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The effectiveness of zinc supplementation in men with isolated hypogonadotropic hypogonadism

Asian Journal of Andrology 2017年第3期19卷 280-285页

作者： Yan-Ling Liu Man-Na Zhang Guo-Yu Tong shou-yuesun Yan-Hua Zhu Ying Cao Jie Zhang Hong Huang Ben Niu Hong Li Qing-Hua Guo Yan Gao Da-Long Zhu Xiao-Ying Li Shanghai Institute of Endocrinology and Metabolism Department of Endocrinology and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Endocrinology Drum Tower Hospital Affiliated to Nanjing University Medical School Nanjing 210008 China Department of Endocrinology The Third Affiliated Hospital Sun Yat-sen University Guangzhou 510630 China Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University Guangzhou 510515 China Department of Endocrinology Guangxi Medical University and First Affiliated Hospital Nanning 530021 China Department of Endocrinology The First People's Hospital of Yunnan Province Kunming 650032 China Department of Endocrinology The Affiliated Hospital of Guiyang Medical College Guiyang 550004 China 00853 China.

A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism （IHH） receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin （uFSH/hCG） replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments of Endocrinology in eight tertiary hospitals and randomly allocated into the sequential uFSH/hCG group （Group A, n = 34） or the sequential uFSH plus zinc supplementation group （Group B, n = 33）. In Group A, patients received sequential uFSH （75 U, three times a week every other 3 months） and hCG （2000 U, twice a week） treatments. In Group B, patients received oral zinc supplementation （40 mg day-1） in addition to the sequential uFSH/hCG treatment given to patients in Group A. The primary outcome was the proportion of patients with a sperm concentration 〉1.0 × 106 ml-1 during the 18 months. The comparison of efficacy between Groups A and B was analyzed. Nineteen of 34 （55.9%） patients receiving sequential uFSH/hCG and 20 of 33 （60.6%） patients receiving sequential uFSH/hCG plus zinc supplementation achieved sperm concentrations ≥1.0 × 106 ml-1 by intention to treat analyses. No differences between Group A and Group B were observed as far as the efficacy of inducing spermatogenesis （P = 0.69）. We concluded that the sequential uFSH/hCG plus zinc supplementation regimen had a similar efficacy to the sequential uFSH/hCG treatment alone. The additional improvement of 40 mg day-1 oral zinc supplementation on spermatogenesis and masculinization in male IHH patients is very subtle.

关键词： gonadotropin isolated hypogonadotropic hypogonadism masculinization spermatogenesis zinc supplementation

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