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Rare Metals 2023年第4期42卷 1306-1315页

作者： De-Zhi Chen Qi wang Rui-Run Chen shu wang Yan-Qing Su Heng-Zhi Fu National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin150001China

Five Nb-16Si-20Ti-xMgO alloys(x=0,0.1,0.5,1.0 and 3.0)were prepared via arc melting in this study,and the effect of MgO addition on their phase composition,microstructure evolution,and mechanical properties was examined.The results demonstrated that MgO reacted with the Nb-Si-Ti alloy while Mg atoms replaced Nb atoms in the Nbss phase.The hypoeutectic alloy was transformed into a hypereutectic alloy upon the addition of 3.0 at%MgO,and the Nb_(3)Si phases decomposed into a fine Nbss/α-Nb5Si3 eutectic structure.The highest fracture toughness was achieved for the Nb-16Si-20Ti-3MgO alloy,with an ambient fracture toughness value of 9.4 MPa·m^(-1/2)due to its largest Nbss phase content and optimal Nbss/α-Nb_(5)Si_(3)eutectic structure.Furthermore,the alloy compressive strength increased with MgO addition.The compressive strength of the Nb-16Si-20Ti-3MgO alloy was 2624.1 MPa,26.0%higher than that of Nb-16Si-20Ti,due to the formation of a solid solution of Mg atoms in the Nbss phase and reinforcement of a small amount of the Ti_(2)O phase.Finally,an increase in the content of the Nbss/α-Nb_(5)Si_(3)eutectic structure increased both the alloy strength and fracture strain.

关键词： Niobium silicon alloy Magnesium oxide Eutectic structure Fracture toughness

Harnessing the cyclization strategy for new drug discovery

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4309-4326页

作者： Kai Tang shu wang Wenshuo Gao Yihui Song Bin Yu School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery.As one of the most commonly used methods in drug discovery,the cyclization represents a feasible strategy to identify new lead compounds by increasing structural novelty,scaffold diversity and complexity.Such strategy could also be potentially used for the follow-on drug discovery without patent infringement.In recent years,the cyclization strategy has witnessed great success in the discovery of new lead compounds against different targets for treating various diseases.Herein,we first briefly summarize the use of the cyclization strategy in the discovery of new small-molecule lead compounds,including the proteolysis targeting chimeras(PROTAC)molecules.Particularly,we focus on four main strategies including fused ring cyclization,chain cyclization,spirocyclization and macrocyclization and highlight the use of the cyclization strategy in lead generation.Finally,the challenges including the synthetic intractability,relatively poor pharmacokinetics(PK)profiles and the absence of the structural information for rational structure-based cyclization are also briefly discussed.We hope this review,not exhaustive,could provide a timely overview on the cyclization strategy for the discovery of new lead compounds.

关键词： Ring cyclization Spirocyclization Macrocyclization Conformational constraint Lead generation New drug discovery

Effect of Al_(82.8)Cu_(17)Fe_(0.2) alloy doping on structure and magnetic properties of SmCo5-based ribbons

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Journal of Rare Earths 2022年第1期40卷 93-101页

作者： Zhixin Dong shu wang Siyi Chen Yunfei Cao Zihui Ge Jibing Sun Key Lab.for New Type of Functional Materials in Hebei Province Hebei University of TechnologyTianjin 300401China

This work tries to improve the magnetic properties by multi-element doping in the form of a ternary alloy.SmCo_(5+)χwt%Al-Cu-Fe(x=0-7)ribbons melt-spun at 40 m/s were produced by adding Al_(82.8)Cu_(17)Fe_(0.2)alloy into SmCo_(5) matrix,and their phases,microstructure,and magnetic properties were investigated.The results show that both x=0 and 3 ribbons form a cellular microstructure.Al-Cu-Fe addition reduces the content of the Sm_(2)(Co,M)_(7) cell wall,narrows its width,and forms the local disordered micro-regions and solute-segregation nanoclusters in the Sm(Co,M)_(5) grains.With x increasing to5,Al-Cu-Fe addition promotes the phase separation between and within grains of the SmCo_(5)-based alloy.The Al-Cu-Fe addition can simultaneously improve the coercivity and magnetization of the SmCo_(5)-based ribbons,in particular,the magnetization of the x=3 ribbons increases by 35%,while the coercivity of the x=5 ribbons increases by 3.9 times.Finally,the microstructure evolution models are built up,and the relationship between the microstructure and the magnetic properties is discussed.

关键词： Rare earth alloys and compounds Rapid solidification Crystal structure Phase transitions Microstructure Magnetic property

Anomalous refinement and uniformization of grains in metallic thin films

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Nano Research 2023年第12期16卷 13358-13365页

作者： Lei wang shu wang Xiaofeng wang Jianming Zhang Jianjie Dong Bin Wei Haiguang Yang Zhongchang wang Ziyang Zhang ChuanFei Guo Qian Liu Chinese Academy of Sciences(CAS)Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology&University of Chinese Academy of SciencesBeijing 100190China College of Mathematics and Physics Qingdao University of Science and TechnologyQingdao 266061China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Materials Sun Yat-Sen UniversityGuangzhou 510275China International Iberian Nanotechnology Laboratory(INL) Department of Quantum and Energy MaterialsBraga 4715-330Portugal School of Electronic and Information Engineering Qingdao UniversityQingdao 266071China The MOE Key Laboratory of Weak-Light Nonlinear Photonics and TEDA Applied Physics Institute and School of Physics Nankai UniversityTianjin 300457China

When a laser beam writes on a metallic film,it usually coarsens and deuniformizes grains because of Ostwald ripening,similar to the case of annealing.Here we show an anomalous refinement effect of metal grains:A metallic silver film with large grains melts and breaks into uniform,close-packed,and ultrafine(~10 nm)grains by laser direct writing with a nanoscale laser spot size and nanosecond pulse that causes localized heating and adaptive shock-cooling.This method exhibits high controllability in both grain size and uniformity,which lies in a linear relationship between the film thickness(h)and grain size(D),D∝h.The linear relationship is significantly different from the classical spinodal dewetting theory obeying a nonlinear relationship(D∝h5/3)in common laser heating.We also demonstrate the application of such a silver film with a grain size of~10.9 nm as a surface-enhanced Raman scattering chip,exhibiting superhigh spatial-uniformity and low detection limit down to 10-15 M.This anomalous refinement effect is general and can be extended to many other metallic films.

关键词： laser direct writing anomalous refinement localized heating ripening linear relationship

Development of artificial intelligence technology in diagnosis,treatment,and prognosis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 124-152页

作者： Feng Liang shu wang Kai Zhang Tong-Jun Liu Jian-Nan Li Department of General Surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Radiotherapy Jilin University Second HospitalChangchun 130041Jilin ProvinceChina

Artificial intelligence(AI)technology has made leaps and bounds since its invention.AI technology can be subdivided into many technologies such as machine learning and deep learning.The application scope and prospect of different technologies are also totally different.Currently,AI technologies play a pivotal role in the highly complex and wide-ranging medical field,such as medical image recognition,biotechnology,auxiliary diagnosis,drug research and development,and nutrition.Colorectal cancer(CRC)is a common gastrointestinal cancer that has a high mortality,posing a serious threat to human health.Many CRCs are caused by the malignant transformation of colorectal polyps.Therefore,early diagnosis and treatment are crucial to CRC prognosis.The methods of diagnosing CRC are divided into imaging diagnosis,endoscopy,and pathology diagnosis.Treatment methods are divided into endoscopic treatment,surgical treatment,and drug treatment.AI technology is in the weak era and does not have communication capabilities.Therefore,the current AI technology is mainly used for image recognition and auxiliary analysis without in-depth communication with patients.This article reviews the application of AI in the diagnosis,treatment,and prognosis of CRC and provides the prospects for the broader application of AI in CRC.

关键词： Artificial intelligence Colorectal cancer Diagnosis Treatment Prognosis

Microcystic adnexal carcinoma misdiagnosed as a“recurrent epidermal cyst”:A case report

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World Journal of Clinical Cases 2022年第22期10卷 8034-8039页

作者： Si-Xuan Yang Yan Mou shu wang Xin Hu Fu-Qiu Li Department of Dermatology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Radiotherapy The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Microbiology Graduate School of MedicineKyoto UniversityKyoto 606-8510Japan

BACKGROUND Microcystic adnexal carcinoma(MAC)is a rare malignant cutaneous adnexal neoplasm,often presenting as a flesh-colored and slow-growing indurated plaque or cystic nodule in the mid-facial region.Its characteristic indolent presentation usually leads to initial misdiagnosis,resulting in tumor mismanagement and added morbidity due to increased propensity for local invasion.CASE SUMMARY A 63-year-old Chinese male patient with a long-term history of excessive ultraviolet irradiation had received two surgeries for an“epidermal cyst”on his glabella and was presented to our hospital’s Dermatology Department for further diagnosis and therapy of the lesion on his glabella.One month ago,his two 7 mm×7 mm subcutaneous nodules were diagnosed as"recurrent epidermal cysts",and he underwent local excision surgery.Additionally,he has post medical history of surgery for right clear cell renal carcinoma.According to his biopsy,the patient was diagnosed as MAC in our hospital,and a tumor remnant was found on his wound.He then underwent wide local excision to achieve negative margins and reconstruction of full-thickness flap transplantation for tissue coverage.He remained tumor-free after six months of follow-up.CONCLUSION This case highlights the importance of MAC’s possible pathogenic factor of excessive ultraviolet exposure,its differential diagnosis to avoid misdiagnosis and mismanagement to adverse prognosis,the patient’s particular medical history of clear cell renal carcinoma,the alert for any tumor recurrence in older patients,and his uncommon multiple nodules mess consisting of two 7 mm×7 mm subcutaneous nodules,that will enrich the existing knowledge of MAC’s clinical features.

关键词： Microcystic adnexal carcinoma Recurrent epidermal cyst Differential diagnosis Clear cell renal carcinoma Excessive ultraviolet radiation Case report

All-atomristor logic gates

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Nano Research 2023年第1期16卷 1688-1694页

作者： shu wang Zhican Zhou Fengyou Yang Shengyao Chen Qiaoxuan Zhang Wenqi Xiong Yusong Qu Zhongchang wang Cong wang Qian Liu CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology&University of Chinese Academy of SciencesBeijing 100190China MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Applied Physics InstituteSchool of PhysicsNankai UniversityTianjin 300457China Electrical Automation Department Hebei University of Water Resources and Electric EngineeringCangzhou 061001China School of Physics and Technology Wuhan UniversityWuhan 430072China International Iberian Nanotechnology Laboratory(INL) Braga 4715-330Portugal College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

The atomristor(monolayer two-dimensional(2D)-material memristor)is competitive in high-speed logic computing due to its binary feature,lower energy consumption,faster switch response,and so on.Yet to date,all-atomristor logic gates used for logic computing have not been reported due to the poor consistency of different atomristors in performance.Here,by studying band structures and electron transport properties of MoS2 atomristor,a comprehensive memristive mechanism is obtained.Guided by the simulation results,monolayer MoS2 with moderated defect concentration has been fabricated in the experiment,which can build atomristors with high performance and good consistency.Based on this,for the first time,MoS2 all-atomristor logic gates are realized successfully.As a demonstration,a half-adder based on the logic gates and a binary neural network(BNN)based on crossbar arrays are evaluated,indicating the applicability in various logic computing circumstances.Owing to shorter transition time and lower energy consumption,all-atomristor logic gates will open many new opportunities for next-generation logic computing and data processing.

关键词： atomristor logic gates combinational logic circuit neural network defect concentration

Physical Properties of 29 sdB+dM Eclipsing Binaries in Zwicky Transient Facility

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Research in Astronomy and Astrophysics 2022年第3期22卷 221-245页

作者： Min Dai Xiao-Dian Chen Kun wang Yang-Ping Luo shu wang Li-Cai Deng School of Physics and Astronomy China West Normal UniversityNanchong 637002China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of the Chinese Academy of SciencesBeijing 101408China

The development of large-scale time-domain surveys provides an opportunity to study the physical properties as well as the evolutionary scenario of B-type subdwarfs(sdBs)and M-type dwarfs(dMs).Here,we obtained 33 sdB+dM eclipsing binaries based on the Zwicky Transient Facility(ZTF)light curves and Gaia Early Data Release3(EDR3)parallaxes.By using the PHOEBE code for light curve analysis,we obtain probability distributions for parameters of 29 sdB+dMs.R1,R2 and i are well determined,and the average uncertainty of mass ratio q is 0.08.Our parameters are in good agreement with previous works if a typical mass of sdB is assumed.Based on parameters of 29 sdB+dMs,we find that both the mass ratio q and the companion’s radius R2 decrease with the shortening of the orbital period.For the three sdB+dMs with orbital periods less than 0.075 days,their companions are all brown dwarfs.The masses and radii of the companions satisfy the mass–radius relation for low-mass stars and brown dwarfs.Companions with radii between 0.12 R_(⊙)and 0.15 R_(⊙)seem to be missing in the observations.As more short-period sdB+dM eclipsing binaries are discovered and classified in the future with ZTF and Gaia,we will have more information to constrain the evolutionary ending of sdB+dMs.

关键词： (stars:)binaries:eclipsing stars:evolution (stars:)subdwarfs (stars:)brown dwarfs

Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian Veronica Lim CHEN Qi ZHAO Zhong Hua wang shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,respectively.Dual-luciferase reporter gene assay was used to determine the target gene of miR-224-5p.The protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western blot.Flow cytometry was used to detect cell cycle and apoptosis.Cell proliferation was measured by CCK8 and EdU assay.Results The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC stage.CRC cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or paracrine.Moreover,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC tissues.Interestingly,ULK2 inhibited CRC cell proliferation in a p53-dependent manner.Furthermore,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC cells.Conclusion Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

Workers’Cerebrocortical Activity in Hot and Humid Condition:An Electroencephalogram Study

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Journal of Beijing Institute of Technology 2022年第1期31卷 112-122页

作者： Yixuan Wei Yifei Xu shu wang Longzhe Jin Tianqi Ding School of Civil Engineering and Resources University of Science and Technology BeijingBeijing 100083China

Hyperthermal environments can harm workers’health and safety.However,it is difficult to include effective protection into standards because heat-related impacts vary significantly accord-ing to individual workers and multiple factors.Studies suggested obvious relationship between en-vironment condition and bio-electricity signal,including electroencephalogram(EEG)signal.We used a detector with 64 electrodes to perform dedicated EEG measurements of nine individual sub-jects to analyze human cerebral activity under hyperthermal(35℃,80%RH)and standard condi-tions(25℃,30%RH).Amplitude changes of the frequency wavebands were analyzed using statist-ical analysis.Seven participants showed increasing beta activity due to high temperature and high humidity in the primary somatosensory cortex(electrode C3)and the temporopolar region(elec-trode FT 8).The amplitude value of alpha wave is increased from 0.194 to 0.213 while the amp-litude value of beta wave is increased from 0.144 to 0.160.Value is decreased due to hyperthermal environment for most people.The results of this study could be used to inform the development of wearable equipment to monitor the health of on-site workers,which is fundamental to improve worker safety and wellbeing.

关键词： confined space electroencephalogram(EEG) hyperthermal environment heat expos-ure workers’health