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Synthesis of Chiral Amino Cyclic Phosphoric Acids

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Wuhan University Journal of Natural Sciences 2000年第4期5卷 497-499页

作者： Zhang Zhan, Hu Quan-yuan, Deng Fa-da, shu jia-you, He jian-she, Hu Xian-ming College of Chemistry and Environmental Science, Wuhan University, Wuhan 430072 College of Chemistry and Environmental Science Wuhan University Wuhan

Chiral amino cyclic phosphoric acids, 5-amino-2-hydroxy-4-(4-nitrophenyl)-1,3,2-dioxaphosphorinane 2-oxide and 2-hydroxy-4-(4-methylsulfonylphenyl)-5-phthalimido-1,3,2-dioxaphos phorinane 2-oxide are synthesized in good over yields (64.2%and 72.8%respectively) from 2-amino-1-aryl-1,3-propanediols. The different reaction conditions are necessary in hydrolysis reactions of amino cyclic phosphonyl chlorides.

关键词： chiral amino cyclic phosphoric acid amino diols synthesis

Flotation separation of chalcopyrite from pyrite using mineral fulvic acid as selective depressant under weakly alkaline conditions

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中国有色金属学报 2025年第1期35卷 313-325页

作者： Zhi-hao SHEN shu-ming WEN jia-mei HAO Qi-cheng FENG State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China

Mineral fulvic acid(MFA)was used as an eco-friendly pyrite depressant to recover chalcopyrite by flotation with the use of the butyl xanthate as a *** experiments showed that MFA produced a stronger inhibition effect on pyrite than on *** separation of chalcopyrite from pyrite was realized by introducing 150 mg/L MFA at a pulp pH of approximately *** copper grade,copper recovery,and separation efficiency were 28.03%,84.79%,and 71.66%,*** adsorption tests,zeta potential determinations,and localized electrochemical impedance spectroscopy tests showed that more MFA adsorbed on pyrite than on chalcopyrite,which weakened the subsequent interactions between pyrite and the *** force microscope imaging further confirmed the adsorption of MFA on pyrite,and X-ray photoelectron spectroscopy results indicated that hydrophilic Fe-based species on the pyrite surfaces increased after exposure of pyrite to MFA,thereby decreasing the floatability of pyrite.

关键词： mineral fulvic acid chalcopyrite pyrite flotation separation

月桂酸二乙醇酰胺修饰利福喷丁脂质体的制备、性质及肺部给药

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药学学报 2006年第8期41卷 761-764页

作者：束家有全向阳束怡广一平刘有成武汉大学药学院湖北武汉430072 武汉结核病院湖北武汉430070

目的制备表面活性剂修饰利福喷丁（RIF）脂质体，进行该脂质体水化性能、载药量、释药速度和肺部给药研究。方法采用薄膜超声法制备利福喷丁脂质体，比较月桂酸二乙醇酰胺（LDEA），Tween80和azone修饰利福喷丁脂质体的形态、包封率... 详细信息

目的制备表面活性剂修饰利福喷丁（RIF）脂质体，进行该脂质体水化性能、载药量、释药速度和肺部给药研究。方法采用薄膜超声法制备利福喷丁脂质体，比较月桂酸二乙醇酰胺（LDEA），Tween80和azone修饰利福喷丁脂质体的形态、包封率、释药速度和离体猪肺膜透过性，通过纤支镜进行肺部给药研究。结果 RIF-LDEA脂质体粒径在15～50nm，包封率为83．0％，表观透膜系数Kp为44.29；LD50为675mg·kg^-1。结论 LDEA修饰使利福喷丁脂质体的载药量增加1倍、释药速度的可调性强及安全性好。经纤支镜介导灌注给药治疗肺内膜结核的效果显著。

关键词：利福喷丁脂质体月桂酸二乙醇酰胺肺部给药

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利福喷丁自乳化胶囊制备及释药特性研究

中国药学杂志 2005年第20期40卷 1556-1558页

作者：周广治阮启蒙孙雪琼束家有武汉大学药学院湖北武汉430072

目的研制利福喷丁自乳化胶囊,探索固态自乳化药物释放系统(SEDDS)的释药特性。方法用正交试验设计优化由利福喷丁、OP 10-司盘85复合乳化剂、PEG 4000辅助表面活性剂组成的SEDDS处方,制备利福喷丁半固态自乳化膏体填充胶囊,测定自乳化... 详细信息

目的研制利福喷丁自乳化胶囊,探索固态自乳化药物释放系统(SEDDS)的释药特性。方法用正交试验设计优化由利福喷丁、OP 10-司盘85复合乳化剂、PEG 4000辅助表面活性剂组成的SEDDS处方,制备利福喷丁半固态自乳化膏体填充胶囊,测定自乳化胶囊的释放度,并考查其模拟体内吸收特性。结果该处方制备的利福喷丁自乳化胶囊能够迅速溶解并乳化,模拟体内吸收是普通利福喷丁胶囊的36倍。结论自乳化胶囊明显提高利福喷丁的释药速率并促进其体内吸收。

关键词：利福喷丁自乳化药物释放系统模拟体内吸收

Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation

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Journal of Animal Science and Biotechnology 2025年第1期16卷 193-205页

作者： Lei jia Wenying Zhang Tao Luo Yongtao Li jianhong shu Julie Strand Yuan Yue Stig Purup jianxin Liu Hengbo Shi Zhejiang Key Laboratory of Cow Genetic Improvement&Milk Quality Research Institute of Dairy ScienceCollege of Animal SciencesZhejiang UniversityHangzhou 310058China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Animal and Veterinary Sciences Aarhus UniversityTjele DK‑8830Denmark Ministry of Education Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou 310058China

Background Although several cell culture systems have been developed to investigate the function of the mam-mary gland in dairy livestock,they have potential limitations,such as the loss of alveolar structure or genetic and phe-notypic differences from their native *** these challenges is crucial for lactation *** of protocols to establish lactating organoid of livestock represents a promising goal for the *** this study,we developed a protocol to establish a culture system for mammary organoids in dairy goats to model the mammary gland development and lactation *** The organoids cultured within an extracellular matrix gel maintained a bilayer structure that closely resem-bled the native architecture of mammary *** expansion of mammary organoids was significantly promoted by growth factors containing epidermal growth factor and fibroblast growth factor 2 whereas the proliferative index of the organoids was significantly inhibited by the treatment with WNT *** stimulation with a lactogenic medium containing prolactin,the mammary organoids exhibited efficient lactation,characterized by the accumu-lation of lipid droplets in the lumen *** lactation could be sustained for more than 3 ***,the expression patterns of genes related to fatty acid synthesis and milk proteins in lactating organoids closely mirrored those observed in mammary *** observations were confirmed by data from proteomic analysis that the bulk of milk proteins was produced in the lactating *** This study is the first to establish a mammary organoid culture system modeling the mammary gland development and lactation process in *** efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.

关键词： Cell-based milk production Lactation Mammary gland Organoid

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian jia William Yi Wang Jun-Lei Yin Xing-Yu Gao shu-Feng Yang Hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

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4,4'-二羟基二苯甲酮的合成

中国医药工业杂志 2005年第4期36卷 197-198页

作者：阮启蒙伍杰束怡周广治束家有武汉大学药学院湖北武汉430072 湖北科兴医药化工股份有限公司湖北襄樊441021

用乙酸酐保护对羟基苯甲酸的羟基,再经氯化亚砜酰氯化、与苯酚成酯得到对乙酰氧基苯甲酸苯酯,最后经脱乙酰保护基和Fries重排得到4,4'-二羟基二苯甲酮,总收率68%。

关键词： 4,4’-二羟基二苯甲酮中间体合成

月桂酸单乙醇酰胺修饰利福平脂质体制备及性能研究

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中国医院药学杂志 2009年第1期29卷 16-19页

作者：陈永顺方侃徐春丽束家有郧阳医学院附属太和医院药学部湖北十堰442000 武汉大学药学院湖北武汉430072

目的:制备表面活性剂修饰的利福平(RFP)脂质体,进行脂质体水化性能、载药量、释药速度和肺膜透过研究。方法:采用薄膜超声法制备利福平脂质体,考察月桂酸单乙醇酰胺(LMEA)、月桂氮芯卓酮、聚山梨醇酯对利福平脂质体形态、粒径分布、包... 详细信息

目的:制备表面活性剂修饰的利福平(RFP)脂质体,进行脂质体水化性能、载药量、释药速度和肺膜透过研究。方法:采用薄膜超声法制备利福平脂质体,考察月桂酸单乙醇酰胺(LMEA)、月桂氮芯卓酮、聚山梨醇酯对利福平脂质体形态、粒径分布、包封率、稳定性和释药速度的影响。结果:LMEA-RFP脂质体粒径25～64nm;包封率为85.3%;8h肺膜累积透过率可达61.84%,表观透膜系数KP=42.9,LD50为610mg·kg-1。结论:LMEA修饰的利福平脂质体载药量增加,具有稳定性好、毒性低的特点。

关键词：利福平脂质体月桂酸单乙醇酰胺

白榆无性系生长特性及离子分布对NaCl胁迫的响应

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北京林业大学学报 2017年第5期39卷 48-57页

作者：苏丹殷小琳董智慕德宇张晓晓贾淑友山东农业大学林学院山东省土壤侵蚀与生态修复重点实验室泰山森林生态站中国水利水电科学研究院西北农林科技大学林学院

白榆是滨海盐碱地最重要的潜在造林树种,以白榆无性系EC7和EC51为实验材料,采用盆栽实验的方法,研究5种NaCl浓度(0、50、85、120、155 mmol/L)下2个无性系生长状况及Na^+、Cl^-和K^+在各器官的积累特点,以期探索白榆无性系各器官离子分... 详细信息

白榆是滨海盐碱地最重要的潜在造林树种,以白榆无性系EC7和EC51为实验材料,采用盆栽实验的方法,研究5种NaCl浓度(0、50、85、120、155 mmol/L)下2个无性系生长状况及Na^+、Cl^-和K^+在各器官的积累特点,以期探索白榆无性系各器官离子分布与积累特征及其对NaCl的响应,比较2个无性系的耐盐性,为白榆无性系在滨海盐碱地的引种栽培提供理论基础。结果显示:1)盐胁迫条件下,白榆无性系叶片黄化、干枯等盐害症状会随着浓度的增大而加重,在155 mmol/L的高盐浓度胁迫下,EC7植株死亡而EC51无死亡现象,且在相同NaCl浓度下EC7的盐害症状较EC51严重;NaCl胁迫明显抑制了白榆无性系生物量的积累,地上部位的抑制现象更加明显,在大于50 mmol/L的盐浓度胁迫下EC7各部分的生物量显著减少(P茎>叶。Cl^-的分布特点为根>叶>茎。在大于85 mmol/L的盐浓度胁迫下,EC51各器官的Na^+含量增加幅度较EC7小;EC51根中的Cl^-积累较叶中多,而EC7在叶中积累较多。EC51的离子分配模式减少了盐害离子在光合器官的积累。Cl^-含量在茎中最少,由此推断,茎器官可能只是一种传输通道。3)K^+在各器官的含量与对照相比显著降低,EC7的降幅较大,在根和叶中尤为明显,EC51在大于85 mmol/L的盐浓度下K^+含量变化较稳定,且EC51各器官中K^+含量均高于EC7。EC51在茎和叶中K^+/Na^+离子比值高于同浓度下EC7,表明EC51更能适应盐胁迫的高渗环境。研究表明,白榆无性系EC7和EC51均有一定的耐盐能力,能够在小于85 mmol/L的环境中良好生长,在盐浓度大于85 mmol/L的胁迫条件下,EC51较EC7有更强的适盐能力。

关键词：白榆无性系盐害症状生物量离子分布适盐能力滨海盐碱地