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Analysis of neurotransmitters validates the importance of the dopaminergic system in autism spectrum disorder

世界儿科杂志:英文版 2023年第8期19卷 770-781页

作者： Sharmistha Saha Mahasweta Chatterjee Nilanjana Dutta Swagata Sinha Kanchan mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector-JE.M.BypassKolkataWest Bengal700107India

Background The reasons behind the cardinal symptoms of communication deficits and repetitive,stereotyped behaviors that characterize autism spectrum disorder(ASD)remain *** dopamine(DA)system,which regulates motor activity,goal-directed behaviors,and reward function,is believed to play a crucial role in ASD,although the exact mechanism is still *** have shown an association of the dopamine receptor D4(DRD4)with various neurobehavioral *** We analyzed the association between ASD and four DRD4 genetic polymorphisms,5′flanking 120-bp duplication(rs4646984),rs1800955 in the promoter,exon 112 bp duplication(rs4646983),and exon 348 bp *** also examined plasma DA and its metabolite levels,DRD4 mRNA expression,and correlations of the studied polymorphisms with these parameters by case–control comparative *** expression of DA transporter(DAT),which is important in regulating the circulating DA level,was also *** A significantly higher occurrence of rs1800955“T/TT”was observed in the *** traits were affected by rs1800955“T”and the higher repeat alleles of the exon 348 bp repeats,rs4646983 and *** probands exhibited lower DA and norepinephrine levels together with higher homovanillic acid levels than the control *** and DRD4 mRNA expression were down-regulated in the probands,especially in the presence of DAT rs3836790“6R”and rs27072“CC”and DRD4 rs4646984 higher repeat allele and rs1800955“T”.Conclusion This pioneering investigation revealed a positive correlation between genetic variants,hypodopaminergic state,and impairment in socio-emotional and communication reciprocity in Indian subjects with ASD,warranting further in-depth analysis.

关键词： Autism spectrum disorder Dopamine Neurotransmitter

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Implementation of quantum optical tristate oscillators based on tristate Pauli-X, Y and Z gates by using joint encoding of phase and intensity

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Optoelectronics Letters 2022年第11期18卷 673-677页

作者： Mir Nadim Sarfaraj Mistu Sebait Sourangshu mukhopadhyay Department of Physics The University of BurdwanGolapbagBurdwanPurba Bardhaman 713104India

Oscillator circuit has the significant role to always repeat the same signal at the output after certain time interval. In quantum computing, intensity and phase of light signal can be made oscillatory at the output of a quantum optical oscillator circuit. In this paper, we have implemented quantum optical tristate oscillator circuits based on tristate Pauli-X, Y and Z gates using phase and intensity encoding technique of light signal. Here, three different oscillator circuits are developed. The phase of light signal is chosen as the oscillating parameter in all proposed circuits. The truth tables and oscillating phase diagrams are also shown for each oscillator circuit in this paper. The operation of one of the oscillator circuits is simulated with MATLAB to prove its feasibility.

关键词： optical quantum oscillator

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Helix Inspired 28 GHz Broadband Antenna with End-Fire Radiation Pattern

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Computers, Materials & Continua 2022年第1期70卷 1935-1944页

作者： Hijab Zahra Wahaj Abbas Awan Niamat Hussain Syed Muzahir Abbas Subhas mukhopadhyay School of Engineering Faculty of Science and EngineeringMacquarie UniversitySydneyNSW2109Australia Department of Integrated IT Engineering Seoul National University of Science and TechnologySeoul01811Korea Department of Information and Communication Engineering Chungbuk National UniversityChungbuk28644Korea BENELEC BotanySydneyNSW2019Australia

This paper presents the design and characterization of a via free planar single turn helix for 28 GHz broadband *** proposed antenna is designed using ROGERS RO4003 material,having a simple structure and end-fire radiation *** antenna comprises of a compact dimension of 1.36λ_(0)×0.9λ_(0) with a thickness of 0.0189λ_(0)(whereλ_(0) is the free-space wavelength at the central frequency of 28 GHz).Parametric study has been carried out to investigate the impact of key design parameters and to achieve an optimum *** show a good agreement between the simulated and measured results.A single turn helical inspired antenna covers−10 dB impedance bandwidth of 26.25-30.14 GHz having a peak gain of 5.83 dB and radiation efficiency up to 85%.Moreover,linear array configurations with 2 and 4 elements have been analyzed for applications with higher gain and space *** array configurations are suitable for applications having space constraints in one *** show that peak gain up to 8.2 dB and 11.1 dB can be achieved with 2 and 4 elements,*** to its simple planar and via free structure,this antenna is suitable for 5G communications and for sensing,imaging,IoT and tracking applications at 28 GHz band spectrum.

关键词： Compact antenna millimeter wave antenna 28 GHz 5G antenna

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Incidental diagnosis of medullary thyroid carcinoma due to persistently elevated procalcitonin in a patient with COVID-19 pneumonia:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7171-7177页

作者： Amitabha Saha Madhusha mukhopadhyay Souvik Paul Arnab Bera Tapas Bandyopadhyay Department of Internal Medicine Critical Care MedicineMedica Superspecialty HospitalKolkata 700099West BengalIndia Department of Internal Medicine Medica Superspecialty HospitalKolkata 700099West BengalIndia Department of Critical Care Medicine Medica Superspecialty HospitalKolkata 700099West BengalIndia

BACKGROUND Procalcitonin(Pct)is a common biomarker in clinical practice,especially in the era of coronavirus disease 2019(COVID-19)*** it is frequently used for the diagnosis and prognostication of bacterial infections or sepsis,it is also elevated in a few other conditions,including medullary thyroid carcinoma(MTC).CASE SUMMARY A 43-year-old female presented with moderately severe COVID-19 pneumonia in April *** gradually recovered clinically;however,despite normalization of other inflammatory markers,Pct levels remained persistently *** workup identified the cause as left lobe MTC with locoregional *** levels were high,and carcinoembryonic antigen levels were *** patient underwent total thyroidectomy and neck dissection,which was followed by another radical neck dissection due to residual ***,she is doing well,nearly having completed her course of external beam radiotherapy with no *** is well documented as a screening tool for MTC,especially because of its stable nature compared to calcitonin in the community *** is important to keep in mind the differential diagnosis of MTC in patients with persistently elevated Pct levels despite normal levels of other acute phase *** the best of our knowledge,this is the first report from Asia of such an incidental diagnosis of MTC due to persistently elevated Pct levels in a patient with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** Persistently elevated Pct levels can occur in any pro-inflammatory state including infections,sepsis,or acute respiratory distress *** the current setting,SARS-CoV-2 infection is one such clinical scenario,and in rare situations of persistent elevation,MTC may need to be ruled out.

关键词： COVID-19 Medullary thyroid carcinoma Procalcitonin SARS-COV-2 Calcitonin Case report

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Effects of thermal radiation on Casson fluid flow and heat transfer over an unsteady stretching surface subjected to suction/blowing

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Chinese Physics B 2013年第11期22卷 362-368页

作者： Swati mukhopadhyay Department of Mathematics The University of Burdwan

The unsteady flow of a Casson fluid and heat transfer over a stretching surface in presence of suction/blowing are investigated. The transformed equations are solved numerically by using the shooting method. The exact solution corre- sponding to the momentum equation for the steady case is obtained. Fluid velocity initially decreases with the increase of unsteadiness parameter. Due to an increasing Casson parameter the velocity field is suppressed. Thermal radiation enhances the effective thermal diffusivity and the temperature rises.

关键词： unsteady flow Casson fluid stretching surface suction/blowing

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Dual solutions in boundary layer flow of a moving fluid over a moving permeable surface in presence of prescribed surface temperature and thermal radiation

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Chinese Physics B 2014年第1期23卷 279-283页

作者： Swati mukhopadhyay Department of Mathematics The University of Burdwan Burdwan-713104 W. B. India

An analysis of the heat transfer for a boundary layer forced convective flow past a moving permeable flat surface parallel to a moving fluid is presented. Prescribed surface temperature at the boundary is considered, A thermal radiation term in the energy equation is considered. The similarity solutions for the problem are obtained and the reduced ordinary differential equations are solved numerically. To support the validity of the numerical results, a comparison is made with the available results for some particular cases of this study. Dual solutions exist when the surface and the fluid move in the opposite directions.

关键词： moving fluid prescribed surface temperature suction thermal radiation

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Casson fluid flow and heat transfer over a nonlinearly stretching surface

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Chinese Physics B 2013年第7期22卷 298-302页

作者： Swati mukhopadhyay Department of Mathematics the University of Burdwan

A boundary layer analysis is presented for non-Newtonian fluid flow and heat transfer over a nonlinearly stretching surface. The Casson fluid model is used to characterize the non-Newtonian fluid behavior. By using suitable transformations, the governing partial differential equations corresponding to the momentum and energy equations are converted into non-linear ordinary differential equations. Numerical solutions of these equations are obtained with the shooting method. The effect of increasing Casson parameter is to suppress the velocity field. However the temperature is enhanced with the increasing Casson parameter.

关键词： nonlinear stretching Casson fluid heat transfer similarity transformations

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Heat Transfer Analysis of the Unsteady Flow of a Maxwell Fluid over a Stretching Surface in the Presence of a Heat Source/Sink

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Chinese Physics Letters 2012年第5期29卷 165-168页

作者： Swati mukhopadhyay Department of Mathematics The University of BurdwanBurdwan-713104W.B.India

The unsteady two-dimensional flow of a MHD non-Newtonian Maxwell fluid over a stretching surface with a prescribed surface temperature in the presence of a heat source/sink is *** solutions for the governing equations are *** transformed boundary layer equations are then solved numerically by using the shooting *** velocity initially decreases with the increasing unsteadiness parameter,and temperature decreases significantly due to *** is also found that the fluid velocity decreases with the increasing magnetic *** the Maxwell parameter values has the effect of suppressing the velocity field and increasing the temperature.

关键词： temperature. parameter. method.

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Heat Transfer in a Moving Fluid over a Moving Non-Isothermal Flat Surface

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Chinese Physics Letters 2011年第12期28卷 183-186页

作者： Swati mukhopadhyay Department of Mathematics The University of BurdwanBurdwan-713104W.B.India

Boundary layer forced convective flow and heat transfer passing a moving flat surface parallel to a moving stream are *** power-law surface temperature of the second degree at the boundary is *** similarity solutions for the problem are obtained and the reduced ordinary differential equations are solved *** numerical results are compared with the known results from the literature for some special cases of the present study to support their *** is found that dual solutions exist when the surface and the fluid move in opposite directions.

关键词： moving ordinary directions

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Effects of Slip on Unsteady Mixed Convective Flow and Heat Transfer Past a Stretching Surface

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Chinese Physics Letters 2010年第12期27卷 113-116页

作者： S. mukhopadhyay Department of Mathematics The University of Burdwan Burdwan-713104 W. B. India

Unsteady mixed convective boundary layer flow and heat transfer over a stretching vertical surface in the presence of slip axe investigated. It is noted that fluid velocity decreases due to the increasing velocity slip parameter resulting in an increase in the temperature field. The rate of heat transfer decreases with the velocity slip parameter while it increases with unsteadiness parameter. The same feature is also noticed for thermal slip parameter.

关键词： Statistical physics and nonlinear systems

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