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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

基于高校管理视角的辅导员能力素质提升策略研究

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价值工程 2014年第16期33卷 236-238页

作者：胡桂花彭小银关树基广州康大职业技术学院广州511363

建设专业化、专家化、职业化的高素质稳定的辅导员队伍是近十年来业界一直在呼吁和努力实践的工作方向。加强辅导员队伍建设,需要从提升辅导员能力素质入手。本文提出可从构建辅导员能力素质提升机制、分阶段实施辅导员能力素质提升、... 详细信息

建设专业化、专家化、职业化的高素质稳定的辅导员队伍是近十年来业界一直在呼吁和努力实践的工作方向。加强辅导员队伍建设,需要从提升辅导员能力素质入手。本文提出可从构建辅导员能力素质提升机制、分阶段实施辅导员能力素质提升、营造良好的培养环境三方面提升辅导员能力素质。

关键词：辅导员能力素质提升策略

Comparison of three fundus inspection methods during phacoemulsification in diabetic white cataract

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1782-1788页

作者： shu Su jian Wu Min ji Yu guan Yao Shen Huai-jin guan Eye Institute Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

AIM:To investigate whether Wild Field Imaging System(WFIS SW-8000),25G endoilluminator,and intraoperative optical coherence tomography(iOCT)can perform realtime screening and diagnosing in patients with suspicious diabetic retinopathy(DR)during phacoemulsification,especially in cases of white ***:A cross-sectional study was carried out.A total of 204 dense diabetic cataractous eyes of 204 patients with suspected DR treated from April 2020 to March 2021 were *** combined with intraocular lens implantation was *** the removal of the lens opacity,the 25G endoilluminator,fundus photography,and iOCT were performed *** coherence tomography(OCT)and/or fundus fluorescein angiography(FFA)were used to verify the fundus findings *** and postoperative results were compared to verify the accuracy of intraoperative diagnosis in each ***:Intraoperative and postoperative examinations revealed 58 and 62 eyes with DR,respectively(positive rate,28.43%and 30.39%,respectively).During the phacoemulsification,WFIS SW-8000 detected 44 eyes with DR(the detection rate,70.97%);25G endo-illuminator found 56 eyes with DR(the detection rate,90.32%);iOCT found 46 eyes with DR(the detection rate,74.19%);and 58 eyes with DR were found by combining the three methods(the detection rate,93.55%).There were statistically significant differences in the diagnostic sensitivity for DR among the methods(χ^(2)=16.36,P=0.001).CONCLUSION:WFIS SW-8000,25G endo-illuminator,iOCT,and especially their combination can be used to inspect the fundus and detect DR intraoperatively;they are helpful for the timely diagnosis and treatment of DR in patients with dense cataract.

关键词： diabetic white cataract fundus inspection phacoemulsification diabetic retinopathy

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民办高职院校大学生参与志愿服务的调查报告

湖南邮电职业技术学院学报 2014年第1期13卷 37-40页

作者：刘永钦关树基廖江龙李金连刘付娟广州康大职业技术学院广东广州511363

基于对广州几所民办高职院校大学生参与志愿服务现状的调查,分析了当前民办高职院校大学生志愿服务的现状以及所面临的困难及其影响因素,并在此基础上,提出了建立健全科学高效的志愿服务规划工作、宣传机制、组织建设、长效服务制度建... 详细信息

基于对广州几所民办高职院校大学生参与志愿服务现状的调查,分析了当前民办高职院校大学生志愿服务的现状以及所面临的困难及其影响因素,并在此基础上,提出了建立健全科学高效的志愿服务规划工作、宣传机制、组织建设、长效服务制度建设等方面的关于推进民办高职院校大学生志愿服务工作的思考,为大力支持与开创民办高职院校自身特色的志愿服务工作发展之路提供研究支持。

关键词：民办高校大学生志愿服务特色发展

Data-driven casting defect prediction model for sand casting based on random forest classification algorithm

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China Foundry 2024年第2期21卷 137-146页

作者： Bang guan Dong-hong Wang Da shu Shou-qin Zhu Xiao-yuan ji Bao-de Sun Shanghai Key Lab of Advanced High-Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Lab of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China Hefei Casting and Forging Factory of Anhui Heli Co. LtdHefei 230000China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China

The complex sand-casting process combined with the interactions between process parameters makes it difficult to control the casting quality,resulting in a high scrap rate.A strategy based on a data-driven model was proposed to reduce casting defects and improve production efficiency,which includes the random forest(RF)classification model,the feature importance analysis,and the process parameters optimization with Monte Carlo *** collected data includes four types of defects and corresponding process parameters were used to construct the RF *** results show a recall rate above 90% for all *** Gini Index was used to assess the importance of the process parameters in the formation of various defects in the RF ***,the classification model was applied to different production conditions for quality *** the case of process parameters optimization for gas porosity defects,this model serves as an experimental process in the Monte Carlo method to estimate a better temperature *** prediction model,when applied to the factory,greatly improved the efficiency of defect *** show that the scrap rate decreased from 10.16% to 6.68%.

关键词： sand casting process data-driven method classification model quality prediction feature importance

Unified Principal S-N Equation for Friction Stir Welding of 5083 and 6061 Aluminum Alloys

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Chinese Journal of Mechanical Engineering 2021年第2期34卷 190-200页

作者： Xiangwei Li ji Fang Xiaoli guan CRRC QIQIHAR ROLLING STOCK CO. LTDQiqihar 161000China College of Locomotive and Rolling Stock Engineering Dalian Jiaotong UniversityDalian 116028China

With the popularization of friction stir welding(FSW),5083-H321 and 6061-T6 aluminum alloy materials are widely used during the FSW *** this study,the fatigue life of friction stir welding with two materials,i.e.,5083-H321 and 6061-T6 aluminum alloy,are *** tests were carried out on the base metal of these two materials as well as on the butt joints and overlapping FSW *** principle of the equivalent structural stress method is used to analyze the FSW test data of these two *** fatigue resistances of these two materials were com-pared and a unified principal S-N curve equation was *** key parameters of the unified principal S-N curve obtained by fitting,Cd is 4222.5,and h is 0.2693.A new method for an FSW fatigue life assessment was developed in this study and can be used to calculate the fatigue life of different welding forms with a single S-N *** main fatigue tests of bending and tension were used to verify the unified principal S-N curve *** results show that the fatigue life calculated by the unified mean 50%master S-N curve parameters are the closest to the fatigue test *** reliability,practicability,and generality of the master S-N curve fitting parameters were verified using the test *** unified principal S-N curve acquired in this study can not only be used in aluminum alloy materials but can also be applied to other materials.

关键词： 5083 and 6061 aluminum alloy Friction stir welding Master S-N curve Fatigue life

Asymmetric neutron stars in the presence of vacuum fluctuations

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Nuclear Science and Techniques 2016年第1期27卷 111-116页

作者： Hong-Hui guan Chen Wu ji-Feng Yang Department of Physics East China Normal University Shanghai Institute of Applied Physics Chinese Academy of Sciences Kavli Institute for Theoretical Physics China Chinese Academy of Sciences

The asymmetric neutron stars are investigated in a relativistic effective model with vacuum fluctuations(VF) taken into account. Due to the VF effects, various properties of the neutron matter become ‘softened' comparing to that obtained in the FSUGold model, and the maximum mass of the enpelT neutron stars is reduced from1.71 M to 1:35M.

关键词：真空涨落中子星非对称中子物质最大质量相对论不对称 COM

Effect of Meridional Characteristic Angle on Aerodynamic Performance of Ram-Rotor

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Journal of Thermal Science 2020年第3期29卷 753-762页

作者： HAN ji'ang guan jian ZHONG jingjun CHEN Luting Naval Architecture and Ocean Engineering College Dalian Maritime UniversityDalian 116026China Merchant Marine College Shanghai Maritime UniversityShanghai 201306China

A kind of meridional concept which has a shape of contraction-expansion(Con-Exp)was applied to the ram-rotor in the paper,and detailed numerical simulation to understand the impact of meridional shape and geometric characteristic angle on the aerodynamic behavior of ram-rotors has been *** to baseline,there was a positive effect in intensifying shock train and suppressing low momentum fluid in Con-Exp scheme,and the pressure ratio and efficiency of Con-Exp scheme increased by 2.075%and 3.160%,*** the contracting angle was increasing,supersonic flow at and after throat region accelerated remarkably,and the static pressure rise was decreased *** terminating shock train was transformed to terminating shock,and the efficiency of ram-rotor was unfavorable to improve due to low throttle *** expanding angle rose,the terminating shock moved forward and turned to shock train *** pressure rise capacity and throttling ability of ram-rotor were *** low momentum fluid was accumulated near the middle and upper flow-path,yielding greater flow loss at large expanding angle.

关键词： ram-rotor meridional shape contracting angle expanding angle numerical simulation

Effect of Vane Opening on Aerodynamic Performance of the Ram-rotor Test System

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Journal of Thermal Science 2016年第3期25卷 207-215页

作者： HAN ji-ang guan jian ZHONG jingjun YUAN Chenguang Marine Engineering College Dalian Maritime University

In order to research the influence of adjustable vane on the aerodynamic performance of the ram-rotor test system, FLUENT soft-ware has been adopted to simulate the flow passage of the ram-rotor test system numerically. The vane opening is controlled by changing the stagger angle of the vane blades. Results show that flow uniformity of vane outlet is influenced by the vane openings, which has an impact on the aerodynamic loss to some extent. Total pressure ratio, adiabatic efficiency and mass flow rate can be regulated by different openings of the vane. Compared with -8° vane opening, top efficiency of the ram-rotor increases by about 13.8% at ＋6° opening. And total pressure ratio drops by 5.87%. The rising opening increases the relative Mach number at inlet of the ram-rotor and weakens the intensity of the tip clearance leakage, which comes to a decreasing aerodynamic loss.

关键词： adjustable vane ram-rotor test system aerodynamic performance numerical simulation