检索结果-南通市图书馆

Traditional Medicine Research 2024年第9期9卷 21-31页

作者： Han-Qing Zhang shuang wu Xin Chen ya-Xuan Fang Qiu-Mei Lan Zi-Jun Zhou yan-Heng Qiao Jie Li yan-Ru Zhao Ming Pei Bo yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

Clathrin light chains negatively regulate plant immunity by hijacking the autophagy pathway

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Plant Communications 2024年第8期5卷 172-188页

作者： Hu-Jiao Lan Jie Ran Wen-Xu Wang Lei Zhang Ni-Ni wu ya-Ting Zhao Min-Jun Huang Min Ni Fen Liu Ninghui Cheng Paul A.Nakata Jianwei Pan Steven A.Whitham Barbara J.Baker Jian-Zhong Liu Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants Zhejiang Normal UniversityJinhua 321004China Institute of Plant Genetics and Developmental Biology College of Chemistry and Life SciencesZhejiang Normal UniversityJinhua 321004China College of Life Sciences Lanzhou UniversityLanzhou 730000China Department of Plant Pathology and Microbiology Iowa State UniversityAmesIA 50011USA Department of Plant and Microbial Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA Plant Gene Expression Center U.S.Department of Agriculture-Agricultural Research ServiceAlbanyCA 94706USA Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332000China U.S.Department of Agriculture-Agricultural Research Service Children’s Nutrition Research CenterDepartment of PediatricsBaylor College of MedicineHoustonTX 77030USA

The crosstalk between clathrin-mediated endocytosis(CME)and the autophagy pathway has been reported in mammals;however,the interconnection of CME with autophagy has not been established in ***,we report that the Arabidopsis CLATHRIN LIGHT CHAIN(CLC)subunit 2 and 3 double mutant,clc2-1 clc3-1,phenocopies Arabidopsis AUTOPHAGY-RELATED GENE(ATG)mutants in both autoimmunity and nutrient ***,the autophagy pathway is significantly compromised in the clc2-1 clc3-1 ***,multiple assays demonstrate that CLC2 directly interacts with ATG8h/ATG8i in a domain-specific *** expected,both GFP-ATG8h/GFP-ATG8i and CLC2-GFP are subjected to autophagic degradation,and degradation of GFP-ATG8h is significantly reduced in the clc2-1 clc3-1 ***,simultaneous knockout of ATG8h and ATG8i by CRISPR-Cas9 results in enhanced resistance against Golovinomyces cichoracearum,supporting the functional relevance of the CLC2-ATG8h/8i *** conclusion,our results reveal a link between the function of CLCs and the autophagy pathway in Arabidopsis.

关键词： autophagy clathrin light chain immunity clathrin-mediated endocytosis senescence cell death

Maternal Preconception Serum Alanine Aminotransferase Levels and Risk of Preterm Birth among Reproductive-Aged Women—China,2013-2017

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China CDC weekly 2024年第10期6卷 181-188,I0001页

作者： Chuanyu Zhao Jiajing Jia Hanbin wu Qin Xu Xinyi Lyu Meiya Liu Xuan Hu Jueming Lei Yuzhi Deng Yuan He Yuanyuan Wang Zuoqi Peng ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai yan Ying yang Xu Ma National Research Institute for Family Planning BeijingChina National Human Genetic Resources Center BeijingChina Graduate School of Peking Union Medical College BeijingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception s... 详细信息

关键词： Serum precise concerning

我国牛肉价格波动影响因素研究——基于VAR模型的实证分析

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饲料研究 2024年第9期47卷 178-182页

作者：吴鸭珠江苏商贸职业学院江苏南通226011

为保证牛肉价格合理稳定、推动牛肉市场持续健康发展,文章基于2011年12月—2022年12月中国畜牧业月度数据,以内部传导和外部冲击为视角,选取玉米价格、生产者预期、犊牛价格、国家政策构建VAR模型,实证检验我国牛肉价格波动影响因素及... 详细信息

为保证牛肉价格合理稳定、推动牛肉市场持续健康发展,文章基于2011年12月—2022年12月中国畜牧业月度数据,以内部传导和外部冲击为视角,选取玉米价格、生产者预期、犊牛价格、国家政策构建VAR模型,实证检验我国牛肉价格波动影响因素及程度。结果显示,玉米价格、生产者预期、犊牛价格、国家政策均可对牛肉价格造成影响。其中,玉米价格可通过内部传导机制对我国牛肉价格波动产生显著影响,且稳定贡献率在8%左右;国家政策可通过外部冲击机制对我国牛肉价格波动形成显著影响,贡献率为15%;前期牛肉价格可显著影响后期牛肉市场价格。因此,文章提出降低肉牛产业饲料成本、加大肉牛产业政府财政支持力度、完善牛肉价格波动市场监管体系的建议,以期为稳定牛肉价格、促进畜牧产业可持续发展提供参考。

关键词：牛肉价格波动 VAR模型供给侧改革格兰杰因果检验

短视频平台的企业社会责任及其动态履责路径——基于快手和抖音的双案例研究

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软科学 2024年第1期38卷 138-144页

作者：王仙雅吴珍天津科技大学经济与管理学院天津300457

运用扎根理论对快手和抖音两个案例资料进行数据分析,提炼了三种类型的社会责任及每种社会责任对应的履责路径。研究发现,短视频平台的履责路径具有顺序性和动态性,底线责任最早履行且贯穿于整个生命周期,合理责任晚于底线责任,始于成... 详细信息

运用扎根理论对快手和抖音两个案例资料进行数据分析,提炼了三种类型的社会责任及每种社会责任对应的履责路径。研究发现,短视频平台的履责路径具有顺序性和动态性,底线责任最早履行且贯穿于整个生命周期,合理责任晚于底线责任,始于成长期后半阶段,贡献责任在平台发展成熟后出现。三种社会责任的履责动因和履责实践存在明显差异,其中底线责任的履责实践呈现出由浅入深,从被动到主动的变化,合理责任彰显了短视频平台的媒体特征和引流责任,贡献责任凸显了短视频平台的高阶社会责任。

关键词：短视频平台企业社会责任动态履责路径案例研究扎根理论

Efficacy of graphene nanocomposites for air disinfection in dental clinics: A randomized controlled study

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World Journal of Clinical Cases 2024年第28期12卷 6173-6179页

作者： ya-Qiong Ju Xiang-Hua Yu Jing wu Ying-Hui Hu Xiang-Yong Han Dan Fang Department of Nursing Minhang District Dental ClinicShanghai 201107China Department of Medical Sciences Minhang District Dental ClinicShanghai 201107China Department of Orthopedics Center for Spinal Minimally Invasive ResearchShanghai Jiao Tong UniversityShanghai 201107China

BACKGROUND Aerosols containing disease-causing microorganisms are produced during oral diagnosis and treatment can cause secondary *** To investigate the use of graphene material for air disinfection in dental clinics by leveraging its adsorption and antibacterial *** Patients who received ultrasonic cleaning at our hospital from April 2023 to April *** were randomly assigned to three groups(n=20 each):Graphene nanocomposite material suction group(Group A),ordinary filter suction group(Group B),and no air suction device group(Group C).The air quality and air colony count in the clinic rooms were assessed before,during,and after the ***,bacterial colony counts were obtained from the air outlets of the suction devices and the filter screens in Groups A and *** Before ultrasonic cleaning,no significant differences in air quality PM2.5 and colony counts were observed among the three ***,significant differences in air quality PM2.5 and colony counts were noted among the three groups during ultrasonic cleaning and after ultrasonic ***,the number of colonies on the exhaust port of the suction device and the surface of the filter were significantly lower in Group A than in Group B(P=0.000 and P=0.000,respectively).CONCLUSION Graphene nanocomposites can effectively sterilize the air in dental clinics by exerting their antimicrobial effects and may be used to reduce secondary pollution.

关键词： Graphene Nanocomposites Oral clinic Air disinfection Secondary contamination

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干扰素基因刺激因子激动剂的研究进展

中国药理学通报 2024年第4期40卷 611-618页

作者：王娅吴硕李玉环中国医学科学院北京协和医学院医药生物技术研究所中国医学科学院抗病毒药物研究重点实验室抗感染药物研究北京市重点实验室北京100050

cGAS-STING通路作为固有免疫系统的重要组成部分,可以识别来自病原微生物和宿主细胞的胞质DNA,诱导Ⅰ型干扰素的分泌和炎症细胞因子的生成,激活机体免疫系统,抵抗病原微生物的入侵及增强机体抗肿瘤活性等。该文简要介绍了cGAS-STING通... 详细信息

cGAS-STING通路作为固有免疫系统的重要组成部分,可以识别来自病原微生物和宿主细胞的胞质DNA,诱导Ⅰ型干扰素的分泌和炎症细胞因子的生成,激活机体免疫系统,抵抗病原微生物的入侵及增强机体抗肿瘤活性等。该文简要介绍了cGAS-STING通路的生物学功能,主要聚焦于STING激动剂的研究进展,包括CDN类和Non-CDN类STING激动剂的药理作用及其研究阶段,总结与展望STING激动剂研发过程中的问题与挑战,以期为后续相关药物的研发和疾病治疗提供思路。

关键词： cGAS-STING通路免疫应答 STING激动剂 Ⅰ型干扰素抗肿瘤免疫抗感染免疫

Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution

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Molecular Plant 2024年第1期17卷 158-177页

作者： Peng Li Meng-Xiao yan Pan Liu Dan-Jie yang Ze-Kun He Yun Gao yan Jiang Yu Kong Xin Zhong Sheng wu Jun yang Hong-Xia Wang yan-Bo Huang Le Wang Xiao-ya Chen Yong-Hong Hu Qing Zhao Ping Xu shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChineseAcademy of SciencesShanghaiChina College of Life Sciences Shanghai Normal UniversityShanghai 200234China State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina University of the Chinese Academy of Sciences Beijing 100049China The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai 201203China College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620China

The Lamiaceae family is renowned for its terpenoid-based medicinal components,but Leonurus,which has traditional medicinal uses,stands out for its alkaloid-rich ***,the principal active compound found in Leonurus,has demonstrated promising effects in reducing blood lipids and treating ***,the biosynthetic pathway of leonurine remains largely ***,we present the chromosome-level genome sequence assemblies of Leonurus japonicus,known for its high leonurine production,and Leonurus sibiricus,characterized by very limited leonurine *** integrating genomics,RNA sequencing,metabolomics,and enzyme activity assay data,we constructed the leonurine biosynthesis pathway and identified the arginine decarboxylase(ADC),uridine diphosphate glucosyltransferase(UGT),and serine carboxypeptidase-like(SCPL)acyltransferase enzymes that catalyze key reactions in this *** analyses revealed that the UGT–SCPL gene cluster evolved by gene duplication in the ancestor of Leonurus and neofunctionalization of SCPL in ***,which contributed to the accumulation of leonurine specifically in ***,our comprehensive study illuminates leonurine biosynthesis and its evolution in Leonurus.

关键词： Lamiaceae Leonurus japonicus Leonurus sibiricus genome sequence alkaloids leonurine gene cluster biosynthetic pathway evolution

Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo yang Vincent C.H.Chung Irene X.Y.wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RCTs were *** binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-Qiong Zhou Li-Jian Fang ya-Xing Wang Ye-Nan Wang Qian Wang yan-Ni yan Xuan yang Shou-Ling wu shuo-Hua Chen Jost B Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination