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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 624-630页

作者： Kai XU Ya-ling HAN Quan-min JING shou-li wang Ying-yan MA Xiao-zeng wang Geng wang Zu-lu wang Department of Cardiology Shenyang Northern HospitalShenyang 110016China

Objective:There is no simple or feasible post-procedural intravascular ultrasound (IVUS) score to predict major adverse cardiac events (MACE) in patients undergoing drug-eluting stents (DES) implantation. The aim of this study is to validate a new IVUS score for predicting MACE. Methods:A total of 295 patients (with 322 lesions) were enrolled. IVUS score was calculated in each lesion based on five IVUS morphological characteristics:inflow/outflow disease, malapposition, underexpansion, tissue protrusion, and edge dissection (iMUTE score). We assigned two points to an underexpansion and one point for each presence of other factors. Patients were divided into low score (iMUTE scorelinical practice, and can provide independent prognostic value for TVR in patients undergoing DES implantation.

关键词： Intravascular ultrasound Drug eluting stents Scoring schemes percutaneous coronary intervention

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A measurement approach of trust relation in web service

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通讯和计算机（中英文版） 2009年第8期6卷 9-17页

作者： wang shou-xin ZHANG li wang Shuai Software Engineering Institute Beihang University Beijing 100191 China

TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression

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Asian Journal of Andrology 2021年第2期23卷 188-196页

作者： Yue-Mei Hu Xiao-li Lou Bao-Zhu liu li Sun Shan Wan Lei Wu Xin Zhao Qing Zhou Mao-Min Sun Kun Tao Yong-Sheng Zhang shou-li wang Department of Pathology School of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China Department of Pathology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China Collaborative Innovation Center of Clinical Immunology between Soochow University and Sihong People's Hospital Sihong 223900China Department of Pathology Sihong People's HospitalSihong 223900China Laboratory Animal Research Center Soochow University School of MedicineSuzhou 215123China Department of Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Suzhou Key Laboratory of Tumor Microenvironment and Pathology Soochow UniversitySuzhou 215006China

Transforming growth factor-β1(TGF-β1)acts as a tumor promoter in advanced prostate cancer(PCa).We speculated that microRNAs(miRNAs)that are inhibited by TGF-β1 might exert anti-tumor *** assess this,we identified several miRNAs downregulated by TGF-β1 in PCa cell lines and selected miR-3691-3p for detailed analysis as a candidate anti-oncogene ***-3691-3p was expressed at significantly lower levels in human PCa tissue compared with paired benign prostatic hyperplasia tissue,and its expression level correlated inversely with aggressive clinical pathological *** of miR-3691-3p in PCa cell lines inhibited proliferation,migration,and invasion,and promoted *** miR-3691-3p target genes E2F transcription factor 3(E2F3)and PR domain containing 1,with ZNF domain(PRDM1)were upregulated in miR-3691-3p-overexpressing PCa cells,and silencing of E2F3 or PRDM1 suppressed PCa cell proliferation,migration,and *** of mice bearing PCa xenografts with a miR-3691-3p agomir inhibited tumor growth and promoted tumor cell *** with the negative regulation of E2F3 and PRDM1 by miR-3691-3p,both proteins were overexpressed in clinical PCa specimens compared with noncancerous prostate *** results indicate that TGF-β1-regulated miR-3691-3p acts as an anti-oncogene in PCa by downregulating E2F3 and *** results provide novel insights into the mechanisms by which TGF-β1 contributes to the progression of PCa.

关键词： E2F transcription factor 3 miR-3691-3p PR domain containing 1,with ZNF domain prostate cancer transforming growth factor-β1

Coronary collateral circulation： Effects on outcomes of acute anterior myocardial infarction after primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2011年第2期8卷 93-98页

作者： Bin wang Ya-ling Han Yi li Quan-Min Jing shou-li wang Ying-Yan Ma Geng wang Bo Luan Xiao-Zeng wang Department of Cardiology Shenyang North Hospital Shenyang 110016 Liao Ning Province China

Background To investigate the effects of collateral coronary circulation on the outcome of the patients with anterior myocardial infarction （MI） with left anterior desending artery occlusion abruptly. Methods Data of 189 patients with acute anterior MI who had a primary percutaneous coronary intervention （PCI） in the first 12 h from the onset of symptoms between January 2004 and December 2008 were retrospective analyzed. Left anterior descending arteries （LAD） of all patients were occluded. LADs were reopened with primary PCI. According to the collateral circulation, all patients were classified to two groups： no collateral group （n = 111）, patients without angiographic collateral filling of LAD or side branches （collateral index 0） and collateral group （n = 78）, and patients with angiographic collateral filling of LAD or side branches （collateral index 1, 2 or 3）. At one year＇ s follow-up, the occurrence of death, reinfarctlon, stent thrombosis （ST）, target vessel revascularization and readmission because of heart failure were observed. Results At one year, the mortality was lower in patients with collateral circulation compared with those without collateral circulation （1% vs. 8%, P = 0.049）, whereas there Were no differences in the occurrence of reinfarction, ST, target vessel revascularization and readmission because of heart failure. The occurrence of composite of endpoint was lower in patients with collateral circulation compared with those without collateral circulation （12% vs. 26%; P = 0.014）. Conclusions Pre-exist collateral circulation may prefigure the satisfactory prognosis to the patients with acute anterior MI after primary PCI in the first 12 h of MI onset.

关键词： collateral circulation myocardial infarction mortality left anterior descending artery

Study on the Expression and Significance of TGF-β1, p-ERK1/2and K-ras in Colorectal Cancer Using Tissue Microarray Technique

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Clinical oncology and cancer researeh 2011年第1期8卷 21-26页

作者： Xin HU Yu-ting KUANG Mao-min SUN Ying-ying wang Yu-juan ZHANG ling-ling GUO shou-li wang Department of Pathology Medical School of Soochow University Suzhou 215123 Jiangsu Province China Department of Surgery The First Hospital Affiliated to Soochow University Suzhou 215123Jiangsu Province China Department of Anatomy Medical School of Soochow University Suzhou 215123 Jiangsu Province China

OBJECTIVE This study aimed to explore the expression and significance of transforming growth factor β1（TGF-β1）,extracellular signal-regulated kinases 1/2 （ERK1/2）, and K-ras in colorectal cancer （CRC） using tissue microarray *** The expressions of TGF-β1, ERK1/2, and K-ras in colon cancer cells taken from the specimens of 92 CRC patients （stage Ⅰ： 16 cases, stage Ⅱ： 28 cases, stage Ⅲ： 24 cases, and stage Ⅳ：24 cases） were analyzed using tissue microarray technology and immunohistochemistry, and compared with those of 20 normal colon tissue *** High immunoreactive scores （IRS） of TGF-β1,p-ERK1/2, and K-ras protein in CRC were obtained, which were 66.3% （61/92）, 59.8% （55/92）, and 48.9% （45/92）, respectively, and those in normal epithelial cells of colon were 10% （2/20）, 20% （4/20）, and 30% （6/20）, respectively （P 〈 0.05）. The expressions of TGF-β1 and ERK1/2 in CRC at stage Ⅰwere 37.5% and 31.3%,respectively, and those in CRC at stage Ⅳ were 83.3% and79.3%, respectively, with statistically significant differences. No significant relationship was found between K-ras expression and tumor stages （P〉0.05）.CONCLUSION High level expressions of TGF-β1 and ERK1/2 are closely related to the clinical stages of colon cancer and crosstalk may exist between the 2 signal pathways.

关键词： colorectal cancer TGF-β1 ERK1/2 K-ras tissue microarray technique

Cilostazol inhibits plasmacytoid dendritic cell activation and antigen presentation

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Journal of Geriatric Cardiology 2015年第4期12卷 388-393页

作者： Fei SUN Zhao YIN Hai-Sheng YU Quan-Xing SHI Bei ZHAO li-Guo ZHANG shou-li wang Department of Cardiology The 306th Hospital of PLA No. 9 Anxiangbeili Street Beijing China CAS Key Laboratory of Infection and immunity Institute of Biophysics Chinese Academy of Sciences Beijing China

Background Cilostazol, an anti-platelet drug for treating coronary heart disease, has been reported to modulate immune cell functions Plasmacytoid dendritic cells （pDCs） have been found to participate in the progression of atherosclerosis mainly through interferon ct （IFN-ct） production. Whether cilostazol influences pDCs activation is still not clear. In this study, we aimed to investigate the effects of cilostazol on cell activation and antigen presentation ofpDCs in vitro in this study. Methods Peripheral blood mononuclear cells isolated by Ficoll cen- trifugation and pDCs sorted by flow cytometry were used in this study. After pretreated with cilostazol for 2 h, cells were stimulated with CpG-A, R848 or virus for 6 h or 20 h, or stimulated with CpG-B for 48 h and then co-cultured with naive T cell for five days. Cytokines in supernatant and intracellular cytokines were analyzed by EliSA or flow cytometry respectively. Results Our data indicated that cilostazol could inhibit IFN-α and tumor necrosis factor α （TNF-α） production from pDCs in a dose-dependent manner. In addition, the ability of priming na ve T cells of pDCs was also impaired by cilostazol. The inhibitory effect was not due to cell killing since the viability of pDCs did not change upon cilostazol treatment. Conclusion Cilostazol inhibits pDCs cell activation and antigen presentation in vitro, which may explain how cilostazol protects against atherosclerosis.

关键词： Antigen presentation Cilostazol Interferon α Plasmacytoid dendritic cell Tumor necrosis factor α

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单轴应变对H在α-Fe中占位及扩散的影响

物理学报 2017年第18期66卷 193-198页

作者：李守英王勇赵卫民中国石油大学(华东)机电工程学院青岛266580 青岛滨海学院机电工程学院青岛266555

采用基于密度泛函理论的第一性原理方法,研究了H在不同单轴应变下α-Fe中的间隙占位,计算了H原子的溶解能、态密度、电荷差分密度和电荷布居.结果表明:不同单轴拉压应变作用下,H原子优先占据四面体间隙(Ts)位,且随着压应变减小、拉应变... 详细信息

采用基于密度泛函理论的第一性原理方法,研究了H在不同单轴应变下α-Fe中的间隙占位,计算了H原子的溶解能、态密度、电荷差分密度和电荷布居.结果表明:不同单轴拉压应变作用下,H原子优先占据四面体间隙(Ts)位,且随着压应变减小、拉应变增加,H原子越易溶于α-Fe.压应变使得Ts位的H获得更多的电子,而拉应变减少了这种电荷转移.应用LST/QST过渡态搜索计算垂直应变方向的扩散.八面体间隙位是邻近Ts位H的扩散过渡态.扩散激活能与应变呈线性关系,且随着压应变的增加,扩散激活能降低,扩散更容易.

关键词：金属Fe 间隙H原子第一性原理应力诱导扩散

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The analysis for stress-strain characteristics of concrete cutoff wall built in deep cladding foundation

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Journal of Energy and Power Engineering 2009年第3期2卷 47-52页

作者： li Yan-long li shou-yi wang Rui-jun GENG Ji-ji ZHANG Xiao-fei Institute of Water Resources and Hydro-electric Engineering Xi ＇an University of Technology Xi ＇an 710048 China

Combined with a proposed homogeneous earth dam in deep cladding foundation, Duncan E-B model is applied to simulate dam-filled material, apply to three-dimensional nonlinear finite element method, attain the stress-strain distribution and alteration in concrete cutoff wall in completion and water storage periods, analysis the stress state in the contact element between concrete cutoff wall and cladding foundation, provide the corresponding measures. The calculation results show that the design of concrete cutoff wall and homogeneous earth dam is reasonable.

关键词： deep cladding foundation homogeneous earth dam concrete cutoff wall stress-strain

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai wang Shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery