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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan lu.Kang Wang Yuanhong Peng Meng Chen Lin Zhong lu.i Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-lu.iferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' uTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu.Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu.Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,inclu.ing neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solu.ion by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.u nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolu.ion

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youlu.n lu.Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolu.ion reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process inclu.es the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolu.ion reaction

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Surface modification of wollastonite by the mechano-activated method and its properties

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International Journal of Minerals,Metallu.gy and Materials 2011年第1期18卷 83-88页

作者： Hao Ding shou-ci lu.Gao-xiang Du School of Materials Science and Technology China University of Geosciences Beijing 100083 China School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

Surface modification of wollastonite particles using titanate as a modification agent incorporated by simultaneous wet ultra-fine grinding in a laboratory stirred mill was *** physical,physic-chemical and application properties of the modified wollastonite were measured and *** results showed that grinding intensity markedly influ.nces the modification effect because of the mechano chemical *** hydrophilic surface of wollastonite was turned into a hydrophobic one after *** interaction between titanate and wollastonite under wet grinding circumstances was *** was suggested that physical adsorption and chemical adsorption of titanate coexisted on the wollastonite *** mechanical properties of polyethylene（PE） filled with the modified wollastonite powder were markedly improved.

关键词： silicate minerals modification surface properties ball milling fillers

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Satellite-based Observational Study of the Tibetan Plateau Vortex:Features of Deep Convective Cloud Tops

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Advances in Atmospheric Sciences 2019年第2期36卷 189-205,248页

作者： Yi-Xuan shou Feng lu.Hui LIu Peng CuI Shaowen shou Jian LIu Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites China Meteorological Administration(LRCVES/CMA) National Satellite Meteorological Center Key Laboratory of Meteorological Disasters Nanjing University of Information Sciences and Technology

In this study, an east-moving Tibetan Plateau vortex(TPV) is analyzed by using the ERA-5 reanalysis and multi-source satellite data, inclu.ing FengYun-2 E, Aqua/MODIS and CALIPSO. The objective is to demonstrate:(i) the usefulness of multi-spectral satellite observations in understanding the evolu.ion of a TPV and the associated rainfall, and(ii) the potential significance of cloud-top quantitative information in improving Southwest China weather forecasts. Results in this study show that the heavy rainfall is caused by the coupling of an east-moving TPV and some low-level weather systems [a Plateau shear line and a Southwest Vortex(SWV)], wherein the TPV is a key component. During the TPV's life cycle, the rainfall and vortex intensity maintain a significant positive correlation with the convective cloud-top fraction and height within a 2.5?radius away from its center. Moreover, its growth is found to be quite sensitive to the cloud phases and particle sizes. In the mature stage when the TPV is coupled with an SWV, an increase of small ice crystal particles and appearance of ring-and u/V-shaped cold cloud-top structures can be seen as the signature of a stronger convection and rainfall enhancement within the TPV. A tropopause folding caused by ageostrophic flows at the upper level may be a key factor in the formation of ring-shaped and u/V-shaped cloud-top structures. Based on these results, we believe that the supplementary quantitative information of an east-moving TPV cloud top collected by multi-spectral satellite observations could help to improve Southwest China short-range/nowcasting weather forecasts.

关键词： Tibetan Plateau vortex multi-spectral satellite observations short-range/nowcasting weather forecasts cold u/V-shaped cloud top tropopause folding

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HEF-19-induced relaxation of colonic smooth muscles and the underlying mechanisms

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World Journal of Gastroenterology 2013年第32期19卷 5314-5319页

作者： Yuan-Yuan Wei lu.lu.Sun shou-Ting Fu Department of Pharmacy Beijing Shijitan HospitalCapital Medical University School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University

AIM:To investigate the relaxant effect of chromane HEF-19 on colonic smooth muscles isolated from rabbits,and the underlying ***:The relaxant effect and action mechanisms of HEF-19 were investigated using descending colon smooth muscle of the *** 1 cm long were mounted in 15-mL tissue baths containing Tyrode’s solu.ion,maintained at 37±0.5℃and aerated with a mixture of 5%CO2in oxygen(Carbogen).The tension and amplitude of the smooth muscle strips were recorded after adding HEF-19(10-6,10-5and 10-4mol/L).After cumulative administration of four antispasmodic agents,inclu.ing acetylcholine chloride(Ach)(10-4mol/L),histamine(10-4mol/L),high-K+(60 mmol/L)and BaCl2(8.2 mmol/L),HEF-19(3×10-7-3×10-4mol/L)was added to investigate the relaxant effect of ***2(10-4-2.5×10-3mol/L)was added cumulatively to the smooth muscle preparations pretreated with and without HEF-19(1×10-6or 3×10-6mol/L)and verapamil(1×10-7mol/L)to study the mechanisms ***,phasic contraction was induced with ACh(15×10-6mol/L),and CaCl2(4×10-3mol/L)was added to the smooth muscle preparations pretreated with and without HEF-19(3×10-6mol/L or 1×10-5mol/L)and verapamil(1×10-7mol/L)in calcium-free medium to further study the underlying ***:HEF-19(1×10-6,1×10-5and 1×10-4mol/L)suppressed spontaneous contraction of rabbit colonic smooth ***-19(3×10-7-3×10-4mol/L)relaxed in a concentration-dependent manner colonic smooth muscle preparations pre-contracted with BaCl2,high-K+solu.ion,Ach or histamine with respective EC50valu.s of 5.15±0.05,5.12±0.08,5.58±0.16and 5.25±0.24,thus showing a spasmolytic ***-19(1×10-6mol/L and 3×10-6mol/L)shifted the concentration-response curves of CaCl2to the right and depressed the maximum response to *** two components contracted by Ach were attenuated with HEF-19(3×10-6mol/L or 10-5mol/L)in calcium-free ***:HEF-19 inhibited rabbit colonic smooth muscle contraction,probably through in

关键词： Colonic smooth muscle Smooth muscle relaxation Ca2+channels

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Alternating Parity Band in Octupole-Soft ^(140)Xe with Axial Vibrational-Rotational Model and Triaxial Rigid Rotor Model

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Chinese Physics Letters 2018年第10期35卷 9-13页

作者： Xiao lu.Bin Qi shou-Yu Wang Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment School of Space Science and Physics Institute of Space Sciences Shandong University

Energies of the yrast positive-and negative-parity excited states in140 Xe are reproduced by two different models considering quadrupole-octupole deformations, namely the axial vibrational-rotational model and the triaxial rigid rotor model, and compared with the stable octupole-deformed222 Th. The origin of the energy difference between the opposite parity sequences is considered from two different mechanisms, the vibration in axial deformed energy minima and the rotation considering the effective triaxial deformation. The success of reproducing the data in both the models implies that these two mechanisms are equivalent on some level for the octupole-soft nuclei. By investigating the probability distributions for projection of total angular momentum in the triaxial rigid rotor model, it is found that such an energy difference is associated with the difference of orientation of the rotational axis.

关键词： Alternating Parity Band in Octupole-Soft Xe with Axial Vibrational-Rotational Model and Triaxial Rigid Rotor Model

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Decreasing Trend of Western North Pacific Tropical Cyclone Inner-Core Size over the Past Decades

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Journal of Meteorological Research 2021年第4期35卷 635-645页

作者： Hanrui shou Tim LI Yuan SuN lu.WANG Jia LIu Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental ChangeNanjing University of Information Science&TechnologyNanjing 210044China International Pacific Research Center and Department of Atmospheric Sciences University of Hawaii at ManoaHonoluluHI96822USA College of Meteorology and Oceanography National University of Defense TechnologyNanjing 211101China

Studies on tropical cyclone(TC)inner-core size have become increasingly active in recent ***,few studies have investigated the trend of TC inner-core ***,we introduce a new index to measure TC inner-core size and calculate the observed *** index can greatly reduce the influ.nce of data heterogeneity and *** also considers public concern because the new index is mainly determined by the inner-core size of strong TCs,which attract more public attention than weak *** results show that in the past decades,TC inner-core size has a significant downtrend that is significant above the 99%confidence level when the new index is *** also show that this trend is probably related to the increase in TC intensity and relatively small inner-core size of strong ***,relative sea surface temperature(SST)is assumed to make contributions to the downtrend of TC inner-core size,which has a significant negative correlation with the new index.

关键词： tropical cyclone(TC) inner-core size trend intensity

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Responses of macrobenthic communities to patchy distributions of heavy metals and petroleum hydrocarbons in sediments:A study in China's Zhoushan Archipelago

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Acta Oceanologica Sinica 2021年第9期40卷 117-125页

作者： Yanbin Tang Qiang Liu Yibo Liao Konglin Zhou lu.shou Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Institute of Oceanography Minjiang UniversityFuzhou 350108China

This study conducted four cruises during 2014–2017 to investigate relationships between macrobenthic communities and sediment contaminations in sea area around the Zhoushan *** sites were categorized into three groups:high total heavy metal contamination content(HHMC),high total petroleum hydrocarbon content(HTPH),and low content ratio of heavy metal contamination content to total petroleum hydrocarbon content(HMC/TPH)*** main taxa of macrofauna(polychaetes,bivalves,gastropods,and crustaceans)were determined to respond to environmental factors *** tolerant polychaetes being the minimal impact by environmental factors,bivalves were threated by heavy metal pollu.ions in ***,body size distribution frequency demonstrated that macrofauna in the low HMC/TPH areas were less disturbed by contamination than those in the HHMC and HTPH *** result represented the presentation of sensitive species while tolerant species are usually considered as small size ***,this study confirmed the hypothesis that the contamination levels of small-scale patches is indicated by the condition of macrobenthic communities.

关键词： macrobenthos heavy metal petroleum hydrocarbon contaminant effect Zhoushan Archipelago

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Simulation and detection of the topological properties of a modulated Rice-Mele model in a one-dimensional circuit-QED lattice

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Science China(Physics,Mechanics & Astronomy) 2018年第8期61卷 17-26页

作者： lu.Qi Yan Xing Ji Cao Xin-Xin Jiang Cheng-shou An Ai-Dong Zhu shou Zhang Hong-Fu Wang Department of Physics College of Science Yanbian University Department of Electronic Information Engineering College of Engineering Yanbian University

Here, we propose a simple scheme to realize a one-dimensional （1D） modulated Rice-Mele model （RMM） and investigate its topological properties with a 1D circuit quantum electrodynamics （QED） lattice. The system can be mapped into a Chern insulator model by introducing a period parameter. Interestingly and surprisingly, we found that the circuit-QED lattice system always exhibits topologically nonttrvial phases if both the nearest-neighbor hopping strength between two resonators and the qubitassisted on-site potentials are alternately changed in the direction of the lattice. The numerical results show that the topological phases can be obtained by introducing an additional modulation parameter and both the edge state and topological invariant can be unambiguously seen with the existence of decay and disorders, even with few resonators in the lattice.

关键词： topological phase topological invariant Rice-Mele model circuit QED

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