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Synergistic Effects of Activin A and Fibroblast Growth Factor 2 in the Modulation of Insulin Expression

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Chemical Research in Chinese Universities 2006年第2期22卷 229-232页

作者： BAO Yong-li JIANG Hong-yu Ji shou-xian WU Yin MENG Xiang-ying LI Yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China The First Affiliated Hospital Jilin University Changchun 130021 P. R. China The Second Affiliated Hospital Jilin University Changchun 130041 P. R. China

Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients worldwide is increasing. The reduction of insulin biosynthes is in pancreatic E-cells is closely associated with the onset and progression of diabetes, therefore, it is important to search for ways to induce insulin-producing cells in non-E-cells. In the present study, it has been reported that activin A and a basic fibroblast growth factor 2 （ FGF2）, can synergistically increase the insulin mRNA level, in both mouse El4 striatal primary cell cultures and the hippocampal neuronal cell line HT22. Activin A and FGF2 can jointly stimulate the nuclear translocation of Smad3 and specifically activate ERK1/2. It is interesting to note that a specific inhibitor for MEK, U0126, can efficiently block the induction of an insulin promoter activity by activin A and FGF2. This indicates that activin A collaborates with FGF2, giving a signal to induce the insulin gene through selective activation of the ERK-type MAP kinase and Smad3 in mouse striatal and HT22 cells. These data suggest that activin A may act in concert with FGF2 for the development of insulin -positive neurons

关键词： Activin A Fibroblast growth factor 2 (FGF2) Insulin

基于模拟数据分析长江调水对棘洪滩水库的影响

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山东农业大学学报（自然科学版） 2024年第3期55卷 466-474页

作者：周守平陈立国张烨徐欣吕慎海刘本文陈建锋山东省调水工程运行维护中心山东济南250100 中国科学院水生生物研究所湖北武汉430072

目前南水北调东线调水工程水源复杂多变,显著影响了受水水体的水质与浮游藻类。为量化与评估这一影响,本研究在调水周期内采集不同季节的供水(长江水)、受水(棘洪滩水库水)水样,同时开展室内藻类生长潜力试验,比较分析了不同比例的供、... 详细信息

目前南水北调东线调水工程水源复杂多变,显著影响了受水水体的水质与浮游藻类。为量化与评估这一影响,本研究在调水周期内采集不同季节的供水(长江水)、受水(棘洪滩水库水)水样,同时开展室内藻类生长潜力试验,比较分析了不同比例的供、受水体混合处理后的理化因子、浮游藻类细胞密度与群落结构的变化情况。结果显示,春、秋季长江水的引入一定程度上削弱了棘洪滩水库的营养负荷;pH在季节间均表现为下降的趋势;秋季长江水的引入导致棘洪滩水体浮游藻类密度峰值显著增加(P<0.05),而在春季,仅当长江调水比例高于40%时,藻类密度峰值才随调水量的增加而显著增大(P<0.05)。群落结构方面,春、秋季长江与棘洪滩水体浮的游藻类均以蓝藻为主要优势,不同的是,春季以色球藻属(Chroococcus)的种类占主要优势,秋季则以假鱼腥藻属(Pseudanabaena)、尖头藻属(Raphidiopsis)与细鞘丝藻属(Leptolyngbya)的种类为优势。随长江水引入比例的增加,春季调水进一步增加了色球藻属的优势度;秋季调水则削弱了尖头藻属优势度同时增加了假鱼腥藻属的优势度。综合表明,不同季节长江调水对棘洪滩水库的浮游藻类生长影响存在差异,浮游藻类群落结构显著受到供水水体与季节的综合影响。

关键词：南水北调棘洪滩水库藻类生长潜力浮游藻类群落结构

The response of Golgi protein 73 to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma may relate to the influence of certain chemotherapeutics

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 406-412页

作者： Jie Pan Ye-Fan Zhang Hua-Yu Yang Hai-Feng Xu xin Lu xin-Ting Sang shou-Xian Zhong Yi-Lei Mao Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Abdominal Surgery Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND： Golgi protein 73 （GP73） is a promising bio- marker of hepatocellular carcinoma （HCC）. It decreases after surgical resection, and resumes upon recurrence, indicating a potential indicator for the effectiveness of the treatment. But changes of GP73 after transcatheter arterial chemoemboliza- tion （TACE） have not been reported so far. This study was to investigate the dynamic changes of GP73 in HCC patients af- ter TACE treatment, and the possible underlying mechanisms in the cell cultures. METHODS： Blood samples were collected from 72 HCC pa- tients, before TACE, at day I and day 30 after TACE. GP73 lev- els were measured by Western blotting. The dynamic changes of GP73 were analyzed and compared with image changes and clinical data. The effects of chemotherapeutic agents （5-FU and pirarubicin） on GP73 expression were tested in three HCC cell lines （HepG2, HCCLM3 and MHCC97H）. RESULTS： The GP73 level was significantly elevated at day 1 and day 30 after TACE in HCC patients compared with that before the procedure （P〈0.05）. There was no statistical differ- ence between the two time points after TACE, nor correlationbetween GP73 levels and dinicopathological features, tumor metastasis, and patient survival. Pirarubicin, not 5-FU, signifi- cantly increased GP73 expression in three cell lines. CONCLUSIONS： Unlike surgical resection which decreases the GP73 level, TACE significantly increased GP73 expression in patients with HCC. No correlations were observed among GP73 levels, tumor characteristics and prognosis of patients with HCC.

关键词： hepatocellular carcinoma transcatheter arterial chemoembolization Golgi protein 73 chemotherapeutics

Preparation and Photocatalytic Application of the Microporous Decatungstate,Na_4W_(10)O_(32)/SiO

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Chemical Research in Chinese Universities 2001年第4期17卷 465-468页

作者： GUO Yi-hang HU Chang-wen WANG xin-long WANG En-bo FENG shou-hua YUE Bin Institute of Polyoxametalate Chemistry Faculty of ChemistryNortheast Normal UniversityChangchun 130024P.R.China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130023P.R.China Department of Chemistry Fudan UniversityShanghai 200433P.R.China

The photochemical behavior of polyoxometalates（POMs）have been studied extensivelyIn homogeneous solutions［1-3]．However，the major drawback to the practical applications ofthe homogeneous systems is the high water solubility of POMs，which impedes the readyrecovery and the reuse of the ***，the preparation of insoluble POMs *** recently，we haveprepared insoluble POMs，i．e，Keggin－type microporousPOMs，H3PW12O40／SiO2 or H4SiW12O40／SiO2，and paratungstate A－containing pillaredcompound，Mg12Al6（OH）36（W7O24）·4H2O，for the purpose of photo－oxidation of aqueous

关键词： Sol-gel Decatungstate Photocatalysis Microporous materials

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花生白绢病防治药剂的筛选

中国油料作物学报 2024年第5期46卷 1113-1119页

作者：宋万朵晏立英于东洋康彦平王前前陈玉宁淮东欣王志慧王欣雷永廖伯寿中国农业科学院油料作物研究所农业农村部油料作物生物学与遗传育种重点实验室湖北武汉430062

为筛选出防治花生白绢病的药剂,采用菌丝生长速率法和菌核萌发法测定了5种杀菌剂对花生白绢病菌的室内毒力,并进行了田间防效试验。室内毒力测定结果表明:噻呋酰胺及其复配制剂对白绢病菌菌丝生长的抑制性较强,EC_(50)为37.12μg/L~80.3... 详细信息

为筛选出防治花生白绢病的药剂,采用菌丝生长速率法和菌核萌发法测定了5种杀菌剂对花生白绢病菌的室内毒力,并进行了田间防效试验。室内毒力测定结果表明:噻呋酰胺及其复配制剂对白绢病菌菌丝生长的抑制性较强,EC_(50)为37.12μg/L~80.35μg/L,菌核·福美双的抑制作用较弱,EC_(50)为9541.39μg/L。含有噻呋酰胺的药剂抑制菌核的产生,浓度越高,菌核产生量越少;而菌核·福美双对产菌核抑制较弱。5种药剂皆抑制菌核的萌发,噻呋酰胺及其复配制剂抑制效果随时间延长而降低,菌核·福美双对菌核萌发的抑制效果较稳定。田间试验结果表明:除噻呋·戊唑醇外,其他四种药剂对花生白绢病都有一定的防治效果,防效为8.36%~28.26%;除噻呋·戊唑醇与菌核·福美双外,其余三种药剂处理对花生的荚果产量均有促进作用,增产率均在20%以上。通过室内和田间试验,筛选获得具有较好防治和增产效果的复配药剂噻呋·吡唑酯和噻呋·嘧菌酯。

关键词：杀菌剂花生白绢病白绢病菌室内毒力田间防效

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A rare porous zinc phosphonocarboxylate framework with high thermal stability and interesting structural transformation

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Chinese Chemical Letters 2018年第6期29卷 959-962页

作者： Yan-Jie Qi Jin-Hua Liu Wen-Xu Zheng xin-Xiong Li shou-Tian Zheng State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A rare porous zinc-organic framework with ultrahigh thermal stability over 500℃ was obtained, which exhibits a CaF2-type topology formed by 8-connected tetranuclear Zn4 clusters and 4-connected phosphonocarboxylate ligands. Interestingly, the similar reactions to the 2 zinc-organic framework but in the absence of H2 O or by the replacement of Zn2＋with Co2＋can yield three different 3 D cluster-based frameworks but with the same CaF2-type topology.

关键词： Phosphonocarboxylate ligand Metal-organic framework Stability Structural transformation Gas adsorption

Comparative study of intestinal tuberculosis and primary small intestinal lymphoma

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World Journal of Gastroenterology 2014年第15期20卷 4446-4452页

作者： Qing-Qiang Zhu Wen-Rong Zhu Jing-Tao Wu Wen-xin Chen shou-An Wang Department of Medical Imaging Subei People’s HospitalMedical School of Yangzhou University

AIM: To characterize the clinical, radiological, endoscopic and pathological features of intestinal tuberculosis (ITB) and primary small intestinal lymphoma (PSIL).

关键词： Intestinal tuberculosis Primary small intestinal lymphoma Clinical features Endoscopic features Computed tomography

High efficiency sub-nanosecond electro-optical Q-switched laser operating at kilohertz repetition frequency

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Chinese Physics B 2020年第8期29卷 286-291页

作者： xin Zhao Zheng Song Yuan-Ji Li Jin-Xia Feng Kuan-shou Zhang State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Based on a theoretical model of Q-switched laser with the influences of the driving signal sent to the Pockels cell and the doping concentration of the gain medium taken into account,a method of achieving high energy sub-nanosecond Q-switched lasers is proposed and verified in *** a Nd:YVO4 crystal with a doping concentration of 0.7 at.%is used as a gain medium and a driving signal with the optimal high-level voltage is applied to the Pockels cell,a stable single-transverse-mode electro-optical Q-switched laser with a pulse width of 0.77 ns and a pulse energy of 1.04 mJ operating at the pulse repetition frequency of 1 kHz is *** precise tuning of the pulse width is also demonstrated.

关键词： milijoule level sub-nanosecond laser kilohertz repetition frequency doping concentration of laser crystal tunable pulse width

Influences of annealing temperature on properties of Fe^2+:ZnSe thin films deposited by electron beam evaporation and their applications to Q-switched fiber laser

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Chinese Physics B 2020年第5期29卷 282-287页

作者： Du-xin Qing Shu-Tong Wang shou-Gui Ning Wei Zhang Xiao-Xu Chen Hong Zhang Guo-Ying Feng shou-Huan Zhou Institute of Laser&Micro/Nano Engineering College of Electronics&Information EngineeringSichuan UniversityChengdu 610064China North China Research Institute of Electro-Optics Beijing 100015China

Fe^2+:ZnSe thin films are prepared on sapphire substrate at room temperature by electron beam evaporation and then annealed in vacuum(about 1×10^-4 Pa)at different *** influences of thermal annealing on the structural and optical properties of these films such as grain size and optical transmittance are *** x-ray diffraction patterns show that the Fe2+:ZnSe thin film is preferred to be oriented along the(111)plane at different annealing *** the film is annealed,the full-width-at-half-maximum(FWHM)of the x-ray diffraction peak profile(111)of the film decreases and its crystal quality is *** electron microscope images show that the films are more dense after being ***,the sample is used as a saturable absorber in ZBLAN fiber *** annealed Fe^2+:ZnSe thin films can be used to realize stable Q-switching modulation on ZBLAN fiber *** results demonstrate that the Fe2+:ZnSe thin film is a promising material for generating the high-power pulses of mid-infrared Q-switched fiber lasers.

关键词： electron beam evaporation thin film optical materials Q-switching