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Gastroprotective effect of aqueous stem bark extract of Ziziphus jujuba *** HCl/Ethanol-induced gastric mucosal injury in rats

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Journal of Traditional Chinese Medicine 2015年第6期35卷 666-670页

作者： shokouhsadat hamedi Amir Ali Arian Mohammad Hosein Farzaei Department of Persian pharmacy School of Persian and Complementary MedicineMashhad University of Medical Sciences Department of Physiology Mashhad University of Medical Sciences Pharmaceutical Sciences Research Center Faculty of PharmacyKermanshah University of Medical Sciences Medical Biology Research Center Kermanshah University of Medical Sciences

OBJECTIVE: To evaluated the gastroprotective effects of standardized aqueous extract of Ziziphus jujuba(Z. jujuba) stem bark against acidified ethanol-induced gastric ulcers as well as anti helicobacter pylori activity of the plant extract in ***: Five groups of rats were orally pre-treated with normal saline(0.9%) as ulcer group, 150 mg/kg of ranitidine as positive control group, 100, 200 and 400 mg of standardized extract solution as the experimental groups. Two hours later, acidified ethanol solution was given by gavages in order to induce of gastric ulcer. The antibacterial effect of extract against clinical strains of Helicobacter pylori(H. pylori) was evaluated through disc diffusion ***: The ulcer group exhibited significantly severe mucosal injury as compared with ranitidine or extract group which shows significant protective action against gastric mucosal injury. The extract showed no effect on H. ***: The present study indicates that *** stem bark extract had a potential antiulcer activity which might be due to its protective activity, providing a direct, protective effect on the gastric mucosa. Our study showed that anti-H. pylori activity was not among gastroprotective mechanism of Z. jujuba. Further pre-clinical and clinical investigations for evaluating natural active agents and efficacy of this plant are recommended.

关键词： Ziziphus jujuba Stomach ulcer Cytopro-tection Antisecretory factor Helicobacter pylori

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Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine

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Journal of Traditional Chinese Medicine 2016年第2期36卷 250-254页

作者： Assie Jokar Fatemeh Masoomi Omid Sadeghpour Mohsen Nassiri-Toosi shokouhsadat hamedi Iranian Traditional Medicine Faculty Tehran University of Medical SciencesTehran ***Iran Department of Iranian Traditional Medicine Mazandaran University of Medical SciencesSari ***Iran Department of Traditional Pharmacy Traditional Medicine FacultyTehran University of Medical SciencesTehran ***Iran Herbal and Traditional Medicine Department Research Institute for Islamic and Complementary MedicineIran University of Medical SciencesTehran ***Iran Department of Internal Medicine Tehran University of Medical SciencesTehran ***Iran Department of Persian Pharmacy School of Persian and Complementary MedicineMashhad University of Medical SciencesMashhad ***Iran

Terminalia chebula(family:Combretaceae)is widely used in the traditional medicine of India and Iran to treat diseases that include dementia,constipation,and *** tree is known in Iranian traditional medicine(ITM)as halileh or halilaj and the fruit is used to develop *** is described in ITM as an astringent that has a"cold"and"dry"*** to the medicinal properties of Terminalia chebula were collected from important ITM sources and from modern medical databases(Pub Med,Scirus,Science Direct,and Scopus).The medicinal properties described for thistree in ITM were compared with those reported in studies of modern *** results confirm that the tree referred to as halileh in traditional books is the Terminalia chebula used in present-day *** that have not been evaluated in modern phytotherapy but have been traditionally treated with Terminalia chebula include fever,and psychological and psychiatric *** article confirms the medicinal uses of Terminalia chebula.

关键词： Fructus chebula Phytochemicals Phar macology Iranian traditional medicine

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Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome:A Randomized,Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2020年第10期26卷 729-735页

作者： Hamide Khorram Pazhouh Seyyd Musa al-Reza Hosseini Ali Taghipour shokouhsadat hamedi Mohammadreza Noras Persian Medicine Faculty of Persian and Complementary MedicineMashhad University of Medical SciencesMashhad(***)Iran Department of Gastroenterology Faculty of MedicineMashhad University of Medical SciencesMashhad(***)Iran Faculty of Health Mashhad University of Medical SciencesMashhad(***)Iran Department of Persian Pharmacy School of Persian and Complementary MedicineMashhad University of Medical SciencesMashhad(***)Iran Persian Traditional Medicine Faculty of Persian Traditional and Complementary MedicineMashhad University of Medical SciencesMashhad(***)Iran

Objective To evaluate the efficacy and safety of administration of the formulated Persian herbal syrup on improving the symptoms of patients with constipation-predominant irritable bowel syndrome(IBS-C).Methods This study was conducted in 70 patients with IBS-C,who were recruited from 3 medical centers in Mashhad,Iran,from November 2017 to August *** patients were randomly assigned to 2 groups including treatment and placebo groups by block randomization,35 cases in each *** in the treatment group received 15 mL of anti-IBS syrup,thrice daily for 6 weeks and followed up for 4 *** syrup was also prepared through similar instruction,BP syrup without plant extract was *** outcome induding IBS Symptom Severity Scale(IBS-SSS)questionnaire and secondary outcomes in terms of Hospital Anxiety and Depression(HADS)questionnaires,the Bristol Stool Form Scale(BSFS)were completed and evaluated at weeks 6 and 10,*** indices were collected at the end of the treatment and Common Terminology Criteria for Adverse Events v4.0(CTCAE)was used to evaluate the adverse *** The response to treatment was 84.4%(27/32)in the treatment group and 46.4%(13/28)in the placebo group,respectively(P=0.002).Compared with pre-treatment,a significant decrease was found on the IBS-SSS and BSFS scores after 6-week intervention in both groups(P0.05).Side effects reported in the treatment group included 2 cases of headache during the first week of the onset of the treatment,1 case of drowsiness,1 case of increase in menstrual bleeding,which did not result in discontinuation of the *** the placebo group,1 case of exacerbation of the disease was *** Anti-IBS syrup significantly reduced th

关键词： irritable bowel syndrome herbal medicine Persian medicine complementary medicine functional digestive disorders randomized controlled trial

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Gastrointestinal effects of Artemisia absinthium Linn. based on traditional Persian medicine and new studies

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Traditional Medicine Research 2020年第6期5卷 498-506页

作者： Hamide Khorram Pazhouh shokouhsadat hamedi Seyyed Musa-al-Reza Hosseini Ali Taghipour Behjat Javadi Mohammadreza Noras Faculty of Persian and Complementary Medicine Mashhad University of Medical SciencesMashhad School of Persian and Complementary Medicine Mashhad University of Medical SciencesMashhadIran Department of Gastroenterology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Faculty of Health Mashhad University of Medical SciencesMashhadIran School of Pharmacy Mashhad University of Medical SciencesMashhadIran Faculty of Persian Mashhad University of Medical SciencesMashhadIran

One of the most extensively used herbs in traditional Persian medicine (TPM) used in the treatment ofgastrointestinal (GI) disorders, is the plant Artemisia absinthium Linn. (AAL). It also has a wide range of activitiessuch as analgesic and anti-inflammatory, anti-oxidant, anti-fungal, and anti-bacterial activities, hepatoprotective,and neuroprotective activities in addition to having gastroprotective effects. This article is a review comparingTPM resources with new medicines. This review investigates this herb in major TPM sources and strives toextrapolate the exact function it serves in the digestive tract and compares the collected information on the functionof AAL with information found in new medical resource databases such as ISI, Pubmed, Scopus, Google Scholar,and Scientific Information Database. AAL from the Asteraceae family of TPM, known as Afsentin, was used in thetreatment of GI weaknesses, stomach pains, swellings, intestinal parasites, diarrhea, and vomiting. AAL increasedappetite, so it was used for insect repellents and insecticide. Recent studies have indicated that the effects of thisplant improved the symptoms of Crohn's disease and played a role in reducing inflammatory factors. It also hasstrong anti-parasitic, anti-insect, hepatoprotective, and antioxidant effects. Given the widespread use of AAL as atraditional medicine currently in use in different countries, particularly in the treatment of GI diseases, furtherclinical studies that focus on the therapeutic qualities of this plant are required in the future.

关键词： Medicinal plants Persian medicine Iranian traditional medicine Artemisia absinthium Linn. Gastrointestinal disorder

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