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Numerical optimization on differential adjusting measures for asymmetrical degenerated warm permafrost railway embankment

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Advances in Climate Change Research 2023年第3期14卷 479-491页

作者： Yan-Dong HOU Wen-Yuan LEI shu-hao liang Ming-Li ZHANG Feng-Xi ZHOU School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Key Laboratory of Disaster Prevention and Mitigation in Civil Engineering of Gansu Province Lanzhou University of TechnologyLanzhou 730050China

Affected by climate warming and shady–sunny slope effect,the permafrost foundation under the railway is undergoing a significant asymmetric degradation process;research on the corresponding regulating or strengthening measures is urgently *** on a well developed of numerical model,we analyzed the‘thermal repair’effect of three redesigned differential thermal reinforcement on the partially degraded permafrost embankment with *** results show that,when used as a strengthening measure,the method of laying crushed rock revetment(CRR)with different thicknesses on the sunny and shady slopes cannot completely eliminate the residual warm permafrost regions formed in the previous thermal *** the TCRR scheme is adopted for reinforcement,although horizontal region from the evaporation section of thermosyphones(TPCTs)to the right side of the embankment is remarkably cooled,permafrost under the sunny slope is still *** the long run,both ETCRR and TCECRR reinforcement schemes can produce a large range of‘cold core’right below the whole ***,from the perspective of the simultaneous functioning range and cold storage capacity,the TCECRR scheme is signally more *** thermal insulation materials in the above composite strengthening measures can not only resist the heat input in the warm season,but also improve their working efficiency by maintaining the temperature difference between the evaporation section of the heat pipe and the external environment in cold *** addition of crushed rock revetment in TCECRR has played its thermal semiconductor effect and further improved the comprehensive thermal repair efficiency of the composite measures.

关键词： Asymmetric degradation Crushed rock revetment Thermal insulation materials TPCT Reinforcement

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MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei Ming Longfu Chen Tianliang Song Moxi Yele hao Zhang Long Yang Gegen Sarula Benliang liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： hao Yin Yanting Li Zhiying Tian Qichao Li Chenhui Jiang Enfu liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

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981抗疲劳耐缺氧食品抗疲劳效能的实验研究

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中国临床康复 2005年第4期9卷 186-187页

作者：李晓莉孙成海郝树亮李钦解放军军事经济学院营养食品研究所湖北省武汉市430035 解放军军事经济学院军需三队湖北省武汉市430035

目的:981抗疲劳耐缺氧食品由军事经济学院研制,在981原液配方的基础上,添加维生素和矿物质,进行小鼠持续游泳实验的抗疲劳效能检测和比较,为研制新一代抗疲劳耐缺氧食品提供理论基础。方法:实验于2004-04/2004-05在解放军军事经济学院... 详细信息

目的:981抗疲劳耐缺氧食品由军事经济学院研制,在981原液配方的基础上,添加维生素和矿物质,进行小鼠持续游泳实验的抗疲劳效能检测和比较,为研制新一代抗疲劳耐缺氧食品提供理论基础。方法:实验于2004-04/2004-05在解放军军事经济学院营养实验室完成。昆明小鼠雄性,体质量(19±1)g,清洁级,合格证号19-052。由华中科技大学同济医学院动物学部提供。共60只,分为3组,每组20只,灌胃981抗疲劳耐缺氧食品1周后做游泳实验,通过分析小鼠游泳持续时间研究其抗疲劳效果。结果:在灌胃1周以后,小鼠原液组与原液添加组体质量增长较快。在游泳实验中在灌胃1h后,原液组游泳时间为(28.54±20.61)min,对照组(17.19±8.67)min有较大的提高,差异有显著性意义(P<0.05),原液添加组的游泳时间为(24.01±12.15)min,也显著高于对照组(P<0.05)。结论:给予适量981抗疲劳耐缺氧食品,可以增强小鼠的抗疲劳性能,并且有促进生长发育的效果。

关键词：抗疲劳食品游泳

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基于CT图像的混凝土三维微观结构在ANSYS中的实现

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混凝土 2009年第3期 13-15,20页

作者：郝书亮党发宁陈厚群梁昕宇西安理工大学岩土工程研究所陕西西安710048 中国水利水电科学研究院工程抗震中心北京100044

基于混凝土的CT平面图像信息,用APDL语言生成的程序对混凝土的三维微观结构在大型商业有限元软件ANSYS中进行三维重建。重建过程没有生成点、线、面、体等几何元素,而是利用CT平面图像信息直接生成节点,连接节点生成单元,避免了网格无... 详细信息

基于混凝土的CT平面图像信息,用APDL语言生成的程序对混凝土的三维微观结构在大型商业有限元软件ANSYS中进行三维重建。重建过程没有生成点、线、面、体等几何元素,而是利用CT平面图像信息直接生成节点,连接节点生成单元,避免了网格无法剖分现象的出现。生成的单元形状规则,长宽比合理。通过建立的更接近实际混凝土微观结构的数值模型,可利用有限元方法进一步研究基于微观结构的混凝土各项力学特性。

关键词：三维重建混凝土 CT ANSYS 微观结构

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多尺度关联规则尺度上推算法

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计算机科学 2017年第8期44卷 285-289页

作者：李超赵书良赵骏鹏高琳池云仙河北师范大学数学与信息科学学院石家庄050024 河北师范大学河北省计算数学与应用重点实验室石家庄050024

数据挖掘在多尺度研究方面取得了一些成果。然而,多尺度数据挖掘研究还不够深入和完善。目前针对空间和图像数据的研究较多,对于一般数据的多尺度数据挖掘的研究较少。随着大数据应用的不断发展,其研究显得尤为重要。针对上述问题,进行... 详细信息

数据挖掘在多尺度研究方面取得了一些成果。然而,多尺度数据挖掘研究还不够深入和完善。目前针对空间和图像数据的研究较多,对于一般数据的多尺度数据挖掘的研究较少。随着大数据应用的不断发展,其研究显得尤为重要。针对上述问题,进行了普适的多尺度关联规则尺度转换方法的研究。首先,基于包含度的相似度理论提出频繁项集的处理方法;然后,以图像金字塔为理论基础,提出了多尺度关联规则尺度上推算法MSARSUA(Multi-Scale Association Rules Scaling Up Algorithm);最后,利用H省1)全员人口真实数据集、UCI公用数据集和IBM数据集对所提算法进行了实验验证与分析,结果表明MSARSUA具有较高的覆盖率、较高的F1-measure值和较低的平均支持度估计误差,在效率上比Apriori算法和FP-Growth算法有较大的提升,在性能上比SU-ARMA有更好的表现。

关键词：多尺度关联规则尺度上推多尺度关联规则挖掘

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao hao Zi-Jian Wang Xiu-liang Xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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新质生产力、科技金融发展与投融资体制变革

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 30-38,F0002页

作者：王曙光梁爽北京大学经济学院北京100871 北京大学产业与文化研究所北京100871

培育新质生产力需要形成与之相适应的新型生产关系,深化金融体制改革,形成与科技创新相适应的科技金融体系尤为关键。当前,中国科技金融发展面临诸多挑战,存在金融资源分配不均、耐心资本短缺、金融服务创新不足等问题。要充分发挥我国... 详细信息

培育新质生产力需要形成与之相适应的新型生产关系,深化金融体制改革,形成与科技创新相适应的科技金融体系尤为关键。当前,中国科技金融发展面临诸多挑战,存在金融资源分配不均、耐心资本短缺、金融服务创新不足等问题。要充分发挥我国社会主义制度优势,寻找政府引导、市场运作与科技型企业创新之间的最佳契合点,以壮大耐心资本为核心,服务初创期及中小规模科技型企业为重点,依托新型举国体制和社会主义市场经济体制,深化科技型企业的投融资体制变革。未来,要着力构建“股贷债保”联动、覆盖全生命周期、全链条、接力式的科技金融体系,为发展新质生产力提供坚实的金融支撑。

关键词：新质生产力科技金融投融资体制耐心资本新型举国体制

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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