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UV and X-ray variability of the narrow-line Seyfert 1 galaxy Ark 564

Research in Astronomy and Astrophysics 2016年第7期16卷 69-76页

作者： Savithri H.Ezhikode Gulab C.Dewangan Ranjeev Misra shruti tripathi Ninan Sajeeth Philip Ajit K.Kembhavi Department of Physics St. Thomas College Kozhencherry Kerala 689641 India Inter-University Centre for Astronomy & Astrophysics Post Bag 4 Ganeshkhind Pune 411 007 India Physics Department Bishop's University 2600 College Street Sherbrooke QC J1M1Z7 Canada

We analyze eight XMM-Newton observations of the bright Narrow Line Seyfert 1 galaxy Arakelian 564（Ark 564）. These observations, separated bye^6 days, allow us to look for correlations between the simultaneous ultraviolet（UV） emission（from th Optical Monitor） with not only the X-ray flux but also with different X-ray spectral parameters. The X-ray spectra from all the observations are found to be adequately fitted by a double Comptonization model where the soft excess and the hard X-ray power law are represented by thermal Comptonization in a low temperature plasma and hot corona, respectively. Apart from the fluxes of each component, the hard X-ray power law index is found to be variable. These results suggest that the variability is associated with changes in the geometry of the inner region. The UV emission is found to be variable and well correlated with the high energy index while the correlations with the fluxes of each component are found to be weaker. Using viscous timescale arguments we rule out the possibility that the UV variation is due to the fluctuating accretion rate in the outer disk. If the UV variation is driven by X-ray reprocessing, then our results indicate that the strength of the X-ray reprocessing depends more on the geometry of the X-ray producing inner region rather than on the X-ray luminosity alone.

关键词： galaxies active galaxies Seyfert galaxies individual(Ark 564) X-rays galaxies

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Stereotactic radiosurgery in the era of novel systemic therapy for lung cancer brain metastases

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 17-25页

作者： Sarah Mudra shruti Bhandari Prashant tripathi Neal Dunlap Goetz Kloecker University of Louisville School of Medicine LouisvilleKY 40202USA Department of Internal Medicine Division of Hematology and Medical OncologyJames Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY 40202USA Division of Infectious Disease University of Louisville School of MedicineLouisvilleKY 40202USA Department of Radiation Oncology James Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleKY 40202USA

The emergence of novel systemic therapies has spurred a dramatic paradigm shift in lung cancer *** has revealed greater intracranial efficacy in targeted agents and immune checkpoint inhibitors(ICI)compared to conventional ***,advances in stereotactic radiosurgery(SRS)have contributed to the increased use of this highly localized,minimally-invasive treatment modality for local tumor *** this era of precision medicine,the combination of these novel agents and SRS demands further prospective exploration-particularly as questions regarding their sequence of administration and the risk of neurotoxicity remain ***,although data are limited and largely retrospective,literature supports the concurrent administration of ICI and radiation,with no observed increases in immune-related adverse events or acute neurologic *** the case of patients with driver mutations,newer generations of tyrosine kinase inhibitors(TKI)display improved intracranial efficacy and are currently preferred alone upfront in patients with asymptomatic brain metastases(BM)due to lack of *** of combining TKI and SRS is limited with mixed *** this review,we explore the evidence regarding the use of novel systemic agents and SRS for treatment of lung cancer *** practice will continue to be refined as larger,prospective studies yield results.

关键词： Lung cancer stereotactic radiosurgery brain metastasis tyrosine kinase inhibitors immunotherapy

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