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Structural engineering of antimicrobials for optimal broad-spectrum activity

Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiarasi Armugam Diane S.W.Lim Siti Nurhanna Riduan shook pui chan Jerome Asugan Yugen Zhang Institute of Bioengineering and Bioimaging 31 Biopolis WayThe Nanos#07-01138669Singapore Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A^(*)STAR)1 Pesek Road Jurong Island627833Singapore Diploma in Biomedical Science School of Chemical and Life SciencesSingapore Polytechnic500 Dover Road139651Singapore

Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious *** are expected to act on a broad-spectrum of microbes,including emerging pathogens which could cause the next Disease ***,we reassessed a series of antimicrobial imidazolium polymers on our shelves and uncovered extended functionality through dual modes of *** redesigning their structures,a truly broadspectrum antimicrobial material with optimized activity against bacteria(G+ve,G-ve)and fungi,as well as enveloped and non-enveloped viruses was *** demonstrated that the imidazolium polymer exhibits dual modes of function against microbes:targeting the microbial membrane and binding *** latter DNA binding affinity was found to be key against non-enveloped *** this insight,we designed small molecule compounds that exhibited optimum broad-spectrum antimicrobial activity and excellent efficacy against ESKAPE group of pathogens that are responsible for some of the deadliest nosocomial infections *** results could also shed light on the design of broad-spectrum antimicrobial compounds against Disease X.

关键词： Broad-spectrum Antimicrobial Polyimidazolium Structure-function Membrane active

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