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2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： shouling luo Jiangnan Pei Yi Yu Chengjie Wang Xiaotian Li Weirong Gu The Department of Obstetrics Obstetrics and Gynecology Hospital of Fudan University

Introduction: To evaluate the predictive utilization of Platelet count, mean platelet volume(MPV) and the platelet distribution width(PDW) in preeclamptic women. Methods: demographic characteristics and laboratory results were collected and compared from 5556 pregnancies pregnancy who received continuous prenatal care and bore in our hospital between 1964 and *** enrolls met the standards were divided into two subgroups depending on the week they had their first antenatal care. The first trimester group who had their first antenatal care before the 14 th week included 175 controls and 73 pregnancies who later developed preeclampsia(PE), and the second trimester group who had their first antenatal care between the 14 th week and the 28 th week included 135 controls and 112 pregnancies who later developed preeclampsia. Their platelet counts, MPV and PDW were measured when they had their first antenatal care. Result: There was no significant difference in age and the basic blood pressure between the study groups. The platelet count( 232.4±3.9 vs 238.9±6.5, p=0.52), MPV(10.3±0.06 vs 10.44±0.10,p=0.84) and PDW(12.0±0.14 vs 12.16±0.24 p=0.45)of the first trimester group had no difference, the PDW(12.02±0.18 vs 12.43±0.21 p=0.60)of the second trimester group had no difference neither, while the platelet count(221.6±4.22 vs 216.3±5.54 p=0.049) was significantly decreased in the PE group compared to the controls, and the MPV(10.25±0.08 vs 10.61±0.13 p<0.0001)was significantly elevated in the PE group compared to the controls. Conclusion: the platelet was significantly decreased and MPV is significantly elevated in the second half of pregnancy in women who later develop PE and might therefore be implemented in combination with other parameters in a PE prediction model.

关键词： preeclampsia platelet platelet indices prediction

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Associations between blood glucose and early- and late-onset colorectal cancer: evidence from two prospective cohorts and Mendelian randomization analyses

Journal of the National Cancer Center

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Journal of the National Cancer Center 2024年第3期4卷 241-248页

作者： Chenyu luo Jiahui luo Yuhan Zhang Bin Lu Na Li Yueyang Zhou Shuohua Chen shouling Wu Qingsong Zhang Min Dai Hongda Chen Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Center for Prevention and Early Intervention National Infrastructures for Translational MedicineInstitute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiology Department Kailuan General HospitalTangshanChina Department of General Surgery Kailuan General HospitalTangshanChina

Background: The incidence of early-onset colorectal cancer (EOCRC), which exhibits differential clinical, patho- logical, and molecular features compared to late-onset CRC (LOCRC), is rising globally. The potential differential effects of blood glucose on EOCRC compared to LOCRC have not been investigated. Methods: This study analyzed 374,568 participants from the UK Biobank cohort and 172,809 participants from the Kailuan cohort. The linear associations between blood glucose and EOCRC/LOCRC were estimated using Cox regression models. Restricted cubic spline (RCS) analysis and non-linear Mendelian randomization (MR) analysis using a 70-SNPs genetic instrument for fasting glucose were used to explore the potential non-linear associations. Results: Participants in the highest quintile of blood glucose had higher overall CRC risk compared to the lowest quintile (HR = 1.10 in the UK Biobank cohort, 95% CI: 1.01-1.21, P -trend = 0.012;HR = 1.23 in the Kailuan cohort, 95% CI: 1.01-1.51, P -trend = 0.036). Elevated glucose ( > 7.0 mmol/L) was more strongly associated with increased risk of EOCRC (HR = 1.61, 95% CI: 1.07-2.44) than with LOCRC (HR = 1.14, 95% CI: 1.02-1.27) in the UK Biobank cohort ( P- heterogeneity = 0.014). Elevated glucose ( > 7.0 mmol/L) was associated with increased risk of LOCRC (HR = 1.25, 95% CI: 1.04-1.65) in the Kailuan cohort as well. There was no evidence for non-linear associations between blood glucose and risks of EOCRC/LOCRC. Conclusions: This study showed a positive association between blood glucose and CRC risk in a dose-response manner, particularly for EOCRC, suggesting that tighter glucose control should be a priority for younger age groups.

关键词： Colorectal cancer Early-onset colorectal cancer Glucose Mendelian randomization Cancer prevention

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面向二进制代码的软错误故障注入器设计与实现

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计算机应用与软件 2021年第10期38卷 8-14页

作者：罗予东董守玲陆璐嘉应学院计算机学院广东梅州514015 华南理工大学计算机科学与工程学院广东广州510641

由于芯片集成度的提高,软错误在现代计算机系统中变得越来越普遍。这些故障对高性能微处理器中的存储器和硬件设备的可靠性造成了重大挑战。设计一种基于PIN的工具来模拟软错误,可以在机器代码级实现硬件故障注入。故障注入器基于二进... 详细信息

由于芯片集成度的提高,软错误在现代计算机系统中变得越来越普遍。这些故障对高性能微处理器中的存储器和硬件设备的可靠性造成了重大挑战。设计一种基于PIN的工具来模拟软错误,可以在机器代码级实现硬件故障注入。故障注入器基于二进制插装,支持准确和低成本的故障注入。在典型的应用程序中进行了示范应用,通过模拟位翻转来分析程序对软错误的响应情况,根据实验结果分析了软错误对程序性能和精度的影响。研究表明,该程序对软错误反应明显,该注入器为未来的故障注入研究提供了一种有效的方法和手段。

关键词：软错误故障注入硬件故障二进制插装位翻转

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Changes in Proteinuria and the Risk of Myocardial Infarction in People with Diabetes or Prediabetes:A Prospective Cohort Study

Changes in Proteinuria and the Risk of Myocardial Infarction...

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2017年中国卫生统计学学术年会

作者： Yang Sun Anxin Wang Xiaoxue Liu Zhaoping Su Junjuan Li Yanxia luo Shuohua Chen Jianli Wang Xia Li Zhao Zhan Huiping Zhu shouling Wu Xiuhua Guo Department of Epidemiology and Health Statistics School of Public HealthCapital Medical University Beijing Municipal Key Laboratory of Clinical Epidemiology Department of Neurology Beijing Tiantan HospitalCapital Medical University Department of Cardiology Tangshan People’s HospitalNorth China University of Science and Technology Department of Epidemiology and Health Statistics Academy of public health and managementWeifang Medical University Department of Nephrology Kailuan General HospitalNorth China University of Science and Technology Department of Cardiology Kailuan General HospitalNorth China University of Science and Technology Department of Mathematics and Statistics La Trobe University State Key Lab. of Transducer Technology Institute of ElectronicsChinese Academy of Sciences Department of Rehabilitation Kailuan General HospitalNorth China University of Science and Technology

Objective The relationship between changes in proteinuria and myocardial infarction（MI）remain unclear in people with diabetes or *** aimed to evaluate the predictive value and independent role of changes in proteinuria over two-year period in the incidence of MI in people with diabetes or *** We used a large Chinese population from the Kailuan prospective study to determine the association between changes in proteinuria over two-year period and risk of *** on the baseline and 2-year dipstick screening results,participants were divided into 4 categories:no proteinuria,remittent proteinuria,incident proteinuria,and persistent *** multivariable Cox proportional hazard models were built to adjust for the effects of different confounding *** 17625 participants were finally included in this *** were a total of 238 incidence of MI during a median follow-up of 6.69 *** adjustment for demography factors and laboratory indexes,the association between persistent proteinuria and MI morbidity were maintained（hazard ratio[HR]2.50,95% confidence interval[CI]1.48 to 4.22）.And each decrease of proteinuria from 2006 to 2008 was responsible for 21% decline of MI morbidity（HR 0.79,95%CI 0.68 to 0.90）.The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI（P=0.3371）.Conclusions Persistent proteinuria is an independent risk factor for incident MI in either diabetic or prediabetic *** findings may help clinicians to interpret proteinuria changes in the outpatient setting and give more attention on prevention for people with prediabetes or diabetes.

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肝硬化患者经颈静脉肝内门体分流术对血流动力学的影响

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中华内科杂志 2020年第9期59卷 700-705页

作者：汪菁峰马婧嶔罗剑钧陈海燕弭守玲陈世耀宿燕岗葛均波复旦大学附属中山医院心内科上海市心血管病研究所上海200032 复旦大学附属中山医院介入治疗科上海200032 复旦大学附属中山医院消化科上海200032

目的探讨肝硬化患者经颈静脉肝内门体分流(TIPS)术对心功能和血流动力学的影响。方法收集2018年1—10月于复旦大学附属中山医院拟行TIPS手术的失代偿肝硬化患者共23例,术前行血清N末端B型利钠肽原(NT-proBNP)、经胸超声心动图检查,心阻... 详细信息

目的探讨肝硬化患者经颈静脉肝内门体分流(TIPS)术对心功能和血流动力学的影响。方法收集2018年1—10月于复旦大学附属中山医院拟行TIPS手术的失代偿肝硬化患者共23例,术前行血清N末端B型利钠肽原(NT-proBNP)、经胸超声心动图检查,心阻抗图法行无创心输出量监测。术后24 h、1个月、6个月对所有患者进行随访,观察TIPS术后心脏功能及血流动力学指标变化特点和趋势。结果与术前比,TIPS术后24 h,右心房面积[(17.2±4.0)cm^2比(15.0±3.4)cm^2,P0.05)。结论心脏对TIPS术后容量负荷增加具有较好适应和代偿能力,以达到新的血流动力学稳态。

关键词：肝硬化门体分流术,经颈静脉肝内心脏功能血流动力学

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粉碎和制粒工艺对孔雀生产性能的影响

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饲料工业 2016年第15期37卷 62-64页

作者：陈玉芹罗琴尹红星许智萍张丽波王明亮李守岭云南省德宏热带农业科学研究所云南瑞丽678600

随着饲料工业的发展及饲养品种的多样化,孔雀的养殖规模逐渐扩大。孔雀作为禽类的一种,除具有禽类的采食习惯外,又有其自身的代谢特点。为避免偏颇,孔雀饲料的质量也日益受到重视。而粉碎和制粒是饲料加工过程中重要的工艺,饲料进行适... 详细信息

随着饲料工业的发展及饲养品种的多样化,孔雀的养殖规模逐渐扩大。孔雀作为禽类的一种,除具有禽类的采食习惯外,又有其自身的代谢特点。为避免偏颇,孔雀饲料的质量也日益受到重视。而粉碎和制粒是饲料加工过程中重要的工艺,饲料进行适当加工可以降低饲料成本、提高经济效益,对饲料利用率和动物生产性能等方面均有重要的作用。文中就饲料生产工序中粉碎和制粒工艺对孔雀生产性能的影响作一综述。

关键词：孔雀粉碎制粒生产性能

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杨春波从“阴虚湿热”论治便秘验案举隅

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浙江中医杂志 2024年第4期59卷 287-288页

作者：罗邦水杨正宁黄守玲倪艺婧黄铭涵福建中医药大学附属第二人民医院福建福州350003

便秘是消化系统的一种常见病,以大便排出困难、排便周期延长,或周期不长但粪质干结、排出艰难,或粪质不硬、虽频有便意但排便不畅为主要表现[1],分为热积秘、寒积秘、气滞秘、气虚秘、血虚秘、阴虚秘、阳虚秘七型[2]。中医药在治疗便秘... 详细信息

便秘是消化系统的一种常见病,以大便排出困难、排便周期延长,或周期不长但粪质干结、排出艰难,或粪质不硬、虽频有便意但排便不畅为主要表现[1],分为热积秘、寒积秘、气滞秘、气虚秘、血虚秘、阴虚秘、阳虚秘七型[2]。中医药在治疗便秘上有很好的疗效,大体将便秘分为虚实两端而治之。而对于证有兼杂,甚至相互矛盾的复合证型的便秘,各医家在治法上各有特色。阴虚湿热秘是便秘的一种特殊证型。杨春波教授系全国第三届国医大师,对湿热证有独到见解,认为阴虚湿热证是湿热证的一种特殊类型,而治疗上仍以清化湿热为总则,把清化为主、滋阴为辅的治疗原则贯穿治疗始终。本文介绍杨老论治“阴虚湿热型”便秘的经验思路,并结合验案一则佐证,以飨同道。

关键词：便秘阴虚湿热名医经验杨春波临床验案

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平胸龟2个地理种群遗传差异的比较

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华中农业大学学报 2008年第4期27卷 510-514页

作者：郑光明马丽莎朱新平刘毅辉陈永乐罗建仁中国水产科学研究院珠江水产研究所广州510380

利用25个随机引物对平胸龟2个种群共49个个体分别进行PCR扩增，结果显示：平均每个个体扩增出209条DNA带，平均每个引物可产生8条带，扩增谱带分子质量大小在100-2000bp之间，多态性比例为72．13％。其中12条引物扩增出16个特异于不同... 详细信息

利用25个随机引物对平胸龟2个种群共49个个体分别进行PCR扩增，结果显示：平均每个个体扩增出209条DNA带，平均每个引物可产生8条带，扩增谱带分子质量大小在100-2000bp之间，多态性比例为72．13％。其中12条引物扩增出16个特异于不同种群的DNA片段，可作为鉴别广东或福建种群的分子标记。用RAPD1．04和Genepop3．2软件分析所得谱带，得出广东、福建2个地理种群的平胸龟具有较高的遗传多样性，且广东种群的遗传多样性高于福建种群。2个种群间的平均遗传距离为0．2786±0．0259，遗传分化指数Gst为0．2857。NJTREE聚类分析显示广东和福建2个地区的平胸龟各自聚成2个类群，有较明显的种群分化。

关键词：平胸龟地理种群遗传差异 RAPD分析

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