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A unique case of a calcifying cystic odontogenic tumor

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Open Journal of Stomatology 2013年第6期3卷 314-317页

作者： Shoko Gamoh Yukako Nakashima Hironori Akiyama Kimishige Shimizutani Takuro Sanuki Junichiro Kotani Koji Yamada shosuke morita Kazuya Tominaga Masahiro Wato Akio Tanaka Department of Anesthesiology Osaka Dental University Osaka Japan Department of Oral and Maxillofacial Surgery Osaka Dental University Osaka Japan Department of Oral Pathology Osaka Dental University Osaka Japan Department of Oral Radiology Osaka Dental University Osaka Japan

The calcifying odontogenic cyst was first reported by Gorlin et al. in 1962. At that time, it was classified as a cyst related to the odontogenic apparatus, although it was later renamed as a calcifying cystic odontogenic tumor by the WHO calcification in 2005 due to its histological complexity, morphological diversity and aggressive proliferation [2]. Here, we describe a case of a calcifying cystic odontogenic tumor in a 4- year-old boy. The lesion was surgically removed, and the histopathological examination revealed it to be a cystic tumor with ghost cells, a stellate reticulum and small amount of dentinoid tissue in the cystic wall.

关键词： Calcifying Cystic Odontogenic Tumor Diagnostic Imaging Computed Tomography

Immunohistochemical study of the lining epithelium in keratocystic odontogenic tumor, orthokeratinized odontogenic cyst and dentigerous cyst

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中国口腔颌面外科杂志 2008年第B5期6卷 158-158页

作者： Kaname Tsuji Masahiro Wato Sakiko Matsuda Akio Tanaka shosuke morita First Department of Oral and Maxillofacial Surgery Osaka Dental University. Hirakata 573-1121 Japan Department of Oral Pathology Osaka Dental University. Hirakata 573-1121 Japan

Relation between FQHE Plateau Width and Valley Energy

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Journal of Modern Physics 2015年第7期6卷 955-971页

作者： shosuke Sasaki Center for Advanced High Magnetic Field Science Graduate School of Science Osaka University Osaka Japan

We have investigated the Fractional Quantum Hall Effect (FQHE) on the fundamental Hamiltonian with the Coulomb interactions between normal electrons without any quasi particle. The electron pairs placed in the Landau orbitals can transfer to many empty orbitals. The number of the quantum transitions decreases discontinuously when the filling factor v deviates from the specific fractional number of v0. The discontinuous decreasing produces the energy valley at the specific filling factors v0 = 2/3, 4/5, 3/5, 4/7, 3/7, 2/5, 1/3 and so on. The diagonal elements of the total Hamiltonian and the number of the quantum transitions give the total energy of the FQH states. The energy per electron has the discontinuous spectrum depending on the filling factor v. We obtain the function form of the energy per electron in the quantum Hall system. Then the theoretical Hall resistance curve is calculated near several filling factors. Therein the quantum Hall plateaus are derived from the energy valleys. The depths of the energy valleys are compared with the widths of the quantum Hall plateaus appearing in the experimental data of the Hall resistance. Our theoretical results are in good agreement with the experimental results.

关键词： Fractional Quantum Hall Effect 2D Electron System Quantum Theory Hall Resistance

Spin Polarization of Fractional Quantum Hall States with <i>ν</i><2

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Journal of Modern Physics 2015年第6期6卷 794-810页

作者： shosuke Sasaki Center for Advanced High Magnetic Field Science Graduate School of Science Osaka University Osaka Japan

The spin polarization of a fractional quantum Hall state shows very interesting properties. The curve of polarization versus magnetic field has wide plateaus. The fractional quantum Hall effect is caused by the Coulomb interaction because the 2D electron system without the Coulomb interaction yields no energy gap at the fractional filling factor. Therefore, the wide plateau in the polarization curve is also caused by the Coulomb interaction. When the magnetic field is weak, some electrons have up-spins and the others down-spins. Therein the spin-exchange transition occurs between two electrons with up and down spins via the Coulomb interaction. Then the charge distribution before the transition is the same as one after the transition. So these two states have the same classical Coulomb energy. Accordingly, the partial Hamiltonian composed of the spin exchange interaction should be treated exactly. We have succeeded in diagonalizing the spin exchange interaction for the first and second nearest electron pairs. The theoretical results reproduce the wide plateaus very well. If the interval modulations between Landau orbitals are taken into the Hamiltonian, the total energy has the Peierls instability. We can diagonalize the Hamiltonian with the interval modulation. The results reproduce wide plateaus and small shoulders which are in good agreement with the experimental data.

关键词： Spin Polarization Fractional Quantum Hall Effect 2D Electron System Quantum Theory

Proposal on Tunneling Effect between Quantum Hall States

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Journal of Modern Physics 2013年第9期4卷 1-7页

作者： shosuke Sasaki Kyokugen (Center for Quantum Science and Technology under Extreme Conditions) Osaka University Toyonaka Osaka Japan

In the integer and fractional quantum Hall effects, the electric current flows through a thin layer under the strong magnetic field. The diagonal resistance becomes very small at integer and specific fractional filling factors where the electron scatterings are very few. Accordingly the coherent length is large and therefore a tunneling effect of electrons may be observed. We consider a new type of a quantum Hall device which has a narrow potential barrier in the thin layer. Then the electrons flow with tunneling effect through the potential barrier. When the oscillating magnetic field is applied in addition to the constant field, the voltage steps may appear in the curve of voltage V versus electric current I. If the voltage steps are found in the experiment, it is confirmed that the 2D electron system yields the same phenomenon as that of the ac-Josephson effect in a superconducting system. Furthermore the step V is related to the transfer charge Q as V = (hf)/Q where f is the frequency of the oscillating field and h is the Planck constant. Then the detection of the step V determines the transfer charge Q. The ratio Q/e (e is the elementary charge) clarifies the origin of the transfer charge. Many conditions are required for us to observe the tunneling phenomenon. The conditions are examined in details in this article.

关键词： Quantum Hall Effect Tunneling Effect ac-Josephson Effect

Fractional Quantum Hall States for Filling Factors 2/3 <<i>ν</i><2

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Journal of Modern Physics 2015年第5期6卷 584-600页

作者： shosuke Sasaki Center for Advanced High Magnetic Field Science Graduate School of Science Osaka University Osaka Japan

Fractional quantum Hall effect (FQHE) is investigated by employing normal electrons and the fundamental Hamiltonian without any quasi particle. There are various kinds of electron configurations in the Landau orbitals. Therein only one configuration has the minimum energy for the sum of the Landau energy, classical Coulomb energy and Zeeman energy at any fractional filling factor. When the strong magnetic field is applied to be upward, the Zeeman energy of down-spin is lower than that of up-spin for electrons. So, all the Landau orbitals in the lowest level are occupied by the electrons with down-spin in a strong magnetic field at 1 ν . On the other hand, the Landau orbitals are partially occupied by up-spins. Two electrons with up-spin placed in the nearest orbitals can transfer to all the empty orbitals of up-spin at the specific filling factors and so on. When the filling factor ν deviates from ν0, the number of allowed transitions decreases abruptly in comparison with that at ν0. This mechanism creates the energy gaps at ν0. These energy gaps yield the fractional quantum Hall effect. We compare the present theory with the composite fermion theory in the region of 2/3 ν .

关键词： Fractional Quantum Hall Effect 2D Electron System Quantum Theory

Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma

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Genes & Diseases 2022年第6期9卷 1727-1741页

作者： Nattawan Suwannakul Napat Armartmuntree Raynoo Thanan Kaoru Midorikawa Tetsuo Kon Shinji Oikawa Hatasu Kobayashi Ning Ma shosuke Kawanishi Mariko Murata Department of Environmental and Molecular Medicine Mie University Graduate School of MedicineTsuMie 514-8507Japan Department of Biochemistry Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Laboratory of Functional Genomics Graduate School of BioscienceNagahama Institute of Bioscience and TechnologyNagahamaShiga 526-0829Japan Graduate School of Health Science Suzuka University of Medical ScienceSuzukaMie 513-8670Japan Faculty of Pharmaceutical Sciences Suzuka University of Medical ScienceSuzukaMie 513-8670Japan

Alterations in cellular metabolism may contribute to tumor proliferation and *** of the facilitative glucose transporter(GLUT)plays a key role in promoting ***5 mediates modulation of fructose utilization,and its overexpression has been associated with poor prognosis in several ***,its metabolic regulation remains poorly ***,we demonstrated elevated GLUT5 expression in human cholangiocarcinoma(CCA),using RNA sequencing data from samples of human tissues and cell lines,as compared to normal liver tissues or a cholangiocyte cell *** exhibiting highexpression of GLUT5 showed increased rates of cell proliferation and ATP production,particularly in a fructose-supplemented *** contrast,GLUT5 silencing attenuated cell proliferation,ATP production,cell migration/invasion,and improved epithelialemesenchymal transition(EMT)***,fructose consumption increased tumor growth in a nude mouse xenograft model,and GLUT5 silencing suppressed growth,supporting the tumor-inhibitory effect of GLUT5 ***,in the metabolic pathways of fructolysis-Warburg effect,the expression levels of relative downstream genes,including ketohexokinase(KHK),aldolase B(ALDOB),lactate dehydrogenase A(LDHA),and monocarboxylate transporter 4(MCT4),as well as hypoxia-inducible factor 1 alpha(HIF1A),were altered in a GLUT5 expression-dependent *** together,these findings indicate that GLUT5 could be a potential target for CCA therapeutic approach via metabolic regulation.

关键词： Cholangiocarcinoma Fructose Glucose transporter 5 Metabolic regulation Warburg effect

VISUAL INFORMATION AND THE PERCEPTION OF PROSODY

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VISUAL INFORMATION AND THE PERCEPTION OF PROSODY

Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion

6～(th) International Conference on Spoken Language Processing

作者： Haruo Kubozono shosuke Haraguchi Kobe University Meikai University

＜正＞ This paper reports the results of a phonetic experiment carried out to explore the potential importance of visual information for the perception of Japanese prosody and its relationship with phonological structure. It specifically examines whether and to what extent native speakers of Japanese are able to accurately perceive the temporal structure of their native language on the sole basis Of visual information. It has been found that the word-final contrast between short and long vowels is totally invisible to the native speakers although other types of temporal differences characteristic of mora-timed languages are readily visible as a crucial distinction in the mora-timed language. Interestingly. essentially the same confusion occurs in Japanese phonology, where word-final long vowels tend to be shortened and neutralized with their short counterparts.

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World Journal of Gastroenterology 2005年第30期11卷 4644-4649页

作者： Somchai Pinlaor Banchob Sripa Ning Ma Yusuke Hiraku Puangrat Yongvanit Sopit Wongkham Chawalit Pairojkul Vajarabhongsa Bhudhisawasdi Shinji Oikawa Mariko Murata Reiji Semba shosuke Kawanishi Department of Parasitology Department of Pathology Department of Anatomy Department of Environmental and Molecular Medicine Department of Biochemistry Department of Surgery

AIM： Nitrative and oxidative DNA damage such as 8-nitroguanine and 8-oxo-7,8-dihydro-2＇-deoxyguanosine （8-oxodG） formation has been implicated in initiation and/ or promotion of inflammation-mediated carcinogenesis. The aim of this study is to clarify whether these DNA lesions participate in the progression of intrahepatic cholangiocarcinoma. METHODS： We investigated the relation of the formation of 8-nitroguanine and 8-oxodG and the expression of hypoxia-inducible factor-1α （HIF-1α） with tumor invasion in 37 patients with intra-hepatic cholangiocarcinoma. RESULTS： Immunohistochemical analyses revealed that 8-nitroguanine and 8-oxodG formation occurred to a much greater extent in cancerous tissues than in non-cancerous tissues. HIF-1α could be detected in cancerous tissues in all patients, suggesting low oxygen tension in the tumors. HIF-1α expression was correlated with inducible niltric oxide synthase （iNOS） expression （r = 0.369 and P = 0.025） and 8-oxodG formation （r = 0.398 and P = 0.015）. Double immunofluorescence study revealed that iNOS and HIF-1α co-localized in cancerous tissues. Notably, the formation of 8-oxodG was correlated significantly with lymphatic invasion （r = 0.386 and P = 0.018）. Moreover, 8- nitroguanine and 8-oxodG in non-cancerous tissues were associated significantly with neural invasion （P = 0.042 and P = 0.026, respectively）. These results suggest that reciprocal activation between HIF-1α and iNOS mediates persistent DNA damage, which induces tumor invasiveness via mutations, resulting in poor prognosis. CONCLUSION： The formation of 8-nitroguanine and 8-oxodG plays an important role in multiple steps of genetic changes leading to tumor progression, including invasiveness.

关键词： 8-Nitroguanine 8-Oxo-7,8-dihydro-2'-deoxyguanosine Hypoxia-inducible factor-1α Cholangiocarcinoma Tumor invasion