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Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing

Molecular Plant 2013年第3期6卷 790-801页

作者： Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi Hiroki Saito Akiko Onishi Kanako Tamura Takatoshi Tanisaka Division of Agronomy and Horticulture Science Graduate School of Agriculture Kyoto University Kitashirakawa Sakyo Kyoto 606-8502 Japan Faculty of Biology-Oriented Science and Technology Kinki University Kinokawa Wakayama 649-6433 Japan

Miniature inverted-repeat transposable elements （MITEs） are widespread in both prokaryotic and eukaryotic genomes, where their copy numbers can attain several thousands. Little is known, however, about the genetic factor（s） affecting their transpositions. Here, we show that disruption of a gene encoding ubiquitin-like protein markedly enhances the transposition activity of a MITE roPing in intact rice plants without any exogenous stresses. We found that the transposition activity of roPing is far higher in the lines harboring a non-functional allele at the Rurml （Rice ubiquitin-related modifier-I） locus than in the wild-type line. Although the alteration of cytosine methylation pattern triggers the activation of transposable elements under exogenous stress conditions, the methylation degrees in the whole genome, the roPing-body region, and the roPing-flanking regions of the non-functional Rurml line were unchanged. This study provides experimental evidence for one of the models of genome shock theory that genetic accidents within cells enhance the transposition activities of transposable elements.

关键词： Oryza sativa MITE mPing ubiquitin-related modifier methylation genome shock theory.

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Application of povacoat as dispersion stabilizer of nanocrystal formulation

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 48-49页

作者： Kayo Yuminoki Fuko Seko shota Horii Haruka Takeuchi Katsuya teramoto Yuichiro Nakada Naofumi Hashimoto Setsunan University 45-1Nagaotoge-choHirakataOsaka 573-0101Japan Santen Pharmaceutical Company Ltd. 40-20OfukachoKita-kuOsaka 530-8552Japan

Nanosizing by wet beads milling is one of the methods to improve the solubility of poorlywater soluble compounds[1,2].Hydrophilic polymers,such as Hydroxypropylcellulose-SSL(HPC),Polyvinylalcohol(PVA),and Polyvinylpyrrolidone-K30(PVP)etc.are used as dispersion stabilizer to prevent aggregation of nanoparticles.However,there are many compounds that cannot be dispersed by ordinary dispersion stabilizers.In this study,we used Povacoat?as a dispersion stabilizer for several poorly water soluble compounds milled to nanoparticles.The influences of aggregation of the nanoparticles on the dissolution behavior and the oral absorption of the compoundswere studied using formulations with high and low dispersion characters.

关键词： Nanocrystal Wet beads milling Poorly water soluble compounds

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