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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022年第2期16卷 216-226页

作者： shoubin zhan Ping Yang Shengkai Zhou Ye Xu Rui Xu Gaoli Liang Chenyu zhang Xi Chen Liuqing Yang Fangfang Jin Yanbo Wang Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy State Key Laboratory of Pharmaceutical Biotechnology and Department of PhysiologyJiangsu Engineering Research Center for MicroRNA Biology and BiotechnologyNJU Advanced Institute of Life Sciences(NAILS)School of Life SciencesNanjing UniversityNanjing 210023China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Infectious Diseases The First People's Hospital of LianyungangThe First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungang 222000China

Hepatocellular carcinoma(HCC),which makes up the majority of liver cancer,is induced by the infection of hepatitis B/C *** are needed to facilitate the early detection of HCC,which is often diagnosed too late for effective *** tRNA-derived small RNAs(tsRNAs)play vital roles in tumorigenesis and are stable in ***,the diagnostic values and biological functions of circulating tsRNAs,especially for HCC,are still *** this study,we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC *** identified tRF-Gln-TTG-006,which was remarkably upregulated in HCC serum(training cohort:24 HCC patients vs.24 healthy controls).In the validation stage,we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity(80.4%)and specificity(79.4%)even in the early stage(Stage I:sensitivity,79.0%;specificity,74.8%;155 healthy controls vs.153 HCC patients from two cohorts).Moreover,in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells,and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis *** summary,our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

关键词： tsRNA biomarker hepatocarcinoma

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