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血能铁制剂对哺乳母猪生产性能及生理生化指标的影响

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农业生物技术学报 2025年第1期33卷 116-123页

作者：胡国明黄昌巧周淑棉韦玉衡谢小东胡庭俊胡永浩甘肃农业大学动物医学院广西大学动物科学技术学院贵港市动物疫病预防控制中心

铁作为一种关键的微量元素，对动物的生长具有重大的意义，铁缺乏将会导致发育障碍、繁殖性能不佳、贫血和腹泻等多种不良影响。本研究以产前7 d至产后21 d的哺乳母猪(Sus scrofa domestica)为对象，探讨饲料中添加血能铁制剂对哺乳母... 详细信息

铁作为一种关键的微量元素，对动物的生长具有重大的意义，铁缺乏将会导致发育障碍、繁殖性能不佳、贫血和腹泻等多种不良影响。本研究以产前7 d至产后21 d的哺乳母猪(Sus scrofa domestica)为对象，探讨饲料中添加血能铁制剂对哺乳母猪生产性能、生理生化指标及仔猪相关指标的影响。结果显示，与空白对照组相比，以1 kg/t饲料添加剂量添加血能铁制剂后，连续饲喂28 d能够显著降低母猪助产率、提高断配率，改善母猪产程，增加仔猪初生窝重、仔猪平均体重、断奶窝重，降低仔猪腹泻率、畸形率、死胎率，从而提高母猪生产性能和仔猪生长性能；同时血能铁制剂可以提高第7天哺乳仔猪血清铁和总铁结合力，起到预防仔猪贫血的作用。本研究为兽医临床应用血能铁制剂提高母猪生产性能提供参考和依据。

关键词：血能铁制剂生产性能血液指标

Study on the flow field uniformity of hydro-floating ship lift combined type hydraulic-driven system based on the residual energy theory

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Journal of Hydrodynamics 2022年第6期34卷 1156-1161页

作者： Bo Wu Ya-an hu shu Xue State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing210029China Key Laboratory of Transport Technology in Navigation Building Construction Nanjing Hydraulic Research InstituteNanjing210029China

The hydro-floating ship lift originally invented in China is a major innovation in the field of navigation *** shaft water levels synchronization of its unique hydraulic-driven system plays a crucial role in reducing the torque of the synchronous shafts and ensuring the safety and stability operation of the ship *** study aims to investigate the muti-shaft water level synchronization and the flow velocity uniformity of the combined type hydraulic-driven *** on the theory of residual energy,a new index m2 proposed in this study is more suitable for evaluating the flow velocity uniformity of the combined hydraulic-driven ***,the critical value of m2=75 is calculated via the results of the scaled physical mode test as the threshold of water flow uniformity,and it provides a basis for determining the reasonable height of the pressure stabilizing chamber.

关键词： Hydro-floating ship lift water levels synchronism residual energy velocity distribution uniformity coefficient

Axonal bleb recording

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Neuroscience Bulletin 2012年第4期28卷 342-350页

作者： Wenqin hu Yousheng shu Institute of Neuroscience State Key Laboratory of NeuroscienceShanghai Institutes for Biological SciencesChineseAcademy of SciencesShanghai 200031China

Patch-clamp recording requires direct accessibility of the cell membrane to patch pipettes and allows the investigation of ion channel properties and functions in specific cellular *** cell body and relatively thick dendrites are the most accessible compartments of a neuron,due to their large diameters and therefore great membrane surface ***,axons are normally inaccessible to patch pipettes because of their thin structure;thus studies of axon physiology have long been hampered by the lack of axon recording ***,a new method of patchclamp recording has been developed,enabling direct and tight-seal recording from cortical *** recordings are performed at the enlarged structure（axonal bleb） formed at the cut end of an axon after slicing *** method has facilitated studies of the mechanisms underlying the generation and propagation of the main output signal,the action potential,and led to the finding that cortical neurons communicate not only in action potential-mediated digital mode but also in membrane potential-dependent analog mode.

关键词： axon patch-clamp recording ion channel action potential

Advancing Modernisation Through Exchanges

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ChinAfrica 2025年第1期17卷 16-17页

作者： ZHOU QIAN hu LANYIN Institute of African Studies Zhejiang Normal University Zhejiang Normal University

In his keynote speech at the open-ing ceremony of the Beijing Summit of the Forum on China Africa Cooperation(FOCAC)in September 2024,Chinese President Xi Jinping emphasised that China will enhance people-to-people and cultural exchanges with Africa,champion mutual respect,inclusiveness and coexistence of di"erent civilisations on the way to modernisation,and strive together for more fruitful outcomes under the Global Civilisation Initiative.

关键词： mutual Africa fruitful

Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAHⅡ/eNOS/NO pathway

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Chinese Journal of Natural Medicines 2022年第1期20卷 22-32页

作者： CheN shu-Ping hu Tian-Hong ZHOU Qing CheN Tian-Peng YIN Dong he huan huANG Qing he Ming Institute of Cardiovascular Diseases Jiangxi Academy of Clinical Medical Sciencesthe First Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Provincial Key Laboratory of Basic Pharmacology School of Pharmaceutical ScienceNanchang UniversityNanchang 330006China Jiangxi Provincial Key Laboratory of Molecular Medicine the Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Provincial Institute of Cardiovascular Diseases Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China

Iron overload injury is considered to be a part of blood stasis syndrome of arthralgia in traditional Chinese *** primary therapies include clearing heat and detoxification,activating blood circulation,and removing blood *** japonica flos(LJF)has long been known as an excellent antipyretic and ***(Lut)is one of the main components of LJF and exhibits antioxidant,anti-inflammatory,and cytoprotective ***,the protection of Lut against iron overload injury and its underlying mechanisms remain ***,huVECs were exposed to 50μmol·L^(−1)iron dextran for 48 h to establish an iron overload damage model and the effects of Lut were *** results showed that 20μmol·L^(−1)Lut not only increased cell viability and weakened LDH activity,but also significantly up-regulated DDAHⅡexpression and activity,increased p-eNOS/eNOS ratio and NO content,and reduced ADMA content in huVECs exposed to iron ***,Lut significantly attenuated intracellular/mitochondrial ROS generation,improved SOD,CAT,and GSH-Px activities,reduced MDA content,maintained MMP,inhibited mPTP opening,prevented cyt c from mitochondria released into cytoplasm,reduced cleaved-caspase3 expression,and ultimately decreased cell apoptosis induced by iron *** effects of Lut were similar to those of L-arginine(an ADMA competitive substrate),cyclosporin A(a mPTP blocker agent),and edaravone(a free radical scavenger)as positive ***,addition of pAD/DDAHⅡ-shRNA adenovirus reversed the above beneficial effects of *** conclusion,Lut can protect huVECs against iron overload injury via the ROS/ADMA/DDAHⅡ/eNOS/NO *** mitochondria are the target organelles of Lut’s protective effects.

关键词： Luteoloside Iron overload Endothelium dysfunction Mitochondria ROS/ADMA/DDAHⅡ/eNOS/NO pathway

Three-dimensional electric field simulation and flashover path analysis of ice-covered suspension insulators

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High Voltage 2020年第3期5卷 327-333页

作者： Lichun shu Yanqing Liu Xingliang Jiang Qin hu Gaohui he Zhou Yu Longfang Xiao State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityNo.174 ShazhengjieShapingbaChongqingPeople's Republic of China

Flashover of ice-covered insulators seriously affects the safe operation of transmission *** is necessary to study the electric field distribution for flashover analysis of ice-covered *** electric field of ice-covered insulators was mostly calculated by a two-dimensional(2D)axisymmetric model that cannot be well corresponded to actual icing *** this study,a 3D electric field simulation model of ice-covered suspension insulators under moderate icing condition with applied DC voltage was *** characteristic parameters,E_(av)and E_(max)were proposed to measure electric field distortion *** on the simulation results,the effects of water film conductivity,icicle length,icicle deviation angle,and icicle distribution on Eav and Emax were *** results showed that icicles have a significant influence on the electric field distribution of insulators.E_(av)increases with the increase of icicle length and decreases with the increase of icicle deviation angle.E_(max)increases with the increase of the icicle length,icicle spacing and adjacent icicle length *** the icicle deviation angle is 45°,E_(max)is the ***,the possible flashover paths were analysed based on the simulation results,which would provide a theoretical basis for building a flashover model of ice-covered insulators.

关键词： mostly flash field

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei hu Jing Yang shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

A Flexible Smart healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors health-monitoring Machine learning

Organic ligand-induced dissolution kinetics of antimony trioxide

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Journal of Environmental Sciences 2017年第6期29卷 87-94页

作者： Xingyun hu Mengchang he State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal University State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesUniversity of Chinese Academy of Sciences

The influence of low-molecular-weight dissolved organic matter （LMWDOM） on the dissolution rate of Sb203 was investigated. Some representative LMWDOMs with carboxyl, hydroxyl, hydrosulfuryl and amidogen groups occurring naturally in the solution were chosen, namely oxalic acid, citric acid, tartaric acid, EDTA, salicylic acid, phthalandione, glycine, thiolactic acid, xylitol, glucose and catechol. These LMWDOMs were dissolved in inert buffers at pH = 3.7, 6.6 and 8.6 and added to powdered Sb203 in a stirred, thermostatted reactor （25℃）. The addition of EDTA, tartaric acid, thiolactic acid, citric acid and oxalic acid solutions at pH 3.7 and catechol at pH 8.6 increased the rate of release of antimony. In the 10 mmol/L thiolactic acid solution, up to 97% by mass of the antimony was released after 120 rain reaction. There was no effect on the dissolution of Sb203 for the other ligands. A weak correlation between dissolution rate with the dissociation constant of ligands and the stability of the dissolved complex was also found. All the results showed that the extent of the promoting effect of ligands on the dissolution of Sb203 was not determined by the stability of the dissolved complex, but by the dissociation constant ofligands and detachment rate of surface chelates from the mineral surface. This study can not only help in further understanding the effect of individual low-molecular-weight organic ligands, but also provides a reference to deduce the effect of natural organic matters with oxygen-bearing functional groups on the dissolution of antimony oxide minerals.

关键词： Antimony pollutionAntimony trioxideDissolutionOrganic ligands