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Phytochemical investigation, antioxidant and wound healing activities of Citrullus colocynthis (bitter apple)

Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 418-424页

作者： Sateesh Chandra Gupta Tusha Tripathi shravan kumar paswan Annie G.Agarwal Chandana V.Rao Om P.Sidhu Department of Phytochemistry CSIR-National Botanical Research Institute Department of Pharmacology CSIR-National Botanical Research Institute

Objective: To undertake metabolite profiling of various plant parts of Citrullus colocynthis, and assess antioxidant and wound healing activities of fractions for therapeutical applications. Methods: Extracts from leaves, stem, root, fruit pulp and seeds were analyzed using gas chromatography-mass spectrometry and high performance liquid chromatography. Variation in antioxidant potential was assayed by 1,1-diphenyl-2-picrylhydrazyl(DPPH) free radical scavenging assay. The extract with highest antioxidant potential was subjected on in-vivo wound healing activity using excision wound model. Results: Metabolite profiling of Citrullus colocynthis identified 70 chemically diverse metabolites from different plant parts by using a combination of GC-MS and HPLC. Concentration of colocynthin, a principal active secondary metabolite, ranged from 3.15 mg/g dry weight to 242.00 mg/g dry weight, the lowest being in leaves and highest in fruit pulp. DPPH radical scavenging activity of free radical(IC50) ranged from 196.44 μg/mL in fruit pulp to 413.33 μg/mL in leaves tissues. Significant wound contraction and increase in hydroxyproline content of granulation tissue were observed with ointment formulated from methanolic extract of fruit pulp. Conclusions: The study indicates that the methanol extract of Citrullus colocynthis fruit pulp when applied topically may promote wound contraction in rat model attributable to the accumulation of colocynthin. The high quantity of colocynthin(242.00 mg/g dry weight) and substantial concentration of 2,4-di-tert butyl phenol(3.2%), squalene(4.2%) and δ-tocopherol(2.5%) make this plant to provide new opportunities for development of medicinal, nutraceutical and dietary supplements with optimized functionality.

关键词： Metabolite profiling Citrullus colocynthis GC-MS Antioxidant Wound healing

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Socio-scientific quantification of the comprehensive benefits of debris flow mitigation measures for villages in western Sichuan, China

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Journal of Mountain Science 2024年第5期21卷 1598-1612页

作者： DENG Ting XU Pei LI Ming LU Yafeng WANG Yukuan LI Zhengyang shravan kumar Ghimire Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610299China University of Chinese Academy of Sciences Beijing 100049China

Debris flow hazards seriously threaten thesafety and sustainable development of mountainousareas. Numerous debris flow mitigation measures havebeen implemented worldwide;however, acomprehensive assessment of the specific disasterreduction effects of these measures and their economic,social and ecological benefits is yet to be *** western region of Sichuan Province frequentlysuffers from geohazards such as debris flow, and thegovernment has adopted many mitigation *** study assessed the benefits of debris flowmitigation measures and identified the key influencingfactors via a field-based study conducted in 81 villagesin western Sichuan province, China. A framework forthe evaluation of the benefits of rural debris flowmitigation measures was constructed andquantitatively evaluated using a survey. Snowballsampling was performed to recruit 81 village leadersand 468 farmers. The results showed that managementand engineering measures were the main methodsused to mitigate debris flow;ecological measures wereauxiliary. The average satisfaction scores of farmers forthese three types of measures were 4.07, 3.90, and 3.56,respectively (as measured on a five-point Likert scale).In contrast, in terms of the benefits of these mitigationmeasures, only a small proportion of villages (11.11%)obtained a high level of comprehensive benefits fromthe debris flow mitigation measures, while the majority(88.89%) received medium to low-level benefits. Toimprove this situation, we further studied and foundthat the main factors that restricted villages fromachieving high-level comprehensive benefits were theunpredictable nature of debris flows, labour forceoutflow and remoteness. Effective control measures, agood economic environment and strong governmentassistance were reported as crucial factors forimproving these comprehensive benefits. This studyprovides socio-scientific references for decisionmakingon rural debris flow mitigation measures while keeping villages at the

关键词： Mitigation measures Comprehensive benefit evaluation Debris flow Mountain development Rural areas

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Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

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Journal of Coastal Life Medicine 2017年第5期5卷 224-232页

作者： Pritt Verma shravan kumar paswan Abhisek Raj Virendra Nath Ramesh kumar Gupta Shikhar Verma Sajal Srivastava ChandanaVenketshwara Rao Pharmacognosy and Ethnopharmacology Division CSIR-National Botanical Research InstituteLucknowIndia Amity Institute of Pharmacy Amity UniversityLucknowIndia Department of Pharmaceutical Sciences Central University of RajasthanRajasthanIndia Sherwood College of Pharmacy Barabanki-225001India

Objective: To investigated the hematological, antioxidant and protective performance of Usnea longissima (U. longissima) on CCl4 induced hepatotoxicity in experimental animals. Methods: Hepatotoxicity was induced by CCl4 (1 mL/kg body weigt 1:1 CCl4 i.p.), ethanolic U. longissima extracts at a doses (200 and 400 mg/kg body weigt) were administered to and compared with Silymarin (25 mg/kg body weigt) and hematological, antioxidant and enzymatic, non-enzymatic parameters were assessed through the liver functions test. All the observation was also supplemented with histopathological examination of liver sections. Results: Phytochemical investigation showed that ethanolic extract contains poly phenolic compounds tannins, flavonoids, alkaloids and saponins and acute toxicity study shows that ethanolic extract was safe up to 2000 mg/kg body weight. The toxicant induced a rise in the plasma enzyme levels of ALT, AST, ALP and total bilirubin level. This increased level was significantly decreased by the extract at 400 mg/kg body weight than 200 mg/kg body weight. The animals were prevented (partly or fully) which was showed in the histopathological changes using ethonolic U. longissima extract. Conclusions: The outcome of this study reveals that, there is a powerful antioxidant and hepatoprotective activity of U. longissima. It is believed that the present constituents are responsible for courting the hepatic disease and alternative components have the power to act as free radical scavenging properties.

关键词： Usnea longissima Carbon tetra chloride (CCl4) Hematological Antioxidant Histopathological

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Metaheuristics with Vector Quantization Enabled Codebook Compression Model for Secure Industrial Embedded Environment

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Intelligent Automation & Soft Computing 2023年第6期36卷 3607-3620页

作者： Adepu shravan kumar S.Srinivasan Department of Biomedical Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesSaveetha UniversitySaveetha NagarThandalamChennai602105India

At the present time,the Industrial Internet of Things(IIoT)has swiftly evolved and emerged,and picture data that is collected by terminal devices or IoT nodes are tied to the user's private *** use of image sensors as an automa-tion tool for the IIoT is increasingly becoming more *** to the fact that this organisation transfers an enormous number of photographs at any one time,one of the most significant issues that it has is reducing the total quantity of data that is sent and,as a result,the available bandwidth,without compromising the image *** compression in the sensor,on the other hand,expedites the transfer of data while simultaneously reducing bandwidth *** traditional method of protecting sensitive data is rendered less effective in an environment dominated by IoT owing to the involvement of third *** image encryp-tion model provides a safe and adaptable method to protect the confidentiality of picture transformation and storage inside an IIoT *** helps to ensure that image datasets are kept *** Linde–Buzo–Gray(LBG)methodology is an example of a vector quantization algorithm that is extensively used and a rela-tively new form of picture reduction known as vector quantization(VQ).As a result,the purpose of this research is to create an artificial humming bird optimi-zation approach that combines LBG-enabled codebook creation and encryption(AHBO-LBGCCE)for use in an IIoT *** the beginning,the AHBO-LBGCCE method used the LBG model in conjunction with the AHBO algorithm in order to construct the *** Burrows-Wheeler Transform(BWT)model is used in order to accomplish codebook *** addition,the Blowfish algorithm is used in order to carry out the encryption procedure so that security may be attained.A comprehensive experimental investigation is carried out in order to verify the effectiveness of the proposed algorithm in comparison to other *** experimental values ensure that the suggeste

关键词： Codebook compression industrial internet of things lbg model metaheuristics vector quantization

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An Optimized Fractional Order PI Controller for Enhancing the Power Quality of Three-phase Solar PV, BESS and Wind Integrated UPQC

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Chinese Journal of Electronics 2023年

作者： shravan kumar Yadav Krishna Bihari Yadav Department of Electrical Engineering National Institute of Technology

This paper focuses on an optimized Fractional order proportional integral(FOPI) Controller for enhancing the power quality of three-phase hybrid energy storage system integrated with Unified Power Quality Conditioner(UPQC). With a view to providing continuous electricity, renewable energy sources(RES) like photovoltaic(PV) array, battery energy storage system(BESS) and wind energy are modeled. To ease the grid’s power quality issues and the harmonics injected by nonlinear loads there endures the UPQC model with series and shunt active filter compensator. Furthermore, PV,wind, and BESS integrated UPQC are capable of solving power quality issues in the event of long voltage interruptions. The shunt compensator of UPQC extracts the power from the hybrid energy systems whereas the load is protected by the series compensator from the grid related power quality issues. Hence, to regulate the voltage of the DC link at the desired level, this paper intends to develop a FOPI controller that exhibits iso-damping properties. Particularly, the gain of the FOPI controller is optimally tuned by a novel hybrid algorithm known as enhanced seagull with rooster update(ES-RU) algorithm that hybrid the concepts of seagull optimization algorithm(SOA) and chicken swarm optimization(CSO).At last, the proposed method was validated during voltage sag/swell, concerning the total harmonic distortion.

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Froth flotation of refuse coal fines and process optimization using 2D surface plots

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Journal of Central South University 2016年第10期23卷 2520-2525页

作者： shravan kumar Veomesh Rawat Department of Fuel and Mineral Engineering Indian School of Mines

Refuse coal fines of size <500 μm was collected from a metallurgical coal preparation plant located in the eastern coalfield region of India. The coal was beneficiated using froth flotation technique to recover clean coal with ash content of about 20% with the highest possible yield. Diesel oil as collector and pine oil as frother were used. Box-Behnken statistical design was followed for analyzing the performance at varying pulp density, collector and frother dosage. Results were discussed using 2D surface plots. Response function predictions determined by the regression analysis show coefficient of correlation(R^2) for yield and the ash content as 0.72 and 0.86, respectively. The highest yield of 45.79% is obtained at pulp density 10%, collector dose 2 kg/t and frother dose 1.5 kg/t. The lowest ash content of 18.9% is obtained at pulp density 10%, collector dose 1 kg/t and frother dose 1 kg/t.

关键词： refuse coal froth flotation Box-Behnken 2D RSM

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Performance analysis of jig for coal cleaning using 3D response surface methodology

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International Journal of Mining Science and Technology 2017年第2期27卷 333-337页

作者： kumar shravan Venugopal R. Department of Fuel and Mineral Engineering Indian Institute of Technology(ISM)Dhanbad826004India

Beneficiation of coal of -4.76 mm + 3 mm size fraction was investigated in a laboratory model Denver *** variables were studied to analyze their effect on the performance of jig in terms of yield and ash content of clean coal. Three-factor three-level Box-Behnken design of experiments with response surface methodology(RSM) was employed to understand the performance behavior of jig. From the study, the bed height was found to be the most significant parameter affecting the yield and ash content of clean coal. It was possible to reduce the ash content from 24.32% in feed to an ash content of 16.55% in clean coal at 2 L/min water flow rate and 10 min jigging time. Influence of operating variables of the jig on responses was presented and discussed in 3D surface plots. The developed model was found to be significant within the range of parameters under investigation with correlation of co-efficient values as 0.99(yield) and 0.98(ash).

关键词：性能分析响应面法三维表面 Box-Behnken设计夹具选煤实验室模型灰分含量

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Transcatheter interventions for severe tricuspid regurgitation:a literature review

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Journal of Geriatric Cardiology 2022年第7期19卷 539-550页

作者： Pramod kumar Ponna Stephen Patin Naga Sai shravan Turaga Dominika M Zoltowska Vishal Devarkonda Ramya Krishna Botta Yashwant Agrawal Gaurav Dhar Internal Medicine Louisiana State University Health Sciences CenterShreveportLAUSA Division of Cardiology University of Arkansas for Medical SciencesLittle RockARUSA Division of Cardiology University of FloridaJacksonvilleFLUSA Division of Infectious Diseases Vanderbilt University Medical CenterNashvilleTNUSA Division of Cardiology Chandler Region Medical CenterChandlerArizonaUSA

The prevalence of tricuspid regurgitation(TR)increases with age,affecting 65%-85%of *** TR is caused by a congenital or acquired abnormality of the tricuspid valve apparatus(leaflets,chordae,papillary muscles,or annulus).Secondary TR is due to insufficient coaptation from dilation of tricuspid valve annulus due to the right ventricle(RV)or right at-rium(RA)remodeling and increased RV *** TR is without increased RV pressures and is associated with atrial *** TR is a benign *** to severe tricuspid regurgitation has independently been associated with in-creased *** of these patients are treated medically due to poor outcomes with surgical repair of isolated *** in-hospital mortality rate is 8.8%,and the median length of stay in hospital is 11 days resulting in higher healthcare *** if the patients undergo surgical repair or replacement,available data do not show improvement in *** a more detailed un-derstanding of the complex anatomy and physiology of the tricuspid valve and significant complications from untreated tricusp-id valve disease,the approach to the management of TR has shifted from a conservative approach to a process of prevention and *** the past decade,transcatheter tricuspid valve interventions and tricuspid annuloplasty rings have been de-veloped,contributing to decreased mortality from surgical *** tricuspid valve intervention techniques have im-proved survival,quality of life,and reduced heart failure *** review summarizes normal anatomy,types of TR,etiology and different mechanisms of TR,echocardiographic assessment of the severe TR,and highlights various percu-taneous transcatheter techniques for tricuspid valve repair.

关键词： anatomy tricuspid regurgitation

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Multipliers on Vector-valued L^1-spaces for Hypergroups

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Acta Mathematica Sinica,English Series 2018年第7期34卷 1059-1073页

作者： R.SARMA N.shravan kumar Vishvesh kumar Department of Mathematics Indian Institute of Technology Delhi

In this article, we extend the well known Wendel＇s theorem to the context of vector-valued L1-spaces on hypergroups. In this regard, various cases have been studied.

关键词： Vector-valued Ll-spaces hypergroups multipliers translation invariant operators Fouriertransform

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The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells

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Journal of Molecular Cell Biology 2014年第4期8卷 312-323页

作者： Tim Ammon shravan kumar Mishra Kaja Kowalska Grzegorz M. Popowicz Tad A. Holak Stefan Jentsch Department of Molecular Cell Biology Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried Germany NMR Spectroscopy Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried Germany Department of Biological Sciences Indian Institute of Science Education and Research (IISER) Mohali Knowledge City Sector 81 SAS Nagar 140306 Punjab India Institute of Structural Biology Helmholtz Zentrum MLinchen Ingolst~idter Landstrasse 1 85764 Neuherberg Germany Faculty of Chemistry Jagiellonian University Ingardena 3 30-060 Cracow Poland

与正规象 ubiquitin 一样蛋白质不同， Hub1 不形成共有原子价与底层结合，但是 proteinsnon-covalently 绑。在 Saccharomyces cerevisiae， Hub1 与 spliceosomes 联系并且调停，没有影响通常拼接的 pre-mRNA SRC1 的其他的拼接。人的... 详细信息

与正规象 ubiquitin 一样蛋白质不同， Hub1 不形成共有原子价与底层结合，但是 proteinsnon-covalently 绑。在 Saccharomyces cerevisiae， Hub1 与 spliceosomes 联系并且调停，没有影响通常拼接的 pre-mRNA SRC1 的其他的拼接。人的 Hub1 高度类似于它的酵母相当或相同的事物，而是它的细胞的 functionremains 大部分未经勘探。这里，我们证明人的 Hub1 作为在酵母绑在 spliceosomal 蛋白质 Snu66；然而， unlikeits S。cerevisiae 相当或相同的事物，人的 Hub1 为生存能力是必要的。在 Hub1 导致的人的 vivo 弄空延长了各种各样的细胞的缺点，包括拼接的点缀畸形，部分原子 retentionof mRNAs，有丝分裂的大祸，并且因而由 apoptosis 的房间死亡。然而， Hub1 弄空的早后果仅仅是严重 splicingdefects 为特定拼接地点导致 exon 跳过和 intron 保留。因此，象 ubiquitin 一样 proteinHub1 不是为拼接，而是其他的拼接的 spliceosome performanceand facilitator 的一个调节的人通常需要的一个正规 spliceosomal 因素。

关键词：选择性剪接细胞功能蛋白质人类泛素保守 RNA剪接 mRNA

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