, martensite austenite（MA） island in steel No. 2 is diffused and no longer distributes along the grain boundary as net or chain shape. More MA islands enriched with Cr element can be found in the ferrite grains, and the increment of Cr element improves the stablity of the austenite so that the austenite has been reserved in MA islands. In addition, the experimental steel with higher chromium exhibits better elongation, lower yield ratio and better formability. The mean hole expanding ratio of steels No. 1 and No. 2 is 161.70% and 192.70%, respectively.

关键词： DP steel high chromium microstructure mechanical property formability