检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

我国兽药生产质量管理规范发展概况

西南民族大学学报（自然科学版） 2005年第S1期31卷 110-113页

作者：丁晓刚田淑琴龙江西南民族大学四川成都610041

通过对国际上GMP和我国GMP的发展情况进行研究,特别是对我国兽药GMP的发展情况和不同版本兽药GMP之间的差异进行了研究,目的在于探讨其内在的发展规律.结果表明,由于受国际以及我国人药GMP发展的影响,我国兽药GMP正在向科学、合理、适... 详细信息

通过对国际上GMP和我国GMP的发展情况进行研究,特别是对我国兽药GMP的发展情况和不同版本兽药GMP之间的差异进行了研究,目的在于探讨其内在的发展规律.结果表明,由于受国际以及我国人药GMP发展的影响,我国兽药GMP正在向科学、合理、适用的方向发展.

关键词：兽药 GMP

Torin2 overcomes sorafenib resistance via suppressing mTORC2-AKT-BAD pathway in hepatocellular carcinoma cells

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 547-554页

作者： Yi-Ting Hu Zhe-Yue shu Jing-Hua jiang qin-Fen Xie shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren UniversityShulan International Medical CollegeHangzhou 310022China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Jinhua Municipal Central HospitalJinhua 321000China

Background:Sorafenib is an oral multi-kinase inhibitor that was approved by the US Food and Drug Administration for the treatment of patients with advanced hepatocellular carcinoma(HCC).However,resistance to sorafenib is an urgent problem to be resolved to improve the therapeutic efficacy of *** the activation of AKT/mTOR played a pivotal role in sorafenib resistance,we evaluated the effect of a dual mTOR complex 1/2 inhibitor Torin2 on overcoming the sorafenib resistance in HCC ***:The sorafenib-resistant Huh7 and Hep3B cell lines were established from their parental cell *** synergistic effect of sorafenib and Torin2 on these cells was measured by cell viability assay and quantified using the Chou-Talalay *** induced by the combination of sorafenib and Torin2 and the alteration in the specific signaling pathways of interest were detected by Western ***:Sorafenib treatment inversely inhibited AKT in parental but activated AKT in sorafenib-resistant Huh7 and Hep3B HCC cells,which underscores the significance of AKT ***2 and sorafenib synergistically suppressed the viability of sorafenib-resistant cells via apoptosis ***2 successfully suppressed the sorafenib-activated mTORC2-AKT axis,leading to the dephosphorylation of Ser136 in BAD protein,and increased the expression of total BAD,which contributed to the apoptosis in sorafenibresistant HCC ***:In this study,Torin2 and sorafenib showed synergistic cytostatic capacity in sorafenibresistant HCC cells,via the suppression of mTORC2-AKT-BAD *** results suggest a novel strategy of drug combination for overcoming sorafenib resistance in HCC.

关键词： Torin2 Sorafenib resistance Hepatocellular carcinoma mTORC2-AKT-BAD pathway

Gold Self-Relay Catalysis Enabling[3,3]-Sigmatropic Rearrange-ment/Nazarov Cyclization and Allylic Alkylation Cascade for Constructing All-Carbon Quaternary Stereocenters

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第6期40卷 687-692页

作者： Fan-Tao Meng Xiao-Yan qin Jing Li Tian-shu Zhang shu-jiang Tu Bo jiang Wen-Juan Hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhouJiangsu 221116China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhouJiangsu 221018China

Molecular scaffolds endowed with all-carbon quaternary stereocenter are ubiquitous in natural products and significant bioactive ***,efficient construction of this type of structure units is full of challenge due to their congested chemical ***,we report a new gold(Ⅰ)self-relay catalysis merging[3,3]-sigmatropic rearrangement/Nazarov cyclization with al-lylic alkylation starting from 1,3-enyne acetates and allylic alcohols,producing a wide range of synthetically important allyl cyclo-pentenones with an all-carbon quaternary stereocenter in good yields under mild *** protocol demonstrates the precise control of regioselectivity,high functional group tolerance of substrates and the low loading of gold catalyst without inert atmos-phere protection,providing a catalytic and efficient entry to all-carbon quaternary stereocenters.

关键词： Allylation Domino reactions Carbocycles Gold self-relay catalysis 1,3-Enynes

Phase equilibria of low-Y side in Mg-Zn-Y system at 400℃

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2020年第3期39卷 262-269页

作者： Bo-shu Liu Hong-Xiao Li Yu-Ping Ren Min jiang Gao-Wu qin Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang110819China

Phase equilibrium relations of the Mg-Zn-Y system in the low-Y side at 400℃were investigated by alloy-equilibrated method,combined with thermal *** results show that there is a liquid phase which could be in equilibrium with an a-Mg solid solution and an icosahedral quasicrystal I phase in the low-Y side of the Mg-Zn-Y system at 400℃.The liquid phase region originates from the binary Mg-Zn system and extends to 0.4 at%Y in the Mg-Zn-Y ***,the hexagonal structure H phase,fee W phase and LPSO phase(X phase)are in equilibrium with *** Y/Zn(atomic ratio,the same as follows)increasing,there exist four three-phase regions consisting of I+liquid+α-Mg,I+H+α-Mg,H+W+α-Mg and W+X+α-Mg,respectively,in the low-Y side of the isothermal section at 400℃.The twophase region a-Mg+I phase exists between I+H+aMg and I+liquid+*** this two-phase region,the Y/Zn ratio is in the range of 0.14-0.17;and a three-phase region of a-Mg+I phase+H phase appears when Y/Zn ratio comes up to *** I but W phase is in equilibrium with a-Mg,when Y/Zn ratio>*** system is in liquid-state phase equilibrium,when Y/Zn ratio<0.14.

关键词： Mg-Zn-Y system Phase equilibrium Icosahedral quasicrystal phase Solid solubility

Solution of Semi-Boundless Mixed Problem for Time-fractional Telegraph Equation

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2007年第4期23卷 611-618页

作者： shu-qin Zhang Department of Mathematics China University of Mining and Technology Beijing 100083 China

In this paper, we study the semi-boundless mixed problem for time-fractional telegraph equation. We are able to use the integral transform method （the Fourier sin and cos transforms） to obtain the solution.

关键词： Time-fractional telegraph equation the Fourier sin and cos transforms mittag-leffier function,H-function

Gold self-relay catalysis for accessing functionalized cyclopentenones bearing an allcarbon quaternary stereocenter

在线全文

学校读者我要写书评

暂无评论

Organic Chemistry Frontiers 2022年第1期9卷 140-146页

作者： Fan-Tao Meng Jing-Long Chen Xiao-Yan qin Tian-shu Zhang shu-jiang Tu Bo jiang Wen-Juan Hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou221116P.R.China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018P.R.China

A new gold(I)self-relay catalysis consisting of a 3,3-rearrangement,Nazarov cyclization and Michael addition cascade of 1,3-enyne acetates with aurones and their derived azadienes is reported,and used to produce a series of densely functionalized cyclopentenones bearing a cyclic quaternary stereocenter in moderate to good yields under mild *** tandem protocol demonstrates high regioselectivity,broad substrate flexibility and good functional group tolerance of substrates without inert atmosphere protection,providing a catalytic and convergent approach for creating all-carbon stereoscopic centers.

关键词： catalysis quaternary functional

Engineering geological classification of the structural planes for hydroelectric projects in Emeishan Basalts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2016年第2期13卷 330-341页

作者： SUN shu-qin HUANG Run-qiu PEI Xiang-jun ZHAO Song-jiang State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology

The scale and characteristics of rock mass are important indexes of the rock mass structural plane classification. This paper firstly analyzes the spatial distribution characteristics, the structural plane types （original structural plane, tectonic structural plane and hypergenic structural plane） and the associated features of the Emeishan basalts and then studies the classification schemes of the built hydropower structure planes of different rock areas （the east district, the central district and the west district） in the Emeishan basalt distribution area, Southwest China. Based on the analysis and comparison of the scale and the engineering geological characteristics of the typical structure planes in the basalt hydroelectric Stations, the types of structural planes are used in the first order classification. The secondary order classification is made by considering the impact factors of rock mass quality, e.g., the state of the structural planes, infilling, joint opening, extending length, the grade of weathering and strength. The engineering geological classification for Emeishan basalt is proposed. Because there are no evidences of a large structure presenting in study area, the first-order （Ⅰ） controlling structural planes do not appear in the classification, there only appear Ⅱ, Ⅲ, Ⅳ and Ⅴ grade structural planes influencing the rock-mass quality. According to the different rock-block types in bedding fault zone, the second-grade （Ⅱ） structural planes consisted of bedding fault zone is further classified into Ⅱ1, Ⅱ2 and Ⅱ3. The third-grade （Ⅲ） structural planes constructed by intraformational faulted zones are not subdivided. According to the different characteristics of intrusion, alteration and weathering unloading structural planes, the Ⅳ grade structure plane is divided into Ⅳ1, Ⅳ2 and Ⅳ3. According to the development characteristics of joints and fractures, the V grade structure plane is divided into fracture Ⅴ1 and columnar joint Ⅴ2. In all, the struc

关键词： Emeishan basalt Hydroelectric project Structural plane Bedding fault zone Engineering geological classification

Calculation of conductive ions distribution in icicle and melting water conductivity

在线全文

学校读者我要写书评

暂无评论

High Voltage 2021年第4期6卷 702-710页

作者： Yanqing Liu Lichun shu qin Hu Xingliang jiang Meilin Zhu Jianbo Yu State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina State Grid Chongqing Electric Power Company ChongqingChina

The flashover problem of ice-covered insulators has seriously affected the safe operation of transmission *** researches have shown that the high conductivity water film on the surface is determined by the conductive ions distribution in the icicle which is the key factor affecting the flashover voltage of ice-covered *** our previous work,the conductive ions distribution in the icicle has been obtained through experi-ments and simulation *** order to calculate the conductivity of the water film,the conductive ion-specific content at different positions in the icicle has been calculated *** addition,based on the simulation of icicle melting process,the icicle melting process is analysed,and the melting water conductivity of the icicle is ***,melting ice test is carried out in artificial climate chamber to verify the validity of the calculation *** calculated results are in good agreement with the test *** conclusion obtained here would provide theoretical basis for establishing a flashover model of ice-covered insulators.

关键词： conductivity conductive distribution

中国儿童青少年遗尿症患病率及影响因素的Meta分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国全科医学 2025年第6期28卷 763-770,776页

作者：刘芹程敏江凤琼李小玉川北医学院护理学院四川省南充市637000 电子科技大学医学院附属绵阳医院绵阳市中心医院四川省绵阳市621000

背景遗尿症是儿科常见疾病之一,近年来,遗尿症对儿童青少年身心健康造成了极大的威胁,严重影响患儿的生活质量,给社会和家庭带来严重的负担。目前,关于儿童青少年遗尿症的影响因素还存在争议,且国内外鲜见相关的系统评价。目的利用Meta... 详细信息

背景遗尿症是儿科常见疾病之一,近年来,遗尿症对儿童青少年身心健康造成了极大的威胁,严重影响患儿的生活质量,给社会和家庭带来严重的负担。目前,关于儿童青少年遗尿症的影响因素还存在争议,且国内外鲜见相关的系统评价。目的利用Meta分析探讨国内儿童青少年遗尿症的患病率和影响因素。方法计算机检索中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普网(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Embase、Web of Science、Cochrane Library数据库中的相关研究,检索时间从建库至2024年5月。由2名研究者独立筛选并交叉核对,横断面研究采用美国医疗保健研究与质量机构进行评估,采用Stata17.0软件进行Meta分析。结果共纳入27篇文献,包括243530例患儿。Meta分析结果显示,中国儿童青少年遗尿症患病率为6.1%(95%CI=5.1%~7.2%),其中,男性(OR=1.52,95%CI=1.41~1.64)、遗尿症家族史(OR=3.46,95%CI=2.01~5.93)、便秘(OR=2.32,95%CI=1.59~3.40)、尿路感染史(OR=2.33,95%CI=1.81~3.01)、睡眠障碍(OR=2.01,95%CI=1.10~3.67)、尿频(OR=1.90,95%CI=1.43~2.52)、尿急(OR=1.67,95%CI=1.31~2.12)、尿失禁(OR=4.85,95%CI=2.78~8.45)是儿童青少年遗尿症的危险因素(P<0.05);排尿训练(OR=0.11,95%CI=0.02~0.46)是儿童青少年遗尿症的保护因素(P<0.05)。结论中国儿童青少年遗尿症患病率较高,性别、遗尿症家族史、便秘、尿路感染史、排尿训练、睡眠障碍、尿频、尿急、尿失禁是儿童青少年遗尿症的主要影响因素。因此,未来应对儿童青少年遗尿症进行早期识别和干预,提高家长对遗尿症的重视,做好疾病宣教普及,减少遗尿症患病率,提高患儿及家庭生活质量。

关键词：遗尿遗尿症儿童青少年患病率影响因素 Meta分析