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Effect of lactic acid bacteria isolated from fermented mustard on immunopotentiating activity

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 281-286页

作者： chen-Kai Chang shu-chen wang Chih-Kwang Chiu Shih-Ying chen Zong-Tsi chen Pin-Der Duh Department of Food Science and Technology Chia Nan University of Pharmacy and Science Department of Health and Nutrition Chia Nan University of Pharmacy and Science Department of Medicinal Chemistry Chia Nan University of Pharmacy and Science

Objective: To investigate the effect of lactic acid bacteria isolated from fermented mustard on immunopotentiating activity Methods: One hundred and fifty nine strains of lactic acid bacteria isolated from traditional Taiwan fermented mustard were evaluated for their immunopotentiating activity on a murine macrophage cell line RAW ***: Of the strains, pronounced increases in the levels of nitric oxide(NO), tumor necrosis factor-α and interleukin-6 were observed in strains B0040, B0110 and B0145. Among them,strain B0145 had the highest NO and tumor necrosis factor-α generation in RAW 264.7 cells;strains B0040 and B0110 were also superior to that of Lactobacillus casei. These results demonstrated that NO and cytokines were effectively induced when the bacterial stimulants were treated with macrophages. In addition, strains B0040 and B0110 were identified as Lactobacillus plantarum, and B0145 as Weissella cibaria using 16 S rDNA ***: The results implicated selected strains may be regarded as a biological response modifier and had a broad application prospects in exploiting new functional food or as a feed additive.

关键词： Immunopotentiating activity Interleukin-6 Lactic acid bacteria Nitric oxide Tumor necrosis factor-α

MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

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Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun wang Mingjie wang Zijie Li Ken chen Jiatian Mei shu Zhang Key Laboratory of Education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan Key Laboratory of Smart Education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

Response of macrophages in rat skeletal muscle after eccentric exercise

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Chinese Journal of Traumatology 2018年第2期21卷 88-95页

作者： Qun Zuo shu-chen wang Xin-Kai Yu Wei-Wei Chao School of Kinesiology Shanghai University of Sport Shanghai 200438 China

Purpose： Macrophages are known to be important for healing numerous injured tissues depending on their functional phenotypes in response to different stimuli. The objective of this study was to reveal macrophage phenotypic changes involved in exercise-induced skeletal muscle injury and regeneration. Methods： Adult male Sprague-Dawley rats experienced one session of downhill running （16~ decline, 16 m/min） for 90 min. After exercise the blood and soleus muscles were collected at 0 h, 6 h, 12 h, 1 d, 2 d, 3 d, 1 w and 2 w after exercise, separately. Results： It was showed that CD6B＋ M1 macrophages mainly infiltrated into musc｜e necrotic sites at 1-3 d, while CD163＋ M2 macrophages were present in muscles from 0 h to 2 weeks after exercise. Using transmission electron microscopy, we observed activated satellite cells 1 d after exercise. Thl-associated transcripts of iNOS and Cc12 were inhibited post exercise, while COX-2 mRNA was dramatically increased 12 h after running （p 〈 0.01 ）. M2 phenotype marker Arg-1 increased 12 h and 3 d （p 〈 0.05, p 〈 0.01 ） after exercise, and Clecl0a and Mrc2 were up-regulated in muscles 12 h following exercise （p 〈 0.05, p 〈 0.05）. Conclusion： The data demonstrate the dynamic patterns of macrophage phenotype in skeletal muscle upon eccentric exercise stimuli, and M1 and M2 phenotypes perform different functions during exercise- induced skeletal muscle injury and recovery.

关键词： Macrophage phenotype Muscle injury Regeneration Eccentric exercise

内蒙古突泉盆地中侏罗统万宝组碎屑岩LA-ICP-MS锆石U-Pb测年、地球化学特征及对源区的制约

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地质通报 2013年第8期32卷 1224-1235页

作者：王杰陈树旺丁秋红中国地质调查局沈阳地质调查中心辽宁沈阳110034

突泉盆地中侏罗统万宝组碎屑岩中砾石、岩屑及重矿物组合研究显示,母岩主要为流纹岩、安山岩、花岗岩、砂泥质岩石和少量中低变质岩;碎屑岩地球化学特征显示,源区形成于大陆岛弧和活动大陆边缘环境。在万宝组砂岩样品中,利用LA-ICP-MS... 详细信息

突泉盆地中侏罗统万宝组碎屑岩中砾石、岩屑及重矿物组合研究显示,母岩主要为流纹岩、安山岩、花岗岩、砂泥质岩石和少量中低变质岩;碎屑岩地球化学特征显示,源区形成于大陆岛弧和活动大陆边缘环境。在万宝组砂岩样品中,利用LA-ICP-MS定年方法获得100个单颗粒碎屑锆石U-Pb年龄介于171Ma±7Ma～1221Ma±23Ma之间,其中1个年轻的年龄为171Ma±7Ma,可近似代表其沉积时的最新年龄,2个较老年龄(1221Ma±23Ma,504Ma±10Ma)可能来自于较古老结晶基底。其余年龄在214Ma±5Ma～359Ma±9Ma之间,为三叠纪—石炭纪的岩石年龄。结合区域地质特征认为,盆地东缘和南缘古隆起在万宝组沉积时已经存在,下伏的大石寨组、哲斯组和古生代侵入岩为盆地提供了主要物源。

关键词：锆石U-Pb测年地球化学特征物源分析中侏罗统万宝组突泉盆地

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基于光谱吸收原则的低成本硫化氢传感器研究

光谱学与光谱分析 2018年第2期38卷 611-615页

作者：陈书旺王昭昭唐东林河北科技大学信息科学与工程学院河北石家庄050018 西南石油大学机电工程学院四川成都610500

H_2S浓度检测的发展趋势是实时检测,基于光谱吸收原则是其中一个发展方向。用宽带光源替代以往使用的成本较高的窄带光源,降低整个系统的成本,可以提高检测系统的实用性。宽带光源经过Bragg光纤光栅滤波后可以得到窄带光。此方法得到的... 详细信息

H_2S浓度检测的发展趋势是实时检测,基于光谱吸收原则是其中一个发展方向。用宽带光源替代以往使用的成本较高的窄带光源,降低整个系统的成本,可以提高检测系统的实用性。宽带光源经过Bragg光纤光栅滤波后可以得到窄带光。此方法得到的光波必然会有噪声和波动,然后对其进行滤波,消除一部分系统的噪声和波动,再通过光线分束器分别通入检测光路和参考光路后做差。此差分信号不仅消除了一部分系统噪声和波动,还消除了基波分量,增大了信噪比。用数学分析的方法推导出二次谐波信号,利用SIMILINK仿真观察此信号,不同浓度的H_2S气体会有不同的输出信号,也就得到了气体的浓度。双光路差分法、谐波检测技术和窄带滤波技术综合起来的优势是降低了成本,增加了信噪比,提高了系统的检测能力。实验仿真结果表明,在LED宽带光源基础上采用提取谐波信号的双光路差分方法检测H_2S气体浓度正确可行,此方法降低了系统成本,为大范围实际应用提供了可能性。

关键词：光谱吸收谐波检测双光路宽带光源

AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong wang chen wang Wenying Zheng Wei Gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

丹参WRKY家族成员TRANSPARENTTESTAGLABRA2(TTG2)基因克隆与生物信息学分析

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陕西师范大学学报（自然科学版） 2017年第4期45卷 79-86页

作者：杨树陈尘王喆之西北濒危药材资源开发国家工程实验室教育部药用资源与天然药物化学重点实验室陕西师范大学生命科学学院陕西西安710119

从丹参转录组数据库中克隆得到丹参WRKY家族成员TRANSPARENT TESTA GLABRA2(TTG2)基因(命名为SmTTG2(Genbank注册号:KC161227)),该基因包含一个长为1 425bp的完整开放读码框,编码475个氨基酸,DNA水平上包含3个内含子。序列分析显示,SmT... 详细信息

从丹参转录组数据库中克隆得到丹参WRKY家族成员TRANSPARENT TESTA GLABRA2(TTG2)基因(命名为SmTTG2(Genbank注册号:KC161227)),该基因包含一个长为1 425bp的完整开放读码框,编码475个氨基酸,DNA水平上包含3个内含子。序列分析显示,SmTTG2编码蛋白具有2个WRKY结构域和C2H2结构,属于I类WRKY家族成员,并且与黄瓜、怪柳等物种WRKY44高度相似。软件预测SmTTG2相对分子量为51.28kDa,等电点为8.58,且其在胞内不稳定,不具跨膜结构。利用DNA步移技术克隆获得SmTTG2基因5′侧翼区序列,分析结果显示该区域除了含有TATA box和CAAT box外,还包含应答环境因子和植物激素的、调节植物发育的顺式作用元件以及MYB转录因子结合位点。实时荧光定量PCR结果表明,SmTTG2基因在丹参花中表达量最高,且随着花期显示出逐步增高的趋势;另外SmTTG2基因的表达伴随丹参种子萌发过程,提示SmTTG2基因可能参与种子的发育和萌发过程。

关键词：丹参 SmTTG2 生物信息学分析表达模式

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内蒙古突泉盆地双低阻层的发现及其地质意义

地质通报 2013年第8期32卷 1253-1259页

作者：方慧钟清陈树旺中国地质科学院地球物理地球化学勘查研究所河北廊坊065000 国土资源部地球物理电磁法探测技术重点实验室河北廊坊065000 中国地质调查局沈阳地质调查中心辽宁沈阳110034

为调查评价大兴安岭南部地区晚古生代以来的油气资源前景,在内蒙古突泉盆地牤牛海凹陷区内实施了MT和AMT剖面测量工作.探测结果显示,在火山岩覆盖层下深度800～2000m和2000～8000m范围内发现2套低阻层.低阻层不仅厚度较大,横向分布也很... 详细信息

为调查评价大兴安岭南部地区晚古生代以来的油气资源前景,在内蒙古突泉盆地牤牛海凹陷区内实施了MT和AMT剖面测量工作.探测结果显示,在火山岩覆盖层下深度800～2000m和2000～8000m范围内发现2套低阻层.低阻层不仅厚度较大,横向分布也很连续.在钻井资料的约束下,结合区域地质资料综合分析认为,第1套低阻层是早侏罗世煤系地层的反映,第2套低阻层可能是晚古生代以泥岩为主地层的反映.结合地面烃源岩调查结果,推定这2套地层都有可能发育较好的烃源岩.研究表明,突泉盆地具有寻找上古生界和下中生界油气资源的潜力.

关键词：内蒙古突泉盆地大地电磁测深低阻层有利烃源岩

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao chen Xinfei wang Shaolei wang Junyi Yin Ming Yang Xuxu chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue